Running Title: Transcriptional Instability and Aging (2008)
Luigi A. Warren, Derrick J. Rossi, Geoffrey R. Schiebinger, Irving L. Weissman, Stuart K, Stephen R. Quake
It has been proposed that cumulating somatic mutations contribute to the aging process by disrupting the transcriptional networks which regulate cell structure and function. Experimental support for...
Dylla, Scott J, Oki, Masayuki, Heremans, Yves, Tolar, Jakub, Jiang, Yuehua, ...
For decades, in vitro expansion of transplantable hematopoietic stem cells (HSCs) has been an elusive goal. Here, we demonstrate that multipotent adult progenitor cells (MAPCs), isolated from green...
Inability to enter S phase and defective RNA polymerase II CTD phosphorylation in mice lacking Mat1
Rossi, Derrick J., Londesborough, Anou, Korsisaari, Nina, Pihlak, Arno, Lehtonen, Eero, Henkemeyer, Mark, ...
The trimeric Cdk7–cyclin H–Mat1 complex comprises the kinase subunit of basal transcription factor TFIIH and has been shown to function as a cyclin-dependent kinase (Cdk)-activating kinase....
Induction of cyclooxygenase-2 in a mouse model of Peutz–Jeghers polyposis
Rossi, Derrick J., Ylikorkala, Antti, Korsisaari, Nina, Salovaara, Reijo, Luukko, Keijo, Launonen, Virpi, ...
Inactivating germ-line mutations of LKB1 lead to Peutz–Jeghers syndrome (PJS). We have generated mice heterozygous for a targeted inactivating allele of Lkb1 and found that they develop severe...
Cell intrinsic alterations underlie hematopoietic stem cell aging
Rossi, Derrick J., Bryder, David, Zahn, Jacob M., Ahlenius, Henrik, Sonu, Rebecca, Wagers, Amy J., ...
Loss of immune function and an increased incidence of myeloid leukemia are two of the most clinically significant consequences of aging of the hematopoietic system. To better understand the...
The Histidine Triad Protein Hint Is Not Required for Murine Development or Cdk7 Function
Korsisaari, Nina, Rossi, Derrick J., Luukko, Keijo, Huebner, Kay, Henkemeyer, Mark, Mäkelä, Tomi P.
The histidine triad (HIT) protein Hint has been found to associate with mammalian Cdk7, as well as to interact both physically and genetically with the budding yeast Cdk7 homologue Kin28. To study...
Inability to enter S phase and defective RNA polymerase II CTD phosphorylation in mice lacking Mat1
Rossi, Derrick J., Londesborough, Anou, Korsisaari, Nina, Pihlak, Arno, Lehtonen, Eero, Henkemeyer, Mark, ...
The trimeric Cdk7–cyclin H–Mat1 complex comprises the kinase subunit of basal transcription factor TFIIH and has been shown to function as a cyclin-dependent kinase (Cdk)-activating kinase....
Induction of cyclooxygenase-2 in a mouse model of Peutz–Jeghers polyposis
Rossi, Derrick J., Ylikorkala, Antti, Korsisaari, Nina, Salovaara, Reijo, Luukko, Keijo, Launonen, Virpi, ...
Inactivating germ-line mutations of LKB1 lead to Peutz–Jeghers syndrome (PJS). We have generated mice heterozygous for a targeted inactivating allele of Lkb1 and found that they develop severe...
The Histidine Triad Protein Hint Is Not Required for Murine Development or Cdk7 Function
Korsisaari, Nina, Rossi, Derrick J., Luukko, Keijo, Huebner, Kay, Henkemeyer, Mark, Mäkelä, Tomi P.
The histidine triad (HIT) protein Hint has been found to associate with mammalian Cdk7, as well as to interact both physically and genetically with the budding yeast Cdk7 homologue Kin28. To study...
Cell intrinsic alterations underlie hematopoietic stem cell aging
Rossi, Derrick J., Bryder, David, Zahn, Jacob M., Ahlenius, Henrik, Sonu, Rebecca, Wagers, Amy J., ...
Loss of immune function and an increased incidence of myeloid leukemia are two of the most clinically significant consequences of aging of the hematopoietic system. To better understand the...
Hematopoietic Stem Cells : The Paradigmatic Tissue-Specific Stem Cell
Bryder, David, Rossi, Derrick J., Weissman, Irving L.
The recent prospective isolation of a wide variety of somatically derived stem cells has affirmed the notion that homeostatic maintenance of most tissues and organs is mediated by tissue-specific...
Bhattacharya, Deepta, Rossi, Derrick J., Bryder, David, Weissman, Irving L.
In the absence of irradiation or other cytoreductive conditioning, endogenous hematopoietic stem cells (HSCs) are thought to fill the unique niches within the bone marrow that allow maintenance of...
Serafini, Marta, Dylla, Scott J., Oki, Masayuki, Heremans, Yves, Tolar, Jakub, Jiang, Yuehua, ...
For decades, in vitro expansion of transplantable hematopoietic stem cells (HSCs) has been an elusive goal. Here, we demonstrate that multipotent adult progenitor cells (MAPCs), isolated from green...
Narala, Swami R., Allsopp, Richard C., Wells, Trystan B., Zhang, Guanglei, Prasad, Prerna, Coussens, Matthew J., ...
SIRT1, the mammalian homolog of SIR2 in Saccharomyces cerevisiae, is an NAD-dependent deacetylase implicated in regulation of lifespan. By designing effective short hairpin RNAs and a silent...
Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development
Müller, Martin R., Sasaki, Yoshiteru, Stevanovic, Irena, Lamperti, Edward D., Ghosh, Srimoyee, Sharma, Sonia, ...
NFAT transcription factors are highly phosphorylated proteins residing in the cytoplasm of resting cells. Upon dephosphorylation by the phosphatase calcineurin, NFAT proteins translocate to the...