B Cell IgD Deletion Prevents Alveolar Bone Loss Following Murine Oral Infection (2009)
Pamela J. Baker, Nicole Ryan Boutaugh, Michaela Tiffany, Derry C. Roopenian
Periodontal disease is one of the most common infectious diseases of humans. Immune responses to infection trigger loss of alveolar bone from the jaw and eventual tooth loss. We investigated the...
B Cell IgD Deletion Prevents Alveolar Bone Loss Following Murine Oral Infection (2009)
Pamela J. Baker, Nicole Ryan Boutaugh, Michaela Tiffany, Derry C. Roopenian
Periodontal disease is one of the most common infectious diseases of humans. Immune responses to infection trigger loss of alveolar bone from the jaw and eventual tooth loss. We investigated the...
Petkova, Stefka B., Akilesh, Shreeram, Sproule, Thomas J., Christianson, Gregory J., Al Khabbaz, Hana, Brown, Aaron C., ...
The MHC class I-like Fc receptor FcRn plays an essential role in extending the half-life (t1/2) of IgG antibodies and IgG-Fc-based therapeutics in the circulation. The goal of this study was to...
Petkova, Stefka B., Akilesh, Shreeram, Sproule, Thomas J., Christianson, Gregory J., Al Khabbaz, Hana, Brown, Aaron C., ...
The MHC class I-like Fc receptor FcRn plays an essential role in extending the half-life (t1/2) of IgG antibodies and IgG-Fc-based therapeutics in the circulation. The goal of this study was to...
Searching QTL by gene expression: analysis of diabesity (2005)
Brown, Aaron C, Olver, William I, Donnelly, Charles J, May, Marjorie E, Naggert, Jürgen K, Shaffer, Daniel J, ...
Abstract Background Recent developments in sequence databases provide the opportunity to relate the expression pattern of genes to their genomic position, thus creating a transcriptome map....
Ikeda, Akihiro, Zheng, Qing Yin, Rosenstiel, Philip, Maddatu, Terry, Zuberi, Aamir R., Roopenian, Derry C., ...
Quantitative trait locus (QTL) analysis of genetic crosses has proven to be a useful tool for identifying loci associated with specific phenotypes and for dissecting genetic components of complex...
Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice (1997)
Christianson, Sherri W., Greiner, Dale L., Hesselton, RuthAnn M., Leif, Jean H., Wagar, Eric James, Schweitzer, Isabelle B., ...
Genetic crosses produced NOD/LtSz mice doubly homozygous for the severe combined immunodeficiency (scid) mutation and the beta2m (B2m) null allele. Both NOD/LtSz-scid/scid and NOD/LtSz-scid/scid...
DiLorenzo, Teresa P., Graser, Robert T., Ono, Toshiro, Christianson, Gregory J., Chapman, Harold D., Roopenian, Derry C., ...
Nonobese diabetic (NOD) mice develop insulin-dependent diabetes mellitus due to autoimmune T lymphocyte-mediated destruction of pancreatic β cells. Although both major histocompatibility complex...
Fleming, Robert E., Holden, Christopher C., Tomatsu, Shunji, Waheed, Abdul, Brunt, Elizabeth M., Britton, Robert S., ...
Hereditary hemochromatosis (HH) is a common disorder of iron metabolism caused by mutation in HFE, a gene encoding an MHC class I-like protein. Clinical studies demonstrate that the severity of iron...
Sproule, Thomas J., Jazwinska, Elizabeth C., Britton, Robert S., Bacon, Bruce R., Fleming, Robert E., Sly, William S., ...
Hereditary hemochromatosis (HH) is a common chronic human genetic disorder whose hallmark is systemic iron overload. Homozygosity for a mutation in the MHC class I heavy chain paralogue gene HFE has...
Baker, Pamela J., Dixon, Mark, Evans, R. Todd, Dufour, Lisa, Johnson, Ellis, Roopenian, Derry C.
In this study, we used a mouse model to examine the role of the adaptive immune response in alveolar bone loss induced by oral infection with the human gram-negative anaerobic bacterium Porphyromonas...
Adhesion Molecule Deficiencies Increase Porphyromonas gingivalis-Induced Alveolar Bone Loss in Mice
Baker, Pamela J., DuFour, Lisa, Dixon, Mark, Roopenian, Derry C.
Alveolar bone resorption can be induced in specific-pathogen-free mice by oral infection with Porphyromonas gingivalis (P. J. Baker, R. T. Evans, and D. C. Roopenian, Arch. Oral Biol. 39:1035–1040,...
Genetic Control of Susceptibility to Porphyromonas gingivalis-Induced Alveolar Bone Loss in Mice
Baker, Pamela J., Dixon, Mark, Roopenian, Derry C.
Periodontal disease affects a large percentage of the human population. Resorption of the alveolar bone of the jaw is a pivotal sequela of periodontal disease, because this bone is the attachment...
Searching QTL by gene expression: analysis of diabesity
Brown, Aaron C, Olver, William I, Donnelly, Charles J, May, Marjorie E, Naggert, Jürgen K, Shaffer, Daniel J, ...
Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases
Li, Ning, Zhao, Minglang, Hilario-Vargas, Julio, Prisayanh, Phillip, Warren, Simon, Diaz, Luis A., ...
Numerous mechanisms of action have been proposed for intravenous Ig (IVIG). In this study, we used IgG passive transfer murine models of bullous pemphigoid (BP), pemphigus foliaceus (PF), and...
Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria
Yoshida, Masaru, Kobayashi, Kanna, Kuo, Timothy T., Bry, Lynn, Glickman, Jonathan N., Claypool, Steven M., ...
The neonatal Fc receptor for IgG (FcRn) plays a major role in regulating host IgG levels and transporting IgG and associated antigens across polarized epithelial barriers. Selective expression of...
DiLorenzo, Teresa P., Graser, Robert T., Ono, Toshiro, Christianson, Gregory J., Chapman, Harold D., Roopenian, Derry C., ...
Nonobese diabetic (NOD) mice develop insulin-dependent diabetes mellitus due to autoimmune T lymphocyte-mediated destruction of pancreatic β cells. Although both major histocompatibility complex...
Fleming, Robert E., Holden, Christopher C., Tomatsu, Shunji, Waheed, Abdul, Brunt, Elizabeth M., Britton, Robert S., ...
Hereditary hemochromatosis (HH) is a common disorder of iron metabolism caused by mutation in HFE, a gene encoding an MHC class I-like protein. Clinical studies demonstrate that the severity of iron...
Sproule, Thomas J., Jazwinska, Elizabeth C., Britton, Robert S., Bacon, Bruce R., Fleming, Robert E., Sly, William S., ...
Hereditary hemochromatosis (HH) is a common chronic human genetic disorder whose hallmark is systemic iron overload. Homozygosity for a mutation in the MHC class I heavy chain paralogue gene HFE has...
Baker, Pamela J., Dixon, Mark, Evans, R. Todd, Dufour, Lisa, Johnson, Ellis, Roopenian, Derry C.
In this study, we used a mouse model to examine the role of the adaptive immune response in alveolar bone loss induced by oral infection with the human gram-negative anaerobic bacterium Porphyromonas...
Adhesion Molecule Deficiencies Increase Porphyromonas gingivalis-Induced Alveolar Bone Loss in Mice
Baker, Pamela J., DuFour, Lisa, Dixon, Mark, Roopenian, Derry C.
Alveolar bone resorption can be induced in specific-pathogen-free mice by oral infection with Porphyromonas gingivalis (P. J. Baker, R. T. Evans, and D. C. Roopenian, Arch. Oral Biol. 39:1035–1040,...
Genetic Control of Susceptibility to Porphyromonas gingivalis-Induced Alveolar Bone Loss in Mice
Baker, Pamela J., Dixon, Mark, Roopenian, Derry C.
Periodontal disease affects a large percentage of the human population. Resorption of the alveolar bone of the jaw is a pivotal sequela of periodontal disease, because this bone is the attachment...
Searching QTL by gene expression: analysis of diabesity
Brown, Aaron C, Olver, William I, Donnelly, Charles J, May, Marjorie E, Naggert, Jürgen K, Shaffer, Daniel J, ...
Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases
Li, Ning, Zhao, Minglang, Hilario-Vargas, Julio, Prisayanh, Phillip, Warren, Simon, Diaz, Luis A., ...
Numerous mechanisms of action have been proposed for intravenous Ig (IVIG). In this study, we used IgG passive transfer murine models of bullous pemphigoid (BP), pemphigus foliaceus (PF), and...
Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria
Yoshida, Masaru, Kobayashi, Kanna, Kuo, Timothy T., Bry, Lynn, Glickman, Jonathan N., Claypool, Steven M., ...
The neonatal Fc receptor for IgG (FcRn) plays a major role in regulating host IgG levels and transporting IgG and associated antigens across polarized epithelial barriers. Selective expression of...
Petkova, Stefka B., Konstantinov, Konstantin N., Sproule, Thomas J., Lyons, Bonnie L., Awwami, Moheeb Al, Roopenian, Derry C.
Rheumatoid arthritis (RA) is a complex autoimmune disease with a poorly understood pathogenesis. The disease is associated with polyclonal B cell activation and the production of autoantibodies...
Yan, Jingbo, Parekh, Vrajesh V., Mendez-Fernandez, Yanice, Olivares-Villagómez, Danyvid, Dragovic, Srdjan, Hill, Timothy, ...
Endoplasmic reticulum (ER)-associated aminopeptidase (ERAP)1 has been implicated in the final proteolytic processing of peptides presented by major histocompatibility complex (MHC) class I molecules....
Zhang, Jian Qiao, Okumura, Cheryl, McCarty, Thomas, Shin, Min Sun, Mukhopadhyay, Partha, Hori, Mitsuo, ...
Germline mutations in Fas and Fasl induce nonmalignant T cell hyperplasia and systemic autoimmunity and also greatly increase the risk of B cell neoplasms. B lymphomas occurring in Fasl mutant (gld)...
Chaudhury, Chaity, Mehnaz, Samina, Robinson, John M., Hayton, William L., Pearl, Dennis K., Roopenian, Derry C., ...
The inverse relationship between serum albumin concentration and its half-life suggested to early workers that albumin would be protected from a catabolic fate by a receptor-mediated mechanism much...
β2-microglobulin–deficient Mice Are Resistant to Bullous Pemphigoid
Liu, Zhi, Roopenian, Derry C., Zhou, Xiaoye, Christianson, Greg J., Diaz, Luis A., Sedmak, Daniel D., ...
Recent understanding of the mechanism of immunoglobulin G (IgG) catabolism has yielded new insight into antibody-mediated diseases. We proposed that β2-microglobulin (β2m)–deficient mice have...
Podocytes use FcRn to clear IgG from the glomerular basement membrane
Akilesh, Shreeram, Huber, Tobias B., Wu, Hui, Wang, Gary, Hartleben, Björn, Kopp, Jeffrey B., ...
The glomerular filtration barrier prevents large serum proteins from being lost into the urine. It is not known, however, why the filter does not routinely clog with large proteins that enter the...
Dependence of antibody-mediated presentation of antigen on FcRn
Qiao, Shuo-Wang, Kobayashi, Kanna, Johansen, Finn-Eirik, Sollid, Ludvig M., Andersen, Jan Terje, Milford, Edgar, ...
The neonatal Fc receptor for IgG (FcRn) is a distant member of the MHC class I protein family. It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them...
Bubier, Jason A., Sproule, Thomas J., Foreman, Oded, Spolski, Rosanne, Shaffer, Daniel J., Morse, Herbert C., ...
Interleukin 21 (IL-21) is a pleiotropic cytokine produced by CD4 T cells that affects the differentiation and function of T, B, and NK cells by binding to a receptor consisting of the common cytokine...
Petkova, Stefka B., Yuan, Rong, Tsaih, Shirng-Wern, Schott, William, Roopenian, Derry C., Paigen, Beverly
Inbred mouse strains are routinely used as genetically defined animal models for studying a wide assortment of biological and pathological processes, including immune system function. However, no...
B Cell IgD Deletion Prevents Alveolar Bone Loss Following Murine Oral Infection
Baker, Pamela J., Boutaugh, Nicole Ryan, Tiffany, Michaela, Roopenian, Derry C.
Periodontal disease is one of the most common infectious diseases of humans. Immune responses to infection trigger loss of alveolar bone from the jaw and eventual tooth loss. We investigated the...