Diana S. Hansen

CXCR3 determines strain susceptibility to murine cerebral malaria by mediating T lymphocyte migration toward IFN-gamma-induced chemokines (2008)

Van Aelst, Ilse, Martens, Erik, ...

Cerebral malaria (CM) results from the binding of infected erythrocytes and leukocytes to brain endothelia. The precise mechanisms underlying lymphocyte recruitment and activation in CM remain...

Blood-stage Plasmodium infection induces CD+ T lymphocytes to parasite-expressed antigens, largely regulated by CDα+ dendritic cells (2008)

Lundie, Rachel J., Davey, Gayle M., Nie, Catherine Q., Hansen, Diana S., Lau, Lei Shong, ...

Although CD8+ T cells do not contribute to protection against the blood stage of Plasmodium infection, there is mounting evidence that they are principal mediators of murine experimental cerebral...

The Natural Killer Complex Regulates Severe Malarial Pathogenesis and Influences Acquired Immune Responses to Plasmodium berghei ANKA

Hansen, Diana S., Evans, Krystal J., D'Ombrain, Marthe C., Bernard, Nicholas J., Sexton, Adrienne C., Buckingham, Lynn, ...

The natural killer complex (NKC) is a genetic region of highly linked genes encoding several receptors involved in the control of NK cell function. The NKC is highly polymorphic, and allelic...

The Natural Killer Complex Regulates Severe Malarial Pathogenesis and Influences Acquired Immune Responses to Plasmodium berghei ANKA

Hansen, Diana S., Evans, Krystal J., D'Ombrain, Marthe C., Bernard, Nicholas J., Sexton, Adrienne C., Buckingham, Lynn, ...

The natural killer complex (NKC) is a genetic region of highly linked genes encoding several receptors involved in the control of NK cell function. The NKC is highly polymorphic, and allelic...

Severe malarial anemia of low parasite burden in rodent models results from accelerated clearance of uninfected erythrocytes

Evans, Krystal J., Hansen, Diana S., Van Rooijen, Nico, Buckingham, Lynn A., Schofield, Louis

Severe malarial anemia (SMA) is the most frequent life-threatening complication of malaria and may contribute to the majority of malarial deaths worldwide. To explore the mechanisms of pathogenesis,...

CD4+ CD25+ Regulatory T Cells Suppress CD4+ T-Cell Function and Inhibit the Development of Plasmodium berghei-Specific TH1 Responses Involved in Cerebral Malaria Pathogenesis▿

Nie, Catherine Q., Bernard, Nicholas J., Schofield, Louis, Hansen, Diana S.

The infection of mice with Plasmodium berghei ANKA constitutes the best available mouse model for human Plasmodium falciparum-mediated cerebral malaria, a devastating neurological syndrome that kills...

Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells

Caminschi, Irina, Ahmet, Fatma, Heger, Klaus, Brady, Jason, Nutt, Stephen L., Vremec, David, ...

Interferon-producing killer dendritic cells (IKDCs) have been described as possessing the lytic potential of NK cells and the antigen-presenting capacity of dendritic cells (DCs). In this study, we...

Blood-stage Plasmodium infection induces CD8+ T lymphocytes to parasite-expressed antigens, largely regulated by CD8α+ dendritic cells

Lundie, Rachel J., Davey, Gayle M., Nie, Catherine Q., Hansen, Diana S., Lau, Lei Shong, ...

Although CD8+ T cells do not contribute to protection against the blood stage of Plasmodium infection, there is mounting evidence that they are principal mediators of murine experimental cerebral...

IP-10-Mediated T Cell Homing Promotes Cerebral Inflammation over Splenic Immunity to Malaria Infection

Nie, Catherine Q., Bernard, Nicholas J., Norman, M. Ursula, Amante, Fiona H., Lundie, Rachel J., Crabb, Brendan S., ...

Plasmodium falciparum malaria causes 660 million clinical cases with over 2 million deaths each year. Acquired host immunity limits the clinical impact of malaria infection and provides protection...