Inhibition of Alpha Interferon Signaling by Hepatitis B Virus▿
Christen, Verena, Duong, Francois, Bernsmeier, Christine, Sun, Dianxing, Nassal, Michael, Heim, Markus H.
Alpha interferon (IFN-α) and pegylated IFN-α (pegIFN-α) are used for the treatment of chronic hepatitis B (CHB). Unfortunately, only a minority of patients can be cured. The mechanisms responsible...
The Level of Viral Antigen Presented by Hepatocytes Influences CD8 T-Cell Function▿
Gehring, Adam J., Sun, Dianxing, Kennedy, Patrick T. F., Nolte-'t Hoen, Esther, Lim, Seng Gee, Wasser, Shanthi, ...
CD8 T cells exert their antiviral function through cytokines and lysis of infected cells. Because hepatocytes are susceptible to noncytolytic mechanisms of viral clearance, CD8 T-cell antiviral...