Rok Frlan, Andreja KovaÄÂ, Didier Blanot, Stanislav Gobec, Slavko PeÄÂar, AleÅ¡ Obreza
A series of novel N-benzylidenesulfonohydrazide compounds were designedand synthesized as inhibitors of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) andUDP-N-acetylmuramoyl-L-alanine:D-glutamate...
Fraipont, Claudine, Sapunaric, Frédéric, Zervosen, Astrid, Auger, Geneviève, Devreese, Bart, Lioux, Thierry, ...
The glycosyl transferase of the Escherichia coli bifunctional penicillin-binding protein (PBP) 1b catalyzes the assembly of lipid-transported...
Travassos, Leonardo H, Girardin, Stephen E, Philpott, Dana J, Blanot, Didier, Nahori, Marie-Anne, Werts, Catherine, ...
Toll-like receptor 2 (TLR2) has been shown to recognize several classes of pathogen-associated molecular patterns including peptidoglycan (PG). However, studies linking PG with TLR2 recognition have...
Travassos, Leonardo H, Girardin, Stephen E, Philpott, Dana J, Blanot, Didier, Nahori, Marie-Anne, Werts, Catherine, ...
Toll-like receptor 2 (TLR2) has been shown to recognize several classes of pathogen-associated molecular patterns including peptidoglycan (PG). However, studies linking PG with TLR2 recognition have...
Mengin-Lecreulx, Dominique, Falla, Tim, Blanot, Didier, Van Heijenoort, Jean, Adams, David J., Chopra, Ian
The monomer units in the Escherichia coli and Staphylococcus aureus cell wall peptidoglycans differ in the nature of the third amino acid in the l-alanyl-γ-d-glutamyl-X-d-alanyl-d-alanine side...
Hesse, Lars, Bostock, Julieanne, Dementin, Sebastien, Blanot, Didier, Mengin-Lecreulx, Dominique, Chopra, Ian
Chlamydiae are unusual obligate intracellular bacteria that cause serious infections in humans. Chlamydiae contain genes that appear to encode products with peptidoglycan biosynthetic activity. The...
Fluorescence Detection-Based Functional Assay for High-Throughput Screening for MraY
Stachyra, Thérèse, Dini, Christophe, Ferrari, Paul, Bouhss, Ahmed, Van Heijenoort, Jean, Mengin-Lecreulx, Dominique, ...
We have developed a novel assay specific to MraY, which catalyzes the first membrane step in the biosynthesis of bacterial cell wall peptidoglycan. This was accomplished by using...
Glycopeptide Resistance vanA Operons in Paenibacillus Strains Isolated from Soil
Guardabassi, Luca, Perichon, Bruno, Van Heijenoort, Jean, Blanot, Didier, Courvalin, Patrice
The sequence and gene organization of the van operons in vancomycin (MIC of >256 μg/ml)- and teicoplanin (MIC of ≥32 μg/ml)-resistant Paenibacillus thiaminolyticus PT-2B1 and Paenibacillus...
Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition
Travassos, Leonardo H, Girardin, Stephen E, Philpott, Dana J, Blanot, Didier, Nahori, Marie-Anne, Werts, Catherine, ...
Toll-like receptor 2 (TLR2) has been shown to recognize several classes of pathogen-associated molecular patterns including peptidoglycan (PG). However, studies linking PG with TLR2 recognition have...
Mengin-Lecreulx, Dominique, Falla, Tim, Blanot, Didier, Van Heijenoort, Jean, Adams, David J., Chopra, Ian
The monomer units in the Escherichia coli and Staphylococcus aureus cell wall peptidoglycans differ in the nature of the third amino acid in the l-alanyl-γ-d-glutamyl-X-d-alanyl-d-alanine side...
Hesse, Lars, Bostock, Julieanne, Dementin, Sebastien, Blanot, Didier, Mengin-Lecreulx, Dominique, Chopra, Ian
Chlamydiae are unusual obligate intracellular bacteria that cause serious infections in humans. Chlamydiae contain genes that appear to encode products with peptidoglycan biosynthetic activity. The...
Fluorescence Detection-Based Functional Assay for High-Throughput Screening for MraY
Stachyra, Thérèse, Dini, Christophe, Ferrari, Paul, Bouhss, Ahmed, Van Heijenoort, Jean, Mengin-Lecreulx, Dominique, ...
We have developed a novel assay specific to MraY, which catalyzes the first membrane step in the biosynthesis of bacterial cell wall peptidoglycan. This was accomplished by using...
Glycopeptide Resistance vanA Operons in Paenibacillus Strains Isolated from Soil
Guardabassi, Luca, Perichon, Bruno, Van Heijenoort, Jean, Blanot, Didier, Courvalin, Patrice
The sequence and gene organization of the van operons in vancomycin (MIC of >256 μg/ml)- and teicoplanin (MIC of ≥32 μg/ml)-resistant Paenibacillus thiaminolyticus PT-2B1 and Paenibacillus...
Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition
Travassos, Leonardo H, Girardin, Stephen E, Philpott, Dana J, Blanot, Didier, Nahori, Marie-Anne, Werts, Catherine, ...
Toll-like receptor 2 (TLR2) has been shown to recognize several classes of pathogen-associated molecular patterns including peptidoglycan (PG). However, studies linking PG with TLR2 recognition have...
Hervé, Mireille, Boniface, Audrey, Gobec, Stanislav, Blanot, Didier, Mengin-Lecreulx, Dominique
The UDP-N-acetylmuramate:l-alanyl-γ-d-glutamyl-meso-diaminopimelate ligase (murein peptide ligase [Mpl]) is known to be a recycling enzyme allowing reincorporation into peptidoglycan (murein) of the...
The GTPase CpgA Is Implicated in the Deposition of the Peptidoglycan Sacculus in Bacillus subtilis▿
Absalon, Cédric, Hamze, Kassem, Blanot, Didier, Frehel, Claude, Carballido-Lopez, Rut, Holland, Barry I., ...
Depletion of the Bacillus subtilis GTPase CpgA produces abnormal cell shapes, nonuniform deposition of cell wall, and five- to sixfold accumulation of peptidoglycan precursors. Nevertheless, the...
Marr, Nico, Tirsoaga, Alina, Blanot, Didier, Fernandez, Rachel, Caroff, Martine
Endotoxins are amphipathic lipopolysaccharides (LPSs), major constituents of the outer membrane of gram-negative bacteria. They consist of a lipid region, covalently linked to a core oligosaccharide,...
Lavollay, Marie, Arthur, Michel, Fourgeaud, Martine, Dubost, Lionel, Marie, Arul, Veziris, Nicolas, ...
Our understanding of the mechanisms used by Mycobacterium tuberculosis to persist in a “dormant” state is essential to the development of therapies effective in sterilizing tissues. Gene...
Bui, Nhat Khai, Gray, Joe, Schwarz, Heinz, Schumann, Peter, Blanot, Didier, Vollmer, Waldemar
Upon nutrient limitation cells of the swarming soil bacterium Myxococcus xanthus form a multicellular fruiting body in which a fraction of the cells develop into myxospores. Spore development...