Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modifications (2009)
Barde, Isabelle, Laurenti, Elisa, Verp, Sonia, Groner, Anna Claire, Towne, Christopher, Padrun, Viviane, ...
KAP1 is an essential cofactor of KRAB zinc finger proteins, a family of vertebrate-specific epigenetic repressors of largely unknown functions encoded in the hundreds by the mouse and human genomes....
Meyer, Kathrin, Marquis, Julien, Trüb, Judith, Nlend Nlend, Rachel, Verp, Sonia, Ruepp, Marc-David, ...
In spinal muscular atrophy (SMA), the leading genetic cause of early childhood death, the survival motor neuron 1 gene (SMN1) is deleted or inactivated. The nearly identical SMN2 gene has a silent...
Characterization of APOBEC3G binding to 7SL RNA. (2008)
Bach, Daniel, Peddy, Shyam, Mangeat, Bastien, Lakkaraju, A, Strub, K, Trono, Didier
ABSTRACT: Human APOBEC3 proteins are editing enzymes that can interfere with the replication of exogenous retroviruses such as human immunodeficiency virus (HIV), hepadnaviruses such as hepatitis B...
Diaz-Griffero, F, Perron, M, McGee-Estrada, K, Hanna, R, Maillard, Pierre V, Trono, Didier, ...
Human TRIM5alpha restricts N-tropic murine leukemia virus (N-MLV) but not B-tropic MLV (B-MLV) infection. Here we study B30.2/SPRY domain mutants of human TRIM5alpha that acquire the ability to...
Dayer, Alexandre G., Jenny, Benoit, Sauvain, Marc-Olivier, Potter, Gael, Salmon, Patrick, Zgraggen, Eloisa, ...
Strategies to enhance the capacity of grafted stem/progenitors cells to generate multipotential, proliferative and migrating pools of cells in the postnatal brain could be crucial for structural...
Ariumi, Yasuo, Serhan, Fatima, Turelli, Priscilla, Telenti, Amalio, Trono, Didier
Integration of human immunodeficiency virus type 1 (HIV-1) into the host genome is catalyzed by the viral integrase (IN) and preferentially occurs within transcriptionally active genes. During the...
Contribution of proteoglycans to human immunodeficiency virus type 1 brain invasion (2004)
Salmon, Patrick, Wang, Lianchun, Esko, Jeffrey D, Gabuzda, Dana, Fiala, Milan, ...
As a neurotropic virus, human immunodeficiency virus type 1 (HIV-1) invades the brain and causes severe neuronal, astrocyte, and myelin damage in AIDS patients. To gain access to the brain, HIV-1...