Katzen, Federico, Ferreiro, Diego U., Oddo, Cristian G., Ielmini, M. Verónica, Becker, Anke, Pühler, Alfred, ...
Xanthan is an industrially important exopolysaccharide produced by the phytopathogenic, gram-negative bacterium Xanthomonas campestris pv. campestris. It is composed of polymerized pentasaccharide...
Katzen, Federico, Ferreiro, Diego U., Oddo, Cristian G., Ielmini, M. Verónica, Becker, Anke, Pühler, Alfred, ...
Xanthan is an industrially important exopolysaccharide produced by the phytopathogenic, gram-negative bacterium Xanthomonas campestris pv. campestris. It is composed of polymerized pentasaccharide...
Ferreiro, Diego U., Walczak, Aleksandra M., Komives, Elizabeth A., Wolynes, Peter G.
Repeat-proteins are made up of near repetitions of 20– to 40–amino acid stretches. These polypeptides usually fold up into non-globular, elongated architectures that are stabilized by the...
Consequences of localized frustration for the folding mechanism of the IM7 protein
Sutto, Ludovico, Lätzer, Joachim, Hegler, Joseph A., Ferreiro, Diego U., Wolynes, Peter G.
In the laboratory, IM7 has been found to have an unusual folding mechanism in which an “on-pathway” intermediate with nonnative interactions is formed. We show that this intermediate is a...
Localizing frustration in native proteins and protein assemblies
Ferreiro, Diego U., Hegler, Joseph A., Komives, Elizabeth A., Wolynes, Peter G.
We propose a method of quantifying the degree of frustration manifested by spatially local interactions in protein biomolecules. This method of localization smoothly generalizes the global criterion...
Transition state for protein–DNA recognition
Ferreiro, Diego U., Sánchez, Ignacio E., De Prat Gay, Gonzalo
We describe the formation of protein–DNA contacts in the two-state route for DNA sequence recognition by a transcriptional regulator. Surprisingly, direct sequence readout establishes in the...