Diego Vergani

Mimicry Between the Hepatitis B Virus DNA Polymerase and the Antigenic Targets of Nuclear and Smooth Muscle Antibodies in Chronic Hepatitis B Virus Infection 1 (2008)

Germana V. Gregorio, Kaushik Choudhuri, Yun Ma, Angela Vegnente, Giorgina Mieli-vergani, Diego Vergani

Autoantibodies to nuclear and smooth muscle are common in hepatitis B virus (HBV) infection. To understand their origin, we scanned protein databases and found that HBV-DNA polymerase (HBV-pol)...

A Study of Molecular Mimicry and Immunological Cross-reactivity between Hepatitis B Surface Antigen and Myelin Mimics (2005)

Dimitrios-Petrou Bogdanos, Heather Smith, Yun Ma, Harold Baum, Giorgina Mieli-Vergani, Diego Vergani

On the basis of the reported association between hepatitis B vaccination (HBvacc) and autoimmune demyelinating complications such as multiple sclerosis (MS), we have looked for aminoacid similarities...

A Study of Molecular Mimicry and Immunological Cross-reactivity between Hepatitis B Surface Antigen and Myelin Mimics (2005)

Dimitrios-Petrou Bogdanos, Heather Smith, Yun Ma, Harold Baum, Giorgina Mieli-Vergani, Diego Vergani

On the basis of the reported association between hepatitis B vaccination (HBvacc) and autoimmune demyelinating complications such as multiple sclerosis (MS), we have looked for aminoacid similarities...

Antibodies to soluble liver antigen and α-enolase in patients with autoimmune hepatitis (2004)

Bogdanos, Dimitrios-Petrou, Gilbert, Daniele, Bianchi, Ilaria, Leoni, Simona, Mitry, Ragai R, Ma, Yun, ...

Abstract Background Antibodies to a cytosolic soluble liver antigen (SLA) are specifically detected in patients with autoimmune hepatitis (AIH). The target of anti-SLA has been identified as a ~50...

Antibodies to soluble liver antigen and alpha-enolase in patients with autoimmune hepatitis. (2004)

Bogdanos, Dimitrios-Petrou, Gilbert, Daniele, Bianchi, Ilaria, Leoni, Simona, Mitry, Ragai, Ma, Yun, ...

BACKGROUND: Antibodies to a cytosolic soluble liver antigen (SLA) are specifically detected in patients with autoimmune hepatitis (AIH). The target of anti-SLA has been identified as a ~50 kDa UGA...

Antibodies to soluble liver antigen and alpha-enolase in patients with autoimmune hepatitis. (2004)

Bogdanos, Dimitrios-Petrou, Gilbert, Daniele, Bianchi, Ilaria, Leoni, Simona, Mitry, Ragai, Ma, Yun, ...

BACKGROUND: Antibodies to a cytosolic soluble liver antigen (SLA) are specifically detected in patients with autoimmune hepatitis (AIH). The target of anti-SLA has been identified as a ~50 kDa UGA...

Antibodies to soluble liver antigen and alpha-enolase in patients with autoimmune hepatitis. (2004)

Bogdanos, Dimitrios-Petrou, Gilbert, Daniele, Bianchi, Ilaria, Leoni, Simona, Mitry, Ragai, Ma, Yun, ...

BACKGROUND: Antibodies to a cytosolic soluble liver antigen (SLA) are specifically detected in patients with autoimmune hepatitis (AIH). The target of anti-SLA has been identified as a ~50 kDa UGA...

Antibodies to soluble liver antigen and alpha-enolase in patients with autoimmune hepatitis. (2004)

Bogdanos, Dimitrios-Petrou, Gilbert, Daniele, Bianchi, Ilaria, Leoni, Simona, Mitry, Ragai, Ma, Yun, ...

BACKGROUND: Antibodies to a cytosolic soluble liver antigen (SLA) are specifically detected in patients with autoimmune hepatitis (AIH). The target of anti-SLA has been identified as a ~50 kDa UGA...

A Study of Molecular Mimicry and Immunological Cross-reactivity between Hepatitis B Surface Antigen and Myelin Mimics

Bogdanos, Dimitrios-Petrou, Smith, Heather, Ma, Yun, Baum, Harold, Mieli-Vergani, Giorgina, Vergani, Diego

On the basis of the reported association between hepatitis B vaccination (HBvacc) and autoimmune demyelinating complications such as multiple sclerosis (MS), we have looked for aminoacid similarities...

The Role of Virus-Specific Cd8+ Cells in Liver Damage and Viral Control during Persistent Hepatitis B Virus Infection

Maini, Mala K., Boni, Carolina, Lee, Chun Kyon, Larrubia, Juan R., Reignat, Stephanie, Ogg, Graham S., ...

Hepatitis B virus (HBV) is a noncytopathic virus, and the recognition of infected hepatocytes by HBV-specific CD8 cells has been assumed to be the central mechanism causing both liver damage and...

Aetiopathogenesis of autoimmune hepatitis

Vergani, Diego, Mieli-Vergani, Giorgina

The histological hallmark of autoimmune hepatitis (AIH) is a dense portal mononuclear cell infiltrate that invades the surrounding parenchyma and comprises T and B lymphocytes, macrophages, and...

Autoimmune paediatric liver disease

Mieli-Vergani, Giorgina, Vergani, Diego

Liver disorders with a likely autoimmune pathogenesis in childhood include autoimmune hepatitis (AIH), autoimmune sclerosing cholangitis (ASC), and de novo AIH after liver transplantation. AIH is...

Autoimmune liver serology: Current diagnostic and clinical challenges

Bogdanos, Dimitrios P, Invernizzi, Pietro, Mackay, Ian R, Vergani, Diego

Liver-related autoantibodies are crucial for the correct diagnosis and classification of autoimmune liver diseases (AiLD), namely autoimmune hepatitis types 1 and 2 (AIH-1 and 2), primary biliary...