Dietmar Gradl

Cold-inducible RNA binding protein (CIRP), a novel XTcf-3 specific target gene regulates neural development in Xenopus (2008)

Van Venrooy, Stephanie, Fichtner, Dagmar, Kunz, Martin, Wedlich, Doris, Gradl, Dietmar

Abstract Background As nuclear mediators of wnt/β-catenin signaling, Lef/Tcf transcription factors play important roles in development and disease. Although it is well established, that the four...

Reduced U snRNP assembly causes motor axon degeneration in an animal model for spinal muscular atrophy (2005)

Winkler, Christoph, Eggert, Christian, Gradl, Dietmar, Meister, Gunter, Giegerich, Marieke, Wedlich, Doris, ...

Spinal muscular atrophy (SMA) is a motoneuron disease caused by reduced levels of survival motoneuron (SMN) protein. Previous studies have assigned SMN to uridine-rich small nuclear ribonucleoprotein...

The Wnt/Wg Signal Transducer β-Catenin Controls Fibronectin Expression

Gradl, Dietmar, Kühl, Michael, Wedlich, Doris

β-Catenin stabilizes the cadherin cell adhesion complex but, as a component of the Wnt/Wg signaling pathway, also controls gene expression by forming a heterodimer with a transcription factor of the...

Reduced U snRNP assembly causes motor axon degeneration in an animal model for spinal muscular atrophy

Winkler, Christoph, Eggert, Christian, Gradl, Dietmar, Meister, Gunter, Giegerich, Marieke, Wedlich, Doris, ...

Spinal muscular atrophy (SMA) is a motoneuron disease caused by reduced levels of survival motoneuron (SMN) protein. Previous studies have assigned SMN to uridine-rich small nuclear ribonucleoprotein...

The Wnt/Wg Signal Transducer β-Catenin Controls Fibronectin Expression

Gradl, Dietmar, Kühl, Michael, Wedlich, Doris

β-Catenin stabilizes the cadherin cell adhesion complex but, as a component of the Wnt/Wg signaling pathway, also controls gene expression by forming a heterodimer with a transcription factor of the...

Reduced U snRNP assembly causes motor axon degeneration in an animal model for spinal muscular atrophy

Winkler, Christoph, Eggert, Christian, Gradl, Dietmar, Meister, Gunter, Giegerich, Marieke, Wedlich, Doris, ...

Spinal muscular atrophy (SMA) is a motoneuron disease caused by reduced levels of survival motoneuron (SMN) protein. Previous studies have assigned SMN to uridine-rich small nuclear ribonucleoprotein...

β-Arrestin is a necessary component of Wnt/β-catenin signaling in vitro and in vivo

Bryja, Vítězslav, Gradl, Dietmar, Schambony, Alexandra, Arenas, Ernest, Schulte, Gunnar

The Wnt/β-catenin signaling pathway is crucial for proper embryonic development and tissue homeostasis. The phosphoprotein dishevelled (Dvl) is an integral part of Wnt signaling and has recently...