ATG deserts define a novel core promoter subclass (2005)
Lee, Maxwell P., Howcroft, Kevin, Kotekar, Aparna, Yang, Howard H., Buetow, Kenneth H., Singer, Dinah S.
The MHC class I gene, PD1, has neither functional TATAA nor Initiator (Inr) elements in its core promoter and initiates transcription at multiple, dispersed sites over an extended region in vitro....
Singer, Dinah S., Singer, Maxine F.
The very lysine rich histone, Hl, isolated from a variety of sources interacts preferentially with superhelical DNA compared to relaxed DNA duplexes13. The nature of this specific interaction has...
Autoregulation of thyroid-specific gene transcription by thyroglobulin
Suzuki, Koichi, Lavaroni, Stefano, Mori, Atsumi, Ohta, Masanori, Saito, Jun, Pietrarelli, Michele, ...
Thyroglobulin (TG), the primary synthetic product of the thyroid, is the macromolecular precursor of thyroid hormones. TG synthesis, iodination, storage in follicles, and degradation control thyroid...
Weissman, Jocelyn D., Brown, Julie A., Howcroft, T. Kevin, Hwang, Jae, Chawla, Ashish, Roche, Paul A., ...
HIV Tat, a transactivator of viral transcription, represses transcription of major histocompatibility (MHC) class I genes. Repression depends exclusively on the C-terminal domain of Tat, although the...
Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides
Suzuki, Koichi, Mori, Atsumi, Ishii, Ken J., Saito, Jun, Singer, Dinah S., Klinman, Dennis M., ...
Abnormal expression of major histocompatibility complex (MHC) class I and class II in various tissues is associated with autoimmune disease. Autoimmune responses can be triggered by viral infections...
TAFII55 binding to TAFII250 inhibits its acetyltransferase activity
Gegonne, Anne, Weissman, Jocelyn D., Singer, Dinah S.
The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the...
Howcroft, T. Kevin, Murphy, Charles, Weissman, Jocelyn D., Huber, Sam J., Sawadogo, Michèle, Singer, Dinah S.
The tissue-specific expression of major histocompatibility complex class I genes is determined by a series of upstream regulatory elements, many of which remain ill defined. We now report that a...
Howcroft, T. Kevin, Raval, Aparna, Weissman, Jocelyn D., Gegonne, Anne, Singer, Dinah S.
Transcription of major histocompatibility complex (MHC) class I genes is regulated by both tissue-specific (basal) and hormone/cytokine (activated) mechanisms. Although promoter-proximal regulatory...
ATG deserts define a novel core promoter subclass
Lee, Maxwell P., Howcroft, Kevin, Kotekar, Aparna, Yang, Howard H., Buetow, Kenneth H., Singer, Dinah S.
The MHC class I gene, PD1, has neither functional TATAA nor Initiator (Inr) elements in its core promoter and initiates transcription at multiple, dispersed sites over an extended region in vitro....
TAF7: A possible transcription initiation check-point regulator
Gegonne, Anne, Weissman, Jocelyn D., Zhou, Meisheng, Brady, John N., Singer, Dinah S.
Transcription consists of a series of highly regulated steps: assembly of a preinitiation complex (PIC) at the promoter nucleated by TFIID, followed by initiation, elongation, and termination. The...
Autoregulation of thyroid-specific gene transcription by thyroglobulin
Suzuki, Koichi, Lavaroni, Stefano, Mori, Atsumi, Ohta, Masanori, Saito, Jun, Pietrarelli, Michele, ...
Thyroglobulin (TG), the primary synthetic product of the thyroid, is the macromolecular precursor of thyroid hormones. TG synthesis, iodination, storage in follicles, and degradation control thyroid...
Weissman, Jocelyn D., Brown, Julie A., Howcroft, T. Kevin, Hwang, Jae, Chawla, Ashish, Roche, Paul A., ...
HIV Tat, a transactivator of viral transcription, represses transcription of major histocompatibility (MHC) class I genes. Repression depends exclusively on the C-terminal domain of Tat, although the...
Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides
Suzuki, Koichi, Mori, Atsumi, Ishii, Ken J., Saito, Jun, Singer, Dinah S., Klinman, Dennis M., ...
Abnormal expression of major histocompatibility complex (MHC) class I and class II in various tissues is associated with autoimmune disease. Autoimmune responses can be triggered by viral infections...
TAFII55 binding to TAFII250 inhibits its acetyltransferase activity
Gegonne, Anne, Weissman, Jocelyn D., Singer, Dinah S.
The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the...
Howcroft, T. Kevin, Murphy, Charles, Weissman, Jocelyn D., Huber, Sam J., Sawadogo, Michèle, Singer, Dinah S.
The tissue-specific expression of major histocompatibility complex class I genes is determined by a series of upstream regulatory elements, many of which remain ill defined. We now report that a...
Howcroft, T. Kevin, Raval, Aparna, Weissman, Jocelyn D., Gegonne, Anne, Singer, Dinah S.
Transcription of major histocompatibility complex (MHC) class I genes is regulated by both tissue-specific (basal) and hormone/cytokine (activated) mechanisms. Although promoter-proximal regulatory...
ATG deserts define a novel core promoter subclass
Lee, Maxwell P., Howcroft, Kevin, Kotekar, Aparna, Yang, Howard H., Buetow, Kenneth H., Singer, Dinah S.
The MHC class I gene, PD1, has neither functional TATAA nor Initiator (Inr) elements in its core promoter and initiates transcription at multiple, dispersed sites over an extended region in vitro....
TAF7: A possible transcription initiation check-point regulator
Gegonne, Anne, Weissman, Jocelyn D., Zhou, Meisheng, Brady, John N., Singer, Dinah S.
Transcription consists of a series of highly regulated steps: assembly of a preinitiation complex (PIC) at the promoter nucleated by TFIID, followed by initiation, elongation, and termination. The...
TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb
Gegonne, Anne, Weissman, Jocelyn D., Lu, Hanxin, Zhou, Meisheng, Dasgupta, Arindam, Ribble, Robert, ...
Transcription consists of a series of highly regulated steps: assembly of the preinitiation complex (PIC) at the promoter, initiation, elongation, and termination. PIC assembly is nucleated by TFIID,...
Kotekar, Aparna S., Weissman, Jocelyn D., Gegonne, Anne, Cohen, Helit, Singer, Dinah S.
To examine the role of chromatin in transcriptional regulation of the major histocompatibility complex (MHC) class I gene, we determined nucleosome occupancy and positioning, histone modifications,...
In Vivo Expression of MHC Class I Genes Depends on the Presence of a Downstream Barrier Element
Cohen, Helit, Parekh, Palak, Sercan, Zeynep, Kotekar, Aparna, Weissman, Jocelyn D., Singer, Dinah S.
Regulation of MHC class I gene expression is critical to achieve proper immune surveillance. In this work, we identify elements downstream of the MHC class I promoter that are necessary for...