Miotto, Benoit, Sagnier, Thierry, Berenger, Hélène, Bohmann, Dirk, Pradel, Jacques, Graba, Yacine
Gene regulation by AP-1 transcription factors in response to Jun N-terminal kinase (JNK) signaling controls essential cellular processes during development and in pathological situations. Here, we...
Synaptic and genomic responses to JNK and AP-1 signaling in Drosophilaneurons (2005)
Etter, Paul D, Narayanan, Radhakrishnan, Navratilova, Zaneta, Patel, Chirag, Bohmann, Dirk, Jasper, Heinrich, ...
Abstract Background The transcription factor AP-1 positively controls synaptic plasticity at the Drosophila neuromuscular junction. Although in motor neurons, JNK has been shown to activate AP-1, a...
Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites (2001)
Ciapponi, Laura, Jackson, David B., Mlodzik, Marek, Bohmann, Dirk
Ein numerisches Verfahren zur Berechnung von Verbundglasscheiben / (1999)
Zugl.: Aachen, Techn. Hochsch., Diss., 1999.
Smith, Susan E., Papavassiliou, Athanasios G., Bohmann, Dirk
Several promoter elements with sequence similarity to the prototype TPA-responsive element (TRE) were compared by mobility-shift analyses. Activities within whole cell extracts were identified that...
Tebb, Graham, Bohmann, Dirk, Mattaj, Lain W.
An analysis, performed by DNase I footprinting, of the interactions between factors present in Molt-4 nuclear extracts and a Xenopus U2 snRNA gene promoter is presented. Four distinct regions of...
Complex Functions of AP-1 Transcription Factors in Differentiation and Survival of PC12 Cells
Leppä, Sirpa, Eriksson, Minna, Saffrich, Rainer, Ansorge, Wilhelm, Bohmann, Dirk
c-Jun activation by mitogen-activated protein kinases has been implicated in various cellular signal responses. We investigated how JNK and c-Jun contribute to neuronal differentiation, cell...
Lafarga, Miguel, Berciano, Maria Teresa, Pena, Emma, Mayo, Isabel, Castaño, Jose G., Bohmann, Dirk, ...
Nuclear bodies represent a heterogeneous class of nuclear structures. Herein, we describe that a subset of nuclear bodies is highly enriched in components of the ubiquitin–proteasome pathway of...
The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription
Westermarck, Jukka, Weiss, Carsten, Saffrich, Rainer, Kast, Jürgen, Musti, Anna-Maria, Wessely, Matthias, ...
Tandem affinity purification (TAP) and mass spectrometric peptide sequencing showed that the DEAD-box RNA helicase RHII/Gu is a functional interaction partner of c-Jun in human cells. The N-terminal...
JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun
Weiss, Carsten, Schneider, Sandra, Wagner, Erwin F., Zhang, Xiaohong, Seto, Edward, Bohmann, Dirk
The AP-1 transcription factor c-Jun is a prototypical nuclear effector of the JNK signal transduction pathway. The integrity of JNK phosphorylation sites at serines 63/73 and at threonines 91/93 in...
A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK
Barilá, Daniela, Mangano, Raffaella, Gonfloni, Stefania, Kretzschmar, Jana, Moro, Marina, Bohmann, Dirk, ...
The nuclear function of the c–Abl tyrosine kinase is not well understood. In order to identify nuclear substrates of Abl, we constructed a constitutively active and nuclear form of the protein. We...
DNA damage induces downregulation of histone gene expression through the G1 checkpoint pathway
Su, Chuan, Gao, Guang, Schneider, Sandra, Helt, Christopher, Weiss, Carsten, O'Reilly, Michael A, ...
Activation of the G1 checkpoint following DNA damage leads to inhibition of cyclin E–Cdk2 and subsequent G1 arrest in higher eucaryotes. Little, however, is known about the molecular events...
DREF Is Required for Efficient Growth and Cell Cycle Progression in Drosophila Imaginal Discs
Hyun, Joogyung, Jasper, Heinrich, Bohmann, Dirk
Based on overexpression studies and target gene analyses, the transcription factor DNA replication-related element factor (DREF) has been proposed to regulate growth and replication in Drosophila...
Synaptic and genomic responses to JNK and AP-1 signaling in Drosophila neurons
Etter, Paul D, Narayanan, Radhakrishnan, Navratilova, Zaneta, Patel, Chirag, Bohmann, Dirk, Jasper, Heinrich, ...
Uhlirova, Mirka, Jasper, Heinrich, Bohmann, Dirk
The role of c-Jun N-terminal kinase (JNK) signaling in cancer is enigmatic, and both tumor-promoting and tumor-suppressing functions have been ascribed to JNK pathway components. We have used the...
Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites
Ciapponi, Laura, Jackson, David B., Mlodzik, Marek, Bohmann, Dirk
During Drosophila development Fos acts downstream from the JNK pathway. Here we show that it can also mediate ERK signaling in wing vein formation and photoreceptor differentiation. Drosophila JNK...
Miotto, Benoit, Sagnier, Thierry, Berenger, Hélène, Bohmann, Dirk, Pradel, Jacques, Graba, Yacine
Gene regulation by AP-1 transcription factors in response to Jun N-terminal kinase (JNK) signaling controls essential cellular processes during development and in pathological situations. Here, we...
Complex Functions of AP-1 Transcription Factors in Differentiation and Survival of PC12 Cells
Leppä, Sirpa, Eriksson, Minna, Saffrich, Rainer, Ansorge, Wilhelm, Bohmann, Dirk
c-Jun activation by mitogen-activated protein kinases has been implicated in various cellular signal responses. We investigated how JNK and c-Jun contribute to neuronal differentiation, cell...
Lafarga, Miguel, Berciano, Maria Teresa, Pena, Emma, Mayo, Isabel, Castaño, Jose G., Bohmann, Dirk, ...
Nuclear bodies represent a heterogeneous class of nuclear structures. Herein, we describe that a subset of nuclear bodies is highly enriched in components of the ubiquitin–proteasome pathway of...
The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription
Westermarck, Jukka, Weiss, Carsten, Saffrich, Rainer, Kast, Jürgen, Musti, Anna-Maria, Wessely, Matthias, ...
Tandem affinity purification (TAP) and mass spectrometric peptide sequencing showed that the DEAD-box RNA helicase RHII/Gu is a functional interaction partner of c-Jun in human cells. The N-terminal...
JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun
Weiss, Carsten, Schneider, Sandra, Wagner, Erwin F., Zhang, Xiaohong, Seto, Edward, Bohmann, Dirk
The AP-1 transcription factor c-Jun is a prototypical nuclear effector of the JNK signal transduction pathway. The integrity of JNK phosphorylation sites at serines 63/73 and at threonines 91/93 in...
A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK
Barilá, Daniela, Mangano, Raffaella, Gonfloni, Stefania, Kretzschmar, Jana, Moro, Marina, Bohmann, Dirk, ...
The nuclear function of the c–Abl tyrosine kinase is not well understood. In order to identify nuclear substrates of Abl, we constructed a constitutively active and nuclear form of the protein. We...
Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites
Ciapponi, Laura, Jackson, David B., Mlodzik, Marek, Bohmann, Dirk
During Drosophila development Fos acts downstream from the JNK pathway. Here we show that it can also mediate ERK signaling in wing vein formation and photoreceptor differentiation. Drosophila JNK...
DNA damage induces downregulation of histone gene expression through the G1 checkpoint pathway
Su, Chuan, Gao, Guang, Schneider, Sandra, Helt, Christopher, Weiss, Carsten, O'Reilly, Michael A, ...
Activation of the G1 checkpoint following DNA damage leads to inhibition of cyclin E–Cdk2 and subsequent G1 arrest in higher eucaryotes. Little, however, is known about the molecular events...
DREF Is Required for Efficient Growth and Cell Cycle Progression in Drosophila Imaginal Discs
Hyun, Joogyung, Jasper, Heinrich, Bohmann, Dirk
Based on overexpression studies and target gene analyses, the transcription factor DNA replication-related element factor (DREF) has been proposed to regulate growth and replication in Drosophila...
Synaptic and genomic responses to JNK and AP-1 signaling in Drosophila neurons
Etter, Paul D, Narayanan, Radhakrishnan, Navratilova, Zaneta, Patel, Chirag, Bohmann, Dirk, Jasper, Heinrich, ...
Uhlirova, Mirka, Jasper, Heinrich, Bohmann, Dirk
The role of c-Jun N-terminal kinase (JNK) signaling in cancer is enigmatic, and both tumor-promoting and tumor-suppressing functions have been ascribed to JNK pathway components. We have used the...
Miotto, Benoit, Sagnier, Thierry, Berenger, Hélène, Bohmann, Dirk, Pradel, Jacques, Graba, Yacine
Gene regulation by AP-1 transcription factors in response to Jun N-terminal kinase (JNK) signaling controls essential cellular processes during development and in pathological situations. Here, we...
Control of G2/M Transition by Drosophila Fos▿ †
Hyun, Joogyung, Bécam, Isabelle, Yanicostas, Constantin, Bohmann, Dirk
The transcription factors of the Fos family have long been associated with the control of cell proliferation, although the molecular and cellular mechanisms that mediate this function are poorly...
JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila
Uhlirova, Mirka, Bohmann, Dirk
Loss of the epithelial polarity gene scribble in clones of Drosophila imaginal disc cells can cooperate with Ras signaling to induce malignant tumors. Such mutant tissue overproliferates, resists...
Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation
Luo, Xi, Puig, Oscar, Hyun, Joogyung, Bohmann, Dirk, Jasper, Heinrich
Cells damaged by environmental insults have to be repaired or eliminated to ensure tissue homeostasis in metazoans. Recent studies suggest that the balance between cell survival signals and...