The BRCT domain of mammalian Pes1 is crucial for nucleolar localization and rRNA processing (2007)
Hölzel, Michael, Grimm, Thomas, Rohrmoser, Michaela, Malamoussi, Anastassia, Harasim, Thomas, Gruber-Eber, Anita, ...
The nucleolar protein Pes1 interacts with Bop1 and WDR12 in a stable complex (PeBoW-complex) and its expression is tightly associated with cell proliferation. The yeast homologue Nop7p (Yph1p)...
Rapid conditional knock-down-knock-in system for mammalian cells (2007)
Hölzel, Michael, Rohrmoser, Michaela, Orban, Mathias, Hömig, Cornelia, Harasim, Thomas, Malamoussi, Anastassia, ...
RNA interference (RNAi) is a powerful tool to analyze gene function in mammalian cells. However, the interpretation of RNAi knock-down phenotypes can be hampered by off-target effects or compound...
Grimm, Thomas, Hölzel, Michael, Rohrmoser, Michaela, Harasim, Thomas, Malamoussi, Anastassia, Gruber-Eber, Anita, ...
The nucleolar PeBoW-complex, consisting of Pes1, Bop1 and WDR12, is essential for cell proliferation and processing of ribosomal RNA in mammalian cells. Here we have analysed the physical and...
Rapid conditional knock-down-knock-in system for mammalian cells (2006)
Hölzel, Michael, Rohrmoser, Michaela, Orban, Mathias, Hömig, Cornelia, Harasim, Thomas, Malamoussi, Anastassia, ...
RNA interference (RNAi) is a powerful tool to analyze gene function in mammalian cells. However, the interpretation of RNAi knock-down phenotypes can be hampered by off-target effects or compound...
The BRCT domain of mammalian Pes1 is crucial for nucleolar localization and rRNA processing (2006)
Hölzel, Michael, Grimm, Thomas, Rohrmoser, Michaela, Malamoussi, Anastassia, Harasim, Thomas, Gruber-Eber, Anita, ...
The nucleolar protein Pes1 interacts with Bop1 and WDR12 in a stable complex (PeBoW-complex) and its expression is tightly associated with cell proliferation. The yeast homologue Nop7p (Yph1p)...
Rapid conditional knock-down-knock-in system for mammalian cells (2006)
Hölzel, Michael, Rohrmoser, Michaela, Orban, Mathias, Hömig, Cornelia, Harasim, Thomas, Malamoussi, Anastassia, ...
RNA interference (RNAi) is a powerful tool to analyze gene function in mammalian cells. However, the interpretation of RNAi knock-down phenotypes can be hampered by off-target effects or compound...
The BRCT domain of mammalian Pes1 is crucial for nucleolar localization and rRNA processing (2006)
Hölzel, Michael, Grimm, Thomas, Rohrmoser, Michaela, Malamoussi, Anastassia, Harasim, Thomas, Gruber-Eber, Anita, ...
The nucleolar protein Pes1 interacts with Bop1 and WDR12 in a stable complex (PeBoW-complex) and its expression is tightly associated with cell proliferation. The yeast homologue Nop7p (Yph1p)...
Chapman, Rob D., Palancade, Benoit, Lang, Andreas, Bensaude, Olivier, Eick, Dirk
The phosphorylation of the RNA polymerase II (Pol II) C‐terminal domain (CTD) has been shown to affect the initiation, and transition to elongation of the Pol II complex. The differential...
A role for c-Myc in the regulation of ribosomal RNA processing (2003)
Schlosser, Isabel, Hölzel, Michael, Mürnseer, Marlies, Burtscher, Helmut, Weidle, Ulrich H., Eick, Dirk
The proto‐oncogene c‐myc encodes a basic helix–loop–helix leucine zipper transcription factor (c‐Myc) that has a profound role in growth control and cell cycle progression....
The transcriptional program of a human B cell line in response to Myc (2001)
Schuhmacher, Marino, Kohlhuber, Franz, Hölzel, Michael, Kaiser, Carmen, Burtscher, Helmut, Jarsch, Michael, ...
The proto-oncogene c-myc (myc) encodes a transcription factor (Myc) that promotes growth, proliferation and apoptosis. Myc has been suggested to induce these effects by induction/repression of...
Identification of two enhancer elements downstream of the human c-myc gene (1995)
Mautner, Josef, Joos, Stefan, Werner, Thomas, Eick, Dirk, Bornkamm, Georg W., Polack, Axel
Expression of the proto-oncogene c-myc is tightly regulated in vivo. Transcription of c-myc is assumed to be controlled by a number of positive and negative cis-acting control elements located...
Wolf, Dieter A., Strobl, Lothar J., Pullner, Andrea, Eick, Dirk
Transcriptional activation of the c-myc proto-oncogene is mediated by the transition of promoter proximal, paused RNA polymerase II (pol II) into a processive transcription mode. Using a...
Grunicke, Hans, Stoeck, Michael, Elsner, J., Seemann, G., Pfeiffer, C., Wegmann, B., ...
Peer Reviewed
Maturation of c-myc mRNA proceeds in a given order in HL60 cells. It starts with splicing of intron 2, continues with splicing of intron 1 and ends with 3′ cleavage and polyadenylation of the...
Regulation des c-myc Gens. (1988)
Enth. zahlr. Sonderabdr. aus verschiedenen Zeitschr. und anderen Publ.
Eick, Dirk, Bornkamm, Georg W.
DMSO (dimethylsulfoxide), a potent inducer of granulocytic differentiation in HL60 cells, causes a rapid decrease of cytoplasmic steady state c-myc RNA. This decrease is regulated mainly at the level...
Identification of CDK4 as a target of c-MYC
Hermeking, Heiko, Rago, Carlo, Schuhmacher, Marino, Li, Qing, Barrett, John F., Obaya, Alvaro J., ...
The prototypic oncogene c-MYC encodes a transcription factor that can drive proliferation by promoting cell-cycle reentry. However, the mechanisms through which c-MYC achieves these effects have been...
The transcriptional program of a human B cell line in response to Myc
Schuhmacher, Marino, Kohlhuber, Franz, Hölzel, Michael, Kaiser, Carmen, Burtscher, Helmut, Jarsch, Michael, ...
The proto-oncogene c-myc (myc) encodes a transcription factor (Myc) that promotes growth, proliferation and apoptosis. Myc has been suggested to induce these effects by induction/repression of...
The Proto-Oncogene c-myc Is a Direct Target Gene of Epstein-Barr Virus Nuclear Antigen 2
Kaiser, Carmen, Laux, Gerhard, Eick, Dirk, Jochner, Nicola, Bornkamm, Georg W., Kempkes, Bettina
Epstein-Barr virus (EBV) infects and transforms primary B lymphocytes in vitro. Viral infection initiates the cell cycle entry of the resting B lymphocytes. The maintenance of proliferation in the...
A role for c-Myc in the regulation of ribosomal RNA processing
Schlosser, Isabel, Hölzel, Michael, Mürnseer, Marlies, Burtscher, Helmut, Weidle, Ulrich H., Eick, Dirk
The proto-oncogene c-myc encodes a basic helix–loop–helix leucine zipper transcription factor (c-Myc) that has a profound role in growth control and cell cycle progression. Previous microarray...
Eick, Dirk, Stabel, Silvia, Doerfler, Walter
Spontaneously arising morphological revertants of the adenovirus type 12 (Ad12)-transformed hamster cell line T637 had been previously isolated, and it had been demonstrated that in these revertants...
The last CTD repeat of the mammalian RNA polymerase II large subunit is important for its stability
Chapman, Rob D., Palancade, Benoit, Lang, Andreas, Bensaude, Olivier, Eick, Dirk
The phosphorylation of the RNA polymerase II (Pol II) C-terminal domain (CTD) has been shown to affect the initiation, and transition to elongation of the Pol II complex. The differential...
Myc/Max/Mad regulate the frequency but not the duration of productive cell cycles
Hölzel, Michael, Kohlhuber, Franz, Schlosser, Isabel, Hölzel, Dieter, Lüscher, Bernhard, Eick, Dirk
Upregulation of the proto-oncoprotein Myc, a basic, helix–loop–helix, leucin zipper domain transcription factor has profound consequences on cell proliferation, cell growth and apoptosis. Cell...
Chapman, Rob D., Conrad, Marcus, Eick, Dirk
The C-terminal domain (CTD) of mammalian RNA polymerase II (Pol II) consists of 52 repeats of the consensus heptapeptide YSPTSPS and links transcription to the processing of pre-mRNA. The length of...
Grimm, Thomas, Hölzel, Michael, Rohrmoser, Michaela, Harasim, Thomas, Malamoussi, Anastassia, Gruber-Eber, Anita, ...
The nucleolar PeBoW-complex, consisting of Pes1, Bop1 and WDR12, is essential for cell proliferation and processing of ribosomal RNA in mammalian cells. Here we have analysed the physical and...
Identification of CDK4 as a target of c-MYC
Hermeking, Heiko, Rago, Carlo, Schuhmacher, Marino, Li, Qing, Barrett, John F., Obaya, Alvaro J., ...
The prototypic oncogene c-MYC encodes a transcription factor that can drive proliferation by promoting cell-cycle reentry. However, the mechanisms through which c-MYC achieves these effects have been...
The transcriptional program of a human B cell line in response to Myc
Schuhmacher, Marino, Kohlhuber, Franz, Hölzel, Michael, Kaiser, Carmen, Burtscher, Helmut, Jarsch, Michael, ...
The proto-oncogene c-myc (myc) encodes a transcription factor (Myc) that promotes growth, proliferation and apoptosis. Myc has been suggested to induce these effects by induction/repression of...
The Proto-Oncogene c-myc Is a Direct Target Gene of Epstein-Barr Virus Nuclear Antigen 2
Kaiser, Carmen, Laux, Gerhard, Eick, Dirk, Jochner, Nicola, Bornkamm, Georg W., Kempkes, Bettina
Epstein-Barr virus (EBV) infects and transforms primary B lymphocytes in vitro. Viral infection initiates the cell cycle entry of the resting B lymphocytes. The maintenance of proliferation in the...
A role for c-Myc in the regulation of ribosomal RNA processing
Schlosser, Isabel, Hölzel, Michael, Mürnseer, Marlies, Burtscher, Helmut, Weidle, Ulrich H., Eick, Dirk
The proto-oncogene c-myc encodes a basic helix–loop–helix leucine zipper transcription factor (c-Myc) that has a profound role in growth control and cell cycle progression. Previous microarray...
Eick, Dirk, Stabel, Silvia, Doerfler, Walter
Spontaneously arising morphological revertants of the adenovirus type 12 (Ad12)-transformed hamster cell line T637 had been previously isolated, and it had been demonstrated that in these revertants...
The last CTD repeat of the mammalian RNA polymerase II large subunit is important for its stability
Chapman, Rob D., Palancade, Benoit, Lang, Andreas, Bensaude, Olivier, Eick, Dirk
The phosphorylation of the RNA polymerase II (Pol II) C-terminal domain (CTD) has been shown to affect the initiation, and transition to elongation of the Pol II complex. The differential...
Myc/Max/Mad regulate the frequency but not the duration of productive cell cycles
Hölzel, Michael, Kohlhuber, Franz, Schlosser, Isabel, Hölzel, Dieter, Lüscher, Bernhard, Eick, Dirk
Upregulation of the proto-oncoprotein Myc, a basic, helix–loop–helix, leucin zipper domain transcription factor has profound consequences on cell proliferation, cell growth and apoptosis. Cell...
Chapman, Rob D., Conrad, Marcus, Eick, Dirk
The C-terminal domain (CTD) of mammalian RNA polymerase II (Pol II) consists of 52 repeats of the consensus heptapeptide YSPTSPS and links transcription to the processing of pre-mRNA. The length of...
Grimm, Thomas, Hölzel, Michael, Rohrmoser, Michaela, Harasim, Thomas, Malamoussi, Anastassia, Gruber-Eber, Anita, ...
The nucleolar PeBoW-complex, consisting of Pes1, Bop1 and WDR12, is essential for cell proliferation and processing of ribosomal RNA in mammalian cells. Here we have analysed the physical and...
Rapid conditional knock-down–knock-in system for mammalian cells
Hölzel, Michael, Rohrmoser, Michaela, Orban, Mathias, Hömig, Cornelia, Harasim, Thomas, Malamoussi, Anastassia, ...
RNA interference (RNAi) is a powerful tool to analyze gene function in mammalian cells. However, the interpretation of RNAi knock-down phenotypes can be hampered by off-target effects or compound...
The BRCT domain of mammalian Pes1 is crucial for nucleolar localization and rRNA processing
Hölzel, Michael, Grimm, Thomas, Rohrmoser, Michaela, Malamoussi, Anastassia, Harasim, Thomas, Gruber-Eber, Anita, ...
The nucleolar protein Pes1 interacts with Bop1 and WDR12 in a stable complex (PeBoW-complex) and its expression is tightly associated with cell proliferation. The yeast homologue Nop7p (Yph1p)...
Rohrmoser, Michaela, Hölzel, Michael, Grimm, Thomas, Malamoussi, Anastassia, Harasim, Thomas, Orban, Mathias, ...
The PeBoW complex is essential for cell proliferation and maturation of the large ribosomal subunit in mammalian cells. Here we examined the role of PeBoW-specific proteins Pes1, Bop1, and WDR12 in...
Hölzel, Michael, Rohrmoser, Michaela, Schlee, Martin, Grimm, Thomas, Harasim, Thomas, Malamoussi, Anastassia, ...
Target genes of the protooncogene c-myc are implicated in cell cycle and growth control, yet the linkage of both is still unexplored. Here, we show that the products of the nucleolar target genes...
Haindl, Markus, Harasim, Thomas, Eick, Dirk, Muller, Stefan
The ubiquitin-like SUMO system functions by a cyclic process of modification and demodification, and recent data suggest that the nucleolus is a site of sumoylation–desumoylation cycles. For...