Dirk K. F. Meijer

A novel lipid-based drug carrier targeted to the non-parenchymal cells, including hepatic stellate cells, in the fibrotic livers of bile duct ligated rats (2007)

Adrian, Joanna E., Scherphof, Gerrit L., Meijer, Dirk K.F., Reker-Smit, Catharina, ...

In fibrotic livers, collagen producing hepatic stellate cells (HSC) represent a major target for antifibrotic therapies. We designed liposomes with surface-coupled mannose 6-phosphate (M6P) modified...

Precision-Cut Liver Slices as a New Model to Study Toxicity-Induced Hepatic Stellate Cell Activation in a Physiologic Milieu (2005)

Van De Bovenkamp, Marja, Groothuis, Geny M. M., Draaisma, Annelies L., Merema, Marjolijn T., Bezuijen, Judith I., Van Gils, Marit J., ...

Hepatic stellate cell (HSC) activation is a key event in the natural process of wound healing as well as in fibrosis development in liver. Current in vitro models for HSC activation contribute...

Precision-cut liver slices as a new model to study toxicity-induced hepatic stellate cell activation in a physiologic milieu (2005)

Van De Bovenkamp, Marja, Groothuis, Geny M. M., Draaisma, Annelies L., Merema, Marjolijn T., Bezuijen, Judith I., Van Gils, Marit J., ...

Hepatic stellate cell (HSC) activation is a key event in the natural process of wound healing as well as in fibrosis development in liver. Current in vitro models for HSC activation contribute...

Deuterium Isotope Effect on the Metabolism of the Flame Retardant Tris(2,3-dibromopropyl) Phosphate in the Isolated Perfused Rat Liver (1995)

PEARSON, PAUL G., MEIJER, DIRK K. F., MULDER, GERARD J., NELSON, SIDNEY D., MEERMAN, JOHN H. N.

The metabolism of tris(2,3-dibromopropyl) phosphate (Tris-BP) was compared with that of completely deuterated Tris-BP (D15-Tris-BP) in an isolated, recirculating rat liver perfusion system in order...

The role of sulfation in the metabolic activation of N-hydroxy-4'-fluoro-4-acetylaminobiphenyl (1989)

Tijdens, Roeline B., Vondrácek, Paul, Bruins, Andries P., Meijer, Dirk K. F., Meerman, John H. N.

The role of sulfation in the metabolic activation of the liver carcinogen N-hydroxy-4′-fluoro-4-acetylaminobiphenyl (N-OH-FAABP) in male rat liver was investigated. N-OH-FAABP was a substrate for...

On the Localisation of d-Tubocurarine in Rat Liver Lysosomes in vivo by Electron Microscopy and Subcellular Fractionation (1975)

Weitering, Jeanette G., Mulder, Gerard J., Meijer, Dirk K.F., Lammers, Wim, Veenhuis, Maarten, Wendelaar Bonga, Sjoerd E.

After i.v. injection in the rat, d-tubocurarine is taken up and concentrated by the liver. A method is developed for the visualisation of d-tubocurarine inside the liver cell by electron microscopy....

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

Sparreboom, Alex, Van Asperen, Judith, Mayer, Ulrich, Schinkel, Alfred H., Smit, Johan W., Meijer, Dirk K. F., ...

In mice, the mdr1a and mdr1b genes encode drug-transporting proteins that can cause multidrug resistance in tumor cells by lowering intracellular drug levels. These P-glycoproteins are also found in...

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

Sparreboom, Alex, Van Asperen, Judith, Mayer, Ulrich, Schinkel, Alfred H., Smit, Johan W., Meijer, Dirk K. F., ...

In mice, the mdr1a and mdr1b genes encode drug-transporting proteins that can cause multidrug resistance in tumor cells by lowering intracellular drug levels. These P-glycoproteins are also found in...

Interactions between P-glycoprotein substrates and other cationic drugs at the hepatic excretory level

Smit, Johan W, Duin, Erik, Steen, Herman, Oosting, Roelof, Roggeveld, Jan, Meijer, Dirk K F

In the present study it was tested whether known P-glycoprotein (P-gp) substrates/MDR reversal agents interact with small (type 1) and bulky (type 2) cationic drugs at the level of biliary excretion...

Hepatobiliary and intestinal clearance of amphiphilic cationic drugs in mice in which both mdr1a and mdr1b genes have been disrupted

Smit, Johan W, Schinkel, Alfred H, Weert, Betty, Meijer, Dirk K F

We have used mice with homozygously disrupted mdr1a and mdr1b genes (mdr1a/1b (−/−) mice) to study the role of the mdr1-type P-glycoprotein (P-gp) in the elimination of cationic amphiphilic...

Stereoselective transport of hydrophilic quaternary drugs by human MDR1 and rat Mdr1b P-glycoproteins

Heegsma, Janette, Montfoort, Jessica E Van, Jansen, Peter L M, Meijer, Dirk K F, Müller, Michael

The present study was performed to evaluate and compare the ability of human MDR1-, and rat Mdr1b- and Mdr2-P-glycoproteins to transport hydrophilic monoquaternary drugs. Transport studies were...

Renal targeting of captopril selectively enhances the intrarenal over the systemic effects of ACE inhibition in rats

Haverdings, R Folgert G, Haas, Marijke, Navis, Gerjan, Meijer, Dirk K F, De Zeeuw, Dick, ...

In previous studies on the renal targeting of the ACE inhibitor captopril, we demonstrated that a 6 fold increased concentration of this drug could be obtained in the kidney after conjugation to the...

Inhibition of Renal Rho Kinase Attenuates Ischemia/Reperfusion-Induced Injury

Prakash, Jai, De Borst, Martin H., Lacombe, Marie, Opdam, Frank, Klok, Pieter A., Van Goor, Harry, ...

The Rho kinase pathway plays an important role in dedifferentiation of epithelial cells and infiltration of inflammatory cells. For testing of the hypothesis that blockade of this cascade within the...