Adapted Boolean network models for extracellular matrix formation (2009)
Wollbold, Johannes, Huber, René, Pohlers, Dirk, Koczan, Dirk, Guthke, Reinhard, Kinne, Raimund W, ...
Abstract Background Due to the rapid data accumulation on pathogenesis and progression of chronic inflammation, there is an increasing demand for approaches to analyse the underlying regulatory...
Huber, René, Hummert, Christian, Gausmann, Ulrike, Pohlers, Dirk, Koczan, Dirk, Guthke, Reinhard, ...
Abstract Introduction Rheumatoid arthritis (RA) is a chronic inflammatory and destructive joint disease characterized by overexpression of pro-inflammatory/pro-destructive genes and other activating...
Expression profiling of a high-fertility mouse line by microarray analysis and qPCR (2008)
Vanselow, Jens, Nürnberg, Gerd, Koczan, Dirk, Langhammer, Martina, Thiesen, Hans-Jürgen, Reinsch, Norbert
Abstract Background In a recent study it was demonstrated that a largely increased ovulation number is responsible for high prolificacy in two mouse lines selected for fertility performance. The...
Koczan, Dirk, Drynda, Susanne, Hecker, Michael, Drynda, Andreas, Guthke, Reinhard, Kekow, Joern, ...
Abstract Introduction About 30% of rheumatoid arthritis patients fail to respond adequately to TNFα-blocking therapy. There is a medical and socioeconomic need to identify molecular markers for an...
Title: In-silico fine-mapping: narrowing disease-associated loci by intergenomics Authors: (2008)
Pablo Serrano-fernández, Saleh M. Ibrahim, Dirk Koczan, Uwe K. Zettl, Steffen Möller
Summary: Genetic linkage and association studies define quantitative trait loci (QTLs) and susceptibility loci (SLs) that influence the phenotype of polygenic traits. A web-accessible application was...
mtDNA nt13708A Variant Increases the Risk of Multiple Sclerosis (2008)
Yu, Xinhua, Koczan, Dirk, Sulonen, Anna-Maija, Akkad, Denis A., Kroner, Antje, Comabella, Manuel, ...
Background: Mitochondrial DNA (mtDNA) polymorphism is a possible factor contributing to the maternal parent-of-origin effect in multiple sclerosis (MS) susceptibility. Methods and Findings: In order...
stages of collagen-induced arthritis (2008)
Philip Gierer, Saleh Ibrahim, Thomas Mittlmeier, Dirk Koczan, Steffen Moeller, Jürgen L, ...
Gene expression profile and synovial microcirculation at early
Pfaff, Michael, Woetzel, Dirk, Driesch, Dominik, Toepfer, Susanne, Huber, René, Pohlers, Dirk, ...
Zum Vol. I von: Computer science meets automation: 52. IWK, Internationales Wissenschaftliches Kolloquium ; proceedings ; 10 - 13 September 2007 Zum Vol. II von: Computer science meets automation:...
Pohlers, Dirk, Beyer, Andreas, Koczan, Dirk, Wilhelm, Thomas, Thiesen, Hans-Jürgen, Kinne, Raimund W
Abstract Genome-wide gene expression was comparatively investigated in early-passage rheumatoid arthritis (RA) and osteoarthritis (OA) synovial fibroblasts (SFBs; n = 6 each) using oligonucleotide...
Yu, Xinhua, Bauer, Kristin, Koczan, Dirk, Thiesen, Hans-Jürgen, Ibrahim, Saleh M
Abstract Quantitative traits such as complex diseases are controlled by many small-effect genes that are difficult to identify. Here we present a novel strategy to identify the candidate genes for...
Hoffmann, Martin, Pohlers, Dirk, Koczan, Dirk, Thiesen, Hans-Jürgen, Wölfl, Stefan, Kinne, Raimund W
Abstract Background Biological tissues consist of various cell types that differentially contribute to physiological and pathophysiological processes. Determining and analyzing cell type-specific...
Vassilis Aidinis, Piero Carninci, Maria Armaka, Walter Witke, Vaggelis Harokopos, Norman Pavelka, ...
Vassilis Aidinis, Piero Carninci, Maria Armaka, Walter Witke, Vaggelis Harokopos, Norman Pavelka, ...
Rheumatoid arthritis is a chronic inflammatory disease with a high prevalence and substantial socioeconomic burden. Despite intense research efforts, its aetiology and pathogenesis remain poorly...
Perforin deficiency attenuates collagen-induced arthritis (2005)
Bauer, Kristin, Knipper, Annika, Tu-Rapp, Hoang, Koczan, Dirk, Kreutzer, Hans-Jürgen, Nizze, Horst, ...
Abstract Collagen-induced arthritis (CIA), an approved animal model for rheumatoid arthritis, is thought to be a T cell-dependent disease. There is evidence that CD8 + T cells are a major subset...
Gierer, Philip, Ibrahim, Saleh, Mittlmeier, Thomas, Koczan, Dirk, Moeller, Steffen, Landes, Jürgen, ...
Abstract A better understanding of the initial mechanisms that lead to arthritic disease could facilitate development of improved therapeutic strategies. We characterized the synovial...
In silico fine-mapping: narrowing disease-associated loci by intergenomics (2005)
Serrano-Fernández, Pablo, Ibrahim, Saleh M., Koczan, Dirk, Zettl, Uwe K., Möller, Steffen
Summary: Genetic linkage and association studies define quantitative trait loci (QTLs) and susceptibility loci (SLs) that influence the phenotype of polygenic traits. A web-accessible application was...
In-silico fine-mapping: narrowing disease-associated loci by intergenomics (2004)
Serrano-Fernández, Pablo, Ibrahim, Saleh M., Koczan, Dirk, Zettl, Uwe K., Möller, Steffen
Summary: Genetic linkage and association studies define quantitative trait loci (QTLs) and susceptibility loci (SLs) that influence the phenotype of polygenic traits. A web-accessible application was...
In-silico fine-mapping: narrowing disease-associated loci by intergenomics (2004)
Serrano-Fernández, Pablo, Ibrahim, Saleh M., Koczan, Dirk, Zettl, Uwe K., Möller, Steffen
Summary: Genetic linkage and association studies define quantitative trait loci (QTLs) and susceptibility loci (SLs) that influence the phenotype of polygenic traits. A web-accessible application was...
Wester, Lena, Koczan, Dirk, Holmberg, Jens, Olofsson, Peter, Thiesen, Hans-Jürgen, Holmdahl, Rikard, ...
Abstract Arthritis susceptibility genes were sought by analysis of differential gene expression between pristane-induced arthritis (PIA)-susceptible DA rats and PIA-resistant E3 rats. Inguinal lymph...
Ruschpler, Peter, Lorenz, Peter, Eichler, Wolfram, Koczan, Dirk, Hänel, Claudia, Scholz, Roger, ...
Abstract To improve our knowledge on the pathophysiology of rheumatoid arthritis (RA), we investigated gene expression patterns in synovial tissue from RA and osteoarthritis (OA) patients. DNA...
Functional analysis of an arthritogenic synovial fibroblast (2003)
Aidinis, Vassilis, Plows, David, Haralambous, Sylva, Armaka, Maria, Papadopoulos, Petros, Kanaki, Maria, ...
Abstract Increasing attention has been directed towards identifying non-T-cell mechanisms as potential therapeutic targets in rheumatoid arthritis. Synovial fibroblast (SF) activation, a hallmark of...
Guy, Jane, Hearn, Tom, Crosier, Moira, Mudge, Jonathan, Viggiano, Luigi, Koczan, Dirk, ...
Contiguous finished sequence from highly duplicated pericentromeric regions of human chromosomes is needed if we are to understand the role of pericentromeric instability in disease, and in gene and...
Wester, Lena, Koczan, Dirk, Holmberg, Jens, Olofsson, Peter, Thiesen, Hans-Jürgen, Holmdahl, Rikard, ...
Arthritis susceptibility genes were sought by analysis of differential gene expression between pristane-induced arthritis (PIA)-susceptible DA rats and PIA-resistant E3 rats. Inguinal lymph nodes of...
Guy, Jane, Hearn, Tom, Crosier, Moira, Mudge, Jonathan, Viggiano, Luigi, Koczan, Dirk, ...
Contiguous finished sequence from highly duplicated pericentromeric regions of human chromosomes is needed if we are to understand the role of pericentromeric instability in disease, and in gene and...
Guy, Jane, Hearn, Tom, Crosier, Moira, Mudge, Jonathan, Viggiano, Luigi, Koczan, Dirk, ...
Contiguous finished sequence from highly duplicated pericentromeric regions of human chromosomes is needed if we are to understand the role of pericentromeric instability in disease, and in gene and...
Guy, Jane, Hearn, Tom, Crosier, Moira, Mudge, Jonathan, Viggiano, Luigi, Koczan, Dirk, ...
Contiguous finished sequence from highly duplicated pericentromeric regions of human chromosomes is needed if we are to understand the role of pericentromeric instability in disease, and in gene and...
Reimer, Toralf, Koczan, Dirk, Müller, Heiner, Friese, Klaus, Thiesen, Hans-Jürgen, Gerber, Bernd
Abstract Background The objective of the present study was to examine the prognostic and predictive significance of the apoptosis-related marker Fas ligand (FasL):Fas ratio in breast cancer. Methods...
Ibrahim, Saleh M., Mix, Eilhard, Böttcher, Tobias, Koczan, Dirk, Gold, Ralf, Rolfs, Arndt, ...
Multiple sclerosis is thought to be a polygenic disease driven by dysregulation of the immune system leading to an autoimmune response against one or several antigens of cerebral white matter tissue....
Functional analysis of an arthritogenic synovial fibroblast
Aidinis, Vassilis, Plows, David, Haralambous, Sylva, Armaka, Maria, Papadopoulos, Petros, Kanaki, Maria Zambia, ...
Increasing attention has been directed towards identifying non-T-cell mechanisms as potential therapeutic targets in rheumatoid arthritis. Synovial fibroblast (SF) activation, a hallmark of...
Ruschpler, Peter, Lorenz, Peter, Eichler, Wolfram, Koczan, Dirk, Hänel, Claudia, Scholz, Roger, ...
To improve our knowledge on the pathophysiology of rheumatoid arthritis (RA), we investigated gene expression patterns in synovial tissue from RA and osteoarthritis (OA) patients. DNA oligonucleotide...
Differential gene expression in pristane-induced arthritis susceptible DA versus resistant E3 rats
Wester, Lena, Koczan, Dirk, Holmberg, Jens, Olofsson, Peter, Thiesen, Hans-Jürgen, Holmdahl, Rikard, ...
Arthritis susceptibility genes were sought by analysis of differential gene expression between pristane-induced arthritis (PIA)-susceptible DA rats and PIA-resistant E3 rats. Inguinal lymph nodes of...
Guy, Jane, Hearn, Tom, Crosier, Moira, Mudge, Jonathan, Viggiano, Luigi, Koczan, Dirk, ...
Contiguous finished sequence from highly duplicated pericentromeric regions of human chromosomes is needed if we are to understand the role of pericentromeric instability in disease, and in gene and...
Gene expression profile and synovial microcirculation at early stages of collagen-induced arthritis
Gierer, Philip, Ibrahim, Saleh, Mittlmeier, Thomas, Koczan, Dirk, Moeller, Steffen, Landes, Jürgen, ...
A better understanding of the initial mechanisms that lead to arthritic disease could facilitate development of improved therapeutic strategies. We characterized the synovial microcirculation of knee...
Perforin deficiency attenuates collagen-induced arthritis
Bauer, Kristin, Knipper, Annika, Tu-Rapp, Hoang, Koczan, Dirk, Kreutzer, Hans-Jürgen, Nizze, Horst, ...
Collagen-induced arthritis (CIA), an approved animal model for rheumatoid arthritis, is thought to be a T cell-dependent disease. There is evidence that CD8+ T cells are a major subset controlling...
Aidinis, Vassilis, Carninci, Piero, Armaka, Maria, Witke, Walter, Harokopos, Vaggelis, Pavelka, Norman, ...
Rheumatoid arthritis is a chronic inflammatory disease with a high prevalence and substantial socioeconomic burden. Despite intense research efforts, its aetiology and pathogenesis remain poorly...
Aidinis, Vassilis, Carninci, Piero, Armaka, Maria, Witke, Walter, Harokopos, Vaggelis, Pavelka, Norman, ...
Hoffmann, Martin, Pohlers, Dirk, Koczan, Dirk, Thiesen, Hans-Jürgen, Wölfl, Stefan, Kinne, Raimund W
Cis- and Trans-Acting Gene Regulation Is Associated with Osteoarthritis
Mahr, Sandra, Burmester, Gerd-Rüdiger, Hilke, Dietmar, Göbel, Udo, Grützkau, Andreas, Häupl, Thomas, ...
Osteoarthritis (OA) is a complex disease of the skeleton and is associated with aging. Both environmental and genetic factors contribute to its pathogenesis. We set out to identify novel genes...
Functional analysis of an arthritogenic synovial fibroblast
Aidinis, Vassilis, Plows, David, Haralambous, Sylva, Armaka, Maria, Papadopoulos, Petros, Kanaki, Maria Zambia, ...
Increasing attention has been directed towards identifying non-T-cell mechanisms as potential therapeutic targets in rheumatoid arthritis. Synovial fibroblast (SF) activation, a hallmark of...
Ruschpler, Peter, Lorenz, Peter, Eichler, Wolfram, Koczan, Dirk, Hänel, Claudia, Scholz, Roger, ...
To improve our knowledge on the pathophysiology of rheumatoid arthritis (RA), we investigated gene expression patterns in synovial tissue from RA and osteoarthritis (OA) patients. DNA oligonucleotide...
Differential gene expression in pristane-induced arthritis susceptible DA versus resistant E3 rats
Wester, Lena, Koczan, Dirk, Holmberg, Jens, Olofsson, Peter, Thiesen, Hans-Jürgen, Holmdahl, Rikard, ...
Arthritis susceptibility genes were sought by analysis of differential gene expression between pristane-induced arthritis (PIA)-susceptible DA rats and PIA-resistant E3 rats. Inguinal lymph nodes of...
Guy, Jane, Hearn, Tom, Crosier, Moira, Mudge, Jonathan, Viggiano, Luigi, Koczan, Dirk, ...
Contiguous finished sequence from highly duplicated pericentromeric regions of human chromosomes is needed if we are to understand the role of pericentromeric instability in disease, and in gene and...
Gene expression profile and synovial microcirculation at early stages of collagen-induced arthritis
Gierer, Philip, Ibrahim, Saleh, Mittlmeier, Thomas, Koczan, Dirk, Moeller, Steffen, Landes, Jürgen, ...
A better understanding of the initial mechanisms that lead to arthritic disease could facilitate development of improved therapeutic strategies. We characterized the synovial microcirculation of knee...
Perforin deficiency attenuates collagen-induced arthritis
Bauer, Kristin, Knipper, Annika, Tu-Rapp, Hoang, Koczan, Dirk, Kreutzer, Hans-Jürgen, Nizze, Horst, ...
Collagen-induced arthritis (CIA), an approved animal model for rheumatoid arthritis, is thought to be a T cell-dependent disease. There is evidence that CD8+ T cells are a major subset controlling...
Aidinis, Vassilis, Carninci, Piero, Armaka, Maria, Witke, Walter, Harokopos, Vaggelis, Pavelka, Norman, ...
Rheumatoid arthritis is a chronic inflammatory disease with a high prevalence and substantial socioeconomic burden. Despite intense research efforts, its aetiology and pathogenesis remain poorly...
Aidinis, Vassilis, Carninci, Piero, Armaka, Maria, Witke, Walter, Harokopos, Vaggelis, Pavelka, Norman, ...
Cis- and Trans-Acting Gene Regulation Is Associated with Osteoarthritis
Mahr, Sandra, Burmester, Gerd-Rüdiger, Hilke, Dietmar, Göbel, Udo, Grützkau, Andreas, Häupl, Thomas, ...
Osteoarthritis (OA) is a complex disease of the skeleton and is associated with aging. Both environmental and genetic factors contribute to its pathogenesis. We set out to identify novel genes...
Hoffmann, Martin, Pohlers, Dirk, Koczan, Dirk, Thiesen, Hans-Jürgen, Wölfl, Stefan, Kinne, Raimund W
Yu, Xinhua, Bauer, Kristin, Koczan, Dirk, Thiesen, Hans-Jürgen, Ibrahim, Saleh M
Quantitative traits such as complex diseases are controlled by many small-effect genes that are difficult to identify. Here we present a novel strategy to identify the candidate genes for...
Kunz, Manfred, Hartmann, Anke, Flory, Egbert, Toksoy, Atiye, Koczan, Dirk, Thiesen, Hans-Jürgen, ...
Besides its proinflammatory properties, interleukin-8 (IL-8) has been suggested as an important promoter for melanoma growth. To study the role of IL-8 in melanoma biology, we determined the in vivo...
Pohlers, Dirk, Beyer, Andreas, Koczan, Dirk, Wilhelm, Thomas, Thiesen, Hans-Jürgen, Kinne, Raimund W
Genome-wide gene expression was comparatively investigated in early-passage rheumatoid arthritis (RA) and osteoarthritis (OA) synovial fibroblasts (SFBs; n = 6 each) using oligonucleotide...
mtDNA nt13708A Variant Increases the Risk of Multiple Sclerosis
Yu, Xinhua, Koczan, Dirk, Sulonen, Anna-Maija, Akkad, Denis A., Kroner, Antje, Comabella, Manuel, ...
Expression profiling of a high-fertility mouse line by microarray analysis and qPCR
Vanselow, Jens, Nürnberg, Gerd, Koczan, Dirk, Langhammer, Martina, Thiesen, Hans-Jürgen, Reinsch, Norbert
Koczan, Dirk, Drynda, Susanne, Hecker, Michael, Drynda, Andreas, Guthke, Reinhard, Kekow, Joern, ...
Huber, René, Hummert, Christian, Gausmann, Ulrike, Pohlers, Dirk, Koczan, Dirk, Guthke, Reinhard, ...
Riclet, Raphaël, Chendeb, Mariam, Vonesch, Jean-Luc, Koczan, Dirk, Thiesen, Hans-Juergen, Losson, Régine, ...
Here, we identified the imprinted mesoderm-specific transcript (MEST) gene as an endogenous TIF1β primary target gene and demonstrated that transcriptional intermediary factor (TIF) 1β, through its...
Günther, Juliane, Koczan, Dirk, Yang, Wei, Nürnberg, Gerd, Repsilber, Dirk, Schuberth, Hans-Joachim, ...
We examined the repertoire and extent of inflammation dependent gene regulation in a bovine mammary epithelial cell (MEC) model, to better understand the contribution of the MEC in the immune defence...