Dmitry Krylov

A general method to design dominant negatives to B-HLHZip proteins that abolish DNA binding

Krylov, Dmitry, Kasai, Kenji, Echlin, Deborah R., Taparowsky, Elizabeth J., Arnheiter, Heinz, Vinson, Charles

We describe a method to design dominant-negative proteins (D-N) to the basic helix–loop–helix–leucine zipper (B-HLHZip) family of sequence-specific DNA binding transcription factors. The D-Ns...

A Dominant-Negative Inhibitor of CREB Reveals that It Is a General Mediator of Stimulus-Dependent Transcription of c-fos

Ahn, Sohyun, Olive, Michelle, Aggarwal, Seema, Krylov, Dmitry, Ginty, David D., Vinson, Charles

Several studies have characterized the upstream regulatory region of c-fos, and identified cis-acting elements termed the cyclic AMP (cAMP) response elements (CREs) that are critical for c-fos...

Cell-Type-Dependent Activity of the Ubiquitous Transcription Factor USF in Cellular Proliferation and Transcriptional Activation

Qyang, Yibing, Luo, Xu, Lu, Tao, Ismail, Preeti M., Krylov, Dmitry, Vinson, Charles, ...

USF1 and USF2 are basic helix-loop-helix transcription factors implicated in the control of cellular proliferation. In HeLa cells, the USF proteins are transcriptionally active and their...

Life without white fat: a transgenic mouse

Moitra, Jaideep, Mason, Mark M., Olive, Michelle, Krylov, Dmitry, Gavrilova, Oksana, Marcus-Samuels, Bernice, ...

We have generated a transgenic mouse with no white fat tissue throughout life. These mice express a dominant-negative protein, termed A-ZIP/F, under the control of the adipose-specific aP2...

A general method to design dominant negatives to B-HLHZip proteins that abolish DNA binding

Krylov, Dmitry, Kasai, Kenji, Echlin, Deborah R., Taparowsky, Elizabeth J., Arnheiter, Heinz, Vinson, Charles

We describe a method to design dominant-negative proteins (D-N) to the basic helix–loop–helix–leucine zipper (B-HLHZip) family of sequence-specific DNA binding transcription factors. The D-Ns...

A Dominant-Negative Inhibitor of CREB Reveals that It Is a General Mediator of Stimulus-Dependent Transcription of c-fos

Ahn, Sohyun, Olive, Michelle, Aggarwal, Seema, Krylov, Dmitry, Ginty, David D., Vinson, Charles

Several studies have characterized the upstream regulatory region of c-fos, and identified cis-acting elements termed the cyclic AMP (cAMP) response elements (CREs) that are critical for c-fos...

Cell-Type-Dependent Activity of the Ubiquitous Transcription Factor USF in Cellular Proliferation and Transcriptional Activation

Qyang, Yibing, Luo, Xu, Lu, Tao, Ismail, Preeti M., Krylov, Dmitry, Vinson, Charles, ...

USF1 and USF2 are basic helix-loop-helix transcription factors implicated in the control of cellular proliferation. In HeLa cells, the USF proteins are transcriptionally active and their...

Life without white fat: a transgenic mouse

Moitra, Jaideep, Mason, Mark M., Olive, Michelle, Krylov, Dmitry, Gavrilova, Oksana, Marcus-Samuels, Bernice, ...

We have generated a transgenic mouse with no white fat tissue throughout life. These mice express a dominant-negative protein, termed A-ZIP/F, under the control of the adipose-specific aP2...

Tissue Transglutaminase Is an Integrin-Binding Adhesion Coreceptor for Fibronectin

Akimov, Sergey S., Krylov, Dmitry, Fleischman, Laurie F., Belkin, Alexey M.

The protein cross-linking enzyme tissue transglutaminase binds in vitro with high affinity to fibronectin via its 42-kD gelatin-binding domain. Here we report that cell surface transglutaminase...