Schols, Dominique, Hamal, Sunil, Cui, Li, Huskens, Dana, Aquaro, Stefano, Bell, Thomas
No abstract available.
Unsung Hero Robert C. Gallo (2009)
Abbadessa, Giovanni, Accolla, Roberto, Aiuti, Fernando, Albini, Adriana, Aldovini, Anna, Alfano, Massimo, ...
Awarding the Nobel prize in physiology or medicine to Francoise Barré-Sinoussi and Luc Montagnier for the discovery of HIV-1, the causative agent of AIDS, is timely given the harm that the virus...
Jenabian, Mohammad-Ali, Saïdi, Héla, Charpentier, Charlotte, Van Herrewege, Yven, Son, Jong Chan, Schols, Dominique, ...
Objectives To block the different mechanisms of HIV mucosal transmission, it is likely that use of several microbicide molecules will lead to the best protection against HIV transmission. Indeed, the...
Saïdi, Hela, Nasreddine, Nadine, Jenabian, Mohammad-Ali, Lecerf, Maxime, Schols, Dominique, Krief, Corinne, ...
Abstract Background Plant lectins such as Galanthus nivalis agglutinin (GNA) and Hippeastrum hybrid agglutinin (HHA) are natural proteins able to link mannose residues, and therefore inhibit...
Balzarini, Jan, Schols, Dominique, Van Laethem, Kristel, De Clercq, Erik, Hocková, Dana, Masojidkova, Milina, ...
Objectives: To discover new potent and selective anti-human immunodeficiency virus (HIV) acyclic nucleoside phosphonate (ANP) drugs with in vivo antiretroviral activity. Methods: New acyclic...
De Klerck, Bert, Geboes, Lies, Hatse, Sigrid, Kelchtermans, Hilde, Meyvis, Yves, Vermeire, Kurt, ...
Abstract CXCL12 (stromal cell-derived factor 1) is a unique biological ligand for the chemokine receptor CXCR4. We previously reported that treatment with a specific CXCR4 antagonist, AMD3100, exerts...
Cyclotriazadisulfonamides: promising new CD4-targeted anti-HIV drugs (2005)
Vermeire, Kurt, Schols, Dominique
It is imperative to continue efforts to identify novel effective therapies that can assist in containing the spread of HIV. Recently acquired knowledge about the HIV entry process points to new...
Balzarini, Jan, Stevens, Miguel, De Clercq, Erik, Schols, Dominique, Pannecouque, Christophe
Pyridine N-oxide derivatives represent a new class of anti-HIV compounds, for which some members exclusively act through inhibition of HIV-1 reverse transcriptase and thus characteristically behave...
Cyclotriazadisulfonamides: promising new CD4-targeted anti-HIV drugs (2005)
Vermeire, Kurt, Schols, Dominique
It is imperative to continue efforts to identify novel effective therapies that can assist in containing the spread of HIV. Recently acquired knowledge about the HIV entry process points to new...
Balzarini, Jan, Stevens, Miguel, De Clercq, Erik, Schols, Dominique, Pannecouque, Christophe
Pyridine N-oxide derivatives represent a new class of anti-HIV compounds, for which some members exclusively act through inhibition of HIV-1 reverse transcriptase and thus characteristically behave...
Princen, Katrien, Hatse, Sigrid, Vermeire, Kurt, De Clercq, Erik, Schols, Dominique
Abstract Background CCR5 and CXCR4 are the two main coreceptors essential for HIV entry. Therefore, these chemokine receptors have become important targets in the search for anti-HIV agents. Here, we...
Willey, Samantha J., Reeves, Jacqueline D., Hudson, Richard, Miyake, Koichi, Dejucq, Nathalie, Schols, Dominique, ...
The chemokine receptors CCR5 and CXCR4 are the major coreceptors for human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). At least 12 other chemokine receptors or close...
Schols, Dominique; U0009441, Proost, Paul; U0019058, Struyf, S, Wuyts, Anja; U0010539, De Meester, I, Scharpe, S, ...
Van Damme, J, Proost, Paul; U0019058, Struyf, S, Wuyts, Anja; U0010539, Lambeir, AM, De Meester, I, ...
Potential chemotherapeutic targets in the replicative cycle of HIV (1994)
De Clercq, Erik; U0003934, Schols, Dominique; U0009441, Debyser, Zeger; U0003374, Vandamme, Anne-Mieke; U0004051
Balzarini, Jan; U0005099, Van Aerschot, Arthur; U0002172, Pauwels, R, Baba, M, Schols, Dominique; U0009441, Herdewijn, Piet; U0010383, ...
The novel 5-chloro-, 5-bromo-, and 5-iodo-derivatives of 3'-fluoro-2',3'-dideoxyuridine (FddUrd), designated FddCIUrd, FddBrUrd, and FddIUrd, respectively, have been synthesized and evaluated for...
Liu, Qing-Hua, Williams, Darlisha A., McManus, Carrie, Baribaud, Frédéric, Doms, Robert W., Schols, Dominique, ...
HIV type 1 (HIV-1) uses the chemokine receptors CCR5 and CXCR4 as coreceptors for entry into target cells. Here we show that the HIV-1 envelope gp120 (Env) activates multiple ionic signaling...
Yi, Yanjie, Isaacs, Stuart N., Williams, Darlisha A., Frank, Ian, Schols, Dominique, De Clercq, Erik, ...
Dual-tropic human immunodeficiency virus type 1 (HIV-1) strains infect both primary macrophages and transformed T-cell lines. Prototype T-cell line-tropic (T-tropic) strains use CXCR4 as their...
Schols, Dominique, Esté, José A., Cabrera, Cecilia, De Clercq, Erik
The NL4.3 T-cell-line-tropic human immunodeficiency virus type 1 strain is sensitive to the CXC chemokine stromal cell-derived factor 1α (SDF-1α), the natural ligand for CXC chemokine receptor 4...
Labrosse, Béatrice, Brelot, Anne, Heveker, Nikolaus, Sol, Nathalie, Schols, Dominique, De Clercq, Erik, ...
The bicyclam AMD3100 is a potent and selective inhibitor of the replication of human immunodeficiency virus type 1 and type 2 (HIV-1 and HIV-2). It was recently demonstrated that the compound...
Simmons, Graham, Reeves, Jacqueline D., McKnight, Áine, Dejucq, Nathalie, Hibbitts, Sam, Power, Christine A., ...
The coreceptors used by primary syncytium-inducing (SI) human immunodeficiency virus type 1 isolates for infection of primary macrophages were investigated. SI strains using only CXCR4 replicated...
Schramm, Birgit, Penn, Michael L., Speck, Roberto F., Chan, Stephen Y., De Clercq, Erik, Schols, Dominique, ...
The chemokine receptors CCR5 and CXCR4 function as the principal coreceptors for human immunodeficiency virus type 1 (HIV-1). Coreceptor function has also been demonstrated for a variety of related...
CXC-Chemokine Receptor 4 Is Not a Coreceptor for Human Herpesvirus 7 Entry into CD4+ T Cells
Zhang, Ying, Hatse, Sigrid, De Clercq, Erik, Schols, Dominique
Human herpesvirus 7 (HHV-7) is a T-lymphotropic virus which utilizes the CD4 receptor as its main receptor to enter the target cells. Hence, HHV-7 can interfere with human immunodeficiency virus type...
Esté, José A., Cabrera, Cecilia, Blanco, Julià, Gutierrez, Arantxa, Bridger, Gary, Henson, Geoffrey, ...
The emergence of X4 human immunodeficiency virus type 1 (HIV-1) strains in HIV-1-infected individuals has been associated with CD4+ T-cell depletion, HIV-mediated CD8+ cell apoptosis, and an impaired...
Egberink, Herman F., De Clercq, Erik, Balzarini, Jan, Bridger, Gary J., Henson, Geoffrey, ...
Bicyclams are low-molecular-weight anti-human immunodeficiency virus (HIV) agents that have been shown to act as potent and selective CXC chemokine receptor 4 (CXCR4) antagonists. Here, we...
Aquaro, Stefano, Menten, Patricia, Struyf, Sofie, Proost, Paul, Van Damme, Jo, De Clercq, Erik, ...
The CC-chemokines RANTES, macrophage inflammatory protein 1α (MIP-1α), and MIP-1β are natural ligands for the CC-chemokine receptor CCR5. MIP-1α, also known as LD78α, has an isoform, LD78β,...
Gorry, Paul R., Bristol, Greg, Zack, Jerome A., Ritola, Kimberly, Swanstrom, Ronald, Birch, Chris J., ...
The viral determinants that underlie human immunodeficiency virus type 1 (HIV-1) neurotropism are unknown, due in part to limited studies on viruses isolated from brain. Previous studies suggest that...
Productive Infection of Primary Macrophages with Human Herpesvirus 7
Zhang, Ying, De Bolle, Leen, Aquaro, Stefano, Van Lommel, Alfons, De Clercq, Erik, Schols, Dominique
Here we demonstrate replication of human herpesvirus 7 (HHV-7), a T-lymphotropic virus, in macrophages. Productive replication was lost after 2 weeks, but HHV-7 DNA was detected up to 1 month after...
Koning, Fransje A., Schols, Dominique, Schuitemaker, Hanneke
In two cases of parenteral transmission of human immunodeficiency virus type 1 (HIV-1) syncitium-inducing (SI) variants, we previously observed selection for macrophagetropic variants. Although...
Naif, Hassan M., Cunningham, Anthony L., Alali, Mohammed, Li, Shan, Nasr, Najla, Buhler, Marc M., ...
The mechanisms of human immunodeficiency virus (HIV) infection of a man (VH) homozygous for the CCR5Δ32 mutation were investigated, and coreceptors other than CCR5 used by HIV type 1 (HIV-1)...
Jekle, Andreas, Schramm, Birgit, Jayakumar, Prerana, Trautner, Verena, Schols, Dominique, De Clercq, Erik, ...
The Sydney Blood Bank Cohort is a group of patients with slowly progressive infection by a human immunodeficiency virus strain containing spontaneous deletions within the nef long terminal repeat...
Pedroza-Martins, Livia, Boscardin, W. John, Anisman-Posner, Deborah J., Schols, Dominique, Bryson, Yvonne J., Uittenbogaart, Christel H.
Early infection of the thymus with the human immunodeficiency virus (HIV) may explain the more rapid disease progression among children infected in utero than in children infected intrapartum....
Interleukin-8 and Growth-Regulated Oncogene Alpha Mediate Angiogenesis in Kaposi's Sarcoma
Lane, Brian R., Liu, Jianguo, Bock, Paul J., Schols, Dominique, Coffey, Michael J., Strieter, Robert M., ...
The development of the complex neoplasm Kaposi's sarcoma is dependent on infection with the Kaposi's sarcoma-associated herpesvirus (KSHV) and appears to be greatly enhanced by cytokines and human...
Jekle, Andreas, Keppler, Oliver T., De Clercq, Erik, Schols, Dominique, Weinstein, Mark, Goldsmith, Mark A.
The destruction of the immune system by progressive loss of CD4 T cells is the hallmark of AIDS. CCR5-dependent (R5) human immunodeficiency virus type 1 (HIV-1) isolates predominate in the early,...
Stalmeijer, Evelien H. B., Van Rij, Ronald P., Boeser-Nunnink, Brigitte, Visser, Janny A., Naarding, Marloes A., Schols, Dominique, ...
CXCR4-using (X4) human immunodeficiency virus type 1 (HIV-1) variants evolve from CCR5-restricted (R5) HIV-1 variants. Early after their first appearance in vivo, X4 HIV-1 variants additionally use...
Holm, Geoffrey H., Zhang, Chengsheng, Gorry, Paul R., Peden, Keith, Schols, Dominique, De Clercq, Erik, ...
Apoptosis of uninfected bystander CD4+ T cells contributes to T-cell depletion during human immunodeficiency virus type 1 (HIV-1) pathogenesis. The viral and host mechanisms that lead to bystander...
Glushakova, Svetlana, Yi, Yanjie, Grivel, Jean-Charles, Singh, Anjali, Schols, Dominique, De Clercq, Erik, ...
Many HIV-1 isolates at the late stage of disease are capable of using both CXCR4 and CCR5 in transfected cell lines, and are thus termed dual-tropic. Here we asked whether these dual-tropic variants...
The LD78β isoform of MIP-1α is the most potent CCR5 agonist and HIV-1–inhibiting chemokine
Menten, Patricia, Struyf, Sofie, Schutyser, Evemie, Wuyts, Anja, De Clercq, Erik, Schols, Dominique, ...
LD78α and LD78β are 2 highly related nonallelic genes that code for different isoforms of the human CC chemokine macrophage inflammatory protein-1α (MIP-1α). Two molecular forms of natural LD78β...
Profile of Resistance of Human Immunodeficiency Virus to Mannose-Specific Plant Lectins
Balzarini, Jan, Van Laethem, Kristel, Hatse, Sigrid, Vermeire, Kurt, De Clercq, Erik, Peumans, Willy, ...
The mannose-specific plant lectins from the Amaryllidaceae family (e.g., Hippeastrum sp. hybrid and Galanthus nivalis) inhibit human immunodeficiency virus (HIV) infection of human lymphocytic cells...
Balzarini, Jan, Hatse, Sigrid, Vermeire, Kurt, Princen, Katrien, Aquaro, Stefano, Perno, Carlo-Federico, ...
The plant lectins derived from Galanthus nivalis (Snowdrop) (GNA) and Hippeastrum hybrid (Amaryllis) (HHA) selectively inhibited a wide variety of human immunodeficiency virus type 1 (HIV-1) and...
Inhibition of Human Immunodeficiency Virus Replication by a Dual CCR5/CXCR4 Antagonist
Princen, Katrien, Hatse, Sigrid, Vermeire, Kurt, Aquaro, Stefano, De Clercq, Erik, Gerlach, Lars-Ole, ...
Here we report that the N-pyridinylmethyl cyclam analog AMD3451 has antiviral activity against a wide variety of R5, R5/X4, and X4 strains of human immunodeficiency virus type 1 (HIV-1) and HIV-2...
Profile of Resistance of Human Immunodeficiency Virus to Mannose-Specific Plant Lectins
Balzarini*, Jan, Van Laethem, Kristel, Hatse, Sigrid, Vermeire, Kurt, De Clercq, Erik, Peumans, Willy, ...
Turville, Stuart G., Vermeire, Kurt, Balzarini, Jan, Schols, Dominique
Both endocytic uptake and viral fusion can lead to human immunodeficiency virus type 1 (HIV-1) transfer to CD4+ lymphocytes, either through directional regurgitation (infectious transfer in trans...
Pro-inflammatory properties of stromal cell-derived factor-1 (CXCL12) in collagen-induced arthritis
De Klerck, Bert, Geboes, Lies, Hatse, Sigrid, Kelchtermans, Hilde, Meyvis, Yves, Vermeire, Kurt, ...
CXCL12 (stromal cell-derived factor 1) is a unique biological ligand for the chemokine receptor CXCR4. We previously reported that treatment with a specific CXCR4 antagonist, AMD3100, exerts a...
Willey, Samantha J., Reeves, Jacqueline D., Hudson, Richard, Miyake, Koichi, Dejucq, Nathalie, Schols, Dominique, ...
The chemokine receptors CCR5 and CXCR4 are the major coreceptors for human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). At least 12 other chemokine receptors or close...
Liu, Qing-Hua, Williams, Darlisha A., McManus, Carrie, Baribaud, Frédéric, Doms, Robert W., Schols, Dominique, ...
HIV type 1 (HIV-1) uses the chemokine receptors CCR5 and CXCR4 as coreceptors for entry into target cells. Here we show that the HIV-1 envelope gp120 (Env) activates multiple ionic signaling...
Yi, Yanjie, Isaacs, Stuart N., Williams, Darlisha A., Frank, Ian, Schols, Dominique, De Clercq, Erik, ...
Dual-tropic human immunodeficiency virus type 1 (HIV-1) strains infect both primary macrophages and transformed T-cell lines. Prototype T-cell line-tropic (T-tropic) strains use CXCR4 as their...
Schols, Dominique, Esté, José A., Cabrera, Cecilia, De Clercq, Erik
The NL4.3 T-cell-line-tropic human immunodeficiency virus type 1 strain is sensitive to the CXC chemokine stromal cell-derived factor 1α (SDF-1α), the natural ligand for CXC chemokine receptor 4...
Labrosse, Béatrice, Brelot, Anne, Heveker, Nikolaus, Sol, Nathalie, Schols, Dominique, De Clercq, Erik, ...
The bicyclam AMD3100 is a potent and selective inhibitor of the replication of human immunodeficiency virus type 1 and type 2 (HIV-1 and HIV-2). It was recently demonstrated that the compound...
Simmons, Graham, Reeves, Jacqueline D., McKnight, Áine, Dejucq, Nathalie, Hibbitts, Sam, Power, Christine A., ...
The coreceptors used by primary syncytium-inducing (SI) human immunodeficiency virus type 1 isolates for infection of primary macrophages were investigated. SI strains using only CXCR4 replicated...
Schramm, Birgit, Penn, Michael L., Speck, Roberto F., Chan, Stephen Y., De Clercq, Erik, Schols, Dominique, ...
The chemokine receptors CCR5 and CXCR4 function as the principal coreceptors for human immunodeficiency virus type 1 (HIV-1). Coreceptor function has also been demonstrated for a variety of related...
CXC-Chemokine Receptor 4 Is Not a Coreceptor for Human Herpesvirus 7 Entry into CD4+ T Cells
Zhang, Ying, Hatse, Sigrid, De Clercq, Erik, Schols, Dominique
Human herpesvirus 7 (HHV-7) is a T-lymphotropic virus which utilizes the CD4 receptor as its main receptor to enter the target cells. Hence, HHV-7 can interfere with human immunodeficiency virus type...
Esté, José A., Cabrera, Cecilia, Blanco, Julià, Gutierrez, Arantxa, Bridger, Gary, Henson, Geoffrey, ...
The emergence of X4 human immunodeficiency virus type 1 (HIV-1) strains in HIV-1-infected individuals has been associated with CD4+ T-cell depletion, HIV-mediated CD8+ cell apoptosis, and an impaired...
Egberink, Herman F., De Clercq, Erik, Balzarini, Jan, Bridger, Gary J., Henson, Geoffrey, ...
Bicyclams are low-molecular-weight anti-human immunodeficiency virus (HIV) agents that have been shown to act as potent and selective CXC chemokine receptor 4 (CXCR4) antagonists. Here, we...
Aquaro, Stefano, Menten, Patricia, Struyf, Sofie, Proost, Paul, Van Damme, Jo, De Clercq, Erik, ...
The CC-chemokines RANTES, macrophage inflammatory protein 1α (MIP-1α), and MIP-1β are natural ligands for the CC-chemokine receptor CCR5. MIP-1α, also known as LD78α, has an isoform, LD78β,...
Gorry, Paul R., Bristol, Greg, Zack, Jerome A., Ritola, Kimberly, Swanstrom, Ronald, Birch, Chris J., ...
The viral determinants that underlie human immunodeficiency virus type 1 (HIV-1) neurotropism are unknown, due in part to limited studies on viruses isolated from brain. Previous studies suggest that...
Productive Infection of Primary Macrophages with Human Herpesvirus 7
Zhang, Ying, De Bolle, Leen, Aquaro, Stefano, Van Lommel, Alfons, De Clercq, Erik, Schols, Dominique
Here we demonstrate replication of human herpesvirus 7 (HHV-7), a T-lymphotropic virus, in macrophages. Productive replication was lost after 2 weeks, but HHV-7 DNA was detected up to 1 month after...
Koning, Fransje A., Schols, Dominique, Schuitemaker, Hanneke
In two cases of parenteral transmission of human immunodeficiency virus type 1 (HIV-1) syncitium-inducing (SI) variants, we previously observed selection for macrophagetropic variants. Although...
Naif, Hassan M., Cunningham, Anthony L., Alali, Mohammed, Li, Shan, Nasr, Najla, Buhler, Marc M., ...
The mechanisms of human immunodeficiency virus (HIV) infection of a man (VH) homozygous for the CCR5Δ32 mutation were investigated, and coreceptors other than CCR5 used by HIV type 1 (HIV-1)...
Jekle, Andreas, Schramm, Birgit, Jayakumar, Prerana, Trautner, Verena, Schols, Dominique, De Clercq, Erik, ...
The Sydney Blood Bank Cohort is a group of patients with slowly progressive infection by a human immunodeficiency virus strain containing spontaneous deletions within the nef long terminal repeat...
Pedroza-Martins, Livia, Boscardin, W. John, Anisman-Posner, Deborah J., Schols, Dominique, Bryson, Yvonne J., Uittenbogaart, Christel H.
Early infection of the thymus with the human immunodeficiency virus (HIV) may explain the more rapid disease progression among children infected in utero than in children infected intrapartum....
Interleukin-8 and Growth-Regulated Oncogene Alpha Mediate Angiogenesis in Kaposi's Sarcoma
Lane, Brian R., Liu, Jianguo, Bock, Paul J., Schols, Dominique, Coffey, Michael J., Strieter, Robert M., ...
The development of the complex neoplasm Kaposi's sarcoma is dependent on infection with the Kaposi's sarcoma-associated herpesvirus (KSHV) and appears to be greatly enhanced by cytokines and human...
Jekle, Andreas, Keppler, Oliver T., De Clercq, Erik, Schols, Dominique, Weinstein, Mark, Goldsmith, Mark A.
The destruction of the immune system by progressive loss of CD4 T cells is the hallmark of AIDS. CCR5-dependent (R5) human immunodeficiency virus type 1 (HIV-1) isolates predominate in the early,...
Willey, Samantha J., Reeves, Jacqueline D., Hudson, Richard, Miyake, Koichi, Dejucq, Nathalie, Schols, Dominique, ...
The chemokine receptors CCR5 and CXCR4 are the major coreceptors for human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). At least 12 other chemokine receptors or close...
Stalmeijer, Evelien H. B., Van Rij, Ronald P., Boeser-Nunnink, Brigitte, Visser, Janny A., Naarding, Marloes A., Schols, Dominique, ...
CXCR4-using (X4) human immunodeficiency virus type 1 (HIV-1) variants evolve from CCR5-restricted (R5) HIV-1 variants. Early after their first appearance in vivo, X4 HIV-1 variants additionally use...
Holm, Geoffrey H., Zhang, Chengsheng, Gorry, Paul R., Peden, Keith, Schols, Dominique, De Clercq, Erik, ...
Apoptosis of uninfected bystander CD4+ T cells contributes to T-cell depletion during human immunodeficiency virus type 1 (HIV-1) pathogenesis. The viral and host mechanisms that lead to bystander...
Glushakova, Svetlana, Yi, Yanjie, Grivel, Jean-Charles, Singh, Anjali, Schols, Dominique, De Clercq, Erik, ...
Many HIV-1 isolates at the late stage of disease are capable of using both CXCR4 and CCR5 in transfected cell lines, and are thus termed dual-tropic. Here we asked whether these dual-tropic variants...
The LD78β isoform of MIP-1α is the most potent CCR5 agonist and HIV-1–inhibiting chemokine
Menten, Patricia, Struyf, Sofie, Schutyser, Evemie, Wuyts, Anja, De Clercq, Erik, Schols, Dominique, ...
LD78α and LD78β are 2 highly related nonallelic genes that code for different isoforms of the human CC chemokine macrophage inflammatory protein-1α (MIP-1α). Two molecular forms of natural LD78β...
Profile of Resistance of Human Immunodeficiency Virus to Mannose-Specific Plant Lectins
Balzarini, Jan, Van Laethem, Kristel, Hatse, Sigrid, Vermeire, Kurt, De Clercq, Erik, Peumans, Willy, ...
The mannose-specific plant lectins from the Amaryllidaceae family (e.g., Hippeastrum sp. hybrid and Galanthus nivalis) inhibit human immunodeficiency virus (HIV) infection of human lymphocytic cells...
Balzarini, Jan, Hatse, Sigrid, Vermeire, Kurt, Princen, Katrien, Aquaro, Stefano, Perno, Carlo-Federico, ...
The plant lectins derived from Galanthus nivalis (Snowdrop) (GNA) and Hippeastrum hybrid (Amaryllis) (HHA) selectively inhibited a wide variety of human immunodeficiency virus type 1 (HIV-1) and...
Inhibition of Human Immunodeficiency Virus Replication by a Dual CCR5/CXCR4 Antagonist
Princen, Katrien, Hatse, Sigrid, Vermeire, Kurt, Aquaro, Stefano, De Clercq, Erik, Gerlach, Lars-Ole, ...
Here we report that the N-pyridinylmethyl cyclam analog AMD3451 has antiviral activity against a wide variety of R5, R5/X4, and X4 strains of human immunodeficiency virus type 1 (HIV-1) and HIV-2...
Profile of Resistance of Human Immunodeficiency Virus to Mannose-Specific Plant Lectins
Balzarini*, Jan, Van Laethem, Kristel, Hatse, Sigrid, Vermeire, Kurt, De Clercq, Erik, Peumans, Willy, ...
Turville, Stuart G., Vermeire, Kurt, Balzarini, Jan, Schols, Dominique
Both endocytic uptake and viral fusion can lead to human immunodeficiency virus type 1 (HIV-1) transfer to CD4+ lymphocytes, either through directional regurgitation (infectious transfer in trans...
Pro-inflammatory properties of stromal cell-derived factor-1 (CXCL12) in collagen-induced arthritis
De Klerck, Bert, Geboes, Lies, Hatse, Sigrid, Kelchtermans, Hilde, Meyvis, Yves, Vermeire, Kurt, ...
CXCL12 (stromal cell-derived factor 1) is a unique biological ligand for the chemokine receptor CXCR4. We previously reported that treatment with a specific CXCR4 antagonist, AMD3100, exerts a...
Balzarini, Jan, Van Laethem, Kristel, Peumans, Willy J., Bolmstedt, Anders, Gago, Federico, ...
Limited data are available on the genotypic and phenotypic resistance profile of the α-(1-2)mannose oligomer-specific prokaryotic lectin cyanovirin (CV-N). Therefore, a more systematic investigation...
Balzarini, Jan, Van Laethem, Kristel, Daelemans, Dirk, Hatse, Sigrid, Bugatti, Antonella, Rusnati, Marco, ...
Pradimicin A (PRM-A), an antifungal nonpeptidic benzonaphtacenequinone antibiotic, is a low-molecular-weight (molecular weight, 838) carbohydrate binding agent (CBA) endowed with a selective...
Lisco, Andrea, Grivel, Jean-Charles, Biancotto, Angélique, Vanpouille, Christophe, Origgi, Francesco, Malnati, Mauro S., ...
Human immunodeficiency virus (HIV) infection is often accompanied by infection with other pathogens that affect the clinical course of HIV disease. Here, we identified another virus, human...
AMD3100, a CxCR4 Antagonist, Attenuates Allergic Lung Inflammation and Airway Hyperreactivity
Lukacs, Nicholas W., Berlin, Aaron, Schols, Dominique, Skerlj, Renato T., Bridger, Gary J.
The role of specific chemokine receptors during allergic asthmatic responses has been relatively undefined. A number of receptors are preferentially expressed on Th2 cells, including CCR4, CCR8, and...
Saïdi, Hela, Nasreddine, Nadine, Jenabian, Mohammad-Ali, Lecerf, Maxime, Schols, Dominique, Krief, Corinne, ...
Stevens, Miguel, Pollicita, Michela, Pannecouque, Christophe, Verbeken, Erik, Tabarrini, Oriana, Cecchetti, Violetta, ...
Two novel 6-desfluoroquinolone derivatives, HM-12 and HM-13, were evaluated for anti-human immunodeficiency virus (anti-HIV) activity in acutely, chronically, and latently HIV type 1 (HIV-1)-infected...
Hatse, Sigrid, Huskens, Dana, Princen, Katrien, Vermeire, Kurt, Bridger, Gary J., De Clercq, Erik, ...
The chemokine receptor CXCR3 can exhibit weak coreceptor function for several human immunodeficiency virus type 1 (HIV-1) and HIV-2 strains and clinical isolates. These viruses produced...
Inhibition of T-tropic HIV Strains by Selective Antagonization of the Chemokine Receptor CXCR4
Schols, Dominique, Struyf, Sofie, Damme, Jo Van, Esté, José A., Henson, Geoffrey, Clercq, Erik De
Bicyclams are a novel class of antiviral compounds that are highly potent and selective inhibitors of the replication of HIV-1 and HIV-2. Surprisingly, however, when the prototype compound AMD3100...
Goethals, Olivia, Clayton, Reginald, Van Ginderen, Marcia, Vereycken, Inge, Wagemans, Elisabeth, Geluykens, Peggy, ...
Integration of viral DNA into the host chromosome is an essential step in the life cycle of retroviruses and is facilitated by the viral integrase enzyme. The first generation of integrase inhibitors...