AGEMAP: A Gene Expression Database for Aging in Mice (2007)
Jacob M. Zahn, Suresh Poosala, Art B. Owen, Donald K. Ingram, Ana Lustig, Arnell Carter, ...
We present the AGEMAP (Atlas of Gene Expression in Mouse Aging Project) gene expression database, which is a resource that catalogs changes in gene expression as a function of age in mice. The AGEMAP...
AUTOMATIC ESTIMATION OF SIZE PARAMETERS USING VERIFIED COMPUTERIZED STEREOANALYSIS (2005)
PETER R MOUTON, JOEL DURGAVICH, DONALD K INGRAM
State-of-the-art computerized stereology systems combine high-resolution video microscopy and hardwaresoftware integration with stereological methods to assist users in quantifying multidimensional...
Is Attempting to Assess Biological Age Worth the Effort? (1995)
Binstock, Robert H., Ingram, Donald K., Shock, Nathan W., Stoll, Siegfried, Baker, George T.
National Statistics on Deaths in Nursing Homes Interpretations and Implications (1977)
Ingram, Donald K., Barry, John R.
National statistics for three data periods over a 10-year span are presented to show the increasing numbers of elderly who are dying in nursing homes. Several statistical indices are presented to...
Vaitkevicius, Peter V., Lane, Mark, Spurgeon, Harold, Ingram, Donald K., Roth, George S., Egan, John J., ...
Nonenzymatic glycosylation and cross-linking of proteins by glucose contributes to an age-associated increase in vascular and myocardial stiffness. Some recently sythesized thiazolium compounds...
Anson, R. Michael, Guo, Zhihong, De Cabo, Rafael, Iyun, Titilola, Rios, Michelle, Hagepanos, Adrienne, ...
Dietary restriction has been shown to have several health benefits including increased insulin sensitivity, stress resistance, reduced morbidity, and increased life span. The mechanism remains...
Involvement of Notch signaling in hippocampal synaptic plasticity
Wang, Yue, Chan, Sic L., Miele, Lucio, Yao, Pamela J., Mackes, Jennifer, Ingram, Donald K., ...
During development of the nervous system, the fate of stem cells is regulated by a cell surface receptor called Notch. Notch is also present in the adult mammalian brain; however, because Notch null...
Maswood, Navin, Young, Jennifer, Tilmont, Edward, Zhang, Zhiming, Gash, Don M., Gerhardt, Greg A., ...
We report that a low-calorie diet can lessen the severity of neurochemical deficits and motor dysfunction in a primate model of Parkinson's disease. Adult male rhesus monkeys were maintained for 6...
Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans
Wilson, Mark A, Shukitt-Hale, Barbara, Kalt, Wilhelmina, Ingram, Donald K, Joseph, James A, Wolkow, Catherine A
The beneficial effects of polyphenol compounds in fruits and vegetables are mainly extrapolated from in vitro studies or short-term dietary supplementation studies. Due to cost and duration,...
Greig, Nigel H., Utsuki, Tadanobu, Ingram, Donald K., Wang, Yue, Pepeu, Giancarlo, Scali, Carla, ...
Like acetylcholinesterase, butyrylcholinesterase (BChE) inactivates the neurotransmitter acetylcholine (ACh) and is hence a viable therapeutic target in Alzheimer's disease, which is characterized by...
Vaitkevicius, Peter V., Lane, Mark, Spurgeon, Harold, Ingram, Donald K., Roth, George S., Egan, John J., ...
Nonenzymatic glycosylation and cross-linking of proteins by glucose contributes to an age-associated increase in vascular and myocardial stiffness. Some recently sythesized thiazolium compounds...
Anson, R. Michael, Guo, Zhihong, De Cabo, Rafael, Iyun, Titilola, Rios, Michelle, Hagepanos, Adrienne, ...
Dietary restriction has been shown to have several health benefits including increased insulin sensitivity, stress resistance, reduced morbidity, and increased life span. The mechanism remains...
Involvement of Notch signaling in hippocampal synaptic plasticity
Wang, Yue, Chan, Sic L., Miele, Lucio, Yao, Pamela J., Mackes, Jennifer, Ingram, Donald K., ...
During development of the nervous system, the fate of stem cells is regulated by a cell surface receptor called Notch. Notch is also present in the adult mammalian brain; however, because Notch null...
Maswood, Navin, Young, Jennifer, Tilmont, Edward, Zhang, Zhiming, Gash, Don M., Gerhardt, Greg A., ...
We report that a low-calorie diet can lessen the severity of neurochemical deficits and motor dysfunction in a primate model of Parkinson's disease. Adult male rhesus monkeys were maintained for 6...
Greig, Nigel H., Utsuki, Tadanobu, Ingram, Donald K., Wang, Yue, Pepeu, Giancarlo, Scali, Carla, ...
Like acetylcholinesterase, butyrylcholinesterase (BChE) inactivates the neurotransmitter acetylcholine (ACh) and is hence a viable therapeutic target in Alzheimer's disease, which is characterized by...
Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans
Wilson, Mark A, Shukitt-Hale, Barbara, Kalt, Wilhelmina, Ingram, Donald K, Joseph, James A, Wolkow, Catherine A
The beneficial effects of polyphenol compounds in fruits and vegetables are mainly extrapolated from in vitro studies or short-term dietary supplementation studies. Due to cost and duration,...
Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates
Messaoudi, Ilhem, Warner, Jessica, Fischer, Miranda, Park, Buyng, Hill, Brenna, Mattison, Julie, ...
Caloric restriction (CR) has long been known to increase median and maximal lifespans and to decreases mortality and morbidity in short-lived animal models, likely by altering fundamental biological...
AGEMAP: A Gene Expression Database for Aging in Mice
Zahn, Jacob M, Poosala, Suresh, Owen, Art B, Ingram, Donald K, Lustig, Ana, Carter, Arnell, ...
We present the AGEMAP (Atlas of Gene Expression in Mouse Aging Project) gene expression database, which is a resource that catalogs changes in gene expression as a function of age in mice. The AGEMAP...
Effects of calorie restriction on chromosomal stability in rhesus monkeys (Macaca mulatta)
Moore, Charleen M., Dunn, Betty G., McMahan, C. Alex, Lane, Mark A., Roth, George S., Ingram, Donald K., ...
The basic tenet of several theories on aging is increasing genomic instability resulting from interactions with the environment. Chromosomal aberrations have been used as classic examples of...
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction
Pearson, Kevin J., Lewis, Kaitlyn N., Price, Nathan L., Chang, Joy W., Perez, Evelyn, Cascajo, Maria Victoria, ...
Caloric restriction (CR) is the most potent intervention known to both protect against carcinogenesis and extend lifespan in laboratory animals. A variety of anticarcinogens and CR mimetics induce...
Allard, Joanne S., Heilbronn, Leonie K., Smith, Carolina, Hunt, Nicole D., Ingram, Donald K., Ravussin, Eric, ...
Calorie restriction (CR) produces several health benefits and increases lifespan in many species. Studies suggest that alternate-day fasting (ADF) and exercise can also provide these benefits....
Neuropathological quantification of dtg APP/PS1: neuroimaging, stereology, and biochemistry
Manaye, Kebreten F., Wang, Paul C., O’Neil, Jahn N., Huang, Sophia Y., Xu, Tao, Lei, De-Liang, ...
Murine models that mimic the neuropathology of Alzheimer’s disease (AD) have the potential to provide insight into the pathogenesis of the disease and lead to new strategies for the therapeutic...