Donna Hochberg

BIOINFORMATICS ORIGINAL PAPER doi:10.1093/bioinformatics/btm044 Systems biology Simulating Epstein-Barr virus infection with C-ImmSim (2008)

Karen Duca, Abdul Jarrah, Reinhard Laubenbacher, Donna Hochberg, David Thorley-lawson

Motivation: Epstein-Barr virus (EBV) infects greater than 90 % of humans benignly for life but can be associated with tumors. It is a uniquely human pathogen that is amenable to quantitative...

Simulating Epstein-Barr virus infection with C-ImmSim (2007)

Castiglione, Filippo, Duca, Karen, Jarrah, Abdul, Laubenbacher, Reinhard, Hochberg, Donna, Thorley-Lawson, David

Motivation: Epstein-Barr virus (EBV) infects greater than 90% of humans benignly for life but can be associated with tumors. It is a uniquely human pathogen that is amenable to quantitative analysis;...

Demonstration of the Burkitt's lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivo

Hochberg, Donna, Middeldorp, Jaap M., Catalina, Michelle, Sullivan, John L., Luzuriaga, Katherine, Thorley-Lawson, David A.

Epstein-Barr virus (EBV) is a herpesvirus that establishes a lifelong, persistent infection. It was first discovered in the tumor Burkitt's lymphoma (BL). Despite intensive study, the role of EBV in...

Acute Infection with Epstein-Barr Virus Targets and Overwhelms the Peripheral Memory B-Cell Compartment with Resting, Latently Infected Cells

Hochberg, Donna, Souza, Tatyana, Catalina, Michelle, Sullivan, John L., Luzuriaga, Katherine, Thorley-Lawson, David A.

In this paper we demonstrate that during acute infection with Epstein-Barr virus (EBV), the peripheral blood fills up with latently infected, resting memory B cells to the point where up to 50% of...

Demonstration of the Burkitt's lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivo

Hochberg, Donna, Middeldorp, Jaap M., Catalina, Michelle, Sullivan, John L., Luzuriaga, Katherine, Thorley-Lawson, David A.

Epstein-Barr virus (EBV) is a herpesvirus that establishes a lifelong, persistent infection. It was first discovered in the tumor Burkitt's lymphoma (BL). Despite intensive study, the role of EBV in...

Acute Infection with Epstein-Barr Virus Targets and Overwhelms the Peripheral Memory B-Cell Compartment with Resting, Latently Infected Cells

Hochberg, Donna, Souza, Tatyana, Catalina, Michelle, Sullivan, John L., Luzuriaga, Katherine, Thorley-Lawson, David A.

In this paper we demonstrate that during acute infection with Epstein-Barr virus (EBV), the peripheral blood fills up with latently infected, resting memory B cells to the point where up to 50% of...