Bayesian Hidden Markov Modeling of Array CGH Data (2006)
Guha, Subharup, Li, Yi, Neuberg, Donna
Genomic alterations have been linked to the development and progression of cancer. The technique of Comparative Genomic Hybridization (CGH) yields data consisting of fluorescence intensity ratios of...
Bayesian Hidden Markov Modeling of Array CGH Data (2006)
Guha, Subharup, Li, Yi, Neuberg, Donna
Genomic alterations have been linked to the development and progression of cancer. The technique of Comparative Genomic Hybridization (CGH) yields data consisting of fluorescence intensity ratios of...
Bayesian Hidden Markov Modeling of Array CGH Data (2006)
Guha, Subharup, Li, Yi, Neuberg, Donna
Genomic alterations have been linked to the development and progression of cancer. The technique of Comparative Genomic Hybridization (CGH) yields data consisting of fluorescence intensity ratios of...
Bayesian Hidden Markov Modeling of Array CGH Data (2006)
Guha, Subharup, Li, Yi, Neuberg, Donna
Genomic alterations have been linked to the development and progression of cancer. The technique of Comparative Genomic Hybridization (CGH) yields data consisting of fluorescence intensity ratios of...
Mutter, George L, Zahrieh, David, Liu, Chunmei, Neuberg, Donna, Finkelstein, David, Baker, Heather E, ...
Abstract Background Primary human tissues are an invaluable widely used tool for discovery of gene expression patterns which characterize disease states. Tissue processing methods remain...
Stover, Elizabeth H, Boulton, Christina L, Gotlib, Jason, Legare, Robert D, Amaral, Sonia M, ...
FIP1L1-PDGFRalpha causes hypereosinophilic syndrome (HES) and is inhibited by the tyrosine kinase inhibitor imatinib (Gleevec). Imatinib is a potent inhibitor of ABL, ARG, PDGFRalpha, PDGFRbeta, and...
Soiffer, Robert, Lynch, Thomas, Mihm, Martin, Jung, Ken, Rhuda, Catherine, Schmollinger, Jan C., ...
We conducted a Phase I clinical trial investigating the biologic activity of vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte–macrophage...
ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction
Hodi, F. Stephen, Schmollinger, Jan C., Soiffer, Robert J., Salgia, Ravi, Lynch, Thomas, Ritz, Jerome, ...
An important goal of cancer immunology is the identification of antigens associated with tumor destruction. Vaccination with irradiated tumor cells engineered to secrete granulocyte/macrophage...
Mohi, M. Golam, Boulton, Christina, Gu, Ting-Lei, Sternberg, David W., Neuberg, Donna, Griffin, James D., ...
Abnormal protein tyrosine kinases (PTKs) cause many human leukemias. For example, BCR/ABL causes chronic myelogenous leukemia (CML), whereas FLT3 mutations contribute to the pathogenesis of acute...
Wu, Catherine J., Yang, Xiao-Feng, McLaughlin, Stephen, Neuberg, Donna, Canning, Christine, Stein, Brady, ...
The effectiveness of donor-lymphocyte infusion (DLI) for treatment of relapsed chronic myelogenous leukemia (CML) after allogeneic bone marrow transplantation is a clear demonstration of the...
Chen, Jing, Wall, Nathan R., Kocher, Kerry, Duclos, Nicole, Fabbro, Doriano, Neuberg, Donna, ...
Small molecule inhibitors, such as imatinib, are effective therapies for tyrosine kinase fusions BCR-ABL–TEL-PDGFβR–mediated human leukemias, but resistance may develop. The unique fusion...
Comparison of frozen and RNALater solid tissue storage methods for use in RNA expression microarrays
Mutter, George L, Zahrieh, David, Liu, Chunmei, Neuberg, Donna, Finkelstein, David, Baker, Heather E, ...
tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors
Berghmans, Stéphane, Murphey, Ryan D., Wienholds, Erno, Neuberg, Donna, Kutok, Jeffery L., Fletcher, Christopher D. M., ...
TP53 is the most frequently mutated tumor suppressor gene in human cancer, with nearly 50% of all tumors exhibiting a loss-of-function mutation. To further elucidate the genetic pathways involving...
Jaeschke, Anja, Rincón, Mercedes, Doran, Beth, Reilly, Judith, Neuberg, Donna, Greiner, Dale L., ...
The c-Jun NH2-terminal kinase isoform (JNK) 1 is implicated in type 2 diabetes. However, a potential role for the JNK2 protein kinase in diabetes has not been established. Here, we demonstrate that...
Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells
Görgün, Güllü, Holderried, Tobias A.W., Zahrieh, David, Neuberg, Donna, Gribben, John G.
To examine the impact of tumors on the immune system, we compared global gene expression profiles of peripheral blood T cells from previously untreated patients with B cell chronic lymphocytic...
A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility
Shepard, Jennifer L., Amatruda, James F., Stern, Howard M., Subramanian, Aravind, Finkelstein, David, Ziai, James, ...
A major goal of cancer research has been to identify genes that contribute to cancer formation. The similar pathology between zebrafish and human tumors, as well as the past success of large-scale...
Soiffer, Robert, Lynch, Thomas, Mihm, Martin, Jung, Ken, Rhuda, Catherine, Schmollinger, Jan C., ...
We conducted a Phase I clinical trial investigating the biologic activity of vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte–macrophage...
ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction
Hodi, F. Stephen, Schmollinger, Jan C., Soiffer, Robert J., Salgia, Ravi, Lynch, Thomas, Ritz, Jerome, ...
An important goal of cancer immunology is the identification of antigens associated with tumor destruction. Vaccination with irradiated tumor cells engineered to secrete granulocyte/macrophage...
Mohi, M. Golam, Boulton, Christina, Gu, Ting-Lei, Sternberg, David W., Neuberg, Donna, Griffin, James D., ...
Abnormal protein tyrosine kinases (PTKs) cause many human leukemias. For example, BCR/ABL causes chronic myelogenous leukemia (CML), whereas FLT3 mutations contribute to the pathogenesis of acute...
Wu, Catherine J., Yang, Xiao-Feng, McLaughlin, Stephen, Neuberg, Donna, Canning, Christine, Stein, Brady, ...
The effectiveness of donor-lymphocyte infusion (DLI) for treatment of relapsed chronic myelogenous leukemia (CML) after allogeneic bone marrow transplantation is a clear demonstration of the...
Chen, Jing, Wall, Nathan R., Kocher, Kerry, Duclos, Nicole, Fabbro, Doriano, Neuberg, Donna, ...
Small molecule inhibitors, such as imatinib, are effective therapies for tyrosine kinase fusions BCR-ABL–TEL-PDGFβR–mediated human leukemias, but resistance may develop. The unique fusion...
Comparison of frozen and RNALater solid tissue storage methods for use in RNA expression microarrays
Mutter, George L, Zahrieh, David, Liu, Chunmei, Neuberg, Donna, Finkelstein, David, Baker, Heather E, ...
tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors
Berghmans, Stéphane, Murphey, Ryan D., Wienholds, Erno, Neuberg, Donna, Kutok, Jeffery L., Fletcher, Christopher D. M., ...
TP53 is the most frequently mutated tumor suppressor gene in human cancer, with nearly 50% of all tumors exhibiting a loss-of-function mutation. To further elucidate the genetic pathways involving...
Jaeschke, Anja, Rincón, Mercedes, Doran, Beth, Reilly, Judith, Neuberg, Donna, Greiner, Dale L., ...
The c-Jun NH2-terminal kinase isoform (JNK) 1 is implicated in type 2 diabetes. However, a potential role for the JNK2 protein kinase in diabetes has not been established. Here, we demonstrate that...
Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells
Görgün, Güllü, Holderried, Tobias A.W., Zahrieh, David, Neuberg, Donna, Gribben, John G.
To examine the impact of tumors on the immune system, we compared global gene expression profiles of peripheral blood T cells from previously untreated patients with B cell chronic lymphocytic...
A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility
Shepard, Jennifer L., Amatruda, James F., Stern, Howard M., Subramanian, Aravind, Finkelstein, David, Ziai, James, ...
A major goal of cancer research has been to identify genes that contribute to cancer formation. The similar pathology between zebrafish and human tumors, as well as the past success of large-scale...
Genome-Wide Analysis of Neuroblastomas using High-Density Single Nucleotide Polymorphism Arrays
George, Rani E., Attiyeh, Edward F., Li, Shuli, Moreau, Lisa A., Neuberg, Donna, Li, Cheng, ...
Palomero, Teresa, Lim, Wei Keat, Odom, Duncan T., Sulis, Maria Luisa, Real, Pedro J., Margolin, Adam, ...
The NOTCH1 signaling pathway directly links extracellular signals with transcriptional responses in the cell nucleus and plays a critical role during T cell development and in the pathogenesis over...
Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia
Gribben, John G., Zahrieh, David, Stephans, Katherine, Bartlett-Pandite, Lini, Alyea, Edwin P., Fisher, David C., ...
We report here on the long-term follow-up on 162 patients with high-risk chronic lymphocytic leukemia (CLL) who have undergone hematopoietic stem cell transplantation (SCT) at a single center from...
Hirano, Naoto, Butler, Marcus O., Xia, Zhinan, Ansén, Sascha, Neuberg, Donna, ...
Following T-cell receptor and CD28 signaling, CD8+ T cells express a receptor for CD83, a molecule up-regulated on functionally mature dendritic cells. Although this expression pattern suggests that...
Zirlik, Katja Mauerer, Zahrieh, David, Neuberg, Donna, Gribben, John G.
Heteroclitic peptide modifications increase immunogenicity, allowing generation of cytotoxic T lymphocytes (CTLs) against weakly immunogenic tumor-associated antigens (TAAs). A critical issue is...
Alu elements mediate MYB gene tandem duplication in human T-ALL
O'Neil, Jennifer, Tchinda, Joelle, Gutierrez, Alejandro, Moreau, Lisa, Maser, Richard S., Wong, Kwok-Kin, ...
Recent studies have demonstrated that the MYB oncogene is frequently duplicated in human T cell acute lymphoblastic leukemia (T-ALL). We find that the human MYB locus is flanked by 257-bp Alu repeats...
Jinushi, Masahisa, Vanneman, Matthew, Munshi, Nikhil C., Tai, Yu-Tzu, Prabhala, Rao H., Ritz, Jerome, ...
Monoclonal gammopathy of undetermined significance (MGUS) is a common disorder of aging and a precursor lesion to full-blown multiple myeloma (MM). The mechanisms underlying the progression from MGUS...
Enzler, Thomas, Gillessen, Silke, Dougan, Michael, Allison, James P., Neuberg, Donna, Oble, Darryl A., ...
The pathogenesis of type 1 diabetes (T1D) involves the immune-mediated destruction of insulin-producing β cells in the pancreatic islets of Langerhans. Genetic analysis of families with a high...
The Identification of Zebrafish Mutants Showing Alterations in Senescence-Associated Biomarkers
Kishi, Shuji, Bayliss, Peter E., Uchiyama, Junzo, Koshimizu, Eriko, Qi, Jie, Nanjappa, Purushothama, ...
There is an interesting overlap of function in a wide range of organisms between genes that modulate the stress responses and those that regulate aging phenotypes and, in some cases, lifespan. We...
Hodi, F. Stephen, Butler, Marcus, Oble, Darryl A., Seiden, Michael V., Haluska, Frank G., Kruse, Andrea, ...
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) functions as a negative regulator of endogenous and vaccine-induced antitumor immunity. The administration of fully human anti-CTLA-4 blocking...
Zhou, Jianbiao, Goldwasser, Meredith A, Li, Aihong, Dahlberg, Suzanne E., Neuberg, Donna, Wang, Hongjun, ...
In a prospective trial in 284 children with B-lineage acute lymphoblastic leukemia (ALL), we assessed the clinical utility of real-time quantitative polymerase chain reaction analysis of antigen...