Alu elements mediate MYB gene tandem duplication in human T-ALL (2007)
O'Neil, Jennifer Elinor, Tchinda, Joelle, Gutierrez, Alejandro, Moreau, Lisa A., Maser, Richard S., Wong, Kwok-Kin, ...
Recent studies have demonstrated that the MYB oncogene is frequently duplicated in human T cell acute lymphoblastic leukemia (T-ALL). We find that the human MYB locus is flanked by 257-bp Alu repeats...
Effects of RAS on the genesis of embryonal rhabdomyosarcoma (2007)
Langenau, David M., Keefe, Matthew D., Storer, Narie Y., Guyon, Jeffrey R., Kutok, Jeffery L., Le, Xiuning, ...
Embryonal rhabdomyosarcoma (ERMS) is a devastating cancer with specific features of muscle differentiation that can result from mutational activation of RAS family members. However, to date, RAS...
Jaeschke, Anja, Rincon, Mercedes, Doran, Beth, Reilly, Judith, Neuberg, Donna S., Greiner, Dale L., ...
The c-Jun NH(2)-terminal kinase isoform (JNK) 1 is implicated in type 2 diabetes. However, a potential role for the JNK2 protein kinase in diabetes has not been established. Here, we demonstrate that...
Heterophile antibodies segregate in families and are associated with protection from type 1 diabetes
She, Jin-Xiong, Ellis, Tamir M., Wilson, S. Brian, Wasserfall, Clive H., Marron, Michele, Reimsneider, Sharon, ...
Markedly elevated levels of serum IL-4 were reported previously in 50% of a small group of type 1 diabetes nonprogessors. To determine the patterns of expression for this phenotype, a larger cohort...
Heterophile antibodies segregate in families and are associated with protection from type 1 diabetes
She, Jin-Xiong, Ellis, Tamir M., Wilson, S. Brian, Wasserfall, Clive H., Marron, Michele, Reimsneider, Sharon, ...
Markedly elevated levels of serum IL-4 were reported previously in 50% of a small group of type 1 diabetes nonprogessors. To determine the patterns of expression for this phenotype, a larger cohort...
Hou, Runhua, Goloubeva, Olga, Neuberg, Donna S, Strominger, Jack L, Wilson, S Brian
Human invariant natural killer (iNK) T cells expressing an invariant Vα24-Jα15 T-cell receptor (TCR) are thought to be important regulators of autoimmunity and tumour surveillance. Two major...
Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia
Haining, W. Nicholas, Neuberg, Donna S., Keczkemethy, Heather L., Evans, John W., Rivoli, Stephen, Gelman, Rebecca, ...
Despite profound T-cell immunodeficiency, most patients treated with chemotherapy do not succumb to infection. The basis for residual protective immunity in lymphopenic patients is not known. We...
Loh, Mignon L., Goldwasser, Meredith A., Silverman, Lewis B., Poon, Wing-Man, Vattikuti, Shashaank, Cardoso, Angelo, ...
In a retrospective analysis, we previously reported that children whose leukemia cells harbored the TEL/AML1 gene rearrangement have excellent outcomes. From 1996 to 2000, we conducted a prospective...
Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia
Palomero, Teresa, Odom, Duncan T., O'Neil, Jennifer, Ferrando, Adolfo A., Margolin, Adam, Neuberg, Donna S., ...
Aberrant expression of 1 or more transcription factor oncogenes is a critical component of the molecular pathogenesis of human T-cell acute lymphoblastic leukemia (T-ALL); however, oncogenic...
Le, Xiuning, Langenau, David M., Keefe, Matthew D., Kutok, Jeffery L., Neuberg, Donna S., Zon, Leonard I.
RAS family members are among the most frequently mutated oncogenes in human cancers. Given the utility of zebrafish in both chemical and genetic screens, developing RAS-induced cancer models will...
Effects of RAS on the genesis of embryonal rhabdomyosarcoma
Langenau, David M., Keefe, Matthew D., Storer, Narie Y., Guyon, Jeffrey R., Kutok, Jeffery L., Le, Xiuning, ...
Embryonal rhabdomyosarcoma (ERMS) is a devastating cancer with specific features of muscle differentiation that can result from mutational activation of RAS family members. However, to date, RAS...
Moghrabi, Albert, Levy, Donna E., Asselin, Barbara, Barr, Ronald, Clavell, Luis, Hurwitz, Craig, ...
The Dana-Farber Cancer Institute (DFCI) Childhood ALL Consortium Protocol 95-01 was designed to minimize therapy-related morbidity for children with newly diagnosed ALL without compromising efficacy....
Rassenti, Laura Z., Jain, Sonia, Keating, Michael J., Wierda, William G., Grever, Michael R., Byrd, John C., ...
Leukemia-cell expression of ZAP-70, CD38, or unmutated immunoglobulin heavy chain variable region genes (U-IGHV) each is associated with aggressive disease in patients with chronic lymphocytic...