Donna Spiegelman

Gender-related differences in the prevalence of cardiovascular disease risk factors and their correlates in urban Tanzania (2009)

Njelekela, Marina A, Mpembeni, Rose, Muhihi, Alfa, Mligiliche, Nuru L, Spiegelman, Donna, Hertzmark, Ellen, ...

Abstract Background Urban areas in Africa suffer a serious problem with dual burden of infectious diseases and emerging chronic diseases such as cardiovascular diseases (CVD) and diabetes which pose...

The Comparison of Alternative Smoothing Methods for Fitting Non-Linear Exposure-Response Relationships with Cox Models in a Simulation Study (2009)

Govindarajulu, Usha S, Malloy, Elizabeth J, Ganguli, Bhaswati, Spiegelman, Donna, Eisen, Ellen A

We examined the behavior of alternative smoothing methods for modeling environmental epidemiology data. Model fit can only be examined when the true exposure-response curve is known and so we used...

The Comparison of Alternative Smoothing Methods for Fitting Non-Linear Exposure-Response Relationships with Cox Models in a Simulation Study (2009)

Govindarajulu, Usha S, Malloy, Elizabeth J, Ganguli, Bhaswati, Spiegelman, Donna, Eisen, Ellen A

We examined the behavior of alternative smoothing methods for modeling environmental epidemiology data. Model fit can only be examined when the true exposure-response curve is known and so we used...

The Comparison of Alternative Smoothing Methods for Fitting Non-Linear Exposure-Response Relationships with Cox Models in a Simulation Study (2009)

Govindarajulu, Usha S, Malloy, Elizabeth J, Ganguli, Bhaswati, Spiegelman, Donna, Eisen, Ellen A

We examined the behavior of alternative smoothing methods for modeling environmental epidemiology data. Model fit can only be examined when the true exposure-response curve is known and so we used...

The Comparison of Alternative Smoothing Methods for Fitting Non-Linear Exposure-Response Relationships with Cox Models in a Simulation Study (2009)

Govindarajulu, Usha S, Malloy, Elizabeth J, Ganguli, Bhaswati, Spiegelman, Donna, Eisen, Ellen A

We examined the behavior of alternative smoothing methods for modeling environmental epidemiology data. Model fit can only be examined when the true exposure-response curve is known and so we used...

Fat, Protein, and Meat Consumption and Renal Cell Cancer Risk: A Pooled Analysis of 13 Prospective Studies (2008)

Lee, Jung Eun, Spiegelman, Donna, Hunter, David J., Albanes, Demetrius, Bernstein, Leslie, Van Den Brandt, Piet A., ...

Background Results of several case–control studies suggest that high consumption of meat (all meat, red meat, or processed meat) is associated with an increased risk of renal cell cancer, but only...

Manganese superoxide dismutase (MnSOD) gene polymorphism, interactions with carotenoid levels and prostate cancer risk (2008)

Mikhak, Bahar, Hunter, David J., Spiegelman, Donna, Platz, Elizabeth A., Wu, Kana, Erdman, John W., ...

Background: The manganese superoxide dismutase (MnSOD) gene encodes an antioxidant enzyme (SOD2) that may protect cells from oxidative damage. The MnSOD allele with Val as amino acid 16 encodes a...

Fruits, Vegetables, and Colon Cancer Risk in a Pooled Analysis of 14 Cohort Studies (2007)

Koushik, Anita, Hunter, David J., Spiegelman, Donna, Beeson, W. Lawrence, Van Den Brandt, Piet A., Buring, Julie E., ...

Background Fruit and vegetable intakes have been associated with a reduced risk of colon cancer; however, in more recent studies associations have been less consistent. Statistical power to examine...

Whole Grain, Bran, and Germ Intake and Risk of Type 2 Diabetes: A Prospective Cohort Study and Systematic Review (2007)

Frank B. Hu, Donna Spiegelman, Mary Franz

BackgroundControl of body weight by balancing energy intake and energy expenditure is of major importance for the prevention of type 2 diabetes, but the role of specific dietary factors in the...

Alcohol Intake and Renal Cell Cancer in a Pooled Analysis of 12 Prospective Studies (2007)

Lee, Jung Eun, Hunter, David J., Spiegelman, Donna, Adami, Hans-Olov, Albanes, Demetrius, Bernstein, Leslie, ...

Background The association between alcohol intake and risk of renal cell cancer has been inconsistent in case–control studies. An inverse association between alcohol intake and risk of renal cell...

Dietary Carotenoids and Risk of Colorectal Cancer in a Pooled Analysis of 11 Cohort Studies (2007)

Männistö, Satu, Yaun, Shiaw-Shyuan, Hunter, David J., Spiegelman, Donna, Adami, Hans-Olov, Albanes, Demetrius, ...

Dietary carotenoids have been hypothesized to protect against epithelial cancers. The authors analyzed the associations between intakes of specific carotenoids (alpha-carotene, beta-carotene,...

Work Characteristics and Incidence of Type 2 Diabetes in Women (2007)

Kroenke, Candyce H., Spiegelman, Donna, Manson, JoAnn, Schernhammer, Eva S., Colditz, Graham A., Kawachi, Ichiro

The authors prospectively investigated associations between potentially stressful work characteristics and type 2 diabetes incidence in 62,574 young and middle-aged women, aged 29–46 years at...

Endogenous Steroid Hormone Concentrations and Risk of Breast Cancer Among Premenopausal Women (2006)

Eliassen, A. Heather, Missmer, Stacey A., Tworoger, Shelley S., Spiegelman, Donna, Barbieri, Robert L., Dowsett, Mitch, ...

Background: Higher levels of endogenous sex steroid hormones are associated with increased risks of breast cancer in postmenopausal women. Data for premenopausal women are sparse, in part because of...

Methods for Pooling Results of Epidemiologic Studies: The Pooling Project of Prospective Studies of Diet and Cancer (2006)

Smith-Warner, Stephanie A., Spiegelman, Donna, Ritz, John, Albanes, Demetrius, Beeson, W. Lawrence, Bernstein, Leslie, ...

With the growing number of epidemiologic publications on the relation between dietary factors and cancer risk, pooled analyses that summarize results from multiple studies are becoming more common....

Adult Recall of Adolescent Diet: Reproducibility and Comparison with Maternal Reporting (2005)

Maruti, Sonia S., Feskanich, Diane, Colditz, Graham A., Frazier, A. Lindsay, Sampson, Laura A., Michels, Karin B., ...

Many cancers have long latency periods, and dietary factors in adolescence may plausibly affect cancer occurrence in adulthood. Because of a lack of prospective data, retrospective collection of data...

Plasma Carotenoids, Retinol, and Tocopherols and Risk of Breast Cancer (2005)

Tamimi, Rulla M., Hankinson, Susan E., Campos, Hannia, Spiegelman, Donna, Zhang, Shumin, Colditz, Graham A., ...

The roles of carotenoids, retinol, and tocopherols in breast cancer etiology have been inconclusive. The authors prospectively assessed the relations between plasma α-carotene, &bgr;-carotene,...

Common ataxia telangiectasia mutated haplotypes and risk of breast cancer: a nested case–control study (2004)

Tamimi, Rulla M, Hankinson, Susan E, Spiegelman, Donna, Kraft, Peter, Colditz, Graham A, Hunter, David J

Abstract Introduction The ataxia telangiectasia mutated ( ATM ) gene is a tumor suppressor gene with functions in cell cycle arrest, apoptosis, and repair of DNA double-strand breaks. Based on family...

Dairy Foods, Calcium, and Colorectal Cancer: A Pooled Analysis of 10 Cohort Studies (2004)

Cho, Eunyoung, Smith-Warner, Stephanie A., Spiegelman, Donna, Beeson, W. Lawrence, Van Den Brandt, Piet A., Colditz, Graham A., ...

Background: Studies in animals have suggested that calcium may reduce the risk of colorectal cancer. However, results from epidemiologic studies of intake of calcium or dairy foods and colorectal...

Incidence of Laparoscopically Confirmed Endometriosis by Demographic, Anthropometric, and Lifestyle Factors (2004)

Missmer, Stacey A., Hankinson, Susan E., Spiegelman, Donna, Barbieri, Robert L., Marshall, Lynn M., Hunter, David J.

The authors investigated the relations of demographic, anthropometric, and lifestyle factors with endometriosis in the Nurses’ Health Study II prospective cohort. During 10 years of follow-up...

Aspirin and the Risk of Hodgkin's Lymphoma in a Population-Based Case–Control Study (2004)

Chang, Ellen T., Zheng, Tongzhang, Weir, Edward G., Borowitz, Michael, Mann, Risa B., Spiegelman, Donna, ...

Background: Regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with decreased risk of several malignancies. NSAIDs may prevent cancer development by blocking the...

Risk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black Women's Health Study (2004)

Wise, Lauren A., Palmer, Julie R., Harlow, Bernard L., Spiegelman, Donna, Stewart, Elizabeth A., Adams-Campbell, Lucile L., ...

BACKGROUND: Tobacco, alcohol and caffeine consumption may influence risk of uterine leiomyomata via changes in ovarian function or hormone metabolism. METHODS: We prospectively assessed the relation...

Changes in Body Weight and Body Fat Distribution as Risk Factors for Clinical Diabetes in US Men (2004)

Koh-Banerjee, Pauline, Wang, Youfa, Hu, Frank B., Spiegelman, Donna, Willett, Walter C., Rimm, Eric B.

Although previous studies have linked obesity to diabetes, the risks associated with weight gain or changes in body fat distribution have not been fully elucidated. The authors therefore...

Reproductive Factors, Hormonal Contraception, and Risk of Uterine Leiomyomata in African-American Women: A Prospective Study (2004)

Wise, Lauren A., Palmer, Julie R., Harlow, Bernard L., Spiegelman, Donna, Stewart, Elizabeth A., Adams-Campbell, Lucile L., ...

The authors assessed the risk of uterine leiomyomata in relation to reproductive factors and hormonal contraception in a prospective cohort study of US Black women. From March 1997 through March...

Physical activity and risk of coronary heart disease in India (2004)

Rastogi, Tanuja, Vaz, Mario, Spiegelman, Donna, Reddy, K. Srinath, Bharathi, A. V., Stampfer, Meir J., ...

Background Physical exercise has been inversely associated with coronary heart disease (CHD) risk in Western populations; however, the association has not been examined in India where physical...

Fruit and Vegetable Intake and Risk of Major Chronic Disease (2004)

Hung, Hsin-Chia, Joshipura, Kaumudi J., Jiang, Rui, Hu, Frank B., Hunter, David, Smith-Warner, Stephanie A., ...

Background: Studies of fruit and vegetable consumption in relation to overall health are limited. We evaluated the relationship between fruit and vegetable intake and the incidence of cardiovascular...

Physical activity and risk of coronary heart disease in India (2004)

Rastogi, Tanuja, Vaz, Mario, Spiegelman, Donna, Reddy, K Srinath, Bharathi, AV, Stampfer, Meir J, ...

Background Physical exercise has been inversely associated with coronary heart disease (CHD) risk in Western populations; however, the association has not been examined in India where physical...

Risk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black Women's Health Study (2004)

Wise, Lauren A., Palmer, Julie R., Harlow, Bernard L., Spiegelman, Donna, Stewart, Elizabeth A., Adams-Campbell, Lucile L., ...

BACKGROUND: Tobacco, alcohol and caffeine consumption may influence risk of uterine leiomyomata via changes in ovarian function or hormone metabolism. METHODS: We prospectively assessed the relation...

Estimating treatment effects in studies of perinatal transmission of HIV (2004)

Bang, Heejung, Spiegelman, Donna

Fetal loss often precludes the ascertainment of infection status in studies of perinatal transmission of HIV. The standard analysis based on liveborn babies can result in biased estimation and...

Premenopausal Fat Intake and Risk of Breast Cancer (2003)

Cho, Eunyoung, Spiegelman, Donna, Hunter, David J., Chen, Wendy Y., Stampfer, Meir J., Colditz, Graham A., ...

Background: International comparisons and case–control studies have suggested a positive relation between dietary fat intake and breast cancer risk, but prospective studies, most of them involving...

Meat and dairy food consumption and breast cancer: a pooled analysis of cohort studies (2002)

Missmer, Stacey A, Smith-Warner, Stephanie A, Spiegelman, Donna, Yaun, Shiaw-Shyuan, Adami, Hans-Olov, Beeson, W Lawrence, ...

Background More than 20 studies have investigated the relation between meat and dairy food consumption and breast cancer risk with conflicting results. Our objective was to evaluate the risk of...

Validation of the Gail et al. Model of Breast Cancer Risk Prediction and Implications for Chemoprevention (2001)

Rockhill, Beverly, Spiegelman, Donna, Byrne, Celia, Hunter, David J., Colditz, Graham A.

Background: Women and their clinicians are increasingly encouraged to use risk estimates derived from statistical models, primarily that of Gail et al., to aid decision making regarding potential...

Assessment of Questionnaire Validity for Measuring Total Fat Intake using Plasma Lipid Levels as Criteria (2001)

Willett, Walter, Stampfer, Meir, Chu, Nain-Feng, Spiegelman, Donna, Holmes, Michelle, Rimm, Eric

The validation of dietary total fat measurements has been elusive because no specific biomarker exists. In metabolic studies with controlled diets, plasma fasting triglyceride levels are reduced with...

Application of the Method of Triads to Evaluate the Performance of Food Frequency Questionnaires and Biomarkers as Indicators of Long-term Dietary Intake (2001)

Kabagambe, Edmond K., Baylin, Ana, Allan, Damon A., Siles, Xinia, Spiegelman, Donna, Campos, Hannia

Little is documented about the performance of the food frequency questionnaire (FFQ) in US minority groups and in populations in developing countries. The authors applied a novel technique, the...

Polymorphic repeat in AIB1 does not alter breast cancer risk (2000)

Christopher A, Haiman, Hankinson, Susan E, Spiegelman, Donna, Colditz, Graham A, Willett, Walter C, Speizer, Frank E, ...

Statement of findings We assessed the association between a glutamine repeat polymorphism in AIB1 and breast cancer risk in a case-control study (464 cases, 624 controls) nested within the Nurses'...

Prospective Study of Dietary Supplements, Macronutrients, Micronutrients, and Risk of Bladder Cancer in US Men (2000)

Michaud, Dominique S., Spiegelman, Donna, Clinton, Steven K., Rimm, Eric B., Willett, Walter C., Giovannucci, Edward

Data derived from laboratory investigations suggest that a number of dietary variables may contribute to bladder carcinogenesis. Although bladder cancer is the fourth leading cause of cancer in men...

Leisure-Time Physical Activity, Television Watching, and Plasma Biomarkers of Obesity and Cardiovascular Disease Risk (2000)

Fung, Teresa T., Hu, Frank B., Yu, Jie, Chu, Nain-Feng, Spiegelman, Donna, Tofler, Geoffrey H., ...

The benefits of physical activity in reducing cardiovascular disease (CVD) are thought to be mediated through changes in blood lipids, insulin sensitivity, and thrombogenic factors. Few studies have...

Electric Blanket Use and Breast Cancer in the Nurses' Health Study (2000)

Laden, Francine, Neas, Lucas M., Tolbert, Paige E., Holmes, Michelle D., Hankinson, Susan E., Spiegelman, Donna, ...

Electric and magnetic fields (EMFs) have been hypothesized to increase the risk of breast cancer, and electric blankets represent an important source of exposure to EMFs. The authors examined the...

Pooled Analysis of Prospective Cohort Studies on Height, Weight, and Breast Cancer Risk (2000)

Van Den Brandt, Piet A., Spiegelman, Donna, Yaun, Shiaw-Shyuan, Adami, Hans-Olov, Beeson, Lawrence, Folsom, Aaron R., ...

The association between anthropometric indices and the risk of breast cancer was analyzed using pooled data from seven prospective cohort studies. Together, these cohorts comprise 337,819 women and...

Evaluation of a Population Roster as a Source of Population Controls: The Massachusetts Resident Lists (1999)

Bohlke, Kari, Harlow, Bernard L., Cramer, Daniel W., Spiegelman, Donna, Mueller, Nancy E.

Published population rosters can serve as a convenient source of population controls. The authors evaluated one such roster, the Massachusetts Resident Lists, by estimating the completeness of the...

Dietary Fat and Coronary Heart Disease: A Comparison of Approaches for Adjusting for Total Energy Intake and Modeling Repeated Dietary Measurements (1999)

Hu, Frank B., Stampfer, Meir J., Rimm, Eric, Ascherio, Alberto, Rosner, Bernard A., Spiegelman, Donna, ...

Previous cohort studies of fat intake and risk of coronary heart disease (CHD) have been inconsistent, probably due in part to methodological differences and various limitations, including inadequate...

Fruit and Vegetable Intake and Incidence of Bladder Cancer in a Male Prospective Cohort (1999)

Michaud, Dominique S., Spiegelman, Donna, Clinton, Steven K., Rimm, Eric B., Willett, Walter C., Giovannucci, Edward L.

BACKGROUND: Previous epidemiologic studies of fruit and vegetable intake and bladder cancer risk have yielded inconsistent results, especially with regard to the types of fruits and vegetables...

Risk Factors for Basal Cell Carcinoma of the Skin in Men: Results from the Health Professionals Follow-up Study (1999)

Dam, Rob M. Van, Huang, Zhiping, Rimm, Eric B., Weinstock, Martin A., Spiegelman, Donna, Colditz, Graham A., ...

The authors examined the relation of constitutional factors and sun exposure to risk of basal cell carcinoma of the skin (BCC) in a prospective cohort of 44,591 predominantly Caucasian US male health...

Glutathione S-Transferase Mu and Theta Polymorphisms and Breast Cancer Susceptibility (1999)

García-Closas, Montserrat, Kelsey, Karl T., Hankinson, Susan E., Spiegelman, Donna, Springer, Kathryn, Willett, Walter C., ...

BACKGROUND: The enzymes encoded by the glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) genes are involved in the metabolism (mainly inactivation, but activation is possible) of a wide...

Evaluation of Old and New Tests of Heterogeneity in Epidemiologic Meta-Analysis (1999)

Takkouche, Bahi, Cadarso-Suárez, Carmen, Spiegelman, Donna

The identification of heterogeneity in effects between studies is a key issue in meta-analyses of observational studies, since it is critical for determining whether it is appropriate to pool the...

Menstrual Cycle Characteristics and History of Ovulatory Infertility in Relation to Breast Cancer Risk in a Large Cohort of US Women (1998)

Garland, Miriam, Hunter, David J., Colditz, Graham A., Manson, JoAnn E., Stampfer, Meir J., Spiegelman, Donna, ...

Menstrual cycle characteristics and ovulatory infertility were evaluated in relation to breast cancer risk among 116,678 women in the Nurses' Health Study II, a prospective cohort study of female...

Oral Contraceptives and Ovulatory Causes of Delayed Fertility (1997)

Chasan-Taber, Lisa, Willett, Walter C., Stampfer, Meir J., Spiegelman, Donna, Rosner, Bernard A., Hunter, David J., ...

The return of fertility for women who discontinue oral contraceptives takes longer as compared with women who discontinue other methods of contraception. It remains unclear, however, whether...

Power and Sample Size Calculations for Case-Control Studies of Gene-Environment Interactions with a Polytomous Exposure Variable (1997)

Foppa, Ivo, Spiegelman, Donna

Genetic polymorphisms may appear to the epidemiologist most commonly as different levels of susceptibility to exposure. Epidemiologic studies of heterogeneity in exposure susceptibility aim at...

Measurement Error Correction for Logistic Regression Models with an "Alloyed Gold Standard" (1997)

Spiegelman, Donna, Schneeweiss, Sebastian, McDermott, Aidan

Recently, some authors have questioned the validity of methods which correct relative risk estimates for measurement error and misclassification when the “gold standard” used to obtain...

Self-Reported Birthweight and History of Having Been Breastfed among Younger Women: An Assessment of Validity (1996)

TROY, LISA M, MICHELS, KARIN B, HUNTER, DAVID J, SPIEGELMAN, DONNA, MANSON, JOANN E, COLDITZ, GRAHAM A, ...

Background Recent evidence suggests potential associations between birthweight and infant feeding history and risk of a variety of health outcomes during adulthood. Because studies may rely on...

Hormone Levels During Dietary Changes in Premenopausal African-American Women (1996)

Woods, Margo N., Barnett, Junaidah B., Spiegelman, Donna, Trail, Nancy, Hertzmark, Ellen, Longcope, Christopher, ...

Background: In the United States, 5-year survival rates of 69% and 84%, respectively, have recently been reported for African-American and Caucasian women diagnosed with breast cancer....

Prospective Study of Beverage Use and the Risk of Kidney Stones (1996)

Curhan, Gary C., Willett, Walter C., Rimm, Eric B., Spiegelman, Donna, Stampfer, Meir J.

Patients with kidney stones are routinely advised to increase their fluid intake to decrease the risk of stone recurrence. However, there has been no detailed examination to determine whether the...

Human Immunodeficiency Virus Infection in Mexico City: Rectal Bleeding and Anal Warts as Risk Factors among Men Reporting Sex with Men (1996)

Coplan, Paul M., Gortmaker, Steven, Hemandez-Avila, Mauricio, Spiegelman, Donna, Uribe-Zuuiga, Patricia, Mueller, Nancy E.

The objectives of this study were to evaluate the frequency and determinants of rectal bleeding and the association between rectal bleeding and risk of human immunodeficiency virus (HIV) infection...

Efficient Derivative Codes through Automatic Differentiation and Interface Contraction: An Application in Biostatistics (1995)

Mario Cassella, Donna Spiegelman, Paul Hovland, Paul Hovland, Christian Bischof, Christian Bischof

Developing code for computing the first- and higher-order derivatives of a function by hand can be very time-consuming and is prone to errors. Automatic differentiation has proven capable of...

Body Size and Fat Distribution as Predictors of Coronary Heart Disease among Middle-aged and Older US Men (1995)

Rimm, Eric B., Stampfer, Meir J., Giovannucci, Edward, Ascherio, Alberto, Spiegelman, Donna, Colditz, Graham A., ...

Obesity, android fat distribution, and other anthropometric measures have been associated with coronary heart disease in long-term prospective studies. However, fluctuations in weight due to...

Validation of the Gail et al. Model for Predicting Individual Breast Cancer Risk (1994)

Spiegelman, Donna, Colditz, Graham A., Hunter, David, Hertzmark, Ellen

Background: The Gail et al. model is considered the best available means for estimating an individual woman's risk of developing breast cancer. Such estimates are useful in decision making on the...

INTERACTIVE ELECTRONIC COMPUTING OF THE MORTALITY ODDS RATIO (1983)

SPIEGELMAN, DONNA, WANG, JUNG-DER, WEGMAN, DAVID

Spiegelman, D. (Harvard School of Public Health, Boston, MA 02115), J.-O. Wang and D. Wegman. Interactive electronic computing of the mortality odds ratio. Am J Epidemiol 1983; 118: 599–607. An...

Polymorphic repeat in AIB1 does not alter breast cancer risk

Haiman, Christopher A, Hankinson, Susan E, Spiegelman, Donna, Colditz, Graham A, Willett, Walter C, Speizer, Frank E, ...

We assessed the association between a glutamine repeat polymorphism in AIB1 and breast cancer risk in a case-control study (464 cases, 624 controls) nested within the Nurses' Health Study cohort. We...

Home Endotoxin Exposure and Wheeze in Infants: Correction for Bias Due to Exposure Measurement Error

Horick, Nora, Weller, Edie, Milton, Donald K., Gold, Diane R., Li, Ruifeng, Spiegelman, Donna

Exposure to elevated levels of endotoxin in family-room dust was previously observed to be significantly associated with increased wheeze in the first year of life among a cohort of 404 children in...

Polymorphic repeat in AIB1 does not alter breast cancer risk

Haiman, Christopher A, Hankinson, Susan E, Spiegelman, Donna, Colditz, Graham A, Willett, Walter C, Speizer, Frank E, ...

We assessed the association between a glutamine repeat polymorphism in AIB1 and breast cancer risk in a case-control study (464 cases, 624 controls) nested within the Nurses' Health Study cohort. We...

Home Endotoxin Exposure and Wheeze in Infants: Correction for Bias Due to Exposure Measurement Error

Horick, Nora, Weller, Edie, Milton, Donald K., Gold, Diane R., Li, Ruifeng, Spiegelman, Donna

Exposure to elevated levels of endotoxin in family-room dust was previously observed to be significantly associated with increased wheeze in the first year of life among a cohort of 404 children in...

Precision and Performance Characteristics of Bisulfite Conversion and Real-Time PCR (MethyLight) for Quantitative DNA Methylation Analysis

Ogino, Shuji, Kawasaki, Takako, Brahmandam, Mohan, Cantor, Mami, Kirkner, Gregory J., Spiegelman, Donna, ...

Assays to measure DNA methylation, which are important in epigenetic research and clinical diagnostics, typically rely on conversion of unmethylated cytosine to uracil by sodium bisulfite. However,...

Whole Grain, Bran, and Germ Intake and Risk of Type 2 Diabetes: A Prospective Cohort Study and Systematic Review

Hu, Frank B, Spiegelman, Donna, Franz, Mary, Van Dam, Rob M

Jeroen de Munter and colleagues found that, in women in the US Nurses' Health Studies, whole grain intake was inversely associated with risk of type 2 diabetes. The association was stronger for bran...

The Comparison of Alternative Smoothing Methods for Fitting Non-Linear Exposure-Response Relationships with Cox Models in a Simulation Study

Usha Govindarajulu, Elizabeth Malloy, Bhaswati Ganguli, Donna Spiegelman, Ellen Eisen

We examined the behavior of alternative smoothing methods for modeling environmental epidemiology data. Model fit can only be examined when the true exposure-response curve is known and so we used...

Combined impact of lifestyle factors on mortality: prospective cohort study in US women

Van Dam, Rob M, Li, Tricia, Spiegelman, Donna, Franco, Oscar H, Hu, Frank B

Objective To evaluate the impact of combinations of lifestyle factors on mortality in middle aged women.

Comparing measures of model selection for penalized splines in Cox models

Malloy, Elizabeth J., Spiegelman, Donna, Eisen, Ellen A.

This article presents an application and a simulation study of model fit criteria for selecting the optimal degree of smoothness for penalized splines in Cox models. The criteria considered were the...