Doreen Harcus

A Human-Curated Annotation of the Candida albicans Genome (2005)

Burkhard R. Braun, Christophe D'Enfert, Mikhail Martchenko, Jan Dungan, Alan Kuo, ...

Recent sequencing and assembly of the genome for the fungal pathogen Candida albicans used simple automated procedures for the identification of putative genes. We have reviewed the entire assembly,...

Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans

Leberer, Ekkehard, Harcus, Doreen, Broadbent, Ian D., Clark, Karen L., Dignard, Daniel, Ziegelbauer, Karl, ...

The CST20 gene of Candida albicans was cloned by functional complementation of a deletion of the STE20 gene in Saccharomyces cerevisiae. CST20 encodes a homolog of the Ste20p/p65PAK family of protein...

Signaling through Adenylyl Cyclase Is Essential for Hyphal Growth and Virulence in the Pathogenic Fungus Candida albicans

Rocha, Cintia R. C., Schröppel, Klaus, Harcus, Doreen, Marcil, Anne, Dignard, Daniel, Taylor, Brad N., ...

The human fungal pathogen Candida albicans switches from a budding yeast form to a polarized hyphal form in response to various external signals. This morphogenetic switching has been implicated in...

Roles of the Candida albicans Mitogen-Activated Protein Kinase Homolog, Cek1p, in Hyphal Development and Systemic Candidiasis†

Csank, Csilla, Schröppel, Klaus, Leberer, Ekkehard, Harcus, Doreen, Mohamed, Othman, Meloche, Sylvain, ...

Extracellular signal-regulated protein kinase (ERK, or mitogen-activated protein kinase [MAPK]) regulatory cascades in fungi turn on transcription factors that control developmental processes, stress...

CDC42 Is Required for Polarized Growth in Human Pathogen Candida albicans†

Ushinsky, Sophia C., Harcus, Doreen, Ash, Josee, Dignard, Daniel, Marcil, Anne, Morchhauser, Joachim, ...

Cdc42p is a member of the RAS superfamily of GTPases and plays an essential role in polarized growth in many eukaryotic cells. We cloned the Candida albicans CaCDC42 by functional complementation in...

Transcription Profiling of Candida albicans Cells Undergoing the Yeast-to-Hyphal TransitionD⃞

Nantel, André, Dignard, Daniel, Bachewich, Catherine, Harcus, Doreen, Marcil, Anne, Bouin, Anne-Pascale, ...

The ability of the pathogenic fungus Candida albicans to switch from a yeast to a hyphal morphology in response to external signals is implicated in its pathogenicity. We used glass DNA microarrays...

Superoxide Dismutases in Candida albicans: Transcriptional Regulation and Functional Characterization of the Hyphal-induced SOD5 Gene

Martchenko, Mikhail, Alarco, Anne-Marie, Harcus, Doreen, Whiteway, Malcolm

Superoxide dismutases (SOD) convert superoxide radicals into less damaging hydrogen peroxide. The opportunistic human pathogen Candida albicans is known to express CuZnSOD (SOD1) and MnSOD (SOD3) in...

Transcription Profiling of Cyclic AMP Signaling in Candida albicansD⃞

Harcus, Doreen, Nantel, André, Marcil, Anne, Rigby, Tracey, Whiteway, Malcolm

We used transcription profiling in Candida albicans to investigate cellular regulation involving cAMP. We found that many genes require the adenylyl cyclase Cdc35p for proper expression. These...

A Human-Curated Annotation of the Candida albicans Genome

Braun, Burkhard R, Van Het Hoog, Marco, D'Enfert, Christophe, Martchenko, Mikhail, Dungan, Jan, Kuo, Alan, ...

Recent sequencing and assembly of the genome for the fungal pathogen Candida albicans used simple automated procedures for the identification of putative genes. We have reviewed the entire assembly,...

Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans

Leberer, Ekkehard, Harcus, Doreen, Broadbent, Ian D., Clark, Karen L., Dignard, Daniel, Ziegelbauer, Karl, ...

The CST20 gene of Candida albicans was cloned by functional complementation of a deletion of the STE20 gene in Saccharomyces cerevisiae. CST20 encodes a homolog of the Ste20p/p65PAK family of protein...

Signaling through Adenylyl Cyclase Is Essential for Hyphal Growth and Virulence in the Pathogenic Fungus Candida albicans

Rocha, Cintia R. C., Schröppel, Klaus, Harcus, Doreen, Marcil, Anne, Dignard, Daniel, Taylor, Brad N., ...

The human fungal pathogen Candida albicans switches from a budding yeast form to a polarized hyphal form in response to various external signals. This morphogenetic switching has been implicated in...

Roles of the Candida albicans Mitogen-Activated Protein Kinase Homolog, Cek1p, in Hyphal Development and Systemic Candidiasis†

Csank, Csilla, Schröppel, Klaus, Leberer, Ekkehard, Harcus, Doreen, Mohamed, Othman, Meloche, Sylvain, ...

Extracellular signal-regulated protein kinase (ERK, or mitogen-activated protein kinase [MAPK]) regulatory cascades in fungi turn on transcription factors that control developmental processes, stress...

CDC42 Is Required for Polarized Growth in Human Pathogen Candida albicans†

Ushinsky, Sophia C., Harcus, Doreen, Ash, Josee, Dignard, Daniel, Marcil, Anne, Morchhauser, Joachim, ...

Cdc42p is a member of the RAS superfamily of GTPases and plays an essential role in polarized growth in many eukaryotic cells. We cloned the Candida albicans CaCDC42 by functional complementation in...

Transcription Profiling of Candida albicans Cells Undergoing the Yeast-to-Hyphal TransitionD⃞

Nantel, André, Dignard, Daniel, Bachewich, Catherine, Harcus, Doreen, Marcil, Anne, Bouin, Anne-Pascale, ...

The ability of the pathogenic fungus Candida albicans to switch from a yeast to a hyphal morphology in response to external signals is implicated in its pathogenicity. We used glass DNA microarrays...

Superoxide Dismutases in Candida albicans: Transcriptional Regulation and Functional Characterization of the Hyphal-induced SOD5 Gene

Martchenko, Mikhail, Alarco, Anne-Marie, Harcus, Doreen, Whiteway, Malcolm

Superoxide dismutases (SOD) convert superoxide radicals into less damaging hydrogen peroxide. The opportunistic human pathogen Candida albicans is known to express CuZnSOD (SOD1) and MnSOD (SOD3) in...

Transcription Profiling of Cyclic AMP Signaling in Candida albicansD⃞

Harcus, Doreen, Nantel, André, Marcil, Anne, Rigby, Tracey, Whiteway, Malcolm

We used transcription profiling in Candida albicans to investigate cellular regulation involving cAMP. We found that many genes require the adenylyl cyclase Cdc35p for proper expression. These...

A Human-Curated Annotation of the Candida albicans Genome

Braun, Burkhard R, Van Het Hoog, Marco, D'Enfert, Christophe, Martchenko, Mikhail, Dungan, Jan, Kuo, Alan, ...

Recent sequencing and assembly of the genome for the fungal pathogen Candida albicans used simple automated procedures for the identification of putative genes. We have reviewed the entire assembly,...