Dorette Freyer

Pneumococcal pneumolysin and H2O2 mediate brain cell apoptosis during meningitis

Braun, Johann S., Sublett, Jack E., Freyer, Dorette, Mitchell, Tim J., Cleveland, John L., Tuomanen, Elaine I., ...

Pneumococcus is the most common and aggressive cause of bacterial meningitis and induces a novel apoptosis-inducing factor–dependent (AIF–dependent) form of brain cell apoptosis. Loss of...

Bacterial programmed cell death of cerebral endothelial cells involves dual death pathways

Bermpohl, Daniela, Halle, Annett, Freyer, Dorette, Dagand, Emilie, Braun, Johann S., Bechmann, Ingo, ...

Major barriers separating the blood from tissue compartments in the body are composed of endothelial cells. Interaction of bacteria with such barriers defines the course of invasive infections, and...

Pneumococcal pneumolysin and H2O2 mediate brain cell apoptosis during meningitis

Braun, Johann S., Sublett, Jack E., Freyer, Dorette, Mitchell, Tim J., Cleveland, John L., Tuomanen, Elaine I., ...

Pneumococcus is the most common and aggressive cause of bacterial meningitis and induces a novel apoptosis-inducing factor–dependent (AIF–dependent) form of brain cell apoptosis. Loss of...

Bacterial programmed cell death of cerebral endothelial cells involves dual death pathways

Bermpohl, Daniela, Halle, Annett, Freyer, Dorette, Dagand, Emilie, Braun, Johann S., Bechmann, Ingo, ...

Major barriers separating the blood from tissue compartments in the body are composed of endothelial cells. Interaction of bacteria with such barriers defines the course of invasive infections, and...

Interplay of Pneumococcal Hydrogen Peroxide and Host-Derived Nitric Oxide

Hoffmann, Olaf, Zweigner, Janine, Smith, Shannon H., Freyer, Dorette, Mahrhofer, Cordula, Dagand, Emilie, ...

Reactive oxygen and nitrogen species are released by immune-competent cells and contribute to cellular damage. On the other hand, certain pathogens, including Streptococcus pneumoniae, are known to...

Pneumococcal Cell Wall-Induced Meningitis Impairs Adult Hippocampal Neurogenesis▿

Hoffmann, Olaf, Mahrhofer, Cordula, Rueter, Nina, Freyer, Dorette, Bert, Bettina, Fink, Heidrun, ...

Bacterial meningitis is a major infectious cause of neuronal degeneration in the hippocampus. Neurogenesis, a continuous process in the adult hippocampus, could ameliorate such loss. Yet the high...

Pneumolysin Causes Neuronal Cell Death through Mitochondrial Damage▿

Braun, Johann S., Hoffmann, Olaf, Schickhaus, Miriam, Freyer, Dorette, Dagand, Emilie, Bermpohl, Daniela, ...

Bacterial toxins such as pneumolysin are key mediators of cytotoxicity in infections. Pneumolysin is a pore-forming toxin released by Streptococcus pneumoniae, the major cause of bacterial...