Fröhlich, Holger, Sahin, Özgür, Arlt, Dorit, Bender, Christian, Beißbarth, Tim
Abstract Background Modern gene perturbation techniques, like RNA interference (RNAi), enable us to study effects of targeted interventions in cells efficiently. In combination with mRNA or protein...
Sahin, Özgür, Fröhlich, Holger, Löbke, Christian, Korf, Ulrike, Burmester, Sara, Majety, Meher, ...
Abstract Background In breast cancer, overexpression of the transmembrane tyrosine kinase ERBB2 is an adverse prognostic marker, and occurs in almost 30% of the patients. For therapeutic...
Extending pathways based on gene lists using InterPro domain signatures (2008)
Hahne, Florian, Mehrle, Alexander, Arlt, Dorit, Poustka, Annemarie, Wiemann, Stefan, Beissbarth, Tim
Abstract Background High-throughput technologies like functional screens and gene expression analysis produce extended lists of candidate genes. Gene-Set Enrichment Analysis is a commonly used and...
Hahne, Florian, Arlt, Dorit, Sauermann, Mamatha, Majety, Meher, Poustka, Annemarie, Wiemann, Stefan, ...
Abstract Highthroughput cell-based assays with flow cytometric readout provide a powerful technique for identifying components of biologic pathways and their interactors. Interpretation of these...
The LIFEdb database in 2006 (2006)
Er Mehrle, Heiko Rosenfelder, Coral Del Val, Dorit Arlt, Florian Hahne, Stephanie Bechtel, ...
LIFEdb
The LIFEdb database in 2006 (2006)
Mehrle, Alexander, Rosenfelder, Heiko, Schupp, Ingo, Del Val, Coral, Arlt, Dorit, Hahne, Florian, ...
LIFEdb (http://www.LIFEdb.de) integrates data from large-scale functional genomics assays and manual cDNA annotation with bioinformatics gene expression and protein analysis. New features of LIFEdb...
From ORFeome to Biology: A Functional Genomics Pipeline (2004)
Wiemann, Stefan, Arlt, Dorit, Huber, Wolfgang, Wellenreuther, Ruth, Schleeger, Simone, Mehrle, Alexander, ...
As several model genomes have been sequenced, the elucidation of protein function is the next challenge toward the understanding of biological processes in health and disease. We have generated a...
From ORFeome to Biology: A Functional Genomics Pipeline
Wiemann, Stefan, Arlt, Dorit, Huber, Wolfgang, Wellenreuther, Ruth, Schleeger, Simone, Mehrle, Alexander, ...
As several model genomes have been sequenced, the elucidation of protein function is the next challenge toward the understanding of biological processes in health and disease. We have generated a...
Mehrle, Alexander, Rosenfelder, Heiko, Schupp, Ingo, Del Val, Coral, Arlt, Dorit, Hahne, Florian, ...
LIFEdb () integrates data from large-scale functional genomics assays and manual cDNA annotation with bioinformatics gene expression and protein analysis. New features of LIFEdb include (i) an...
From ORFeome to Biology: A Functional Genomics Pipeline
Wiemann, Stefan, Arlt, Dorit, Huber, Wolfgang, Wellenreuther, Ruth, Schleeger, Simone, Mehrle, Alexander, ...
As several model genomes have been sequenced, the elucidation of protein function is the next challenge toward the understanding of biological processes in health and disease. We have generated a...
Mehrle, Alexander, Rosenfelder, Heiko, Schupp, Ingo, Del Val, Coral, Arlt, Dorit, Hahne, Florian, ...
LIFEdb () integrates data from large-scale functional genomics assays and manual cDNA annotation with bioinformatics gene expression and protein analysis. New features of LIFEdb include (i) an...
Hahne, Florian, Arlt, Dorit, Sauermann, Mamatha, Majety, Meher, Poustka, Annemarie, Wiemann, Stefan, ...
A software tool for the analysis of high-throughput cell-based assays is presented.
Combinatorial RNAi for quantitative protein network analysis
Sahin, Özgür, Löbke, Christian, Korf, Ulrike, Appelhans, Heribert, Sültmann, Holger, Poustka, Annemarie, ...
The elucidation of cross-talk events between intersecting signaling pathways is one main challenge in biological research. The complexity of protein networks, composed of different pathways, requires...
Extending pathways based on gene lists using InterPro domain signatures
Hahne, Florian, Mehrle, Alexander, Arlt, Dorit, Poustka, Annemarie, Wiemann, Stefan, Beissbarth, Tim