on IDEAL Article DEFOG: A Practical Scheme for Deciphering Families of Genes (2009)
Tania Fuchs, Barbora Malecova, Chaim Linhart, Roded Sharan, Miriam Khen, Dmitry Shmulevich, ...
*These authors contributed equally to this work. To whom correspondence and reprint requests should be addressed. Fax: +972-3-6405384.
GIFtS: annotation landscape analysis with GeneCards (2009)
Harel, Arye, Inger, Aron, Stelzer, Gil, Strichman-Almashanu, Liora, Dalah, Irina, Safran, Marilyn, ...
Abstract Background Gene annotation is a pivotal component in computational genomics, encompassing prediction of gene function, expression analysis, and sequence scrutiny. Hence, quantitative...
Common peptides shed light on evolution of Olfactory Receptors (2009)
Gottlieb, Assaf, Olender, Tsviya, Lancet, Doron, Horn, David
Abstract Background Olfactory Receptors (ORs) form the largest multigene family in vertebrates. Their evolution and their expansion in the vertebrate genomes was the subject of many studies. In this...
GeneCards TM 2002: An Evolving Human Gene Compendium (2008)
Marilyn Safran, Irina Solomon, Orit Shmueli, Michal Lapidot, Shai Shen-orr, Avital Adato, ...
GeneCards TM
Anu Sharma, Vineet K. Sharma, Shirley Horn-saban, Doron Lancet, Samir K. Brahmachari
Articles in PresS. Physiol Genomics (January 11, 2005). doi:10.1152/physiolgenomics.00228.2003 Assessing natural variations in gene expression in humans by comparing with
Hum Genet (2001) 108:1–13 DOI 10.1007/s004390000436 ORIGINAL INVESTIGATION (2008)
Tania Fuchs, Gustavo Glusman, Shirley Horn-saban, Doron Lancet, Yitzhak Pilpel
Abstract Olfactory receptors (ORs) constitute the largest multigene family in multicellular organisms. Their evolutionary proliferation has been driven by the need to provide recognition capacity for...
Early Systems Biology and Prebiotic Networks (2008)
Barak Shenhav, Ariel Solomon, Doron Lancet, Ran Kafri
Abstract. Systems Biology constitutes tools and approaches aimed at deciphering complex biological entities. It is assumed that such complexity arose gradually, beginning from a few relatively simple...
Genome analysis of the platypus reveals unique signatures of evolution (2008)
Warren, Wesley C., Hillier, LaDeana W., Marshall Graves, Jennifer A., Birney, Ewan, Ponting, Chris P., Grützner, Frank, ...
We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits a fascinating combination of reptilian and mammalian characters. For example, platypuses have a...
Novel definition files for human GeneChips based on GeneAnnot (2007)
Ferrari, Francesco, Bortoluzzi, Stefania, Coppe, Alessandro, Sirota, Alexandra, Safran, Marilyn, Shmoish, Michael, ...
Abstract Background Improvements in genome sequence annotation revealed discrepancies in the original probeset/gene assignment in Affymetrix microarray and the existence of differences between...
Genetic Elucidation of Human Hyperosmia to Isovaleric Acid (2007)
Idan Menashe, Tatjana Abaffy, Yehudit Hasin, Sivan Goshen, Vered Yahalom, Charles W. Luetje, ...
The genetic basis of odorant-specific variations in human olfactory thresholds, and in particular of enhanced odorant sensitivity (hyperosmia), remains largely unknown. Olfactory receptor (OR)...
Novel definition files for human GeneChips based on GeneAnnot (2007)
Ferrari, Francesco, Bortoluzzi, Stefania, Coppe, Alessandro, Sirota, Alexandra, Safran, Marilyn, Shmoish, Michael, ...
Background Improvements in genome sequence annotation revealed discrepancies in the original probeset/gene assignment in Affymetrix microarray and the existence of differences between annotations and...
Feldmesser, Ester, Bercovich, Dani, Avidan, Nili, Halbertal, Shmuel, Haim, Liora, Gross-Isseroff, Ruth, ...
Anosmia affects the western world population, mostly the elderly, reaching to 5% in subjects over the age of 45 years and strongly lowering their quality of life. A smaller minority (about 0.01%) is...
Sharma, Vineet K, Sharma, Anu, Kumar, Naveen, Khandelwal, Mamta, Mandapati, Kiran, Horn-Saban, Shirley, ...
Abstract Background Quantitative variation in gene expression has been proposed to underlie phenotypic variation among human individuals. A facilitating step towards understanding the basis for gene...
Ancient genomic architecture for mammalian olfactory receptor clusters (2006)
Aloni, Ronny, Olender, Tsviya, Lancet, Doron
Abstract Background Mammalian olfactory receptor (OR) genes reside in numerous genomic clusters of up to several dozen genes. Whole-genome sequence alignment nets of five mammals allow their...
A probabilistic classifier for olfactory receptor pseudogenes (2006)
Menashe, Idan, Aloni, Ronny, Lancet, Doron
Abstract Background Olfactory receptors (ORs), the largest mammalian gene superfamily (900–1400 genes), has >50% pseudogenes in humans. While most of these inactive genes are identified via coding...
Widespread ectopic expression of olfactory receptor genes (2006)
Feldmesser, Ester, Olender, Tsviya, Khen, Miriam, Yanai, Itai, Ophir, Ron, Lancet, Doron
Abstract Background Olfactory receptors (ORs) are the largest gene family in the human genome. Although they are expected to be expressed specifically in olfactory tissues, some ectopic expression...
Feldmesser, Ester, Bercovich, Dani, Avidan, Nili, Halbertal, Shmuel, Haim, Liora, Gross-Isseroff, Ruth, ...
Anosmia affects the western world population, mostly the elderly, reaching to 5% in subjects over the age of 45 years and strongly lowering their quality of life. A smaller minority (about 0.01%) is...
Feldmesser, Ester, Bercovich, Dani, Avidan, Nili, Halbertal, Shmuel, Haim, Liora, Gross-Isseroff, Ruth, ...
Anosmia affects the western world population, mostly the elderly, reaching to 5% in subjects over the age of 45 years and strongly lowering their quality of life. A smaller minority (about 0.01%) is...
Idan Menashe, Ronny Aloni, Doron Lancet, Doron Lancet
This is an Open Access article distributed under the terms of the Creative Commons Attribution License
Conservation anchors in the vertebrate genome (2005)
Abstract Genomic segments that do not code for proteins yet show high conservation among vertebrates have recently been identified by various computational methodologies. We refer to them as ANCORs...
Shklar, Maxim, Strichman-Almashanu, Liora, Shmueli, Orit, Shmoish, Michael, Safran, Marilyn, Lancet, Doron
GeneCards® is an automatically mined database of human genes that strives to create, along with its auxiliary databases—GeneLoc, GeneNote and GeneAnnot—the most inclusive resource of...
Yanai, Itai, Benjamin, Hila, Shmoish, Michael, Chalifa-Caspi, Vered, Shklar, Maxim, Ophir, Ron, ...
Motivation: Genes are often characterized dichotomously as either housekeeping or single-tissue specific. We conjectured that crucial functional information resides in genes with midrange profiles of...
Yoav Gilad, Victor Wiebe, Molly Przeworski, Doron Lancet, Svante Pääbo
Examination of olfactory receptor genes in 19 primate species suggests that the olfactory repertoire lost complexity as our ancestors acquired full-color vision.
Yoav Gilad, Victor Wiebe, Molly Przeworski, Doron Lancet, Svante Pääbo
Olfactory receptor (OR) genes constitute the molecular basis for the sense of smell and are encoded by the largest gene family in mammalian genomes. Previous studies suggested that the proportion of...
Gilad, Yoav, Wiebe, Victor, Przeworski, Molly, Lancet, Doron, Pääbo, Svante
Olfactory receptor (OR) genes constitute the molecular basis for the sense of smell and are encoded by the largest gene family in mammalian genomes. Previous studies suggested that the proportion of...
Itai Yanai, Hila Benjamin, Michael Shmoish, Vered Chalifa-caspi, Ron Ophir, Arren Bar-even, ...
*To whom correspondence should be addressed Running head: Midrange genome-wide transcription profiles
Itai Yanai, Hila Benjamin, Michael Shmoish, Vered Chalifa-caspi, Ron Ophir, Arren Bar-even, ...
in human tissue specification
Chalifa-Caspi, Vered, Yanai, Itai, Ophir, Ron, Rosen, Naomi, Shmoish, Michael, Benjamin-Rodrig, Hila, ...
Motivation: High density oligonucleotide arrays are usually annotated in a one-to-one fashion, with each probeset assigned to one gene. However, in reality, subsets of oligonucleotides in a probeset...
Yanai, Itai, Benjamin, Hila, Shmoish, Michael, Chalifa-Caspi, Vered, Shklar, Maxim, Ophir, Ron, ...
Motivation: Genes are often characterized dichotomously as either housekeeping or single-tissue specific. We conjectured that crucial functional information resides in genes with midrange profiles of...
Yanai, Itai, Benjamin, Hila, Shmoish, Michael, Chalifa-Caspi, Vered, Shklar, Maxim, Ophir, Ron, ...
Motivation: Genes are often characterized dichotomously as either housekeeping or single-tissue specific. We conjectured that crucial functional information resides in genes with midrange profiles of...
Chalifa-Caspi, Vered, Yanai, Itai, Ophir, Ron, Rosen, Naomi, Shmoish, Michael, Benjamin-Rodrig, Hila, ...
Motivation: High density oligonucleotide arrays are usually annotated in a one-to-one fashion, with each probeset assigned to one gene. However, in reality, subsets of oligonucleotides in a probeset...
Man, Orna, Gilad, Yoav, Lancet, Doron
Olfactory receptors (ORs) are a large family of proteins involved in the recognition and discrimination of numerous odorants. These receptors belong to the G-protein coupled receptor (GPCR)...
Chalifa-Caspi, Vered, Yanai, Itai, Ophir, Ron, Rosen, Naomi, Shmoish, Michael, Benjamin-Rodrig, Hila, ...
Motivation: High density oligonucleotide arrays are usually annotated in a one-to-one fashion, with each probeset assigned to one gene. However, in reality, subsets of oligonucleotides in a probeset...
Yanai, Itai, Benjamin, Hila, Shmoish, Michael, Chalifa-Caspi, Vered, Shklar, Maxim, Ophir, Ron, ...
Motivation: Genes are often characterized dichotomously as either housekeeping or single-tissue specific. We conjectured that crucial functional information resides in genes with midrange profiles of...
Yanai, Itai, Benjamin, Hila, Shmoish, Michael, Chalifa-Caspi, Vered, Shklar, Maxim, Ophir, Ron, ...
Motivation: Genes are often characterized dichotomously as either housekeeping or single-tissue specific. We conjectured that crucial functional information resides in genes with midrange profiles of...
Natural Selection on the Olfactory Receptor Gene Family in Humans and Chimpanzees (2003)
Gilad, Yoav, Bustamante, Carlos D., Lancet, Doron, Pääbo, Svante
Population Differences in the Human Functional Olfactory Repertoire (2003)
Olfactory receptors (OR) constitute the molecular basis for the sense of smell. They are encoded by a large multigene family, that in humans includes ∼400 functional genes and ∼600 putative...
Safran, Marilyn, Chalifa-Caspi, Vered, Shmueli, Orit, Olender, Tsviya, Lapidot, Michal, Rosen, Naomi, ...
Recent enhancements and current research in the GeneCards (GC) (http://bioinfo.weizmann.ac.il/cards/) project are described, including the addition of gene expression profiles and integrated gene...
GeneAnnot: Interfacing GeneCards with high-throughput gene expression compendia (2003)
Chalifa-Caspi, Vered, Shmueli, Orit, Benjamin-Rodrig, Hila, Rosen, Naomi, Shmoish, Michael, Yanai, Itai, ...
The interpretation of microarray expression results often includes extensive efforts to identify and annotate the gene representatives immobilised on the arrays. In this paper we describe the usage...
GeneLoc: exon-based integration of human genome maps (2003)
Rosen, Naomi, Chalifa-Caspi, Vered, Shmueli, Orit, Adato, Avital, Lapidot, Michal, Stampnitzky, Julie, ...
Motivation:Despite the numerous available whole-genome mapping resources, no comprehensive, integrated map of the human genome yet exists. Results: GeneLoc, software adjunct to GeneCards and UDB,...
Population Differences in the Human Functional Olfactory Repertoire (2003)
Olfactory receptors (OR) constitute the molecular basis for the sense of smell. They are encoded by a large multigene family, that in humans includes ∼400 functional genes and ∼600 putative...
DEFOG: A Practical Scheme for Deciphering Families of Genes (2002)
Fuchs,Tania, Malecova,Barbora, Linhart,Chaim, Sharan,Roded, Khen,Miriam, Herwig,Ralf, ...
We developed a novel efficient scheme, DEFOG (for "deciphering families of genes"), for determining sequences of numerous genes from a family of interest. The scheme provides a powerful means to...
DEFOG: A Practical Scheme for Deciphering Families of Genes (2002)
Fuchs, Tania, Malecova, Barbora, Linhart, Chaim, Sharan, Roded, Khen, Miriam, Herwig, Ralf, ...
We developed a novel efficient scheme, DEFOG (for "deciphering families of genes"), for determining sequences of numerous genes from a family of interest. The scheme provides a powerful means to...
Population differences in haplotype structure within a human olfactory receptor gene cluster (2002)
Menashe, Idan, Man, Orna, Lancet, Doron, Gilad, Yoav
We investigated the population differences in patterns of single nucleotide polymorphisms (SNPs) for a 400 kb olfactory receptor (OR) gene cluster on human chromosome 17p13.3. Samples were...
GeneCardsTM 2002: towards a complete, object-oriented, human gene compendium (2002)
Safran, Marilyn, Solomon, Irina, Shmueli, Orit, Lapidot, Michal, Shen-Orr, Shai, Adato, Avital, ...
Motivation: In the post-genomic era, functional analysis of genes requires a sophisticated interdisciplinary arsenal. Comprehensive resources are challenged to provide consistently improving,...
Glusman, Gustavo, Lancet, Doron
Summary: The GESTALT Workbench is a WWW-based tool for genomic sequence analysis, comparison and annotation, with strong emphasis on visualization. GESTALT integrates graphically the output of...
The Properties of Water in Capillary Systems. (1998)
Frommer,Moshe A., Lancet,Doron, Shporer,Mordechai
The relative amounts of freezing and non-freezing water in various cellulose acetate (CA) membranes have been determined by differential scanning calorimetry. It has been found that: A significant...
A Report to the U.S. Army Research Office, (1998)
This document discusses work in the area of Olfactory transduction. Keywords: Membranes(biology), Army research, Proteins, Enzymes, Glycoproteins, Clones, Olfactory nerve, Epithelium, Borines,...
Most of the Senses Begin to Make Some Sense, (1998)
SENSORY cells convert different forms of energy to the brain's 'currency' - trans-membrane potentials. But they do more. They have mechanisms for self-modulation, and their built-in diversity...
Olfaction: from signal transduction and termination to human genome mapping (1993)
Lancet, Doron, Gross-Isseroff, Ruth, Margalit, Talia, Seidemann, Eyal, Ben-Arie, Nissim
Concentration-dependent changes of perceived odor quality (1988)
Gross-Isseroff, Ruth, Lancet, Doron
In order to assess the dependence of perceived odor quality on odorant concentration, we studied 21 subjects. For eight subjects all possible pairs from a pool of six odorants at three decimal...
Isolated Frog Olfactory Cilia: A Preparation of Dendritic Membranes from Chemosensory Neurons (1986)
Zehava Chen, Umberto Pace, Judith Heldman, Amnon Shapira, Doron Lancet
The recently introduced frog olfactory cilia preparation (Chen and Lancet, 1984, Pace et al., 1985) has been useful for studies of molecular chemosensory mechanisms. Here we describe in detail the...
High resolution 2-deoxyglucose localization in olfactory epithelium (1981)
Lancet, Doron, Kauer, John S., Greer, Charles A., Shepherd, Gordon M.
The olfactory epithelium of the salamander and the mouse has been analyzed for patterns of activity elicited by odor stimulation. A high-resolution adaptation of the 2-deoxyglucose (2DG) method was...
Compositional genomes: Prebiotic information transfer in mutually catalytic noncovalent assemblies
Segré, Daniel, Ben-Eli, Dafna, Lancet, Doron
Mutually catalytic sets of simple organic molecules have been suggested to be capable of self-replication and rudimentary chemical evolution. Previous models for the behavior of such sets have...
Evidence for positive selection and population structure at the human MAO-A gene
Gilad, Yoav, Rosenberg, Shai, Przeworski, Molly, Lancet, Doron, Skorecki, Karl
We report the analysis of human nucleotide diversity at a genetic locus known to be involved in a behavioral phenotype, the monoamine oxidase A gene. Sequencing of five regions totaling 18.8 kb and...
Human specific loss of olfactory receptor genes
Gilad, Yoav, Man, Orna, Pääbo, Svante, Lancet, Doron
Olfactory receptor (OR) genes constitute the basis for the sense of smell and are encoded by the largest mammalian gene superfamily of >1,000 genes. In humans, >60% of these are pseudogenes. In...
Human Gene-Centric Databases at the Weizmann Institute of Science: GeneCards, UDB, CroW 21 and HORDE
Safran, Marilyn, Chalifa-Caspi, Vered, Shmueli, Orit, Olender, Tsviya, Lapidot, Michal, Rosen, Naomi, ...
Recent enhancements and current research in the GeneCards (GC) (http://bioinfo.weizmann.ac.il/cards/) project are described, including the addition of gene expression profiles and integrated gene...
Gilad, Yoav, Wiebe, Victor, Przeworski, Molly, Lancet, Doron, Pääbo, Svante
Olfactory receptor (OR) genes constitute the molecular basis for the sense of smell and are encoded by the largest gene family in mammalian genomes. Previous studies suggested that the proportion of...
Shklar, Maxim, Strichman-Almashanu, Liora, Shmueli, Orit, Shmoish, Michael, Safran, Marilyn, Lancet, Doron
GeneCards® is an automatically mined database of human genes that strives to create, along with its auxiliary databases—GeneLoc, GeneNote and GeneAnnot—the most inclusive resource of...
Textbooks often assert that life began with specialized complex molecules, such as RNA, that are capable of making their own copies. This scenario has serious difficulties, but an alternative has...
Conservation anchors in the vertebrate genome
The frequency of individual ancestral non-coding conserved regions within the genome helps in assessing the probability that they function in transcription regulation or RNA coding.
Lahat, Hadas, Pras, Elon, Olender, Tsviya, Avidan, Nili, Ben-Asher, Edna, Man, Orna, ...
Catecholamine-induced polymorphic ventricular tachycardia (PVT) is characterized by episodes of syncope, seizures, or sudden death, in response to physical activity or emotional stress. Two modes of...
Widespread ectopic expression of olfactory receptor genes
Feldmesser, Ester, Olender, Tsviya, Khen, Miriam, Yanai, Itai, Ophir, Ron, Lancet, Doron
Sharma, Vineet K, Sharma, Anu, Kumar, Naveen, Khandelwal, Mamta, Mandapati, Kiran Kumar, Horn-Saban, Shirley, ...
Compositional genomes: Prebiotic information transfer in mutually catalytic noncovalent assemblies
Segré, Daniel, Ben-Eli, Dafna, Lancet, Doron
Mutually catalytic sets of simple organic molecules have been suggested to be capable of self-replication and rudimentary chemical evolution. Previous models for the behavior of such sets have...
Evidence for positive selection and population structure at the human MAO-A gene
Gilad, Yoav, Rosenberg, Shai, Przeworski, Molly, Lancet, Doron, Skorecki, Karl
We report the analysis of human nucleotide diversity at a genetic locus known to be involved in a behavioral phenotype, the monoamine oxidase A gene. Sequencing of five regions totaling 18.8 kb and...
Human specific loss of olfactory receptor genes
Gilad, Yoav, Man, Orna, Pääbo, Svante, Lancet, Doron
Olfactory receptor (OR) genes constitute the basis for the sense of smell and are encoded by the largest mammalian gene superfamily of >1,000 genes. In humans, >60% of these are pseudogenes. In...
Human Gene-Centric Databases at the Weizmann Institute of Science: GeneCards, UDB, CroW 21 and HORDE
Safran, Marilyn, Chalifa-Caspi, Vered, Shmueli, Orit, Olender, Tsviya, Lapidot, Michal, Rosen, Naomi, ...
Recent enhancements and current research in the GeneCards (GC) (http://bioinfo.weizmann.ac.il/cards/) project are described, including the addition of gene expression profiles and integrated gene...
Gilad, Yoav, Wiebe, Victor, Przeworski, Molly, Lancet, Doron, Pääbo, Svante
Olfactory receptor (OR) genes constitute the molecular basis for the sense of smell and are encoded by the largest gene family in mammalian genomes. Previous studies suggested that the proportion of...
Congenital Dyserythropoietic Anemia Type I Is Caused by Mutations in Codanin-1
Dgany, Orly, Avidan, Nili, Delaunay, Jean, Krasnov, Tatyana, Shalmon, Lea, Shalev, Hanna, ...
Congenital dyserythropoietic anemias (CDAs) constitute a rare group of inherited red-blood-cell disorders associated with dysplastic changes in late erythroid precursors. CDA type I (CDAI [MIM...
Shklar, Maxim, Strichman-Almashanu, Liora, Shmueli, Orit, Shmoish, Michael, Safran, Marilyn, Lancet, Doron
GeneCards® is an automatically mined database of human genes that strives to create, along with its auxiliary databases—GeneLoc, GeneNote and GeneAnnot—the most inclusive resource of...
Textbooks often assert that life began with specialized complex molecules, such as RNA, that are capable of making their own copies. This scenario has serious difficulties, but an alternative has...
Conservation anchors in the vertebrate genome
The frequency of individual ancestral non-coding conserved regions within the genome helps in assessing the probability that they function in transcription regulation or RNA coding.
Natural Selection on the Olfactory Receptor Gene Family in Humans and Chimpanzees
Gilad, Yoav, Bustamante, Carlos D., Lancet, Doron, Pääbo, Svante
The olfactory receptor (OR) genes constitute the largest gene family in mammalian genomes. Humans have >1,000 OR genes, of which only ∼40% have an intact coding region and are therefore putatively...
Lahat, Hadas, Pras, Elon, Olender, Tsviya, Avidan, Nili, Ben-Asher, Edna, Man, Orna, ...
Catecholamine-induced polymorphic ventricular tachycardia (PVT) is characterized by episodes of syncope, seizures, or sudden death, in response to physical activity or emotional stress. Two modes of...
Widespread ectopic expression of olfactory receptor genes
Feldmesser, Ester, Olender, Tsviya, Khen, Miriam, Yanai, Itai, Ophir, Ron, Lancet, Doron
Sharma, Vineet K, Sharma, Anu, Kumar, Naveen, Khandelwal, Mamta, Mandapati, Kiran Kumar, Horn-Saban, Shirley, ...
Ancient genomic architecture for mammalian olfactory receptor clusters
Aloni, Ronny, Olender, Tsviya, Lancet, Doron
A new tool for genome-wide definition of genomic gene clusters conserved in multiple species was applied to olfactory receptors in five mammals, demonstrating that most mammalian olfactory receptor...
Haplotype structure and selection of the MDM2 oncogene in humans
Atwal, Gurinder Singh, Bond, Gareth L., Metsuyanim, Sally, Papa, Moshe, Friedman, Eitan, Distelman-Menachem, Tal, ...
The MDM2 protein is an ubiquitin ligase that plays a critical role in regulating the levels and activity of the p53 protein, which is a central tumor suppressor. A SNP in the human MDM2 gene (SNP309...
Genetic Elucidation of Human Hyperosmia to Isovaleric Acid
Menashe, Idan, Abaffy, Tatjana, Hasin, Yehudit, Goshen, Sivan, Yahalom, Vered, Luetje, Charles W, ...
The genetic basis of odorant-specific variations in human olfactory thresholds, and in particular of enhanced odorant sensitivity (hyperosmia), remains largely unknown. Olfactory receptor (OR)...
Novel definition files for human GeneChips based on GeneAnnot
Ferrari, Francesco, Bortoluzzi, Stefania, Coppe, Alessandro, Sirota, Alexandra, Safran, Marilyn, Shmoish, Michael, ...
Prediction of the odorant binding site of olfactory receptor proteins by human–mouse comparisons
Man, Orna, Gilad, Yoav, Lancet, Doron
Olfactory receptors (ORs) are a large family of proteins involved in the recognition and discrimination of numerous odorants. These receptors belong to the G-protein coupled receptor (GPCR)...
MESOBIOTIC EMERGENCE: MOLECULAR AND ENSEMBLE COMPLEXITY IN EARLY EVOLUTION
BARAK SHENHAV, DANIEL SEGRÃ, DORON LANCET
In addition to the visible complexity expressed in the morphogenesis of multicellular organisms, two levels of microscopic complexity may be discerned within every living cell. The first level is...
Coevolution of compositional protocells and their environment
Shenhav, Barak, Oz, Aia, Lancet, Doron
The coevolution of environment and living organisms is well known in nature. Here, it is suggested that similar processes can take place before the onset of life, where protocellular entities, rather...
High-Resolution Copy-Number Variation Map Reflects Human Olfactory Receptor Diversity and Evolution
Hasin, Yehudit, Olender, Tsviya, Khen, Miriam, Gonzaga-Jauregui, Claudia, Kim, Philip M., Urban, Alexander Eckehart, ...
Olfactory receptors (ORs), which are involved in odorant recognition, form the largest mammalian protein superfamily. The genomic content of OR genes is considerably reduced in humans, as reflected...