Proteomic view of mitochondrial function (2008)
Abstract Genomic and proteomic studies have identified hundreds of proteins from mitochondria. A recent study has added a functional twist to these systematic approaches and identified novel...
Vorlesung Biochemie III, 28. Stunde (2006)
Rapaport, Doron, Dodt, Gabriele, Duszenko, Michael, Feil, Robert, Hamprecht, Bernd, Stehle, Thilo
Vorlesung im WiSe 2005-2006; Dienstag, 10. Januar 2006
Vorlesung Biochemie III, 28. Stunde (2006)
Rapaport, Doron, Dodt, Gabriele, Duszenko, Michael, Feil, Robert, Hamprecht, Bernd, Stehle, Thilo
Vorlesung im WiSe 2005-2006; Dienstag, 10. Januar 2006
Structural Requirements of Tom40 for Assembly into Preexisting TOM Complexes of Mitochondria
Rapaport, Doron, Taylor, Rebecca D., Käser, Michael, Langer, Thomas, Neupert, Walter, Nargang, Frank E.
Tom40 is the major subunit of the translocase of the outer mitochondrial membrane (the TOM complex). To study the assembly pathway of Tom40, we have followed the integration of the protein into the...
Nargang, Frank E., Rapaport, Doron, Ritzel, R. Gary, Neupert, Walter, Lill, Roland
TOM22 is an essential mitochondrial outer membrane protein required for the import of precursor proteins into the organelles. The amino-terminal 84 amino acids of TOM22 extend into the cytosol and...
Dynamics of the TOM Complex of Mitochondria during Binding and Translocation of Preproteins
Rapaport, Doron, Künkele, Klaus-Peter, Dembowski, Markus, Ahting, Uwe, Nargang, Frank E., Neupert, Walter, ...
Translocation of preproteins across the mitochondrial outer membrane is mediated by the TOM complex. This complex consists of receptor components for the initial contact with preproteins at the...
Mitochondrial Protein Import: Recognition of Internal Import Signals of BCS1 by the TOM Complex
Stan, Tincuta, Brix, Jan, Schneider-Mergener, Jens, Pfanner, Nikolaus, Neupert, Walter, Rapaport, Doron
BCS1, a component of the inner membrane of mitochondria, belongs to the group of proteins with internal, noncleavable import signals. Import and intramitochondrial sorting of BCS1 are encoded in the...
Recognition of preproteins by the isolated TOM complex of mitochondria
Stan, Tincuta, Ahting, Uwe, Dembowski, Markus, Künkele, Klaus-Peter, Nussberger, Stephan, Neupert, Walter, ...
A multisubunit complex in the mitochondrial outer membrane, the TOM complex, mediates targeting and membrane translocation of nuclear-encoded preproteins. We have isolated the TOM holo complex,...
Vasiljev, Andreja, Ahting, Uwe, Nargang, Frank E., Go, Nancy E., Habib, Shukry J., Kozany, Christian, ...
Precursor proteins of the solute carrier family and of channel forming Tim components are imported into mitochondria in two main steps. First, they are translocated through the TOM complex in the...
Tob38, a novel essential component in the biogenesis of β-barrel proteins of mitochondria
Waizenegger, Thomas, Habib, Shukry J, Lech, Maciej, Mokranjac, Dejana, Paschen, Stefan A, Hell, Kai, ...
Insertion of β-barrel proteins into the outer membrane of mitochondria is mediated by the TOB complex. Known constituents of this complex are Tob55 and Mas37. We identified a novel component, Tob38....
Mim1, a protein required for the assembly of the TOM complex of mitochondria
Waizenegger, Thomas, Schmitt, Simone, Zivkovic, Jelena, Neupert, Walter, Rapaport, Doron
The translocase of the outer mitochondrial membrane (TOM complex) is the general entry site for newly synthesized proteins into mitochondria. This complex is essential for the formation and...
Finding the right organelle: Targeting signals in mitochondrial outer-membrane proteins
The mitochondrial outer membrane contains a diverse set of proteins that includes enzymes, components of the preprotein translocation machinery, pore-forming proteins, regulators of programmed cell...
Association of Bcl-2 with Misfolded Prion Protein Is Linked to the Toxic Potential of Cytosolic PrP
Rambold, Angelika S., Miesbauer, Margit, Rapaport, Doron, Bartke, Till, Baier, Michael, Winklhofer, Konstanze F., ...
Protein misfolding is linked to different neurodegenerative disorders like Alzheimer’s disease, polyglutamine, and prion diseases. We investigated the cytotoxic effects of aberrant conformers of...
Structural Requirements of Tom40 for Assembly into Preexisting TOM Complexes of Mitochondria
Rapaport, Doron, Taylor, Rebecca D., Käser, Michael, Langer, Thomas, Neupert, Walter, Nargang, Frank E.
Tom40 is the major subunit of the translocase of the outer mitochondrial membrane (the TOM complex). To study the assembly pathway of Tom40, we have followed the integration of the protein into the...
Nargang, Frank E., Rapaport, Doron, Ritzel, R. Gary, Neupert, Walter, Lill, Roland
TOM22 is an essential mitochondrial outer membrane protein required for the import of precursor proteins into the organelles. The amino-terminal 84 amino acids of TOM22 extend into the cytosol and...
Dynamics of the TOM Complex of Mitochondria during Binding and Translocation of Preproteins
Rapaport, Doron, Künkele, Klaus-Peter, Dembowski, Markus, Ahting, Uwe, Nargang, Frank E., Neupert, Walter, ...
Translocation of preproteins across the mitochondrial outer membrane is mediated by the TOM complex. This complex consists of receptor components for the initial contact with preproteins at the...
Mitochondrial Protein Import: Recognition of Internal Import Signals of BCS1 by the TOM Complex
Stan, Tincuta, Brix, Jan, Schneider-Mergener, Jens, Pfanner, Nikolaus, Neupert, Walter, Rapaport, Doron
BCS1, a component of the inner membrane of mitochondria, belongs to the group of proteins with internal, noncleavable import signals. Import and intramitochondrial sorting of BCS1 are encoded in the...
Recognition of preproteins by the isolated TOM complex of mitochondria
Stan, Tincuta, Ahting, Uwe, Dembowski, Markus, Künkele, Klaus-Peter, Nussberger, Stephan, Neupert, Walter, ...
A multisubunit complex in the mitochondrial outer membrane, the TOM complex, mediates targeting and membrane translocation of nuclear-encoded preproteins. We have isolated the TOM holo complex,...
Vasiljev, Andreja, Ahting, Uwe, Nargang, Frank E., Go, Nancy E., Habib, Shukry J., Kozany, Christian, ...
Precursor proteins of the solute carrier family and of channel forming Tim components are imported into mitochondria in two main steps. First, they are translocated through the TOM complex in the...
Tob38, a novel essential component in the biogenesis of β-barrel proteins of mitochondria
Waizenegger, Thomas, Habib, Shukry J, Lech, Maciej, Mokranjac, Dejana, Paschen, Stefan A, Hell, Kai, ...
Insertion of β-barrel proteins into the outer membrane of mitochondria is mediated by the TOB complex. Known constituents of this complex are Tob55 and Mas37. We identified a novel component, Tob38....
Mim1, a protein required for the assembly of the TOM complex of mitochondria
Waizenegger, Thomas, Schmitt, Simone, Zivkovic, Jelena, Neupert, Walter, Rapaport, Doron
The translocase of the outer mitochondrial membrane (TOM complex) is the general entry site for newly synthesized proteins into mitochondria. This complex is essential for the formation and...
Finding the right organelle: Targeting signals in mitochondrial outer-membrane proteins
The mitochondrial outer membrane contains a diverse set of proteins that includes enzymes, components of the preprotein translocation machinery, pore-forming proteins, regulators of programmed cell...
Association of Bcl-2 with Misfolded Prion Protein Is Linked to the Toxic Potential of Cytosolic PrP
Rambold, Angelika S., Miesbauer, Margit, Rapaport, Doron, Bartke, Till, Baier, Michael, Winklhofer, Konstanze F., ...
Protein misfolding is linked to different neurodegenerative disorders like Alzheimer’s disease, polyglutamine, and prion diseases. We investigated the cytotoxic effects of aberrant conformers of...
Hoppins, Suzanne C., Go, Nancy E., Klein, Astrid, Schmitt, Simone, Neupert, Walter, Rapaport, Doron, ...
Tob55 is the major component of the TOB complex, which is found in the outer membrane of mitochondria. A sheltered knockout of the tob55 gene was developed in Neurospora crassa. When grown under...
Habib, Shukry J., Waizenegger, Thomas, Niewienda, Agathe, Paschen, Stefan A., Neupert, Walter, Rapaport, Doron
β-Barrel proteins constitute a distinct class of mitochondrial outer membrane proteins. For import into mitochondria, their precursor forms engage the TOM complex. They are then relayed to the TOB...
A multisubunit translocase of the outer mitochondrial membrane (TOM complex) mediates both the import of mitochondrial precursor proteins into the internal compartments of the organelle and the...
Biogenesis of Tom40, Core Component of the Tom Complex of Mitochondria
Rapaport, Doron, Neupert, Walter
Tom40 is an essential component of the preprotein translocase of the mitochondrial outer membrane (TOM complex) in which it constitutes the core element of the protein conducting pore. We have...
Connection of the Mitochondrial Outer and Inner Membranes by Fzo1 Is Critical for Organellar Fusion
Fritz, Stefan, Rapaport, Doron, Klanner, Elisabeth, Neupert, Walter, Westermann, Benedikt
Mitochondrial membrane fusion is a process essential for the maintenance of the structural integrity of the organelle. Since mitochondria are bounded by a double membrane, they face the challenge of...
Krimmer, Thomas, Rapaport, Doron, Ryan, Michael T., Meisinger, Chris, Kassenbrock, C. Kenneth, Blachly-Dyson, Elizabeth, ...
Porin, also termed the voltage-dependent anion channel, is the most abundant protein of the mitochondrial outer membrane. The process of import and assembly of the protein is known to be dependent on...
Proteomic view of mitochondrial function
Dimmer, Kai Stefan, Rapaport, Doron
A screen for genes affecting mitochondrial function in Drosophila suggests that many modulators of mitochondrial function act outside the organelle.
Walther, Dirk M., Rapaport, Doron, Tommassen, Jan
Membrane-embedded β-barrel proteins span the membrane via multiple amphipathic β-strands arranged in a cylindrical shape. These proteins are found in the outer membranes of Gram-negative bacteria,...
Walther, Dirk M., Papic, Drazen, Bos, Martine P., Tommassen, Jan, Rapaport, Doron
The outer membranes of Gram-negative bacteria, mitochondria, and chloroplasts harbor β-barrel proteins. The signals that allow precursors of such proteins to be targeted to mitochondria were not...
Stapleford, Kenneth A., Rapaport, Doron, Miller, David J.
One characteristic of all positive-strand RNA viruses is the necessity to assemble viral RNA replication complexes on host intracellular membranes, a process whose molecular details are poorly...