Identification of loci associated with schizophrenia by genome-wide association and follow-up (2008)
Donovan, Michael C., Craddock, Nicholas, Norton, Nadine, Williams, Hywel, Peirce, Timothy, Moskvina, Valentina, ...
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong...
Significance levels for studies with correlated test statistics (2008)
Shi, Jianxin, Levinson, Douglas F., Whittemore, Alice S.
When testing large numbers of null hypotheses, one needs to assess the evidence against the global null hypothesis that none of the hypotheses is false. Such evidence typically is based on the test...
Shi, Jianxin, Siegmund, David O, Levinson, Douglas F
Abstract Morley et al. ( Nature 2004, 430: 743–747) detected significant linkages to the expression levels of 142 genes (of 3554) at a reported threshold of genome-wide p = 0.001 (LOD ≈ 5.3),...
QuickSNP: an automated web server for selection of tagSNPs (2007)
Grover, Deepak, Woodfield, Alonzo S., Verma, Ranjana, Zandi, Peter P., Levinson, Douglas F., Potash, James B.
Although large-scale genetic association studies involving hundreds to thousands of SNPs have become feasible, the associated cost is substantial. Even with the increased efficiency introduced by the...
Genetics of recurrent early-onset major depression (GenRED): final genome scan report (2007)
Holmans, Peter Alan, Weissman, Myrna M., Zubenko, George S., Scheftner, William A., Crowe, Raymond R., DePaulo, J. Raymond Jr., ...
Genetics of recurrent early-onset major depression (GenRED): final genome scan report (2007)
Holmans, Peter Alan, Weissman, Myrna M., Zubenko, George S., Scheftner, William A., Crowe, Raymond R., DePaulo, J. Raymond Jr., ...
Suarez, Brian K., Duan, Jubao, Sanders, Alan R., Hinrichs, Anthony L., Jin, Carol H., Hou, Cuiping, ...
We report the clinical characteristics of a schizophrenia sample of 409 pedigrees-263 of European ancestry ( EA) and 146 of African American ancestry ( AA)-together with the results of a genome scan...
The effect of linkage disequilibrium on linkage analysis of incomplete pedigrees (2005)
Levinson, Douglas F, Holmans, Peter
Abstract Dense SNP maps can be highly informative for linkage studies. But when parental genotypes are missing, multipoint linkage scores can be inflated in regions with substantial marker-marker...
GSMA: software implementation of the genome search meta-analysis method (2005)
Pardi, Fabio, Levinson, Douglas F., Lewis, Cathryn M.
Meta-analysis can be used to pool results of genome-wide linkage scans. This is of great value in complex diseases, where replication of linked regions occurs infrequently. The genome search...
GSMA: software for analysis of the genome-search meta-analysis method (2005)
Pardi, Fabio, Levinson, Douglas F., Lewis, Cathryn M.
Meta-analysis can be used to pool results of genome-wide linkage scans. This is of great value in complex diseases, where replication of linked regions occurs infrequently. The Genome Search...
Holmans, Peter Alan, Zubenko, George S., Crowe, Raymond R., DePaulo, J. Raymond Jr., Scheftner, William A., Weissman, Myrna M., ...
Holmans, Peter Alan, Zubenko, George S., Crowe, Raymond R., DePaulo, J. Raymond Jr., Scheftner, William A., Weissman, Myrna M., ...
Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia (2003)
Lewis, Cathryn M, Levinson, Douglas F, Wise, Lesley H, DeLisi, Lynn E, Straub, Richard E, Hovatta, Iiris, ...
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Genome scan meta-analysis of schizophrenia and bipolar disorder, Part III : bipolar disorder (2003)
Segurado, Ricardo, Detera-Wadleigh, Sevilla D, Ekholm, Jenny, Donald, Jennifer A, Levinson, Douglas F, Lewis, Cathryn M, ...
Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an...
Genome scan meta-analysis of schizophrenia and bipolar disorder, Part III : bipolar disorder (2003)
Segurado, Ricardo, Detera-Wadleigh, Sevilla D, Ekholm, Jenny, Donald, Jennifer A, Levinson, Douglas F, Lewis, Cathryn M, ...
Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an...
Genome scan meta-analysis of schizophrenia and bipolar disorder, Part III : bipolar disorder (2003)
Segurado, Ricardo, Detera-Wadleigh, Sevilla D, Ekholm, Jenny, Donald, Jennifer A, Levinson, Douglas F, Lewis, Cathryn M, ...
Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an...
Is Schizophrenia Linked to Chromosome 1q? (Response to Technical Comments) (2002)
Levinson, Douglas F., Holmans, Peter A., Laurent, Claudine, Mallet, Jacques, Riley, Brien, Kendler, Kenneth S., ...
The Lifetime Dimensions of Psychosis Scale (LDPS): description and interrater reliability (2002)
Levinson, Douglas F., Mowry, Bryan J., Escamilla, Michael A., Faraone, Stephen V.
A new rating scale, the Lifetime Dimensions of Psychosis Scale (LDPS), is described. The LDPS creates a profile of the lifetime characteristics of each case based on retrospective ratings,...
The Lifetime Dimensions of Psychosis Scale (LDPS): Description and Interrater Reliability (2002)
Levinson, Douglas F., Mowry, Bryan J., Escamilla, Michael A., Faraone, Stephen V.
A new rating scale, the Lifetime Dimensions of Psychosis Scale (LDPS), is described. The LDPS creates a profile of the lifetime characteristics of each case based on retrospective ratings,...
Simulation Studies of Detection of a Complex Disease in a Partially Isolated Population (2001)
Levinson, Douglas F., Kirby, Andrew, Slepner, Stephen, Nolte, Ilja, Spijker, Geert T., Meerman, Gerard Te
Simulation studies were undertaken with POPGEN, a new population simulation program, to explore strategies for detecting loci underlying rare and common disorders in a small population that has been...
Delusions in Schizophrenia Spectrum Disorders: Diagnostic Issues (1994)
Gladis, Madeline M., Levinson, Douglas F., Mowry, Bryan J.
Family studies of schizophrenia frequently include relatives of schizophrenia probands with diagnoses falling within the schizophrenia spectrum. As part of an ongoing genetic linkage study of...
Defining the Schizophrenia Spectrum: Issues for Genetic Linkage Studies (1991)
Levinson, Douglas F., Mowry, Bryan J.
Genetic linkage studies of schizophrenia depend on accurate psychiatric diagnosis of relatives within multiply affected families. Each investigator makes a series of explicit or implicit decisions to...
Prevalence of Substance Abuse in Schizophrenia: Demographic and Clinical Correlates (1990)
Mueser, Kim T., Yarnold, Paul R., Levinson, Douglas F., Singh, Hardeep, Bellack, Alan S., Kee, Kimmy, ...
Methodological issues involved in assessing the prevalence of substance abuse in schizophrenia are discussed, and previous research in this area is comprehensively reviewed. Many studies suffer from...
Levinson, Douglas F., Holmans, Peter, Straub, Richard E., Owen, Michael J., Wildenauer, Dieter B., Gejman, Pablo V., ...
Schizophrenia candidate regions 33–51 cM in length on chromosomes 5q, 6q, 10p, and 13q were investigated for genetic linkage with mapped markers with an average spacing of 5.64 cM. We studied 734...
Identification and Analysis of Error Types in High-Throughput Genotyping
Ewen, Kelly R., Bahlo, Melanie, Treloar, Susan A., Levinson, Douglas F., Mowry, Bryan, Barlow, John W., ...
Although it is clear that errors in genotyping data can lead to severe errors in linkage analysis, there is as yet no consensus strategy for identification of genotyping errors. Strategies include...
Suarez, Brian K., Duan, Jubao, Sanders, Alan R., Hinrichs, Anthony L., Jin, Carol H., Hou, Cuiping, ...
We report the clinical characteristics of a schizophrenia sample of 409 pedigrees—263 of European ancestry (EA) and 146 of African American ancestry (AA)—together with the results of a genome...
Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part I: Methods and Power Analysis
Levinson, Douglas F., Levinson, Matthew D., Segurado, Ricardo, Lewis, Cathryn M.
This is the first of three articles on a meta-analysis of genome scans of schizophrenia (SCZ) and bipolar disorder (BPD) that uses the rank-based genome scan meta-analysis (GSMA) method. Here we used...
Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part II: Schizophrenia
Lewis, Cathryn M., Levinson, Douglas F., Wise, Lesley H., DeLisi, Lynn E., Straub, Richard E., Hovatta, Iiris, ...
Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkage. To...
Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part III: Bipolar Disorder
Segurado, Ricardo, Detera-Wadleigh, Sevilla D., Levinson, Douglas F., Lewis, Cathryn M., Gill, Michael, ...
Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an...
Duan, Jubao, Martinez, Maria, Sanders, Alan R., Hou, Cuiping, Saitou, Naruya, Kitano, Takashi, ...
Several linkage studies across multiple population groups provide convergent support for a susceptibility locus for schizophrenia—and, more recently, for bipolar disorder—on chromosome 6q13-q26....
Genomewide Significant Linkage to Recurrent, Early-Onset Major Depressive Disorder on Chromosome 15q
Holmans, Peter, Zubenko, George S., Crowe, Raymond R., DePaulo Jr., J. Raymond, Scheftner, William A., Weissman, Myrna M., ...
A genome scan was performed on the first phase sample of the Genetics of Recurrent Early-Onset Depression (GenRED) project. The sample consisted of 297 informative families containing 415 independent...
Levinson, Douglas F., Holmans, Peter, Straub, Richard E., Owen, Michael J., Wildenauer, Dieter B., Gejman, Pablo V., ...
Schizophrenia candidate regions 33–51 cM in length on chromosomes 5q, 6q, 10p, and 13q were investigated for genetic linkage with mapped markers with an average spacing of 5.64 cM. We studied 734...
Identification and Analysis of Error Types in High-Throughput Genotyping
Ewen, Kelly R., Bahlo, Melanie, Treloar, Susan A., Levinson, Douglas F., Mowry, Bryan, Barlow, John W., ...
Although it is clear that errors in genotyping data can lead to severe errors in linkage analysis, there is as yet no consensus strategy for identification of genotyping errors. Strategies include...
Suarez, Brian K., Duan, Jubao, Sanders, Alan R., Hinrichs, Anthony L., Jin, Carol H., Hou, Cuiping, ...
We report the clinical characteristics of a schizophrenia sample of 409 pedigrees—263 of European ancestry (EA) and 146 of African American ancestry (AA)—together with the results of a genome...
QuickSNP: an automated web server for selection of tagSNPs
Grover, Deepak, Woodfield, Alonzo S., Verma, Ranjana, Zandi, Peter P., Levinson, Douglas F., Potash, James B.
Although large-scale genetic association studies involving hundreds to thousands of SNPs have become feasible, the associated cost is substantial. Even with the increased efficiency introduced by the...
Authority and leadership in the school : a case study in organizational dynamics /
Thesis (A.B., Honors)--Harvard University, 1970.
Statistical corrections of linkage data suggest predominantly cis regulations of gene expression
Shi, Jianxin, Siegmund, David O, Levinson, Douglas F
Morley et al. (Nature 2004, 430:743–747) detected significant linkages to the expression levels of 142 genes (of 3554) at a reported threshold of genome-wide p = 0.001 (LOD ≈ 5.3), using 14...