HIV-1 infection induces retrotransposition of LINE-1 elements (2009)
Jones, R Brad, Garrison, Keith E, Song, Haihan, Buzdin, Anton, Anwar, Naveed, Meiklejohn, Duncan A, ...
No abstract available.
Paleovirology of human endogenous retroviruses (2009)
Gifford, Robert J, Katzourakis, Aris, Belshaw, Robert, Nixon, Douglas F
No abstract available.
Jha, Aashish R., Pillai, Satish K., York, Vanessa A., Sharp, Elizabeth R., Storm, Emily C., Wachter, Douglas J., ...
The human genome, human endogenous retroviruses (HERV), of which HERV-K113 and HERV-K115 are the only known full-length proviruses that are insertionally polymorphic. Although a handful of previously...
Michaëlsson, Jakob, Barbosa, Hugo, Jordan, Kimberley A, Chapman, Joan M, Brunialti, Milena KC, Neto, Walter, ...
Abstract Background CD4 + CD25 high regulatory T (T Reg ) cells modulate antigen-specific T cell responses, and can suppress anti-viral immunity. In HTLV-1 infection, a selective decrease in the...
T Cell Responses to Human Endogenous Retroviruses in HIV-1 Infection (2007)
Keith E. Garrison, R. Brad Jones, Duncan A. Meiklejohn, Naveed Anwar, Lishomwa C. Ndhlovu, Joan M. Chapman, ...
Human endogenous retroviruses (HERVs) are remnants of ancient infectious agents that have integrated into the human genome. Under normal circumstances, HERVs are functionally defective or controlled...
Metzner, Karin J, Binley, James M, Gettie, Agegnehu, Marx, Preston, Nixon, Douglas F, Connor, Ruth I
Abstract Background Emergence of drug-resistant strains of human immunodeficiency virus type 1 (HIV-1) is a major obstacle to successful antiretroviral therapy (ART) in HIV-infected patients. Whether...
IL-2 production correlates with effector cell differentiation in HIV-specific CD8+ T cells (2006)
Nomura, Laurel E, Emu, Brinda, Hoh, Rebecca, Haaland, Perry, Deeks, Steven G, Martin, Jeffrey N, ...
Abstract Background Diminished IL-2 production and lack of effector differentiation have been reported for HIV-specific T cells. In this study, we examined the prevalence of these phenomena using...
Michaëlsson, Jakob, Mold, Jeff E, McCune, Joseph M, Nixon, Douglas F
No abstract available.
Jin, Xia, Roberts, Caroline G. P., Nixon, Douglas F., Cao, Yunzhen, Ho, David D., Walker, Bruce D., ...
The ARIEL Project for the Prevention of HIV Transmission from Mother to Infant was established to evaluate virologic and immunologic parameters during vertical transmission. To determine the strength...
Cytotoxic T cell immunity in HIV infection. (1990)
Thesis (Ph. D.)--University of Oxford, 1990.
Huet, Stephane, Nixon, Douglas F., Rothbard, Jonathan B., Townsend, Alain, Ellis, Shirley A., McMichael, Andrew J.
Recently we described an HLA B27-restrlcted peptide derived from HIV gag p24 protein. In this study we have isolated an HLA B27-restrlcted peptide from the nucleoprotein (NP) of influenza A virus....
Structured antiretroviral treatment interruptions in chronically HIV-1-infected subjects
Ortiz, Gabriel M., Wellons, Melissa, Brancato, Jason, Vo, Ha T. T., Zinn, Rebekah L., Clarkson, Daniel E., ...
The risks and benefits of structured treatment interruption (STI) in HIV-1-infected subjects are not fully understood. A pilot study was performed to compare STI with continuous highly active...
Dyer, Wayne B., Ogg, Graham S., Demoitie, Marie-Ange, Jin, Xia, Geczy, Andrew F., Rowland-Jones, Sarah L., ...
Proposals for the use of live attenuated human immunodeficiency virus (HIV) type 1 (HIV-1) as a vaccine candidate in humans have been based on the protection afforded by attenuated simian...
Spiegel, Hans M. L., Ogg, Graham S., DeFalcon, Elizabeth, Sheehy, Megan E., Monard, Simon, Haslett, Patrick A. J., ...
CD4+ T cells are thought to be critical in the maintenance of virus-specific CD8+ cytotoxic T-cell (CTL) responses. In human immunodeficiency virus type 1 (HIV-1) infection, a selective decline in...
Hioe, Catarina E., Tuen, Michael, Chien, Peter C., Jones, Gareth, Ratto-Kim, Silvia, Norris, Philip J., ...
Human immunodeficiency virus (HIV)-specific CD4 T-cell responses, particularly to the envelope glycoproteins of the virus, are weak or absent in most HIV-infected patients. Although these poor...
Ortiz, Gabriel M., Hu, Jennifer, Goldwitz, Joshua A., Chandwani, Rohit, Larsson, Marie, Bhardwaj, Nina, ...
Human immunodeficiency virus type 1 (HIV-1)-infected subjects treated early after infection have preserved HIV-1-specific CD4+ T-cell function. We studied the effect of highly active antiretroviral...
Selective Loss of Innate CD4+ Vα24 Natural Killer T Cells in Human Immunodeficiency Virus Infection
Sandberg, Johan K., Fast, Noam M., Palacios, Emil H., Fennelly, Glenn, Dobroszycki, Joanna, Palumbo, Paul, ...
Vα24 natural killer T (NKT) cells are innate immune cells involved in regulation of immune tolerance, autoimmunity, and tumor immunity. However, the effect of human immunodeficiency virus type 1...
Shacklett, Barbara L., Cox, Catherine A., Sandberg, Johan K., Stollman, Neil H., Jacobson, Mark A., Nixon, Douglas F.
Gut-associated lymphoid tissue (GALT) is a significant but understudied lymphoid organ, harboring a majority of the body's total lymphocyte population. GALT is also an important portal of entry for...
Karlsson, Annika C., Deeks, Steven G., Barbour, Jason D., Heiken, Brandon D., Younger, Sophie R., Hoh, Rebecca, ...
Human immunodeficiency virus (HIV)-specific CD8+ T-lymphocyte pressure can lead to the development of viral escape mutants, with consequent loss of immune control. Antiretroviral drugs also exert...
Aandahl, Einar M., Michaëlsson, Jakob, Moretto, Walter J., Hecht, Frederick M., Nixon, Douglas F.
Regulatory T (TR) cells maintain tolerance to self-antigens and control immune responses to alloantigens after organ transplantation. Here, we show that CD4+ CD25+ human TR cells suppress...
Ramsburg, Elizabeth, Rose, Nina F., Marx, Preston A., Mefford, Megan, Nixon, Douglas F., Moretto, Walter J., ...
Previous studies have shown that vaccination and boosting of rhesus macaques with attenuated vesicular stomatitis virus (VSV) vectors encoding Env and Gag proteins of simian immunodeficiency...
Sandberg, Johan K., Stoddart, Cheryl A., Brilot, Fabienne, Jordan, Kimberly A., Nixon, Douglas F.
Natural killer (NK) T cells are innate CD1d-restricted immune cells involved in regulation of immune tolerance, tumor immunity, and immunity to infectious pathogens. Human α-chain variable gene...
Ortiz, Gabriel M., Nixon, Douglas F., Trkola, Alexandra, Binley, James, Jin, Xia, Bonhoeffer, Sebastian, ...
Therapeutic intervention with highly active antiretroviral therapy (HAART) can lead to suppression of HIV-1 plasma viremia to undetectable levels for 3 or more years. However, adherence to complex...
Dhodapkar, Madhav V., Steinman, Ralph M., Sapp, Mark, Desai, Hema, Fossella, Coraleen, Krasovsky, Joseph, ...
Dendritic cells (DCs) are potent antigen-presenting cells that initiate protective T-cell immunity in mice. To study the immunogenicity of DCs in humans, we injected 9 healthy subjects subcutaneously...
Schweighardt, Becky, Roy, Ann-Marie, Meiklejohn, Duncan A., Grace, Edward J., Moretto, Walter J., Heymann, Jonas J., ...
In this report, we present evidence that R5 human immunodeficiency virus type 1 (HIV-1) replicates more efficiently in primary CD4+ T cells than X4 HIV-1. By comparing CD3/CD28-costimulated CD4+...
Emu, Brinda, Sinclair, Elizabeth, Favre, David, Moretto, Walter J., Hsue, Priscilla, Hoh, Rebecca, ...
The human immunodeficiency virus (HIV)-mediated immune response may be beneficial or harmful, depending on the balance between expansion of HIV-specific T cells and the level of generalized immune...
IL-2 production correlates with effector cell differentiation in HIV-specific CD8+ T cells
Nomura, Laurel E, Emu, Brinda, Hoh, Rebecca, Haaland, Perry, Deeks, Steven G, Martin, Jeffrey N, ...
Structured antiretroviral treatment interruptions in chronically HIV-1-infected subjects
Ortiz, Gabriel M., Wellons, Melissa, Brancato, Jason, Vo, Ha T. T., Zinn, Rebekah L., Clarkson, Daniel E., ...
The risks and benefits of structured treatment interruption (STI) in HIV-1-infected subjects are not fully understood. A pilot study was performed to compare STI with continuous highly active...
Dyer, Wayne B., Ogg, Graham S., Demoitie, Marie-Ange, Jin, Xia, Geczy, Andrew F., Rowland-Jones, Sarah L., ...
Proposals for the use of live attenuated human immunodeficiency virus (HIV) type 1 (HIV-1) as a vaccine candidate in humans have been based on the protection afforded by attenuated simian...
Spiegel, Hans M. L., Ogg, Graham S., DeFalcon, Elizabeth, Sheehy, Megan E., Monard, Simon, Haslett, Patrick A. J., ...
CD4+ T cells are thought to be critical in the maintenance of virus-specific CD8+ cytotoxic T-cell (CTL) responses. In human immunodeficiency virus type 1 (HIV-1) infection, a selective decline in...
Hioe, Catarina E., Tuen, Michael, Chien, Peter C., Jones, Gareth, Ratto-Kim, Silvia, Norris, Philip J., ...
Human immunodeficiency virus (HIV)-specific CD4 T-cell responses, particularly to the envelope glycoproteins of the virus, are weak or absent in most HIV-infected patients. Although these poor...
Ortiz, Gabriel M., Hu, Jennifer, Goldwitz, Joshua A., Chandwani, Rohit, Larsson, Marie, Bhardwaj, Nina, ...
Human immunodeficiency virus type 1 (HIV-1)-infected subjects treated early after infection have preserved HIV-1-specific CD4+ T-cell function. We studied the effect of highly active antiretroviral...
Selective Loss of Innate CD4+ Vα24 Natural Killer T Cells in Human Immunodeficiency Virus Infection
Sandberg, Johan K., Fast, Noam M., Palacios, Emil H., Fennelly, Glenn, Dobroszycki, Joanna, Palumbo, Paul, ...
Vα24 natural killer T (NKT) cells are innate immune cells involved in regulation of immune tolerance, autoimmunity, and tumor immunity. However, the effect of human immunodeficiency virus type 1...
Shacklett, Barbara L., Cox, Catherine A., Sandberg, Johan K., Stollman, Neil H., Jacobson, Mark A., Nixon, Douglas F.
Gut-associated lymphoid tissue (GALT) is a significant but understudied lymphoid organ, harboring a majority of the body's total lymphocyte population. GALT is also an important portal of entry for...
Karlsson, Annika C., Deeks, Steven G., Barbour, Jason D., Heiken, Brandon D., Younger, Sophie R., Hoh, Rebecca, ...
Human immunodeficiency virus (HIV)-specific CD8+ T-lymphocyte pressure can lead to the development of viral escape mutants, with consequent loss of immune control. Antiretroviral drugs also exert...
Aandahl, Einar M., Michaëlsson, Jakob, Moretto, Walter J., Hecht, Frederick M., Nixon, Douglas F.
Regulatory T (TR) cells maintain tolerance to self-antigens and control immune responses to alloantigens after organ transplantation. Here, we show that CD4+ CD25+ human TR cells suppress...
Ramsburg, Elizabeth, Rose, Nina F., Marx, Preston A., Mefford, Megan, Nixon, Douglas F., Moretto, Walter J., ...
Previous studies have shown that vaccination and boosting of rhesus macaques with attenuated vesicular stomatitis virus (VSV) vectors encoding Env and Gag proteins of simian immunodeficiency...
Sandberg, Johan K., Stoddart, Cheryl A., Brilot, Fabienne, Jordan, Kimberly A., Nixon, Douglas F.
Natural killer (NK) T cells are innate CD1d-restricted immune cells involved in regulation of immune tolerance, tumor immunity, and immunity to infectious pathogens. Human α-chain variable gene...
Ortiz, Gabriel M., Nixon, Douglas F., Trkola, Alexandra, Binley, James, Jin, Xia, Bonhoeffer, Sebastian, ...
Therapeutic intervention with highly active antiretroviral therapy (HAART) can lead to suppression of HIV-1 plasma viremia to undetectable levels for 3 or more years. However, adherence to complex...
Dhodapkar, Madhav V., Steinman, Ralph M., Sapp, Mark, Desai, Hema, Fossella, Coraleen, Krasovsky, Joseph, ...
Dendritic cells (DCs) are potent antigen-presenting cells that initiate protective T-cell immunity in mice. To study the immunogenicity of DCs in humans, we injected 9 healthy subjects subcutaneously...
Schweighardt, Becky, Roy, Ann-Marie, Meiklejohn, Duncan A., Grace, Edward J., Moretto, Walter J., Heymann, Jonas J., ...
In this report, we present evidence that R5 human immunodeficiency virus type 1 (HIV-1) replicates more efficiently in primary CD4+ T cells than X4 HIV-1. By comparing CD3/CD28-costimulated CD4+...
Emu, Brinda, Sinclair, Elizabeth, Favre, David, Moretto, Walter J., Hsue, Priscilla, Hoh, Rebecca, ...
The human immunodeficiency virus (HIV)-mediated immune response may be beneficial or harmful, depending on the balance between expansion of HIV-specific T cells and the level of generalized immune...
IL-2 production correlates with effector cell differentiation in HIV-specific CD8+ T cells
Nomura, Laurel E, Emu, Brinda, Hoh, Rebecca, Haaland, Perry, Deeks, Steven G, Martin, Jeffrey N, ...
Legrand, Fatema A., Nixon, Douglas F., Loo, Christopher P., Ono, Erika, Chapman, Joan M., Miyamoto, Maristela, ...
Metzner, Karin J, Binley, James M, Gettie, Agegnehu, Marx, Preston, Nixon, Douglas F, Connor, Ruth I
Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape
Karlsson, Annika C., Iversen, Astrid K.N., Chapman, Joan M., De Oliveira, Tulio, Spotts, Gerald, McMichael, Andrew J., ...
Moll, Markus, Snyder-Cappione, Jennifer, Spotts, Gerald, Hecht, Frederick M., Sandberg, Johan K., Nixon, Douglas F.
Innate CD1d-restricted natural killer T (NKT) cells are infected and lost in HIV-1–infected patients, and this could contribute to HIV-1 pathogenesis because NKT cells play an important role in...
Northfield, John W., Loo, Christopher P., Barbour, Jason D., Spotts, Gerald, Hecht, Frederick M., Klenerman, Paul, ...
CD8+ T cells are believed to play an important role in the control of human immunodeficiency virus type 1 (HIV-1) infection. However, despite intensive efforts, it has not been possible to...
HIV-1/HSV-2 Co-Infected Adults in Early HIV-1 Infection Have Elevated CD4+ T Cell Counts
Barbour, Jason D., Sauer, Mariana M., Sharp, Elizabeth R., Garrison, Keith E., Long, Brian R., Tomiyama, Helena, ...
T Cell Responses to Human Endogenous Retroviruses in HIV-1 Infection
Garrison, Keith E, Jones, R. Brad, Meiklejohn, Duncan A, Anwar, Naveed, Ndhlovu, Lishomwa C, Chapman, Joan M, ...
Human endogenous retroviruses (HERVs) are remnants of ancient infectious agents that have integrated into the human genome. Under normal circumstances, HERVs are functionally defective or controlled...
Jones, R. Brad, Garrison, Keith E., Wong, Jessica C., Duan, Erick H., Nixon, Douglas F., Ostrowski, Mario A.
HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function
Appay, Victor, Nixon, Douglas F., Donahoe, Sean M., Gillespie, Geraldine M.A., Dong, Tao, King, Abigail, ...
The use of peptide–human histocompatibility leukocyte antigen (HLA) class I tetrameric complexes to identify antigen-specific CD8+ T cells has provided a major development in our understanding of...
Long, Brian R., Michaelsson, Jakob, Loo, Christopher P., Ballan, Wassim M., Vu, Bien-Aimee N., Hecht, Frederick M., ...
Recent studies indicate that innate immunity in influenza virus infection is an area of substantial importance for our understanding of influenza virus pathogenesis, yet our knowledge of the...
Lee, Andrew W., Sharp, Elizabeth R., O'Mahony, Alison, Rosenberg, Michael G., Israelski, Dennis M., Nolan, Garry P., ...
Despite extensive evidence of cell signaling alterations induced by human immunodeficiency virus type 1 (HIV-1) in vitro, the relevance of these changes to the clinical and/or immunologic status of...
Michaëlsson, Jakob, Barbosa, Hugo Marcelo R, Jordan, Kimberley A, Chapman, Joan M, Brunialti, Milena KC, Neto, Walter Kleine, ...
Long, Brian R., Ndhlovu, Lishomwa C., Oksenberg, Jorge R., Lanier, Lewis L., Hecht, Frederick M., Nixon, Douglas F., ...
A flurry of recent reports on the role of activating and inhibitory forms of the killer cell immunoglobulin-like receptors (KIR) in natural killer (NK) cell activity against human immunodeficiency...
Immunity to HIV-1 Is Influenced by Continued Natural Exposure to Exogenous Virus
Willberg, Christian B., McConnell, J. Jeff, Eriksson, Emily M., Bragg, Larry A., York, Vanessa A., Liegler, Teri J., ...
Unprotected sexual intercourse between individuals who are both infected with HIV-1 can lead to exposure to their partner's virus, and potentially to super-infection. However, the immunological...
Jones, R. Brad, Ndhlovu, Lishomwa C., Barbour, Jason D., Sheth, Prameet M., Jha, Aashish R., Long, Brian R., ...
Progressive loss of T cell functionality is a hallmark of chronic infection with human immunodeficiency virus 1 (HIV-1). We have identified a novel population of dysfunctional T cells marked by...
A Decreased Frequency of Regulatory T Cells in Patients with Common Variable Immunodeficiency
Melo, Karina M., Carvalho, Karina I., Bruno, Fernanda R., Ndhlovu, Lishomwa C., Ballan, Wassim M., Nixon, Douglas F., ...
Jha, Aashish R., Pillai, Satish K., York, Vanessa A., Sharp, Elizabeth R., Storm, Emily C., Wachter, Douglas J., ...
The human genome, human endogenous retroviruses (HERV), of which HERV-K113 and HERV-K115 are the only known full-length proviruses that are insertionally polymorphic. Although a handful of previously...
Paleovirology of human endogenous retroviruses
Gifford, Robert J, Katzourakis, Aris, Belshaw, Robert, Nixon, Douglas F
HIV-1 infection induces retrotransposition of LINE-1 elements
Jones, R Brad, Garrison, Keith E, Song, Haihan, Buzdin, Anton, Anwar, Naveed, Meiklejohn, Duncan A, ...
Tregs control the development of symptomatic West Nile virus infection in humans and mice
Lanteri, Marion C., O’Brien, Katie M., Purtha, Whitney E., Cameron, Mark J., Lund, Jennifer M., Owen, Rachel E., ...
West Nile virus (WNV) causes asymptomatic infection in most humans, but for undefined reasons, approximately 20% of immunocompetent individuals develop West Nile fever, a potentially debilitating...