Ligand-induced conformational changes allosterically activate Toll-like receptor 9 (2007)
Latz, Eicke, Verma, Anjali, Visintin, Alberto, Gong, Mei, Sirois, Cherilyn M., Klein, Dionne C. G., ...
Microbial and synthetic DNA rich in CpG dinucleotides stimulates Toll-like receptor 9 (TLR9), whereas DNA lacking CpG either is inert or can inhibit TLR9 activation. The molecular mechanisms by which...
Schoenemeyer, Annett, Barnes, Betsy J., Mancl, Margo E., Latz, Eicke, Goutagny, Nadege, Pitha, Paula M., ...
Interferon regulatory factors (IRFs) are critical components of virus-induced immune activation and type I interferon regulation. IRF3 and IRF7 are activated in response to a variety of viruses or...
Endotoxin recognition and signal transduction by the TLR4/MD2-complex (2004)
Fitzgerald, Katherine A., Rowe, Daniel C., Golenbock, Douglas
Bacterial lipopolysaccharides are recognized in mammals by a receptor complex composed of CD14, Toll-like receptor (TLR)-4 and MD-2. Transduction of signaling is achieved following the recruitment of...
LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF (2003)
Fitzgerald, Katherine A., Rowe, Daniel C., Barnes, Betsy J., Caffrey, Daniel R., Visintin, Alberto, Latz, Eicke, ...
Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF)-related adaptor molecule (TRAM) is the fourth TIR domain-containing adaptor protein to be described that participates in...
Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling (2003)
Sandor, Frantisek, Latz, Eicke, Re, Fabio, Mandell, Leisa, Repik, Galina, Golenbock, Douglas, ...
Recognition of ligands by toll-like receptor (TLR) 2 requires interactions with other TLRs. TLRs form a combinatorial repertoire to discriminate between the diverse microbial ligands. Diversity...
Visintin, Alberto, Latz, Eicke, Monks, Brian G., Espevik, Terje, Golenbock, Douglas
Three cell-surface proteins have been recognized as components of the mammalian signaling receptor for bacterial lipopolysaccharide (LPS): CD14, Toll-like receptor-4 (TLR4), and MD-2. Biochemical and...
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway (2003)
Fitzgerald, Katherine A., McWhirter, Sarah M., Faia, Kerrie L., Rowe, Daniel C., Latz, Eicke, Golenbock, Douglas, ...
The transcription factors interferon regulatory factor 3 (IRF3) and NF-kappaB are required for the expression of many genes involved in the innate immune response. Viral infection, or the binding of...
Latz, Eicke, Visintin, Alberto, Lien, Egil, Fitzgerald, Kate A., Monks, Brian G., Kurt-Jones, Evelyn A., ...
Mammalian responses to LPS require the expression of Toll-like receptor 4 (TLR4), CD14, and MD-2. We expressed fluorescent TLR4 in cell lines and found that TLR4 densely localized to the surface and...
Comparative Toll-Like Receptor 4-Mediated Innate Host Defense to Bordetella Infection
Mann, Paul B., Wolfe, Daniel, Latz, Eicke, Golenbock, Douglas, Preston, Andrew, Harvill, Eric T.
Bordetella pertussis, B. parapertussis, and B. bronchiseptica are closely related species associated with respiratory disease in humans and other mammals. While B. bronchiseptica has a wide host...
Chen, Chun-Jen, Shi, Yan, Hearn, Arron, Fitzgerald, Kate, Golenbock, Douglas, Reed, George, ...
While it is known that monosodium urate (MSU) crystals cause the disease gout, the mechanism by which these crystals stimulate this inflammatory condition has not been clear. Here we find that the...
Comparative Toll-Like Receptor 4-Mediated Innate Host Defense to Bordetella Infection
Mann, Paul B., Wolfe, Daniel, Latz, Eicke, Golenbock, Douglas, Preston, Andrew, Harvill, Eric T.
Bordetella pertussis, B. parapertussis, and B. bronchiseptica are closely related species associated with respiratory disease in humans and other mammals. While B. bronchiseptica has a wide host...
Chen, Chun-Jen, Shi, Yan, Hearn, Arron, Fitzgerald, Kate, Golenbock, Douglas, Reed, George, ...
While it is known that monosodium urate (MSU) crystals cause the disease gout, the mechanism by which these crystals stimulate this inflammatory condition has not been clear. Here we find that the...
Miggin, Sinead M., Pålsson-McDermott, Eva, Dunne, Aisling, Jefferies, Caroline, Pinteaux, Emmanuel, Banahan, Kathy, ...
Toll-like receptors (TLRs)-2 and -4 are important proteins in innate immunity, recognizing microbial products and eliciting host defense responses. Both use the adapter proteins MyD88 and MyD88...
A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2
Wang, Qun, McLoughlin, Rachel M., Cobb, Brian A., Charrel-Dennis, Marie, Zaleski, Kathleen J., Golenbock, Douglas, ...
Commensalism is critical to a healthy Th1/Th2 cell balance. Polysaccharide A (PSA), which is produced by the intestinal commensal Bacteroides fragilis, activates CD4+ T cells, resulting in a Th1...
Wurfel, Mark M., Monks, Brian G., Ingalls, Robin R., Dedrick, Russell L., Delude, Russell, Zhou, Dahua, ...
Gram-negative bacterial lipopolysaccharide (LPS) stimulates phagocytic leukocytes by interacting with the cell surface protein CD14. Cellular responses to LPS are markedly potentiated by the...