Douglas M. Noonan

Angiostatin anti-angiogenesis requires IL-12: The innate immune system as a key target (2009)

Albini, Adriana, Brigati, Claudio, Ventura, Agostina, Lorusso, Girieca, Pinter, Marta, Morini, Monica, ...

Abstract Background Angiostatin, an endogenous angiogenesis inhibitor, is a fragment of plasminogen. Its anti-angiogenic activity was discovered with functional assays in vivo, however, its direct...

Biological assays and genomic analysis reveal lipoic acid modulation of endothelial cell behavior and gene expression (2007)

Larghero, Patrizia, Venè, Roberta, Minghelli, Simona, Travaini, Giorgia, Morini, Monica, Ferrari, Nicoletta, ...

Lipoic acid (LA) is a sulfated antioxidant produced physiologically as a coenzyme of the pyruvate dehydrogenase complex; it is currently used for treatment of non-insulin-dependent diabetes to favor...

The Akt inhibitor deguelin, is an angiopreventive agent also acting on the NF-{kappa}B pathway (2007)

Dell'Eva, Raffaella, Ambrosini, Claudia, Minghelli, Simona, Noonan, Douglas M., Albini, Adriana, Ferrari, Nicoletta

Several natural compounds, especially plant products and dietary constituents, are able to exhibit ‘angiopreventive’ (anti-angiogenic chemoprevention) activities both in vitro and in vivo....

The Akt inhibitor deguelin, is an angiopreventive agent also acting on the NF-{kappa}B pathway (2006)

Dell'Eva, Raffaella, Ambrosini, Claudia, Minghelli, Simona, Noonan, Douglas M., Albini, Adriana, Ferrari, Nicoletta

Several natural compounds, especially plant products and dietary constituents, are able to exhibit "angiopreventive" (anti-angiogenic chemoprevention) activities both in vitro and in vivo. Deguelin...

Hypomethylation of the interphotoreceptor retinoid-binding protein (IRBP) promoter and first exon is linked to expression of the gene (1990)

Albini, Adriana, Toffenetti, Judith, Zhu, Zhen, Chader, Gerald J., Noonan, Douglas M.

The interphotoreceptor retinoid-binding protein (IRBP) is limited in expression to retinal photoreceptor cells and a subset of pinealocytes. We have obtained a genomic clone containing the entire...

HIV-1 Tat protein mimicry of chemokines

Albini, Adriana, Ferrini, Silvano, Benelli, Roberto, Sforzini, Sabrina, Giunciuglio, Daniela, Aluigi, Maria Grazia, ...

The HIV-1 Tat protein is a potent chemoattractant for monocytes. We observed that Tat shows conserved amino acids corresponding to critical sequences of the chemokines, a family of molecules known...

HIV-1 Tat protein mimicry of chemokines

Albini, Adriana, Ferrini, Silvano, Benelli, Roberto, Sforzini, Sabrina, Giunciuglio, Daniela, Aluigi, Maria Grazia, ...

The HIV-1 Tat protein is a potent chemoattractant for monocytes. We observed that Tat shows conserved amino acids corresponding to critical sequences of the chemokines, a family of molecules known...

Inhibition of Angiogenesis and Vascular Tumor Growth by Interferon-Producing Cells : A Gene Therapy Approach

Albini, Adriana, Marchisone, Chiara, Del Grosso, Federica, Benelli, Roberto, Masiello, Luciana, Tacchetti, Carlo, ...

We developed an in vivo gene therapy approach to characterize and optimize the anti-angiogenic activity of class I interferons (IFNs), using packaging cell lines producing an amphotropic LXSN-based...

Prediction of breast cancer metastasis by genomic profiling: where do we stand?

Pfeffer, Ulrich, Romeo, Francesco, Noonan, Douglas M., Albini, Adriana

Current concepts conceive “breast cancer” as a complex disease that comprises several very different types of neoplasms. Nonetheless, breast cancer treatment has considerably improved through...

Identification, Isolation and Expansion of Myoendothelial Cells Involved in Leech Muscle Regeneration

Grimaldi, Annalisa, Banfi, Serena, Gerosa, Laura, Tettamanti, Gianluca, Noonan, Douglas M., Valvassori, Roberto, ...

Adult skeletal muscle in vertebrates contains myoendothelial cells that express both myogenic and endothelial markers, and which are able to differentiate into myogenic cells to contribute to muscle...