Transcription Regulation by Class III Histone Deacetylases (HDACs)—Sirtuins (2008)
Sirtuins are NAD+-dependent histone deacetylases (Class III HDACs). Recently, Sirtuins have been shown to play important roles, both direct and indirect, in transcriptional regulation. This...
Roles of Prohibitin in Growth Control and Tumor Suppression in Human Cancers (2008)
Tumor formation results from alterations in the normal control of cell proliferation. In the past decade, much attention in cancer research has been focused on the function of proto-oncogenes and...
Dai, Yan, Ngo, Duyen, Jacob, Johanna, Forman, Lora W., Faller, Douglas V.
Androgen antagonists or androgen deprivation are the primary therapeutic modalities for the treatment of prostate cancer. Invariably, however, the disease becomes progressive and unresponsive to...
Jian Gu, Xianshi Zhao, Remco A. Spanjaard, Tai C. Chen, John N. Flanagan, Michael Boosalis, ...
AIM: Retinoids have achieved some promise as chemopreventive agents in aerodigestive cancers, and have potential activity in the chemoprevention of prostate cancer. Despite their anti-proliferative...
Virus-Targeted Therapeutic for Breast Cancer (1998)
We have developed small molecules to alter the transcriptional response of viral genes for the treatment of human breast cancer. The transcriptional activity of certain viral genes, including the...
Virus-Targeted Therapeutic for Breast Cancer. (1998)
Epstein-Barr Virus (EBV)-infection of the malignant cells can be found in as many as 50% of breast cancers. We have recently developed a successful virus-directed strategy for treating EBV-associated...
Virus-Targeted Therapeutic for Breast Cancer (1998)
We have developed small molecules to alter the transcriptional response of viral genes for the treatment of human breast cancer. We have previously successfully used these compounds as therapeutic...
Liposome encapsulation of retrovirus allows efficient superinfection of resistant cell lines (1984)
Faller, Douglas V., Baltimore, David
Cell lines which are infected with retrovirus are resistant to superinfection by a related retrovirus. Packaging of whole virions within synthetic lipid vesicles allows efficient infection of such...
Ghosh, Sajal K., Roy-Burman, Pradip, Faller, Douglas V.
We have previously reported that the long terminal repeat (LTR) region of feline leukemia viruses (FeLVs) can enhance expression of certain cellular genes such as the collagenase IV gene and MCP-1 in...
Feline Leukemia Virus Long Terminal Repeat Activates Collagenase IV Gene Expression through AP-1
Ghosh, Sajal K., Faller, Douglas V.
Leukemia and lymphoma induced by feline leukemia viruses (FeLVs) are the commonest forms of illness in domestic cats. These viruses do not contain oncogenes, and the source of their pathogenic...
Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth
Wang, Sheng, Zhang, Baohua, Faller, Douglas V.
E2F transcription factors play a major role in controlling mammalian cell cycle progression. We recently reported that a potential tumor suppressor, prohibitin, which interacts with retinoblastoma...
BRG1/BRM and prohibitin are required for growth suppression by estrogen antagonists
Wang, Sheng, Zhang, Baohua, Faller, Douglas V
Estrogen antagonists are universally employed in the breast cancer therapy, although antagonist therapy is limited by the inevitable development of cellular resistance. The molecular mechanisms by...
Ghosh, Sajal K., Roy-Burman, Pradip, Faller, Douglas V.
We have previously reported that the long terminal repeat (LTR) region of feline leukemia viruses (FeLVs) can enhance expression of certain cellular genes such as the collagenase IV gene and MCP-1 in...
Feline Leukemia Virus Long Terminal Repeat Activates Collagenase IV Gene Expression through AP-1
Ghosh, Sajal K., Faller, Douglas V.
Leukemia and lymphoma induced by feline leukemia viruses (FeLVs) are the commonest forms of illness in domestic cats. These viruses do not contain oncogenes, and the source of their pathogenic...
Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth
Wang, Sheng, Zhang, Baohua, Faller, Douglas V.
E2F transcription factors play a major role in controlling mammalian cell cycle progression. We recently reported that a potential tumor suppressor, prohibitin, which interacts with retinoblastoma...
BRG1/BRM and prohibitin are required for growth suppression by estrogen antagonists
Wang, Sheng, Zhang, Baohua, Faller, Douglas V
Estrogen antagonists are universally employed in the breast cancer therapy, although antagonist therapy is limited by the inevitable development of cellular resistance. The molecular mechanisms by...
Mankidy, Rishikesh, Faller, Douglas V., Mabaera, Rodwell, Lowrey, Christopher H., Boosalis, Michael S., White, Gary L., ...
High-level induction of fetal (γ) globin gene expression for therapy of β-hemoglobinopathies likely requires local chromatin modification and dissociation of repressor complexes for γ-globin...
Perrine, Susan P., Hermine, Olivier, Small, Trudy, Suarez, Felipe, O'Reilly, Richard, Boulad, Farid, ...
Malignancies associated with latent Epstein-Barr virus (EBV) are resistant to nucleoside-type antiviral agents because the viral enzyme target of these antiviral drugs, thymidine kinase (TK), is not...
Dai, Yan, Ngo, Duyen, Jacob, Johanna, Forman, Lora W., Faller, Douglas V.
Androgen antagonists or androgen deprivation are the primary therapeutic modalities for the treatment of prostate cancer. Invariably, however, the disease becomes progressive and unresponsive to...
Development of a Malignancy-Associated Proteomic Signature for Diffuse Large B-Cell Lymphoma
Romesser, Paul B., Perlman, David H., Faller, Douglas V., Costello, Catherine E., McComb, Mark E., Denis, Gerald V.
The extreme pathological diversity of non-Hodgkin’s lymphomas has made their accurate histological assessment difficult. New diagnostics and treatment modalities are urgently needed for these...