Modelling within-Host Spatiotemporal Dynamics of Invasive Bacterial Disease (2008)
Andrew J. Grant, Olivier Restif, Trevelyan J. McKinley, Mark Sheppard, Duncan J. Maskell, Pietro Mastroeni
Mechanistic determinants of bacterial growth, death, and spread within mammalian hosts cannot be fully resolved studying a single bacterial population. They are also currently poorly understood....
Intracellular Demography and the Dynamics of Salmonella enterica Infections (2006)
Sam P. Brown, Stephen J. Cornell, Mark Sheppard, Andrew J. Grant, Duncan J. Maskell, Bryan T. Grenfell, ...
An understanding of within-host dynamics of pathogen interactions with eukaryotic cells can shape the development of effective preventive measures and drug regimes. Such investigations have been...
Parkhill,Julian, Sebaihia,Mohammed, Preston,Andrew, Murphy,Lee D., Thomson,Nicholas, Harris,David E., ...
Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica are closely related Gram-negative -proteobacteria that colonize the respiratory tracts of mammals. B. pertussis is a...
Parkhill, Julian, Sebaihia, Mohammed, Preston, Andrew, Murphy, Lee D., Thomson, Nicholas, Harris, David E., ...
Isobe, Tomoko, White, Kimberley A., Allen, Andrew G., Peacock, Michael, Raetz, Christian R. H., Maskell, Duncan J.
Bordetella pertussis lipopolysaccharide (LPS) contains a single 2-keto-3-deoxy-d-manno-octulosonic acid (Kdo) residue, whereas LPS from Escherichia coli contains at least two. Here we report that B....
Genetic Basis for Lipopolysaccharide O-Antigen Biosynthesis in Bordetellae
Preston, Andrew, Allen, Andrew G., Cadisch, Joanna, Thomas, Richard, Stevens, Kim, Churcher, Carol M., ...
Bordetella bronchiseptica and Bordetella parapertussis express a surface polysaccharide, attached to a lipopolysaccharide, which has been called O antigen. This structure is absent from Bordetella...
Watson, Patricia R., Benmore, Annette, Khan, Shahid A., Jones, Philip W., Maskell, Duncan J., Wallis, Timothy S.
Mutation of waaN, a gene involved in lipid A biosynthesis, reduced enteropathogenic responses induced by Salmonella enterica serovar Typhimurium in bovine ligated ileal loops. However, the secretion...
Multiple Roles for Bordetella Lipopolysaccharide Molecules during Respiratory Tract Infection
Harvill, Eric T., Preston, Andrew, Cotter, Peggy A., Allen, Andrew G., Maskell, Duncan J., Miller, Jeff F.
Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica are closely related subspecies that cause respiratory tract infections in humans and other mammals and express many...
Allen, Andrew G., Isobe, Tomoko, Maskell, Duncan J.
A DNA locus from Bordetella pertussis capable of reconstituting lipopolysaccharide (LPS) O-antigen biosynthesis in Salmonella typhimurium SL3789 (rfaF511) has been isolated, by using selection with...
Role of Bordetella O Antigen in Respiratory Tract Infection
Burns, Valorie C., Pishko, Elizabeth J., Preston, Andrew, Maskell, Duncan J., Harvill, Eric T.
Lipopolysaccharide (LPS), as the major surface molecule of gram-negative bacteria, interacts with the host in complex ways, both inducing and protecting against aspects of inflammatory and adaptive...
Unexpected Similarities between Bordetella avium and Other Pathogenic Bordetellae
Spears, Patricia A., Temple, Louise M., Miyamoto, David M., Maskell, Duncan J., Orndorff, Paul E.
Bordetella avium causes an upper respiratory tract disease (bordetellosis) in avian species. Commercially raised turkeys are particularly susceptible. Like other pathogenic members of the genus...
Jones, Michael A., Tötemeyer, Sabine, Maskell, Duncan J., Bryant, Clare E., Barrow, Paul A.
Campylobacter jejuni can cause an enteritis that is associated with an acute inflammatory response at the gut epithelial surface. The signals inducing inflammation are unknown. C. jejuni can...
Tötemeyer, Sabine, Foster, Neil, Kaiser, Pete, Maskell, Duncan J., Bryant, Clare E.
Here, we have investigated the mRNA expression of Toll-like receptor 2 (TLR-2), TLR-4, and MD-2 in spleens and livers of C3H/HeN mice (carrying wild-type TLR-4) and C3H/HeJ mice (carrying mutated...
Liu, Minghsun, Gingery, Mari, Doulatov, Sergei R., Liu, Yichin, Hodes, Asher, Baker, Stephen, ...
Liu et al. recently described a group of related temperate bacteriophages that infect Bordetella subspecies and undergo a unique template-dependent, reverse transcriptase-mediated tropism switching...
Pilione, Mylisa R., Pishko, Elizabeth J., Preston, Andrew, Maskell, Duncan J., Harvill, Eric T.
To efficiently colonize and persist in the lower respiratory tract, bacteria must survive multiple host immune mechanisms. Bordetella bronchiseptica is a gram-negative respiratory pathogen that...
Jones, Michael A., Marston, Kerrie L., Woodall, Claire A., Maskell, Duncan J., Linton, Dennis, Karlyshev, Andrey V., ...
The genome sequence of the human pathogen Campylobacter jejuni NCTC11168 has been determined recently, but studies on colonization and persistence in chickens have been limited due to reports that...
King, Samantha J., Allen, Andrew G., Maskell, Duncan J., Dowson, Christopher G., Whatmore, Adrian M.
Although Streptococcus suis is an economically important pathogen of pigs and an occasional cause of zoonotic infections of humans knowledge of crucial virulence factors, and as a consequence targets...
Tötemeyer, Sabine, Kaiser, Pete, Maskell, Duncan J., Bryant, Clare E.
Sublethal infection of C57BL/6 mice with Salmonella enterica serovar Typhimurium M525P initiates a strong inflammatory response. We measured organ expression of mRNA for Toll-like receptors and their...
Iqbal, Muhammad, Philbin, Victoria J., Withanage, G. S. K., Wigley, Paul, Beal, Richard K., Goodchild, Marianne J., ...
Toll-like receptors (TLRs) are a major component of the pattern recognition receptor repertoire that detect invading microorganisms and direct the vertebrate immune system to eliminate infection. In...
Grant, Andrew J., Coward, Christopher, Jones, Michael A., Woodall, Claire A., Barrow, Paul A., Maskell, Duncan J.
We have constructed plasmids to be used for in vitro signature-tagged mutagenesis (STM) of Campylobacter jejuni and used these to generate STM libraries in three different strains. Statistical...
Coward, Chris, Grant, Andrew J., Swift, Craig, Philp, Jennifer, Towler, Rebecca, Heydarian, Mohammad, ...
This study characterizes the interaction between Campylobacter jejuni and the 16 phages used in the United Kingdom typing scheme by screening spontaneous mutants of the phage-type strains and...
Intracellular Demography and the Dynamics of Salmonella enterica Infections
Brown, Sam P, Cornell, Stephen J, Sheppard, Mark, Grant, Andrew J, Maskell, Duncan J, Grenfell, Bryan T, ...
An understanding of within-host dynamics of pathogen interactions with eukaryotic cells can shape the development of effective preventive measures and drug regimes. Such investigations have been...
Sebaihia, Mohammed, Preston, Andrew, Maskell, Duncan J., Kuzmiak, Holly, Connell, Terry D., King, Natalie D., ...
Bordetella avium is a pathogen of poultry and is phylogenetically distinct from Bordetella bronchiseptica, Bordetella pertussis, and Bordetella parapertussis, which are other species in the...
Isobe, Tomoko, White, Kimberley A., Allen, Andrew G., Peacock, Michael, Raetz, Christian R. H., Maskell, Duncan J.
Bordetella pertussis lipopolysaccharide (LPS) contains a single 2-keto-3-deoxy-d-manno-octulosonic acid (Kdo) residue, whereas LPS from Escherichia coli contains at least two. Here we report that B....
Genetic Basis for Lipopolysaccharide O-Antigen Biosynthesis in Bordetellae
Preston, Andrew, Allen, Andrew G., Cadisch, Joanna, Thomas, Richard, Stevens, Kim, Churcher, Carol M., ...
Bordetella bronchiseptica and Bordetella parapertussis express a surface polysaccharide, attached to a lipopolysaccharide, which has been called O antigen. This structure is absent from Bordetella...
Watson, Patricia R., Benmore, Annette, Khan, Shahid A., Jones, Philip W., Maskell, Duncan J., Wallis, Timothy S.
Mutation of waaN, a gene involved in lipid A biosynthesis, reduced enteropathogenic responses induced by Salmonella enterica serovar Typhimurium in bovine ligated ileal loops. However, the secretion...
Multiple Roles for Bordetella Lipopolysaccharide Molecules during Respiratory Tract Infection
Harvill, Eric T., Preston, Andrew, Cotter, Peggy A., Allen, Andrew G., Maskell, Duncan J., Miller, Jeff F.
Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica are closely related subspecies that cause respiratory tract infections in humans and other mammals and express many...
Allen, Andrew G., Isobe, Tomoko, Maskell, Duncan J.
A DNA locus from Bordetella pertussis capable of reconstituting lipopolysaccharide (LPS) O-antigen biosynthesis in Salmonella typhimurium SL3789 (rfaF511) has been isolated, by using selection with...
Role of Bordetella O Antigen in Respiratory Tract Infection
Burns, Valorie C., Pishko, Elizabeth J., Preston, Andrew, Maskell, Duncan J., Harvill, Eric T.
Lipopolysaccharide (LPS), as the major surface molecule of gram-negative bacteria, interacts with the host in complex ways, both inducing and protecting against aspects of inflammatory and adaptive...
Unexpected Similarities between Bordetella avium and Other Pathogenic Bordetellae
Spears, Patricia A., Temple, Louise M., Miyamoto, David M., Maskell, Duncan J., Orndorff, Paul E.
Bordetella avium causes an upper respiratory tract disease (bordetellosis) in avian species. Commercially raised turkeys are particularly susceptible. Like other pathogenic members of the genus...
Jones, Michael A., Tötemeyer, Sabine, Maskell, Duncan J., Bryant, Clare E., Barrow, Paul A.
Campylobacter jejuni can cause an enteritis that is associated with an acute inflammatory response at the gut epithelial surface. The signals inducing inflammation are unknown. C. jejuni can...
Tötemeyer, Sabine, Foster, Neil, Kaiser, Pete, Maskell, Duncan J., Bryant, Clare E.
Here, we have investigated the mRNA expression of Toll-like receptor 2 (TLR-2), TLR-4, and MD-2 in spleens and livers of C3H/HeN mice (carrying wild-type TLR-4) and C3H/HeJ mice (carrying mutated...
Liu, Minghsun, Gingery, Mari, Doulatov, Sergei R., Liu, Yichin, Hodes, Asher, Baker, Stephen, ...
Liu et al. recently described a group of related temperate bacteriophages that infect Bordetella subspecies and undergo a unique template-dependent, reverse transcriptase-mediated tropism switching...
Pilione, Mylisa R., Pishko, Elizabeth J., Preston, Andrew, Maskell, Duncan J., Harvill, Eric T.
To efficiently colonize and persist in the lower respiratory tract, bacteria must survive multiple host immune mechanisms. Bordetella bronchiseptica is a gram-negative respiratory pathogen that...
Jones, Michael A., Marston, Kerrie L., Woodall, Claire A., Maskell, Duncan J., Linton, Dennis, Karlyshev, Andrey V., ...
The genome sequence of the human pathogen Campylobacter jejuni NCTC11168 has been determined recently, but studies on colonization and persistence in chickens have been limited due to reports that...
King, Samantha J., Allen, Andrew G., Maskell, Duncan J., Dowson, Christopher G., Whatmore, Adrian M.
Although Streptococcus suis is an economically important pathogen of pigs and an occasional cause of zoonotic infections of humans knowledge of crucial virulence factors, and as a consequence targets...
Tötemeyer, Sabine, Kaiser, Pete, Maskell, Duncan J., Bryant, Clare E.
Sublethal infection of C57BL/6 mice with Salmonella enterica serovar Typhimurium M525P initiates a strong inflammatory response. We measured organ expression of mRNA for Toll-like receptors and their...
Iqbal, Muhammad, Philbin, Victoria J., Withanage, G. S. K., Wigley, Paul, Beal, Richard K., Goodchild, Marianne J., ...
Toll-like receptors (TLRs) are a major component of the pattern recognition receptor repertoire that detect invading microorganisms and direct the vertebrate immune system to eliminate infection. In...
Grant, Andrew J., Coward, Christopher, Jones, Michael A., Woodall, Claire A., Barrow, Paul A., Maskell, Duncan J.
We have constructed plasmids to be used for in vitro signature-tagged mutagenesis (STM) of Campylobacter jejuni and used these to generate STM libraries in three different strains. Statistical...
Coward, Chris, Grant, Andrew J., Swift, Craig, Philp, Jennifer, Towler, Rebecca, Heydarian, Mohammad, ...
This study characterizes the interaction between Campylobacter jejuni and the 16 phages used in the United Kingdom typing scheme by screening spontaneous mutants of the phage-type strains and...
Sebaihia, Mohammed, Preston, Andrew, Maskell, Duncan J., Kuzmiak, Holly, Connell, Terry D., King, Natalie D., ...
Bordetella avium is a pathogen of poultry and is phylogenetically distinct from Bordetella bronchiseptica, Bordetella pertussis, and Bordetella parapertussis, which are other species in the...
Intracellular Demography and the Dynamics of Salmonella enterica Infections
Brown, Sam P, Cornell, Stephen J, Sheppard, Mark, Grant, Andrew J, Maskell, Duncan J, Grenfell, Bryan T, ...
An understanding of within-host dynamics of pathogen interactions with eukaryotic cells can shape the development of effective preventive measures and drug regimes. Such investigations have been...
Smyth, Tomoko, Harris, Hayley J, Brown, Andrew, Tötemeyer, Sabine, Farnfield, Belinda A, Maskell, Duncan J, ...
Annexin-1 (ANXA1) is a glucocorticoid-regulated protein that modulates the effects of bacterial lipopolysaccharide (LPS) on macrophages. Exogenous administration of peptides derived from the...
Hamilton, Andrea, Robinson, Carl, Sutcliffe, Iain C., Slater, Josh, Maskell, Duncan J., Davis-Poynter, Nick, ...
Streptococcus equi is the causative agent of strangles, a prevalent and highly contagious disease of horses. Despite the animal suffering and economic burden associated with strangles, little is...
King, Jerry D., Harmer, Nicholas J., Preston, Andrew, Palmer, Colin M., Rejzek, Martin, Field, Robert A., ...
The pathogenic bacteria Bordetella parapertussis and Bordetella bronchiseptica express a lipopolysaccharide O antigen containing a polymer of 2,3-diacetamido-2,3-dideoxy-l-galacturonic acid. The...