Dylan R. Edwards

Tumour-associated tenascin-C isoforms promote breast cancer cell invasion and growth by matrix metalloproteinase-dependent and independent mechanisms (2009)

Hancox, Rachael A, Allen, Michael D, Holliday, Deborah L, Edwards, Dylan R, Pennington, Caroline J, Guttery, David S, ...

Abstract Introduction The stromal microenvironment has a profound influence on tumour cell behaviour. In tumours, the extracellular matrix (ECM) composition differs from normal tissue and allows...

Developmental expression of tissue inhibitor of metalloproteinase (TIMP) RNA (2008)

Shintaro Nomura, Alan J. Wills, John K. Heath, Dylan R. Edwards

Single-stranded antisense RNA probes have been used to study the expression of the metalloproteinase inhibitor TIMP (tissue inhibitor of raetalloproteinases), during mouse embryogenesis and in adult...

Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. (2007)

Rooprai, Harcharan K., Kyriazis, Ioannis, Nuttall, Robert K., Edwards, Dylan R., Zicha, Daniel, Aubyn, Deborah, ...

Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. (2007)

Rooprai, Harcharan K., Kyriazis, Ioannis, Nuttall, Robert K., Edwards, Dylan R., Zicha, Daniel, Aubyn, Deborah, ...

Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption (2005)

Young, David A, Lakey, Rachel L, Pennington, Caroline J, Jones, Debra, Kevorkian, Lara, Edwards, Dylan R, ...

Abstract Cartilage destruction in the arthritides is thought to be mediated by two main enzyme families: the matrix metalloproteinases (MMPs) are responsible for cartilage collagen breakdown, and...

Extracellular protease mRNAs are predominantly expressed in the stromal areas of microdissected mouse breast carcinomas (2005)

Pedersen, Tanja Xenia, Pennington, Caroline J., Almholt, Kasper, Christensen, Ib Jarle, Nielsen, Boye Schnack, Edwards, Dylan R., ...

Solid tumors synthesize a number of extracellular matrix-degrading proteases that are important for tumor progression. Based on qualitative in situ hybridization studies in human cancer tissue, a...

Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3 (2005)

Singh, Robert J.R., Mason, Justin C., Lidington, Elaine A., Edwards, Dylan R., Nuttall, Robert K., Khokha, Rama, ...

Objectives: Vascular cell adhesion molecule-1 (VCAM-1) is a cell surface adhesion molecule involved in the recruitment of leukocytes to endothelial cells on arterial walls during the pathogenesis of...

Protease mRNAs are predominantly expressed in the stromal areas of microdissected mouse breast carcinomas (2005)

Pedersen, Tanja Xenia, Pennington, Caroline J., Almholt, Kasper, Christensen, Ib Jarle, Nielsen, Boye Schnack, Edwards, Dylan R., ...

Solid tumors synthesize a number of extracellular matrix-degrading proteases that are important for tumor progression. Based on qualitative in situ hybridization studies in human cancer tissue, a...

Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis (2003)

Bar-Or, Amit, Nuttall, Robert K., Duddy, Martin, Alter, Andrea, Kim, Ho Jin, Ifergan, Igal, ...

Matrix metalloproteinases (MMPs) are implicated in multiple sclerosis where one of their roles may be to facilitate the transmigration of circulating leukocytes into the CNS. Studies have focused on...

Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis (2003)

Bar-Or, Amit, Nuttall, Robert K., Duddy, Martin, Alter, Andrea, Kim, Ho Jin, Ifergan, Igal, ...

Matrix metalloproteinases (MMPs) are implicated in multiple sclerosis where one of their roles may be to facilitate the transmigration of circulating leukocytes into the CNS. Studies have focused on...

Localization of gelatinase-A and gelatinase-B mRNA and protein in human gliomas (2000)

Raithatha, Sheetal A., Muzik, Huong, Rewcastle, N. Barry, Johnston, Randal N., Edwards, Dylan R., Forsyth, Peter A.

Malignant gliomas maintain a poor prognosis and survival rate due to their marked local invasive growth and neovascularization. Matrix metalloproteinases (MMPs) have been implicated in glioma...

Telomere-dependent senescence (1999)

Kipling, David, Wynford-Thomas, David, Jones, Chris J., Akbar, Arne, Aspinall, Richard, Bacchetti, Silvia, ...

A growth-responsive gene (16C8) in normal mouse fibroblasts homologous to a human collagenase inhibitor with erythroid-potentiating activity: evidence for inducible and constitutive transcripts (1986)

Edwards, Dylan R., Waterhouse, Paul, Holman, Martha L., Denhardt, David T.

We present the DNA sequence of an essentially full-length cDNA clone of 16C8, a growth factor-lnducible gene isolated from a mouse embryo fibroblast cDNA library. The 0.9-kb mRNA encodes an Mr 22,500...

Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption

Young, David A, Lakey, Rachel L, Pennington, Caroline J, Jones, Debra, Kevorkian, Lara, Edwards, Dylan R, ...

Cartilage destruction in the arthritides is thought to be mediated by two main enzyme families: the matrix metalloproteinases (MMPs) are responsible for cartilage collagen breakdown, and enzymes from...

Identification of an initiator-like element essential for the expression of the tissue inhibitor of metalloproteinases-4 (Timp-4) gene.

Young, David A, Phillips, Blaine W, Lundy, Caroline, Nuttall, Robert K, Hogan, Aileen, Schultz, Gilbert A, ...

We have used real-time quantitative reverse transcriptase PCR (TaqMan) to quantify the expression of the four tissue inhibitor of metalloproteinases (Timp) genes in mouse tissues during development...

Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP).

Worley, Joanna R, Thompkins, Philip B, Lee, Meng H, Hutton, Mike, Soloway, Paul, Edwards, Dylan R, ...

Fundamental cellular processes including angiogenesis and cell migration require a proteolytic cascade driven by interactions of membrane-type matrix metalloproteinase 1 (MT1-MMP) and progelatinase A...

Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption

Young, David A, Lakey, Rachel L, Pennington, Caroline J, Jones, Debra, Kevorkian, Lara, Edwards, Dylan R, ...

Cartilage destruction in the arthritides is thought to be mediated by two main enzyme families: the matrix metalloproteinases (MMPs) are responsible for cartilage collagen breakdown, and enzymes from...

Identification of an initiator-like element essential for the expression of the tissue inhibitor of metalloproteinases-4 (Timp-4) gene.

Young, David A, Phillips, Blaine W, Lundy, Caroline, Nuttall, Robert K, Hogan, Aileen, Schultz, Gilbert A, ...

We have used real-time quantitative reverse transcriptase PCR (TaqMan) to quantify the expression of the four tissue inhibitor of metalloproteinases (Timp) genes in mouse tissues during development...

Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP).

Worley, Joanna R, Thompkins, Philip B, Lee, Meng H, Hutton, Mike, Soloway, Paul, Edwards, Dylan R, ...

Fundamental cellular processes including angiogenesis and cell migration require a proteolytic cascade driven by interactions of membrane-type matrix metalloproteinase 1 (MT1-MMP) and progelatinase A...

Altered Balance Between Matrix Metalloproteinases and Their Inhibitors in Experimental Biliary Fibrosis

Kossakowska, Anna E., Edwards, Dylan R., Lee, Samuel S., Urbanski, Lawrence S., Stabbler, Andrea L., Zhang, Chun-Li, ...

A rat model of common bile duct ligation (BDL)-induced hepatic fibrosis was used to assess the expression and activities of collagen-degrading proteinases and their inhibitors during the progression...

Identification, regulation and role of tissue inhibitor of metalloproteinases-4 (TIMP-4) in human platelets

Radomski, Anna, Jurasz, Paul, Sanders, Esmond J, Overall, Christopher M, Bigg, Heather F, Edwards, Dylan R, ...

Matrix metalloproteinase-2 (MMP-2) released during activation of human platelets by aggregating agents and cancer cells is known to stimulate platelet aggregation.The expression, activity and role of...

Matrix Metalloproteinase 13 Is Induced in Fibroblasts in Polyomavirus Middle T Antigen-Driven Mammary Carcinoma without Influencing Tumor Progression

Nielsen, Boye S., Egeblad, Mikala, Rank, Fritz, Askautrud, Hanne A., Pennington, Caroline J., Pedersen, Tanja X., ...

Matrix metalloproteinase (MMP) 13 (collagenase 3) is an extracellular matrix remodeling enzyme that is induced in myofibroblasts during the earliest invasive stages of human breast carcinoma,...

Tumour-associated tenascin-C isoforms promote breast cancer cell invasion and growth by matrix metalloproteinase-dependent and independent mechanisms

Hancox, Rachael A, Allen, Michael D, Holliday, Deborah L, Edwards, Dylan R, Pennington, Caroline J, Guttery, David S, ...