Law, C.M., Shiell, A.W., Newsome, C.A., Syddall, H.E., Shinebourne, E.A., Fayers, P.M., ...
Background: People who are small at birth tend to have higher blood pressure in later life. However, it is not clear whether it is fetal growth restriction or the accelerated postnatal growth that...
Law, C.M., Shiell, A.W., Newsome, C.A., Syddall, H.E., Shinebourne, E.A., Fayers, P.M., ...
Background: people who are small at birth tend to have higher blood pressure in later life. However, it is not clear whether it is fetal growth restriction or the accelerated postnatal growth that...
Carvalho, J. S., Silva, C. M. C., Shinebourne, E. A., Redington, A. N.
M-mode indices of left ventricular dimension and posterior wall thickness were derived from echocardiograms of children presenting with dilated cardiomyopathy/myocarditis and were related to outcome....
Further observations on conduction tissues in univentricular hearts--surgical implications (1981)
ESSED, C. E., HO, S. YEN, SHINEBOURNE, E. A., JOSEPH, M. C., ANDERSON, R. H.
Two univentricular hearts are described with particular reference to the surgical anatomy of their conduction tissues. The first was of left ventricular type with right-sided outlet chamber. The...
The Effect of Noradrenaline on the Calcium Uptake of the Sarcoplasmic Reticulum (1969)
Shinebourne, E. A., Hess, M. L., White, R. J., Hamer, J.
Authors' SynopsisIt is known that noradrenaline has a profound effect on myocardial contractility, but no satisfactory explanation of this process at a cellular level has been available previously....
Apnoeic episodes induced by smothering: two cases identified by covert video surveillance.
Southall, D P, Stebbens, V A, Rees, S V, Lang, M H, Warner, J O, Shinebourne, E A
Recurrent cyanotic episodes associated on some occasions with loss of consciousness due to cerebral hypoxia were investigated by long term tape recordings of breathing activity, oxygen saturation,...
Value of repeated blood pressure measurements in children--the Brompton study.
De Swiet, M, Fayers, P, Shinebourne, E A
Systolic blood pressure were measured in 1797 infants aged 4 days and then repeated at 6 weeks, 6 months, 1 year and then yearly until 4 years of age. The mean pressure rose from 76 mm Hg at 4 days...
Cardiac conduction disorders in six infants with "near-miss" sudden infant deaths.
Keeton, B R, Southall, E, Rutter, N, Anderson, R H, Shinebourne, E A, Southall, D P
Cardiac conduction disorders caused sudden serious illnesses in six infants that might have been fatal if diagnosis and treatment had been delayed. These cases provide circumstantial evidence to...
Study of cardiac arrhythmias and other forms of conduction abnormality in newborn infants.
Southall, D P, Orrell, M J, Talbot, J F, Brinton, R J, Vulliamy, D G, Johnson, A M, ...
In an unselected population of 2030 newborn infants studied by electrocardiography (ECG) between April 1975 and April 1977, 35 were found to have arrhythmias or other cardiac conduction...
Adult respiratory distress syndrome. Advances in diagnosis and ventilatory management.
Turner, J S, Evans, T W, Hunter, D N, Keogh, B F, Hansell, D M, Sheppard, M N, ...
Blood pressure survey in a population of newborn infants.
De Swiet, M, Fayers, P, Shinebourne, E A
Systolic blood pressure in the arm was measured in infants at the ages of 4 to 6 days and 5 to 7 weeks by the Doppler ultrasound technique. At the age of 4 to 6 days the mean blood pressure (+/- SE...
A new look at the neonatal electrocardiogram.
Southall, D P, Vulliamy, D G, Davies, M J, Anderson, R H, Shinebourne, E A, Johnson, A M
Among 818 newborn babies whose electrocardiograms (ECGs) were recorded between April 1975 and April 1976 were 57 babies with recordings that fell outside the accepted normal range. Preliminary...
Apnoeic episodes induced by smothering: two cases identified by covert video surveillance.
Southall, D P, Stebbens, V A, Rees, S V, Lang, M H, Warner, J O, Shinebourne, E A
Recurrent cyanotic episodes associated on some occasions with loss of consciousness due to cerebral hypoxia were investigated by long term tape recordings of breathing activity, oxygen saturation,...
Value of repeated blood pressure measurements in children--the Brompton study.
De Swiet, M, Fayers, P, Shinebourne, E A
Systolic blood pressure were measured in 1797 infants aged 4 days and then repeated at 6 weeks, 6 months, 1 year and then yearly until 4 years of age. The mean pressure rose from 76 mm Hg at 4 days...
Cardiac conduction disorders in six infants with "near-miss" sudden infant deaths.
Keeton, B R, Southall, E, Rutter, N, Anderson, R H, Shinebourne, E A, Southall, D P
Cardiac conduction disorders caused sudden serious illnesses in six infants that might have been fatal if diagnosis and treatment had been delayed. These cases provide circumstantial evidence to...
Study of cardiac arrhythmias and other forms of conduction abnormality in newborn infants.
Southall, D P, Orrell, M J, Talbot, J F, Brinton, R J, Vulliamy, D G, Johnson, A M, ...
In an unselected population of 2030 newborn infants studied by electrocardiography (ECG) between April 1975 and April 1977, 35 were found to have arrhythmias or other cardiac conduction...
Adult respiratory distress syndrome. Advances in diagnosis and ventilatory management.
Turner, J S, Evans, T W, Hunter, D N, Keogh, B F, Hansell, D M, Sheppard, M N, ...
Blood pressure survey in a population of newborn infants.
De Swiet, M, Fayers, P, Shinebourne, E A
Systolic blood pressure in the arm was measured in infants at the ages of 4 to 6 days and 5 to 7 weeks by the Doppler ultrasound technique. At the age of 4 to 6 days the mean blood pressure (+/- SE...
A new look at the neonatal electrocardiogram.
Southall, D P, Vulliamy, D G, Davies, M J, Anderson, R H, Shinebourne, E A, Johnson, A M
Among 818 newborn babies whose electrocardiograms (ECGs) were recorded between April 1975 and April 1976 were 57 babies with recordings that fell outside the accepted normal range. Preliminary...
Blood pressure in first 10 years of life: the Brompton study.
De Swiet, M., Fayers, P., Shinebourne, E. A.
OBJECTIVES--To determine the normal range of blood pressure and its pattern of change in the first 10 years of life. To estimate at what age (if any) children consistently appear in one part of the...
Recognition of imperforate atrioventricular valves by two dimensional echocardiography.
Rigby, M L, Gibson, D G, Joseph, M C, Lincoln, J C, Shinebourne, E A, Shore, D F, ...
The majority of hearts in which selective right or left atrial angiography shows no direct communication between one atrium and a ventricular chamber are considered to be examples of atresia of the...
Cor triatriatum sinistrum. Diagnostic features on cross sectional echocardiography.
Ostman-Smith, I, Silverman, N H, Oldershaw, P, Lincoln, C, Shinebourne, E A
M mode and cross sectional echocardiography was carried out in three cases of cor triatriatum sinistrum (two infants and one adult). In two cases a peculiar double arch appearance, not previously...
The spectrum of atrioventricular discordance. A clinical study.
De Albuquerque, A T, Rigby, M L, Anderson, R H, Lincoln, C, Shinebourne, E A
The clinical, investigative, and surgical findings were reviewed in 47 patients with atrioventricular discordance who presented to the Brompton Hospital between January 1962 and June 1981. Although...
Scott, D J, Rigby, M L, Miller, G A, Shinebourne, E A
The diagnoses and age at presentation of 1665 infants with symptomatic heart disease, who were admitted to the Brompton Hospital, London, during the period 1973-82 were reviewed. The frequency of...
Subpulmonary pleural effusions in children after cardiac surgery.
O'Callaghan, C, Cooke, J, Kerr, I H, Shinebourne, E A
Postoperative chest radiographs on 100 children who had undergone cardiac operations were evaluated to determine the frequency of subpulmonary effusions after surgery. Of the 83 patients in whom...
Nomenclature and classification of congenital heart disease.
Tynan, M J, Becker, A E, Macartney, F J, Jiménez, M Q, Shinebourne, E A, Anderson, R H
At present there is no universally accepted nomenclature for congenital cardiac malformations. Much of the controversy results from failure to distinguish the structural connections of the heart from...
Two-chambered right ventricle: simulating two-chambered left ventricle.
Beitzke, A, Anderson, R H, Wilkinson, J L, Shinebourne, E A
Two cases are described of a most unusual variant of two-chambered right ventricle. In both the ventricular septal defect was between the distal chamber of the right ventricle and the left ventricle....
Dextrocardia--value of segmental analysis in its categorisation.
Calcaterra, G, Anderson, R H, Lau, K C, Shinebourne, E A
Dextrocardia can be defined as a heart in the right chest with the major axis to the right. This definition, however, conveys no information regarding the chamber arrangements and internal anatomy of...
Study of cardiac rhythm in healthy newborn infants.
Southall, D P, Richards, J, Mitchell, P, Brown, D J, Johnston, P G, Shinebourne, E A
Twenty-four-hour electrocardiograms were recorded in the first 10 days of life on 134 healthy full-term infants with birthweights greater than 2.5 kg. The highest heart rate a minute, measured over...
A previously undescribed anomaly is presented in which right and left pulmonary arteries arise via a single vessel from the ascending aorta while the main pulmonary artery arises normally from the...
Earley, A, Joseph, M C, Shinebourne, E A, De Swiet, M
Systolic blood pressure was measured at rest and during exercise in 43 children who had undergone operation for correction of coarctation of the aorta, five children awaiting surgery for...
Southall, D P, Johnston, F, Shinebourne, E A, Johnston, P G
Twenty-four hour electrocardiographic recordings were made on 104 randomly selected, healthy 7 to 11-year-old children. Ninety-two were technically adequate and suitable for analysis. The mean...
Rigby, M L, Anderson, R H, Gibson, D, Jones, O D, Joseph, M C, Shinebourne, E A
Most univentricular hearts have two chambers in their ventricular mass, only one of which possesses an atrioventricular connection. Categorisation into univentricular heart of right, left, or...
Double outlet right ventricle with 1-malposition of the aorta.
Lincoln, C, Anderson, R H, Shinebourne, E A, English, T A, Wilkinson, J L
Four patients are described with a recently recognized variant of double outlet right ventricle. Clinical examination favoured tetralogy of Fallot, but the chest X-ray suggested corrected...
Shinebourne, E A, Anderson, R H, Bowyer, J J
Striking variability has been observed in the presenting features in infancy of patients subsequently shown to have tetralogy of Fallot. Some patients presented with severe cyanosis in the neonatal...
Hislop, A, Haworth, S G, Shinebourne, E A, Reid, L
Structural changes in the pulmonary circulation were studied in the lungs of 5 infants dying with ventricular septal defect. Applying precise quantitative morphological techniques to the pulmonary...
Sequential chamber localization--logical approach to diagnosis in congenital heart disease.
Shinebourne, E A, Macartney, F J, Anderson, R H
A nomenclature is described for congenital heart disease employing sequential chamber localization. It is an eclectic system based in part upon the previous classifications of Van Praagh and Kirklin....
Coarctation of the aorta in infancy and childhood.
Shinebourne, E A, Tam, A S, Elseed, A M, Paneth, M, Lennox, S C, Cleland, W P
The management and results of treatment in 181 children with coarctation of the aorta are presented. In this series, 79% of the patients presented in the first year of life and 55% presented as...
Gatzoulis, M. A., Shinebourne, E. A., Redington, A. N., Rigby, M. L., Ho, S. Y., Shore, D. F.
OBJECTIVE--To show that abnormal systemic venous channels in patients who undergo cavopulmonary anastomoses can become manifest and haemodynamically important only after surgery despite detailed...
Haworth, S G, Shinebourne, E A, Miller, G A
Haemodynamic and angiographic findings are described in 5 cases with rare anomalies of the right ventricle and the second there was isolated congenital 'absence' of the tricuspid valve. The remaining...
Familial neonatal atrial tachycardia.
Balaji, S., Sullivan, I. D., Shinebourne, E. A.
A father and his two sons each presented with atrial tachycardia in the newborn period. The father went on to develop dilated cardiomyopathy. The first son (who also had transposition of the great...
Open valvotomy for critical aortic stenosis in infancy.
Burch, M, Redington, A N, Carvalho, J S, Rusconi, P, Shinebourne, E A, Rigby, M L, ...
Over a 5 year period open valvotomy was performed on 13 patients under the age of one year with critical aortic stenosis. All 13 survived operation. There were two late deaths--one 38 days after...
Redington, A N, Rigby, M L, Shinebourne, E A, Oldershaw, P J
Ventricular pressure-volume diagrams were obtained from the right ventricle in patients before and after relief of right ventricular pressure load, in patients with volume loaded right ventricles,...
Carvalho, J S, Redington, A N, Shinebourne, E A, Rigby, M L, Gibson, D
Indices of the severity of coarctation derived from non-invasive Doppler echocardiography were compared with measurements derived from cardiac catheterisation and angiography. In 24 Doppler studies...
Bush, A, Busst, C M, Knight, W B, Carvalho, J S, Rigby, M L, Shinebourne, E A
Transposition of the great arteries is frequently complicated by the early onset of pulmonary vascular disease. It is difficult to measure pulmonary blood flow by the Fick principle because the...
Redington, A N, Chan, K Y, Carvalho, J S, Shinebourne, E A
M mode echocardiograms and simultaneous phonocardiograms were recorded in four patients with early diastolic clicks on auscultation. All had double inlet left ventricle and had undergone the Fontan...
Early complications of interventional balloon catheterisation in infants and children.
Booth, P, Redington, A N, Shinebourne, E A, Rigby, M L
Interventional balloon catheterisation is now the recommended procedure for several congenital heart defects. The overall complication rate in the first 160 children (median age 3 years) to undergo...
Pulmonary blood flow after total cavopulmonary shunt.
Redington, A N, Penny, D, Shinebourne, E A
The pattern of pulmonary blood flow was studied in three patients after a total cavopulmonary shunt procedure. Doppler studies showed a phasic pattern of flow which varied with the respiratory cycle....
Carvalho, J S, Redington, A N, Oldershaw, P J, Shinebourne, E A, Lincoln, C R, Gibson, D G
Five infants who underwent direct reimplantation or redirection of an anomalous left coronary artery from the pulmonary artery to the aorta were studied. There were no deaths from the procedure....
Phrenic nerve injury in infants and children undergoing cardiac surgery.
Mok, Q, Ross-Russell, R, Mulvey, D, Green, M, Shinebourne, E A
Fifty infants and 50 children less than 15 years undergoing palliative or corrective cardiac surgery in the Brompton Hospital between March and October 1988 had direct percutaneous stimulation of the...
Raine, J, Samuels, M P, Mok, Q, Shinebourne, E A, Southall, D P
OBJECTIVE--To investigate the feasibility of negative extrathoracic pressure ventilation as a respiratory support following phrenic nerve palsy after cardiac surgery. DESIGN--An uncontrolled pilot...
Carvalho, J S, Shinebourne, E A, Busst, C, Rigby, M L, Redington, A N
OBJECTIVE--To determine the effects of residual pulmonary regurgitation on exercise tolerance after complete repair of tetralogy of Fallot. DESIGN--Prospective study of symptom free patients more...
Angiographic diagnosis of anomalous coronary artery in tetralogy of Fallot.
Carvalho, J S, Silva, C M, Rigby, M L, Shinebourne, E A
OBJECTIVE--To obtain angiographic views in tetralogy of Fallot that can show whether or not an anomalous coronary artery passes anterior to the right ventricular outflow tract. DESIGN--(a) A 10 year...
Complete atrioventricular septal defect with tetralogy of Fallot: diagnosis and management.
Gatzoulis, M. A., Shore, D., Yacoub, M., Shinebourne, E. A.
OBJECTIVE--To report recent experience of patients with complete atrioventricular septal defect and tetralogy of Fallot, with emphasis on anatomical features, diagnosis, and management. DESIGN--Case...
Peak expiratory nitric oxide differences in men and women: relation to the menstrual cycle.
Kharitonov, S A, Logan-Sinclair, R B, Busset, C M, Shinebourne, E A
OBJECTIVE--To develop a method to measure end expiratory nitric oxide concentration and to use it to determine whether there are sex related differences between healthy men and women....
Darvell, F J, Rossi, I R, Rossi, M B, Fayers, P, Anderson, R H, Rigby, M L, ...
Overall survival after Mustard's operation was assessed in 130 patients with complete transposition of the great arteries and an intact ventricular septum who were operated on at the Brompton...
Bush, A, Busst, C M, Haworth, S G, Hislop, A A, Knight, W B, Corrin, B, ...
Pulmonary vascular resistance was measured in air, oxygen, and after administration of vasodilators in 14 children with pulmonary hypertension and congenital heart disease. Lung morphology was...
Redington, A N, Oldershaw, P J, Shinebourne, E A, Rigby, M L
Biplane right ventriculograms with simultaneous high fidelity pressure recordings were obtained in 24 patients with tetralogy of Fallot. Twelve patients were studied before repair and 12 were studied...
Comparison of the haemodynamic effects of epoprostenol (prostacyclin) and tolazoline.
Bush, A, Busst, C M, Knight, W B, Shinebourne, E A
The haemodynamic effects of infusion of epoprostenol (prostacyclin) and bolus injection of tolazoline were compared in a crossover study in 11 children with pulmonary hypertension caused by pulmonary...
Imperforate tricuspid valve with single cardiac outlet from right ventricle.
A cyanosed neonate was diagnosed as having concordant atrioventricular connection and single cardiac outlet and aorta from right ventricle with atresia of the pulmonary valve. She underwent a...
Redington, A N, Knight, B, Oldershaw, P J, Shinebourne, E A, Rigby, M L
Fourteen patients with double inlet left ventricle and nine patients with tricuspid atresia had biplane left ventricular angiography with simultaneous measurement of left ventricular pressure by...
Carvalho, J S, Rigby, M L, Shinebourne, E A, Anderson, R H
The cross sectional echocardiograms of 150 children with atrioventricular septal defects were reviewed to determine the spatial orientation of the ventricles. In 125 cases with usual atrial...
Till, J A, Shinebourne, E A, Rowland, E, Ward, D E, Bhamra, R, Haga, P, ...
Twenty three children with recurrent supraventricular tachycardia were treated with flecainide. Twenty one of these received intravenous treatment during an attack (2 mg/kg over 10 minutes). The...
Till, J, Shinebourne, E A, Rigby, M L, Clarke, B, Ward, D E, Rowland, E
One hundred and seventeen episodes of supraventricular tachycardia in 50 children, including 28 infants, were treated with intravenous adenosine. Adenosine was prepared in a sterile solution of 0.9%...
Redington, A N, Rigby, M L, Oldershaw, P, Gibson, D G, Shinebourne, E A
Biplane right ventriculograms were obtained in 18 symptom free patients 109 (26) months (mean (SD)) after Mustard repair of transposition of the great arteries. Ventricular size, shape, and wall...
Burch, M, Till, J A, Rigby, M L, Shinebourne, E A, Carter, N D, Jeffery, S, ...
Plasma atrial natriuretic peptide was measured in 13 children between the ages of 1 week and 2 years 9 months during atrioventricular re-entrant tachycardia and 15 minutes after the restoration of...
Redington, A N, Raine, J, Shinebourne, E A, Rigby, M L
Anomalous pulmonary venous connections were found in seven (0.6%) of 1183 patients with tetralogy of Fallot. Three patients had totally anomalous connections (one supracardiac, one direct to coronary...
Effect of long term oxygen treatment at home in children with pulmonary vascular disease.
Bowyer, J J, Busst, C M, Denison, D M, Shinebourne, E A
Inhalation of 100% oxygen by nine children with pulmonary vascular disease increased pulmonary blood flow measured at cardiac catheterisation; there was no significant change in pulmonary artery...
Lincoln, C, Redington, A N, Li, K, Mattos, S, Shinebourne, E A, Rigby, M L
Thirty three patients were followed up after anatomical correction of transposition of the great arteries or double outlet right ventricle and subpulmonary ventricular septal defect (Taussig-Bing...
Improving the effectiveness of routine prenatal screening for major congenital heart defects
Carvalho, J S, Mavrides, E, Shinebourne, E A, Campbell, S, Thilaganathan, B
Objective: To evaluate the effectiveness of adding outlet views to the four chamber view in routine prenatal ultrasound screening for major congenital heart defects (CHD) as performed by trained...
Clinical impact of first and early second trimester fetal echocardiography on high risk pregnancies
Carvalho, J S, Moscoso, G, Tekay, A, Campbell, S, Thilaganathan, B, Shinebourne, E A
Objective: To evaluate the clinical impact of fetal echocardiography before 16 weeks’ gestation on the management of pregnancies with fetuses at risk of congenital heart disease.
Pulmonary vascular resistance in children with congenital heart disease.
Davies, N J, Shinebourne, E A, Scallan, M J, Sopwith, T A, Denison, D M
Pulmonary and systemic blood flow and pulmonary vascular resistance were measured in 21 children with congenital heart disease. Blood flow was calculated by the direct Fick method, using measurements...
Clements, B S, Warner, J O, Shinebourne, E A
Congenital malformations of the bronchopulmonary airway and related arterial blood supply are a complex group of lesions in which abnormalities of venous drainage and lung parenchyma may coexist....
Covert video surveillance and the principle of double effect: a response to criticism.
In some young children brought by their parents for diagnosis of acute life-threatening events investigations suggested imposed apnoea as the cause rather than spontaneous occurrence. Covert video...
Effect of measurement conditions on measured levels of peak exhaled nitric oxide
Byrnes, C. A., Dinarevic, S., Busst, C. A., Shinebourne, E. A., Bush, A.
BACKGROUND: It is possible to measure nitric oxide (NO) levels in exhaled air. The absolute concentrations of exhaled NO obtained by separate workers in similar patient groups and normal subjects...
Contemporary results of balloon valvuloplasty and surgical valvotomy for congenital aortic stenosis.
Gatzoulis, M A, Rigby, M L, Shinebourne, E A, Redington, A N
The purpose of this study was to compare contemporary results of balloon dilatation and surgery for valvar aortic stenosis in infants and children in the five years between August 1988 and October...
Whyte, R K, Elseed, A M, Fraser, C B, Shinebourne, E A, De Swiet, M
A recently developed instrument uses the Doppler shift technique to detect vessel wall movement, and it has been suggested that in conjunction with a conventional sphygmomanometer systolic and...
Aortic arch interruption presenting with absence of all limb pulses.
Sharratt, G P, Leanage, R, Monro, J L, Shinebourne, E A
Three patients with aortic arch anomalies presented with severe heart failure, acidaemia, and poor or absent upper and lower limb pulses. Prominent carotid arterial pulsations were detected which...
Southall, D P, Arrowsmith, W A, Oakley, J R, McEnery, G, Anderson, R H, Shinebourne, E A
Two neonates with arrhythmias and the long QT syndrome are described. The arrhythmias were detected in utero and both infants were apparently well after birth. The first infant, although well, had a...
Jones, R W, Baumer, J H, Joseph, M C, Shinebourne, E A
Arterial oxygen tension was measured from radial artery samples in 276 infants referred for cardiological investigation. Values obtained during air breathing in infants with congenital heart disease...
Fatal persistent pulmonary hypertension presenting late in the neonatal period.
Raine, J, Hislop, A A, Redington, A N, Haworth, S G, Shinebourne, E A
Two cases of fatal idiopathic persistent pulmonary hypertension presented late in the neonatal period. Lungs were examined histologically by light and electron microscopy, and immunocytochemical...
Southall, D P, Richards, Jean, Brown, D J, Johnston, P G B, De Swiet, M, Shinebourne, E A
A system for simultaneous 24-hour tape recording of ECG and respiration has been developed and used in the study of 4 groups of newborn infants. In 50 randomly selected, healthy term infants, the...
An explanation for failure of impedance apnoea alarm systems.
Southall, D P, Richards, J M, Lau, K C, Shinebourne, E A
24-hour recordings of the ECG and respiration, the latter from an impedance technique, have shown a phenomenon which could account for hitherto unexplained failures of impedance apnoea alarm systems....
Prospective study of fetal heart rate and rhythm patterns.
Southall, D P, Richards, J, Hardwick, R A, Shinebourne, E A, Gibbens, G L, Thelwall-Jones, H, ...
The fetal heart beat, detected by ultrasound, was recorded for five minutes from 934 antenatal women--266 at 30 to 35 weeks' gestation and 718 at 36 to 41 weeks. Episodes of bradycardia < 100/minute...
Blood pressure in the first 6 weeks of life.
Earley, A, Fayers, P, Ng, S, Shinebourne, E A, De Swiet, M
Systolic blood pressure was measured at frequent intervals during the first 6 weeks of life in 99 normal neonates. Blood pressure rose from a mean of 70 mmHg at age 2 days, to 93 mmHg at age 6 weeks...
Selective criteria for differential diagnosis of infants with symptoms of congenital heart disease.
Warburton, D, Rehan, M, Shinebourne, E A
147 case records of infants referred to the Brompton Hospital in the first year of life with a provisional diagnosis of congenital heart disease were examined. Statistical analyses were performed to...
Ward, D E, Signy, M, Oldershaw, P, Jones, S, Shinebourne, E A
Twenty patients aged between 12 months and 13 years underwent permanent pacemaker implantation. The main indication for pacing was post-surgical atrioventricular block. The complication rate was high...
Hambleton, G., Shinebourne, E. A.
Investigation of FEV1·0 and pulse rates in 10 asthmatic children who were given inhalations of isoprenaline, salbutamol, and placebo separately showed that both drugs had a similar effect on airways...
Difference between upper and lower limb blood pressure in normal neonates using Doppler technique
De Swiet, M., Peto, J., Shinebourne, E. A.
Using the Doppler technique, systolic upper limb blood pressure was found to be greater than lower limb blood pressure (mean difference 17 mmHg) in 20 normal neonates. Therefore, the finding of such...
Discrete sub-aortic stenosis and ventricular septal defect.
Smith, L D, Charalmbopoulos, C, Rigby, M L, Pallides, S, Hunter, S, Lincoln, C, ...
We present details of 15 children, aged 3 months to 11 years, with discrete sub-aortic stenosis and ventricular septal defect. We emphasise a high index of clinical suspicion and echocardiography as...
Cardiovascular effects of tolazoline and ranitidine.
Bush, A, Busst, C M, Knight, W B, Shinebourne, E A
The cardiovascular effects of ranitidine were studied in 12 children with congenital heart disease who had been given tolazoline as a pulmonary vasodilator. Ranitidine was given as prophylaxis...
Treatment of refractory supraventricular arrhythmias with flecainide acetate.
Till, J A, Rowland, E, Shinebourne, E A, Ward, D E
We treated 13 children aged 0.2 years to 15.7 years (median 7.1 years) with flecainide acetate for refractory symptomatic supraventricular tachycardia. Six children had direct atrioventricular...
Survival after balloon atrial septostomy for complete transposition of great arteries.
Mok, Q, Darvell, F, Mattos, S, Smith, T, Fayers, P, Rigby, M L, ...
Mortality before surgery must be taken into account when comparing the surgical mortality of atrial redirection procedures (Mustard's or Senning's operation) and the arterial switch operation for...
Sudden and unexpected death between 1 and 5 years.
Southall, D P, Stebbens, V, Shinebourne, E A
Of a population of 9856 children followed up from birth, 9251 of whom underwent 24 hour tape recordings of electrocardiograms and abdominal wall breathing movements during early infancy, five died...
Changes in pulmonary circulation in severe bronchopulmonary dysplasia.
Bush, A, Busst, C M, Knight, W B, Hislop, A A, Haworth, S G, Shinebourne, E A
Eight patients with severe bronchopulmonary dysplasia underwent cardiac catheterisation. Seven had a pulmonary vascular resistance greater than 3 mm Hg.l-1 min.m2 (mean 8.9, range 2.2-13.8). All had...
Exercise ability after Mustard's operation.
Bowyer, J J, Busst, C M, Till, J A, Lincoln, C, Shinebourne, E A
Twenty children who were well six to 12 years after undergoing Mustard's operation for transposition of the great arteries were studied. Each child performed a graded maximal treadmill test with...
Complications of supra-annular mitral valve placement in infants
Barker, C L, Daubeney, P E F, Shinebourne, E A
Two infants underwent supra-annular placement of prosthetic mitral valves. The objective of this strategy was to insert a larger valve and delay replacement. This approach was initially successful...
Can atrioventricular septal defects exist with intact septal structures?
Kaski, J P, Wolfenden, J, Josen, M, Daubeney, P E F, Shinebourne, E A
The hallmark of an atrioventricular septal defect (AVSD) is a common atrioventricular junction, giving rise to a trileaflet left atrioventricular valve. AVSDs have the potential for interatrial...