Rapid tumor cell swelling and bursting: beware of collateral damage- Response (2009)
Tannous, Bakhos A., Chiocca, E. Antonio, Jacobs, Andreas H., Corey, David P., Breakefield, Xandra O.
Pattern Formation of Glioma Cells: Effects of Adhesion (2008)
Khain, Evgeniy, Nowicki, Michal O., Chiocca, E. Antonio, Lawler, S. E., Sander, Leonard M.
Glioblastoma multiforme is a malignant brain tumor. We investigate the clustering of glioma cells in vitro in order to shed light on brain tumor formation. In vitro experiments in a gel found a cell...
Lithium inhibits invasion of glioma cells; possible involvement of glycogen synthase kinase-3 (2008)
Nowicki, Michal O., Dmitrieva, Nina, Stein, Andrew M., Cutter, Jennifer L., Godlewski, Jakub, Saeki, Yoshinaga, ...
Therapies targeting glioma cells that diffusely infiltrate normal brain are highly sought after. Our aim was to identify novel approaches to this problem using glioma spheroid migration assays....
Effect of Tumor Microenvironment Modulation on the Efficacy of Oncolytic Virus Therapy (2007)
Kurozumi, Kazuhiko, Hardcastle, Jayson, Thakur, Roopa, Yang, Ming, Christoforidis, Gregory, Fulci, Giulia, ...
Background The tumor microenvironment is being increasingly recognized as an important determinant of tumor progression as well as of therapeutic response. We investigated oncolytic virus (OV)...
Liao, Wei-Chen, Chang, Wun-Shaing Wayne, Wu, Felicia Ying-Hsiueh, Aghi, Manish, Chou, Ting-Chao, Breakefield, Xandra O., ...
Chung, Richard Y., Saeki, Yoshinaga, Chiocca, E. Antonio
Deletion of the γ34.5 gene coding for virulence markedly reduces cytotoxicity mediated by herpes simplex virus type 1 (HSV-1) (J. M. Markert et al., Neurosurgery 32:597–603, 1993; N. S. Markovitz...
Ikeda, Keiro, Wakimoto, Hiroaki, Ichikawa, Tomotsugu, Jhung, Sarah, Hochberg, Fred H., Louis, David N., ...
Intravascular routes of administration can provide a means to target gene- and virus-based therapies to multiple tumor foci located within an organ, such as the brain. However, we demonstrate here...
Sena-Esteves, Miguel, Saeki, Yoshinaga, Camp, Sara M., Chiocca, E. Antonio, Breakefield, Xandra O.
We report here on the development and characterization of a novel herpes simplex virus type 1 (HSV-1) amplicon-based vector system which takes advantage of the host range and retention properties of...
Nakamura, Hideo, Kasuya, Hideki, Mullen, John T., Yoon, Sam S., Pawlik, Timothy M., Chandrasekhar, Soundararajalu, ...
Myb34.5 is a herpes simplex virus 1 (HSV-1) mutant deleted in the gene for ribonucleotide reductase (ICP6). It also carries a version of γ134.5 (a viral gene product that promotes the...
Packard, Scott D, Mandeville, Joseph B, Ichikawa, Tomotsugu, Ikeda, Keiro, Terada, Kinya, Niloff, Stephanie, ...
In order to identify differences in functional activity, we compared the reactivity of glioma vasculature and the native cerebral vasculature to both dilate and constrict in response to altered...
MRI of Transgene Expression: Correlation to Therapeutic Gene Expression
Ichikawa, Tomotsugu, Högemanny, Dagmar, Saeki, Yoshinaga, Tyminski, Edyta, Terada, Kinya, Weissleder, Ralph, ...
Magnetic resonance imaging (MRI) can provide highresolution 3D maps of structural and functional information, yet its use of mapping in vivo gene expression has only recently been explored. A...
Chung, Richard Y., Saeki, Yoshinaga, Chiocca, E. Antonio
Deletion of the γ34.5 gene coding for virulence markedly reduces cytotoxicity mediated by herpes simplex virus type 1 (HSV-1) (J. M. Markert et al., Neurosurgery 32:597–603, 1993; N. S. Markovitz...
Ikeda, Keiro, Wakimoto, Hiroaki, Ichikawa, Tomotsugu, Jhung, Sarah, Hochberg, Fred H., Louis, David N., ...
Intravascular routes of administration can provide a means to target gene- and virus-based therapies to multiple tumor foci located within an organ, such as the brain. However, we demonstrate here...
Sena-Esteves, Miguel, Saeki, Yoshinaga, Camp, Sara M., Chiocca, E. Antonio, Breakefield, Xandra O.
We report here on the development and characterization of a novel herpes simplex virus type 1 (HSV-1) amplicon-based vector system which takes advantage of the host range and retention properties of...
Nakamura, Hideo, Kasuya, Hideki, Mullen, John T., Yoon, Sam S., Pawlik, Timothy M., Chandrasekhar, Soundararajalu, ...
Myb34.5 is a herpes simplex virus 1 (HSV-1) mutant deleted in the gene for ribonucleotide reductase (ICP6). It also carries a version of γ134.5 (a viral gene product that promotes the...
Packard, Scott D, Mandeville, Joseph B, Ichikawa, Tomotsugu, Ikeda, Keiro, Terada, Kinya, Niloff, Stephanie, ...
In order to identify differences in functional activity, we compared the reactivity of glioma vasculature and the native cerebral vasculature to both dilate and constrict in response to altered...
MRI of Transgene Expression: Correlation to Therapeutic Gene Expression
Ichikawa, Tomotsugu, Högemanny, Dagmar, Saeki, Yoshinaga, Tyminski, Edyta, Terada, Kinya, Weissleder, Ralph, ...
Magnetic resonance imaging (MRI) can provide highresolution 3D maps of structural and functional information, yet its use of mapping in vivo gene expression has only recently been explored. A...
Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses
Fulci, Giulia, Breymann, Laura, Gianni, Davide, Kurozomi, Kazuhiko, Rhee, Sarah S., Yu, Jianhua, ...
Clinical trials are testing oncolytic viruses (OVs) as therapies for cancer. We have shown that animals that have brain tumors and are treated with a herpes simplex virus (HSV)-derived OV live...
Dang, David, Baig, Mirza N., Christoforidis, Greg, Chiocca, E. Antonio, Gabriel, Joshue
We will discuss a potential role of percutaneous vertebroplasty (PVP) in the management of patients with severe fibrous dysplasia of the spine with multiple cervical lesions and C2–C3 pathologic...
Lithium inhibits invasion of glioma cells; possible involvement of glycogen synthase kinase-3
Nowicki, Michal O., Dmitrieva, Nina, Stein, Andrew M., Cutter, Jennifer L., Godlewski, Jakub, Saeki, Yoshinaga, ...
Therapies targeting glioma cells that diffusely infiltrate normal brain are highly sought after. Our aim was to identify novel approaches to this problem using glioma spheroid migration assays....