E. DeClercq

Extension of the intensive phase reduces unfavourable outcomes with the 8-month thioacetazone regimen (2006)

Van Deun, A., Aung, K. J. M., Hamid Salim, A., Ali, M. A., Naha, M. S., Das, P. K., ...

SETTING: Damien Foundation tuberculosis (TB) control projects in Bangladesh. OBJECTIVE: To assess the effectiveness of a 1-month extension of the intensive phase for smear-positives at 2 months of an...

Performance of variations of carbolfuchsin staining of sputum smears for AFB under field conditions (2005)

Van Deun, A., Salim, A. H., Aung, K. J. M., Hossain, M. A., Chambugonj, N., Hye, M. A., ...

SETTING: A field project in Bangladesh. OBJECTIVE: To compare the effectiveness of commonly used carbolfuchsin staining variations. DESIGN: Routine hot Ziehl-Neelsen (ZN) 1% basic fuchsin staining...

Gender differences in tuberculosis: a prevalence survey done in Bangladesh (2004)

Salim, A. H., Declercq, E., Van Deun, A., Saki, K. A. R.

SETTING: Bangladesh national tuberculosis control programme districts supported by the Damien Foundation (population 18 million). OBJECTIVE: To determine whether the observed gender difference is...

Structure assignment, total synthesis, and antiviral evaluation of cycloviracin B1 (2003)

Fürstner, A., Albert, M., Mlynarski, J., Matheu, M., DeClercq, E.

Optimal tuberculosis case detection by direct sputum smear microscopy: how much better is more? (2002)

Van Deun, A., Salim, A. H., Cooreman, E., Hossain, A., Rema, A., Chambugonj, N., ...

SETTING: A tuberculosis control project in Bangladesh. OBJECTIVE: To define the efficiency of numbers of microscopic fields screened and the sputum collection scheme used for diagnostic smear...

Cytotoxic 2,6-bis(arylidene)cyclohexanones and related compounds (2000)

Kumar, P, Nazarali, A J, Motaganahalli, N L, Kowalchuk, T P, Beazely, M A, ...

A number of 2-arylidenecyclohexanones 1, 2, 6-bis(arylidene)cyclohexanones 2 and related Mannich bases 3-5 were prepared. Various torsion angles as well as atomic charges on olefinic carbon atoms...

Differential anti-HBV activity in vitro of three potent inhibitors of inosine monophosphate dehydrogenase: Mycophenolic acid 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR) and ribavirin (1998)

Gong, ZJ, Clarysse, C, Coopmans, T, ...

Relative water level change in the intracoastal zone of Belgium and Northern France over the last 2500 years. (1998)

Louwye, Stephen, DECLERCQ, E

Mycophenolic acid, an immunosuppressive agent, inhibits replication in cultures of primary an immortalized human hepatocytes (1997)

Gong, ZJ, DeMeyer, S, Clarysse, C, Neyts, Johan; U0014425, DeClercq, E, Yap, Sing Hiem; U0010976

Synthesis and conformational study of 3-hydroxy-4-(hydroxymethyl)-1-cyclohexanyl purines and pyrimidines (1997)

Maurinsh, Y, Schraml, J, DeWinter, H, Blaton, Norbert; U0008061, Peeters, Oswald; U0017816, Lescrinier, Eveline; U0004247, ...

The cyclohexane nucleosides with a 1,4-relationship between nucleoside base and hydroxymethyl moiety were synthesized using a conjugated addition reaction of the nucleobases to ethyl...

Antiviral and tumor cell antiproliferative SAR studies on tetracyclic eudistomins .2 (1997)

Kruse, C.G., Balzarini, J., DeClercq, E., Scheeren, H.W., VanMaarseveen, J.H.

Synthesis, conformational analysis and biological evaluation of 2-(5-deoxy-beta-D-ribofuranosyl)pyridine-4-carboxamide. (1996)

JOOS, PE, DEGROOT, A, ESMANS, EL, ALDERWEIRELDT, FC, De Bruyn, André, BALZARINI, J, ...

Synthesis, conformation analysis and biological evaluation of 2-(2,3-dideoxy-beta-D-ribofuranosyl)pyridine-4-carboxamide. (1996)

JOOS, PE, ESMANS, EL, ALDERWEIRELDT, FC, De Bruyn, André, BALZARINI, J, DECLERCQ, E

A two plasmid co-expression system in Escherichia coli for the production of virion-like reverse transcriptase of the human immunodeficiency virus type 1. (1996)

JONCKHEERE, H, DEVREESE, K, DEBYSER, Z, Vandekerckhove, Joël, BALZARINI, J, DESMYTER, J, ...

Global change and sea level variations. (1996)

Louwye, Stephen, DECLERCQ, E, DE MOORR, G, VERNEMMEN, C

Sea level variations of the last 2000 years in Belgium and Northern France. (1996)

Louwye, Stephen, DECLERCQ, E, DE MOORR, G, VERNEMMEN, C

Short term sea level variations induced by astronomical, meteorological and local geomorphologically associated factors. (1996)

Louwye, Stephen, DECLERCQ, E, DE MOORR, G, VERNEMMEN, C

Evaluation of surges and surge frequenties of the last decennia. (1996)

Louwye, Stephen, DECLERCQ, E, DE MOORR, G, VERNEMMEN, C

High speed HPLC determination of bis(pivaloyloxymethyl)-PMEA and its degradation products, mono(POM)-PMEA and PMEA (1996)

Augustijns, Patrick; U0004215, Annaert, Pieter; U0049621, Adriaens, S, DeClercq, E, Kinget, Renaat; U0016947

A high-speed HPLC gradient method for the determination of the antiviral ester prodrug bis(POM)-PMEA and its degradation products mono(POM)-PMEA and PMEA, is described. Perfusion chromatography...

USE OF BLOOD-TESTS IN GENERAL-PRACTICE - A COLLABORATIVE STUDY IN 8 EUROPEAN COUNTRIES. (1995)

LEURQUIN, P, VANCASTEREN, V, DEMAESENEER, J, DECLERCQ, E, BARTELDS, A, BOLLAG, G, ...

Use of blood-tests in general-practice - a collaborative study in 8 european countries (1995)

Leurquin, P, Vancasteren, V, Demaeseneer, J, Declercq, E, Bartelds, A, Bollag, G, ...

Background. Laboratory tests are routine examinations in general practice and are associated with increasing costs in industrialized countries.

Discovery, development and characterization of agents active against the aids virus (1995)

Pauwels, R, Debethune, Mp, Andries, K, Stoffels, P, Janssen, P, Declercq, E

Despite major efforts by academic and pharmaceutical research teams, no definitive prevention or cure of AIDS has been achieved. Nevertheless, this research has yielded important information on how...

Declining trends in some sexually transmitted diseases in Belgium between 1983 and 1989 (1991)

Walckiers, Denise, Piot, Peter, Stroobant, André, Van Der Veken, Jos, Declercq, E

Objective - To examine trends in some sexually transmitted diseases in Belgium and to discuss them in the light of the European background. Design - Analysis of the time trends of C trachomatis and N...

3'-fluoro-2',3'-dideoxy-5-chlorouridine - most selective anti-hiv-1 agent among a series of new 2'-fluorinated and 3'-fluorinated 2',3'-dideoxynucleoside analogs (1989)

Van Aerschot, Arthur; U0002172, Herdewijn, Piet; U0010383, Balzarini, Jan; U0005099, Pauwels, R, DeClercq, E

A series of 2'- and 3'-fluorinated 2',3'-dideoxynucleosides and 3'-azido-2',3'-dideoxynucleosides were synthesized and evaluated for their inhibitory activity against human immunodeficiency virus-1...

3'-fluoro-azido-substituted and 3'-azido-substituted pyrimidine 2',3'-dideoxynucleoside derivatives are potent anti-retrovirus agents (1988)

Balzarini, J, Baba, M, Pauwels, R, Herdewijn, Piet; U0010383, Declercq, E

Studies on the mechanism of antiviral action of 5-(2-chloroethyl)-2'-deoxyuridine against herpes-simplex virus (1988)

Bernaerts, R, Sterkens, P, Herdewijn, Piet; U0010383, Rosenwirth, B, Declercq, E

Incorporation of (e)-5-(2-iodovinyl)-2'-deoxyuridine into deoxyribonucleic acids of varicella-zoster virus (tk+ and tk- strains)-infected cells (1987)

Yokota, T, Konno, K, Shigeta, S, Declercq, E

The incorporation of (E)-5-(2-iodovinyl)-2'-deoxyuridine (IVDU) into DNA of varicella-zoster virus (VZV)-infected human embryo fibroblasts was studied, using thymidine kinase-positive (TK+) and...

2',3'-Dideoxycytidine: regulation of its metabolism and anti-retroviral potency by natural pyrimidine nucleosides and by inhibitors of pyrimidine nucleotide synthesis (1987)

Cooney, D A, Dalal, M, Kang, G J, Cupp, J E, DeClercq, E, ...

The antiretroviral action of 2',3'-dideoxycytidine (ddCyd) depends on its intracellular conversion to the 5'-triphosphate metabolite ddCTP. The effect of natural pyrimidines and pyrimidine...

Simple quantitative radioiodination of "(e)-5-(2-iodovinyl)-2'-deoxyuridine (ivdu) by exchange labeling (1986)

Julien, C, Declercq, E, Deroo, M

The synthesis of [125I]-(E)-5-(2-iodovinyl)-2'-deoxyuridine [( 125I]IVDU) by a halogen isotope exchange reaction has been monitored in various reaction conditions. Quantitative incorporation of...

Affinity of "(e)-5-(2-iodovinyl)-2'-deoxyuridine for herpes-simplex virus type-1 (hsv-1)-encoded thymidine kinase determines its eventual incorporation into dna of hsv-1-transformed cells (1985)

Declercq, E, Crumpacker, C, Ayusawa, D, Seno, T

Comparison of the antitumour and antimetabolic properties of 5-nitro-2'-deoxyuridine with its corresponding carbocyclic analog (1984)

Robins, Mj, Desgranges, C, Declercq, E

Inhibition of pyrimidine degradation by (E)-5-(2-bromovinyl)uracil in vivo (1984)

Razaka, G, Drouillet, F, Bricaud, H, Declercq, E

Isolation and characterization of a human fibroblast interferon gene and its expression in escherichia-coli (1981)

Derynck, R, Devos, R, Remaut, E, Saman, E, Stanssens, P, Tavernier, J, ...

Isolation and structure of a human fibroblast interferon gene (1980)

Derynck, R, Content, J, Declercq, E, Volckaert, Guido; U0006538, Tavernier, J, Devos, R, ...

Novel acyclic adenosine analogs inhibit Epstein-Barr virus replication.

Lin, J C, DeClercq, E, Pagano, J S

The effect of three new acyclic adenosine analogs, (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA], 9-(2-phosphonylmethoxyethyl)adenine (PMEA), and (S)-9-(2,3-dihydroxypropyl)adenine...

Studies on the Toxicity and Antiviral Activity of Various Polynucleotides1

Black, D. R., Eckstein, F., DeClercq, E., Merigan, T. C.

Various polynucleotides were examined for antiviral activity and toxicity in mice. Although the antiviral potency of the various interferon inducers varied, there was a concomitant variation in...

Novel acyclic adenosine analogs inhibit Epstein-Barr virus replication.

Lin, J C, DeClercq, E, Pagano, J S

The effect of three new acyclic adenosine analogs, (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA], 9-(2-phosphonylmethoxyethyl)adenine (PMEA), and (S)-9-(2,3-dihydroxypropyl)adenine...

Studies on the Toxicity and Antiviral Activity of Various Polynucleotides1

Black, D. R., Eckstein, F., DeClercq, E., Merigan, T. C.

Various polynucleotides were examined for antiviral activity and toxicity in mice. Although the antiviral potency of the various interferon inducers varied, there was a concomitant variation in...

Declining trends in some sexually transmitted diseases in Belgium between 1983 and 1989.

Walckiers, D, Piot, P, Stroobant, A, Declercq, E

OBJECTIVE--To examine trends in some sexually transmitted diseases in Belgium and to discuss them in the light of the European background. DESIGN--Analysis of the time trends of C trachomatis and N...

Turning liabilities into resources: informal village doctors and tuberculosis control in Bangladesh.

Hamid Salim, M. A., Uplekar, Mukund, Daru, Paul, Aung, Maug, Declercq, E., Lönnroth, Knut

In 1998, the Damien Foundation Bangladesh invited semi-qualified, private "gram dakter" (Bangla for "village doctors") to participate in tuberculosis (TB) programmes in a population of 26 million...