Inactivation of contraceptive steroid hormones by human intestinal clostridia.
Bokkenheuser, V D, Winter, J, Cohen, B I, O'Rourke, S, Mosbach, E H
Steroid hormones reduced in ring-A are devoid of hormonal activity. In metabolic experiments we found that human fecal flora reduced the delta 4-3-keto structure of natural progestins to 3...
Increased formation of ursodeoxycholic acid in patients treated with chenodeoxycholic acid.
Salen, G, Tint, G S, Eliav, B, Deering, N, Mosbach, E H
The formation of ursodeoxycholic acid, the 7 beta-hydroxy epimer of chenodeoxycholic acid, was investigated in three subjects with cerebrotendinous xanthomatosis and in four subjects with gallstones....
Setoguchi, T., Salen, Gerald, Tint, G. S., Mosbach, E. H.
Bile acid production in cerebrotendinous xanthomatosis (CTX) is subnormal, yet the activity of cholesterol 7α-hydroxylase, the rate-determining enzyme of bile acid synthesis, is elevated. To explain...
Salen, G, Shefer, S, Setoguchi, T, Mosbach, E H
To study the role of C25-HYDROXY BILE ALCOHOLS AS PRECURSORS OF CHOlic acid, [G-3-H]5beta-cholestane-3alpha,7alpha12alpha,25-tetrol was administered intravenously to two subjects with...
A 25-hydroxylation pathway of cholic acid biosynthesis in man and rat.
Shefer, S, Cheng, F W, Dayal, B, Hauser, S, Tint, G S, Salen, G, ...
This paper describes a pathway of cholic acid synthesis, in man and in the rat, which involves 25-hydroxylated intermediates and is catalyzed by microsomal and soluble enzymes. The subcellular...
Bile Acid Synthesis in the Isolated, Perfused Rabbit Liver
Mosbach, E. H., Rothschild, M. A., Bekersky, I., Oratz, M., Mongelli, J.
These experiments were carried out to demonstrate the usefulness of the perfused rabbit liver for studies of bile acid metabolism, and to determine the rate-limiting enzyme of bile acid synthesis....
Inactivation of contraceptive steroid hormones by human intestinal clostridia.
Bokkenheuser, V D, Winter, J, Cohen, B I, O'Rourke, S, Mosbach, E H
Steroid hormones reduced in ring-A are devoid of hormonal activity. In metabolic experiments we found that human fecal flora reduced the delta 4-3-keto structure of natural progestins to 3...
Increased formation of ursodeoxycholic acid in patients treated with chenodeoxycholic acid.
Salen, G, Tint, G S, Eliav, B, Deering, N, Mosbach, E H
The formation of ursodeoxycholic acid, the 7 beta-hydroxy epimer of chenodeoxycholic acid, was investigated in three subjects with cerebrotendinous xanthomatosis and in four subjects with gallstones....
Setoguchi, T., Salen, Gerald, Tint, G. S., Mosbach, E. H.
Bile acid production in cerebrotendinous xanthomatosis (CTX) is subnormal, yet the activity of cholesterol 7α-hydroxylase, the rate-determining enzyme of bile acid synthesis, is elevated. To explain...
Salen, G, Shefer, S, Setoguchi, T, Mosbach, E H
To study the role of C25-HYDROXY BILE ALCOHOLS AS PRECURSORS OF CHOlic acid, [G-3-H]5beta-cholestane-3alpha,7alpha12alpha,25-tetrol was administered intravenously to two subjects with...
A 25-hydroxylation pathway of cholic acid biosynthesis in man and rat.
Shefer, S, Cheng, F W, Dayal, B, Hauser, S, Tint, G S, Salen, G, ...
This paper describes a pathway of cholic acid synthesis, in man and in the rat, which involves 25-hydroxylated intermediates and is catalyzed by microsomal and soluble enzymes. The subcellular...
Bile Acid Synthesis in the Isolated, Perfused Rabbit Liver
Mosbach, E. H., Rothschild, M. A., Bekersky, I., Oratz, M., Mongelli, J.
These experiments were carried out to demonstrate the usefulness of the perfused rabbit liver for studies of bile acid metabolism, and to determine the rate-limiting enzyme of bile acid synthesis....
Deming, Q. B., Mosbach, E. H., Bevans, M., Daly, M. M., Abell, L. L., Martin, E., ...
Rats on a stock diet with added cholesterol, cholic acid, and thiouracil developed increased concentrations of cholesterol, total lipide, and beta lipoprotein in the serum, and an increased content...