FOLATE STATUS IN A GERIATRIC POPULATION AND ITS RELATION TO DEMENTIA (1973)
SNEATH, PAULA, CHANARIN, I., HODKINSON, H. M., MCPHERSON, C. K., REYNOLDS, E. H.
Anaemia was present in 20 per cent of 113 consecutive admissions to a geriatric unit. This was microcytic in 8 per cent and macrocytic in 11 per cent. Sixteen per cent of patients had folate...
ANTICONVULSANT THERAPY, MEGALOBLASTIC HAEMOPOIESIS AND FOLIC ACID METABOLISM (1966)
REYNOLDS, E. H., MILNER, G., MATTHEWS, D. M., CHANARIN, I.
A clinical, haematological, and biochemical investigation of 62 epileptics is reported. Fifty-four of the patients were receiving anticonvulsant drugs and eight were untreated. None of the treated...
Reversible absorptive defects in anticonvulsant megaloblastic anaemia
Reynolds, E. H., Hallpike, J. F., Phillips, B. M., Matthews, D. M.
Two cases of anticonvulsant megaloblastic anaemia are described, showing features of unusual interest. Though both cases were apparently deficient in folic acid, the Figlu tests were negative. One...
Differential diagnosis of dementia
Chary, T K N, Carney, M W P, Chanarin, I, Laundy, Malcolm, Reynolds, E H, Toone, Brian
When do epileptic patients need treatment? Starting and stopping medication.
Decisions about when to start and stop antiepileptic treatment have important implications for patients with epilepsy. Clinical practice varies and is determined more by dogmatic teaching than by...
Chronic toxicity in epileptic patients receiving single-drug treatment
Dellaportas, D I, Shorvon, S D, Galbraith, A W, Laundy, M, Reynolds, E H, Marshall, W J, ...
In 94 previously untreated new referrals to a neurological clinic with tonic-clonic or partial seizures or both the failure rate for optimum single-drug treatment with phenytoin or carbamazepine...
Cerebrotendinous xanthomatosis: biochemical response to inhibition of cholesterol synthesis.
Lewis, B, Mitchell, W D, Marenah, C B, Cortese, C, Reynolds, E H, Shakir, R
Myopathy associated with anticonvulsant osteomalacia.
Marsden, C D, Reynolds, E H, Parsons, V, Harris, R, Duchen, L
Neurological Disease associated with Folate Deficiency
Reynolds, E. H., Rothfeld, P., Pincus, Jonathen H.
In a general medical hospital population the neurological status of 24 patients with severe folate deficiency was compared with that of a control group of 21 patients with normal serum folate. A...
Reduction in polypharmacy for epilepsy.
A two-year prospective study of 40 adult outpatients with chronic epilepsy was carried out in which blood drug concentrations were monitored, and anticonvulsant polypharmacy was reduced to treatment...
Shorvon, S D, Chadwick, D, Galbraith, A W, Reynolds, E H
We performed prospective trials of phenytoin and carbamazepine, assisted by blood level monitoring, in untreated patients newly referred with grand mal or partial seizures, or both, to a neurological...
Water intoxication due to carbamazepine.
Stephens, W P, Espir, M L, Tattersall, R B, Quinn, N P, Gladwell, S R, Galbraith, A W, ...
Unnecessary polypharmacy for epilepsy.
A retrospective survey of 50 adult epileptic outpatients who were taking two anticonvulsants drugs showed that seizure control had improved in the six months after the introduction of the second drug...
Interaction of phenytoin and primidone.
Reynolds, E H, Fenton, G, Fenwick, P, Johnson, A L, Laundy, M
The ratio of derived phenobarbitone to unmetabolized primidone in the serum was significantly higher in 50 epileptic patients on a combination of primidone and phenytoin than in 12 patients on...
Reversible absorptive defects in anticonvulsant megaloblastic anaemia
Reynolds, E. H., Hallpike, J. F., Phillips, B. M., Matthews, D. M.
Two cases of anticonvulsant megaloblastic anaemia are described, showing features of unusual interest. Though both cases were apparently deficient in folic acid, the Figlu tests were negative. One...
Differential diagnosis of dementia
Chary, T K N, Carney, M W P, Chanarin, I, Laundy, Malcolm, Reynolds, E H, Toone, Brian
When do epileptic patients need treatment? Starting and stopping medication.
Decisions about when to start and stop antiepileptic treatment have important implications for patients with epilepsy. Clinical practice varies and is determined more by dogmatic teaching than by...
Chronic toxicity in epileptic patients receiving single-drug treatment
Dellaportas, D I, Shorvon, S D, Galbraith, A W, Laundy, M, Reynolds, E H, Marshall, W J, ...
In 94 previously untreated new referrals to a neurological clinic with tonic-clonic or partial seizures or both the failure rate for optimum single-drug treatment with phenytoin or carbamazepine...
Cerebrotendinous xanthomatosis: biochemical response to inhibition of cholesterol synthesis.
Lewis, B, Mitchell, W D, Marenah, C B, Cortese, C, Reynolds, E H, Shakir, R
Myopathy associated with anticonvulsant osteomalacia.
Marsden, C D, Reynolds, E H, Parsons, V, Harris, R, Duchen, L
Neurological Disease associated with Folate Deficiency
Reynolds, E. H., Rothfeld, P., Pincus, Jonathen H.
In a general medical hospital population the neurological status of 24 patients with severe folate deficiency was compared with that of a control group of 21 patients with normal serum folate. A...
Reduction in polypharmacy for epilepsy.
A two-year prospective study of 40 adult outpatients with chronic epilepsy was carried out in which blood drug concentrations were monitored, and anticonvulsant polypharmacy was reduced to treatment...
Shorvon, S D, Chadwick, D, Galbraith, A W, Reynolds, E H
We performed prospective trials of phenytoin and carbamazepine, assisted by blood level monitoring, in untreated patients newly referred with grand mal or partial seizures, or both, to a neurological...
Water intoxication due to carbamazepine.
Stephens, W P, Espir, M L, Tattersall, R B, Quinn, N P, Gladwell, S R, Galbraith, A W, ...
Unnecessary polypharmacy for epilepsy.
A retrospective survey of 50 adult epileptic outpatients who were taking two anticonvulsants drugs showed that seizure control had improved in the six months after the introduction of the second drug...
Interaction of phenytoin and primidone.
Reynolds, E H, Fenton, G, Fenwick, P, Johnson, A L, Laundy, M
The ratio of derived phenobarbitone to unmetabolized primidone in the serum was significantly higher in 50 epileptic patients on a combination of primidone and phenytoin than in 12 patients on...
The neuropsychiatry of megaloblastic anaemia.
Shorvon, S D, Carney, M W, Chanarin, I, Reynolds, E H
The neuropsychiatric states of 50 patients with vitamin B12 deficiency and 34 patients with folate deficiency presenting with megaloblastosis in a general hospital were examined and compared....
The course of untreated epilepsy.
Elwes, R. D., Johnson, A. L., Reynolds, E. H.
As little is known about the course of untreated epilepsy the time intervals between untreated tonic clonic seizures were examined retrospectively in a series of 183 patients presenting to a...
Chadwick, D, Gorrod, J W, Jenner, P, Marsden, C D, Reynolds, E H
1 Acute administration of clonazepam, diazepam, and diphenylhydantoin to mice elevated cerebral 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA); chronic administration had less...
Vigabatrin: rational treatment for chronic epilepsy.
Ring, H A, Heller, A J, Farr, I N, Reynolds, E H
Vigabatrin is a selective, irreversible suicide inhibitor of GABA transaminase and thus increases brain and CSF GABA. In 33 adult patients with long standing refractory epilepsy on treatment with one...
Bottiglieri, T, Godfrey, P, Flynn, T, Carney, M W, Toone, B K, Reynolds, E H
Cerebrospinal fluid (CSF) S-adenosylmethionine (SAM) levels were significantly lower in severely depressed patients than in a neurological control group. The administration of SAM either...
Previous studies of phenytoin neuropathy in selected groups of chronic epileptic patients on polytherapy have indicated a widely varying incidence of clinical or electrophysiological abnormalities....
Anticonvulsant-induced dyskinesias: a comparison with dyskinesias induced by neuroleptics.
Chadwick, D, Reynolds, E H, Marsden, C D
Anticonvulsants cause dyskinesias more commonly than has been appreciated. Diphenylhydantoin (DPH), carbamazepine, primidone, and phenobarbitone may cause asterixis. DPH, but not other...
The distribution of plasma phenytoin levels in epileptic patients
Lascelles, P. T., Kocen, R. S., Reynolds, E. H.
Plasma phenytoin levels were estimated in 111 adult epileptic patients. A wide scatter of values was found, with over half outside the therapeutic limits of 10 to 20 μg/ml. Phenytoin tolerance tests...
Ring, H A, Crellin, R, Kirker, S, Reynolds, E H
Ten patients who developed a major depressive episode in association with vigabatrin treatment for intractable epilepsy are reported. The depression usually occurred early in the course of treatment,...
Pratt, J A, Jenner, P, Johnson, A L, Shorvon, S D, Reynolds, E H
In epileptic patients carbamazepine and diphenylhydantoin have opposite effects on whole and free plasma tryptophan concentrations, the former elevating and the latter depressing them. It is unlikely...
Neuropathy and myopathy in two patients with anorexia and bulimia nervosa.
Alloway, R, Reynolds, E H, Spargo, E, Russell, G F
Two adolescent patients with eating disorders and severe weight loss presented with neuromyopathy. The first was female and had a twenty months' history of bulimia nervosa with weight loss and...
Lever, E G, Elwes, R D, Williams, A, Reynolds, E H
Subacute combined degeneration of the cord is a rare complication of folate deficiency. Disturbance of methylation reactions in nervous tissue probably underlie subacute combined degeneration of the...
Heller, A J, Chesterman, P, Elwes, R D, Crawford, P, Chadwick, D, Johnson, A L, ...
Recent studies have shown that most newly diagnosed epileptic patients can be satisfactorily treated with a single antiepileptic drug. We therefore undertook a prospective randomised pragmatic trial...
Folate metabolism in epileptic and psychiatric patients
Reynolds, E. H., Preece, J., Johnson, A. L.
Serum and red cell folate levels and serum vitamin B12 levels have been estimated in 33 normal controls; 34 epileptic outpatients, 19 of whom also suffered from psychiatric illness; 33 epileptic...
The early treatment and prognosis of epilepsy.
Recent community- and hospital-based studies of epilepsy from its onset suggest a much better prognosis than previously recognized, with about three-quarters of patients entering long-term remission...