E. Jeffrey Metter

Gait speed under varied challenges and cognitive decline in older persons: a prospective study (2009)

Deshpande, Nandini, Metter, E. Jeffrey, Bandinelli, Stefania, Guralnik, Jack, Ferrucci, Luigi

Objective: to examine whether usual gait speed, fast gait speed or speed while walking with a cognitive or neuromuscular challenge predicts evolving cognitive decline over 3 years. Design:...

Association of Adiposity Status and Changes in Early to Mid-Adulthood With Incidence of Alzheimer's Disease (2008)

Beydoun, May A., Lhotsky, April, Wang, Youfa, Forno, Gloria Dal, An, Yang, Metter, E. Jeffrey, ...

Adiposity status and change are potential risk factors for Alzheimer's disease (AD). The authors used data on 2,322 participants in the Baltimore Longitudinal Study of Aging to analyze the relation...

Detection of Life-Threatening Prostate Cancer With Prostate-Specific Antigen Velocity During a Window of Curability (2006)

Carter, H. Ballentine, Ferrucci, Luigi, Kettermann, Anna, Landis, Patricia, Wright, E. James, Epstein, Jonathan I., ...

Background: Prostate-specific antigen (PSA) level is typically used as a dichotomous test for prostate cancer, resulting in overdiagnosis for a substantial number of men. The rate at which serum PSA...

The relationship between ciliary neurotrophic factor (CNTF) genotype and motor unit physiology: preliminary studies (2005)

Conwit, Robin A, Ling, Shari, Roth, Stephen, Stashuk, Daniel, Hurley, Ben, Ferrell, Robert, ...

Abstract Background Ciliary neurotrophic factor (CNTF) is important for neuronal and muscle development, and genetic variation in the CNTF gene has been associated with muscle strength. The effect of...

One-year Age Changes in MRI Brain Volumes in Older Adults (2000)

Resnick, Susan M., Goldszal, Alberto F., Davatzikos, Christos, Golski, Stephanie, Kraut, Michael A., Metter, E. Jeffrey, ...

Longitudinal studies indicate that declines in cognition and memory accelerate after age 70 years. The neuroanatomic and neurophysiologic underpinnings of cognitive change are unclear, as there is...

A new xeroderma pigmentosum group C poly(AT) insertion/deletion polymorphism (2000)

Khan, Sikandar G., Metter, E.Jeffrey, Tarone, Robert E., Bohr, Vilhelm A., Grossman, Lawrence, Hedayati, Mohammad, ...

We found a common biallelic polymorphism (PAT) in the xeroderma pigmentosum complementation group C (XPC) DNA repair gene consisting of an insertion of 83 bases of A and T [poly(AT)] and a...

Prostate-Specific Antigen Testing of Older Men (1999)

Carter, H. Ballentine, Landis, Patricia K., Metter, E. Jeffrey, Fleisher, Lee A., Pearson, Jay D.

BACKGROUND: Elevated serum prostate-specific antigen (PSA) levels are predictive of a future diagnosis of prostate cancer. To test the hypothesis that older men with low PSA levels may require less...

Capsid Size and Deoxyribonucleic Acid Length: the Petite Variant of Bacteriophage T4

Eiserling, Frederick A., Geiduschek, E. Peter, Epstein, Richard H., Metter, E. Jeffrey

A mutant which produces a small-headed (“petite”) variant of bacteriophage T4 is described. The mutation (E920g) maps in a new gene (66) between genes 23 and 24. Petite phage particles composed...

Capsid Size and Deoxyribonucleic Acid Length: the Petite Variant of Bacteriophage T4

Eiserling, Frederick A., Geiduschek, E. Peter, Epstein, Richard H., Metter, E. Jeffrey

A mutant which produces a small-headed (“petite”) variant of bacteriophage T4 is described. The mutation (E920g) maps in a new gene (66) between genes 23 and 24. Petite phage particles composed...

TNF promoter polymorphisms associated with muscle phenotypes in humans

Liu, Dongmei, Metter, E. Jeffrey, Ferrucci, Luigi, Roth, Stephen M.

Tumor necrosis factor-α (TNF-α) is a potent catabolic factor to skeletal muscle. Single-nucleotide polymorphisms (SNPs) in the promoter region of the TNF-α coding gene, TNF, have been implicated...

Sequential Use of Transcriptional Profiling, Expression Quantitative Trait Mapping, and Gene Association Implicates MMP20 in Human Kidney Aging

Wheeler, Heather E., Metter, E. Jeffrey, Tanaka, Toshiko, Absher, Devin, Higgins, John, Zahn, Jacob M., ...

Kidneys age at different rates, such that some people show little or no effects of aging whereas others show rapid functional decline. We sequentially used transcriptional profiling and expression...

ACTN3 genotype is associated with muscle phenotypes in women across the adult age span

Walsh, Sean, Liu, Dongmei, Metter, E. Jeffrey, Ferrucci, Luigi, Roth, Stephen M.

The R577X polymorphism in the α-actinin-3 encoding gene (ACTN3) has been associated with elite athletic performance, and recently with differences in isometric and dynamic muscle strength and power...