Monocyte procoagulant activity in glomerulonephritis associated with systemic lupus erythematosus.
Cole, E H, Schulman, J, Urowitz, M, Keystone, E, Williams, C, Levy, G A
Monocyte infiltration and activation of the coagulation system have been implicated in the pathophysiology of glomerulonephritis. In this study, spontaneous procoagulant activity (PCA) was measured...
Monocyte procoagulant activity in glomerulonephritis associated with systemic lupus erythematosus.
Cole, E H, Schulman, J, Urowitz, M, Keystone, E, Williams, C, Levy, G A
Monocyte infiltration and activation of the coagulation system have been implicated in the pathophysiology of glomerulonephritis. In this study, spontaneous procoagulant activity (PCA) was measured...
Infliximab in active early rheumatoid arthritis
Breedveld, F, Emery, P, Keystone, E, Patel, K, Furst, D, Kalden, J, ...
Objective: To examine the impact of the combination of infliximab plus methotrexate (MTX) on the progression of structural damage in patients with early rheumatoid arthritis (RA).
Access to disease modifying treatments for rheumatoid arthritis patients
FURST, D, BREEDVELD, F, BURMESTER, G, CROFFORD, L, EMERY, P, FELDMAN, M, ...
FURST, D, KEYSTONE, E, BREEDVELD, F, KALDEN, J, SMOLEN, J, ANTONI, C, ...
Furst, D, Breedveld, F, Kalden, J, Smolen, J, Antoni, C, Bijlsma, J, ...
Matsubayashi, S, Akasu, F, Kasuga, Y, Snow, K, Keystone, E, Volpé, R
The production of interferon-gamma (IFN-gamma) by peripheral blood mononuclear cells (PBMC), CD4 cells, or CD8 cells in response to interleukin-2 (IL-2) stimulation has been studied; the samples were...
Aberrations in lymphocyte subpopulations and function during psychological stress.
Dorian, B, Garfinkel, P, Brown, G, Shore, A, Gladman, D, Keystone, E
Eight trainees in psychiatry taking their final oral fellowship examinations were compared with 16 controls to determine the effect of stress on their immune system. Two measures of stress were...
Impaired antigen-specific suppressor cell activity in patients with systemic lupus erythematosus.
Gladman, D, Keystone, E, Urowitz, M, Cane, D, Poplonski, L
Antigen-specific suppressor cell activity of peripheral blood mononuclear cells was investigated in twenty-nine patients with systemic lupus erythematosus (SLE) and sixteen normal, age- and...
Broder, I., Baumal, R., Keystone, E.
We have defined criteria for distinguishing several macromolecular histamine releasers derived from serum. The agents characterized were aggregated γ-globulin (AGG), soluble antigen–antibody...
The utility of tumour necrosis factor blockade in orphan diseases
A variety of rheumatic disorders have been successfully treated with tumour necrosis factor (TNF) blockers. However, TNF blockade may be useful in a number of rare diseases. Preliminary data suggest...