Investigation of the role of Kv1.3 as a potential regulator of peripheral insulin sensitivity (2006)
Gillings, A. S., Yang, J., Marley, A. E., Holman, G. D., Peckham, M., Kilgour, E., ...
Subcellular localization and hormone sensitivity of adipocyte cyclic AMP phosphodiesterase.
Anderson, N G, Kilgour, E, Houslay, M D
Treatment of intact adipocytes with either or both insulin and adrenaline stimulated membrane cyclic AMP phosphodiesterase activity only in the endoplasmic reticulum subfraction. The cyclic...
Vernon, R G, Doris, R, Finley, E, Houslay, M D, Kilgour, E, Lindsay-Watt, S
The effect of lactation on the regulation of lipolysis by beta- and alpha 2-adrenergic agents and by adenosine has been investigated. When changes in adipocyte mean cell volume (which decreases with...
Doris, R, Vernon, R G, Houslay, M D, Kilgour, E
The effect of growth hormone (GH) in vivo on the Gi-mediated anti-lipolytic signalling system of rat adipocytes has been investigated. Lowering of serum GH levels, by treatment of rats with an...
Kilgour, E, Anderson, N G, Houslay, M D
Incubation of a hepatocyte particulate fraction with ATP and the isolated catalytic unit of cyclic AMP-dependent protein kinase (A-kinase) selectively activated the high-affinity 'dense-vesicle'...
Catecholamine activation of pyruvate dehydrogenase in white adipose tissue of the rat in vivo.
Intraperitoneal injections of noradrenaline or adrenaline into rats increased the proportion of pyruvate dehydrogenase in the active state in white adipose tissue; this effect of catecholamines was...
Changes are described in the total pyruvate dehydrogenase (PDH) activity, the proportion of PDH in the active state and its control by insulin and noradrenaline in vivo, in white adipose tissue,...
1. The mechanism responsible for the failure of insulin to activate pyruvate dehydrogenase (PDH) in white adipose tissue in vivo during lactation was investigated. 2. Insulin failed to increase PDH...
Kilgour, E, Gout, I, Anderson, N G
Pituitary growth hormone (GH) co-ordinately stimulates three distinct signalling pathways in 3T3-F442A preadipocytes, the STAT (signal transducer and activator of transcription) pathway, the...
MacKenzie, S, Fleming, I, Houslay, M D, Anderson, N G, Kilgour, E
Previous studies have shown that the activation of p44 and p42 mitogen-activated protein (MAP) kinases (ERK1 and ERK2) by growth hormone (GH) and phorbol esters, but not by epidermal growth factor,...
Protein kinase C isoforms play differential roles in the regulation of adipocyte differentiation.
Fleming, I, MacKenzie, S J, Vernon, R G, Anderson, N G, Houslay, M D, Kilgour, E
In this study we first established, by immunoblotting with specific antibodies, the temporal changes in cellular levels of protein kinase C (PKC) isoforms during differentiation of 3T3-F442A...
Subcellular localization and hormone sensitivity of adipocyte cyclic AMP phosphodiesterase.
Anderson, N G, Kilgour, E, Houslay, M D
Treatment of intact adipocytes with either or both insulin and adrenaline stimulated membrane cyclic AMP phosphodiesterase activity only in the endoplasmic reticulum subfraction. The cyclic...
Vernon, R G, Doris, R, Finley, E, Houslay, M D, Kilgour, E, Lindsay-Watt, S
The effect of lactation on the regulation of lipolysis by beta- and alpha 2-adrenergic agents and by adenosine has been investigated. When changes in adipocyte mean cell volume (which decreases with...
Doris, R, Vernon, R G, Houslay, M D, Kilgour, E
The effect of growth hormone (GH) in vivo on the Gi-mediated anti-lipolytic signalling system of rat adipocytes has been investigated. Lowering of serum GH levels, by treatment of rats with an...
Kilgour, E, Anderson, N G, Houslay, M D
Incubation of a hepatocyte particulate fraction with ATP and the isolated catalytic unit of cyclic AMP-dependent protein kinase (A-kinase) selectively activated the high-affinity 'dense-vesicle'...
Catecholamine activation of pyruvate dehydrogenase in white adipose tissue of the rat in vivo.
Intraperitoneal injections of noradrenaline or adrenaline into rats increased the proportion of pyruvate dehydrogenase in the active state in white adipose tissue; this effect of catecholamines was...
Changes are described in the total pyruvate dehydrogenase (PDH) activity, the proportion of PDH in the active state and its control by insulin and noradrenaline in vivo, in white adipose tissue,...
1. The mechanism responsible for the failure of insulin to activate pyruvate dehydrogenase (PDH) in white adipose tissue in vivo during lactation was investigated. 2. Insulin failed to increase PDH...
Kilgour, E, Gout, I, Anderson, N G
Pituitary growth hormone (GH) co-ordinately stimulates three distinct signalling pathways in 3T3-F442A preadipocytes, the STAT (signal transducer and activator of transcription) pathway, the...
MacKenzie, S, Fleming, I, Houslay, M D, Anderson, N G, Kilgour, E
Previous studies have shown that the activation of p44 and p42 mitogen-activated protein (MAP) kinases (ERK1 and ERK2) by growth hormone (GH) and phorbol esters, but not by epidermal growth factor,...
Protein kinase C isoforms play differential roles in the regulation of adipocyte differentiation.
Fleming, I, MacKenzie, S J, Vernon, R G, Anderson, N G, Houslay, M D, Kilgour, E
In this study we first established, by immunoblotting with specific antibodies, the temporal changes in cellular levels of protein kinase C (PKC) isoforms during differentiation of 3T3-F442A...