Evidence from in vitro replication that O6-methylguanine can adopt multiple conformations.
Dosanjh, M K, Loechler, E L, Singer, B
The effect of O6-methylguanine (m6G) on replication, in a partially double-stranded defined 25-base oligonucleotide, has been studied under nonlimiting conditions of unmodified dNTPs and over an...
Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies.
Basu, A K, Loechler, E L, Leadon, S A, Essigmann, J M
The mutational specificity and genetic requirements for mutagenesis by 5,6-dihydroxy-5,6-dihydrothymine (thymine glycol), one of the principal DNA lesions induced by oxidation and ionizing radiation,...
Green, C L, Loechler, E L, Fowler, K W, Essigmann, J M
Organic synthesis and recombinant DNA technology were used to situate a putatively premutagenic DNA lesion, O6-methylguanine (O6MeGua), at a specific location in the genomes of two bacterial viruses,...
In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome.
Loechler, E L, Green, C L, Essigmann, J M
The mutagenicity of O6-methylguanine (O6MeGua), a chemical carcinogen-DNA adduct, has been studied in vivo by using a single-stranded M13mp8 genome in which a single O6MeGua residue was positioned in...
The precautionary principle in environmental science.
Kriebel, D, Tickner, J, Epstein, P, Lemons, J, Levins, R, Loechler, E L, ...
Environmental scientists play a key role in society's responses to environmental problems, and many of the studies they perform are intended ultimately to affect policy. The precautionary principle,...
Essigmann, J M, Fowler, K W, Green, C L, Loechler, E L
This work examines the mutagenic activity of O6-methylguanine (O6MeGua), a DNA adduct formed by certain carcinogenic alkylating agents. A tetranucleotide, 5'-HOTpm6GpCpA-3', was synthesized and...
Evidence from in vitro replication that O6-methylguanine can adopt multiple conformations.
Dosanjh, M K, Loechler, E L, Singer, B
The effect of O6-methylguanine (m6G) on replication, in a partially double-stranded defined 25-base oligonucleotide, has been studied under nonlimiting conditions of unmodified dNTPs and over an...
Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies.
Basu, A K, Loechler, E L, Leadon, S A, Essigmann, J M
The mutational specificity and genetic requirements for mutagenesis by 5,6-dihydroxy-5,6-dihydrothymine (thymine glycol), one of the principal DNA lesions induced by oxidation and ionizing radiation,...
Green, C L, Loechler, E L, Fowler, K W, Essigmann, J M
Organic synthesis and recombinant DNA technology were used to situate a putatively premutagenic DNA lesion, O6-methylguanine (O6MeGua), at a specific location in the genomes of two bacterial viruses,...
In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome.
Loechler, E L, Green, C L, Essigmann, J M
The mutagenicity of O6-methylguanine (O6MeGua), a chemical carcinogen-DNA adduct, has been studied in vivo by using a single-stranded M13mp8 genome in which a single O6MeGua residue was positioned in...
The precautionary principle in environmental science.
Kriebel, D, Tickner, J, Epstein, P, Lemons, J, Levins, R, Loechler, E L, ...
Environmental scientists play a key role in society's responses to environmental problems, and many of the studies they perform are intended ultimately to affect policy. The precautionary principle,...
Essigmann, J M, Fowler, K W, Green, C L, Loechler, E L
This work examines the mutagenic activity of O6-methylguanine (O6MeGua), a DNA adduct formed by certain carcinogenic alkylating agents. A tetranucleotide, 5'-HOTpm6GpCpA-3', was synthesized and...