Aerosol and parenteral pneumocandins are effective in a rat model of pulmonary aspergillosis.
Kurtz, M B, Bernard, E M, Edwards, F F, Marrinan, J A, Dropinski, J, Douglas, C M, ...
The pneumocandins are semisynthetic analogs of echinocandin-like compounds that have shown efficacy in animal models of systemic candidiasis, disseminated aspergillosis, and pneumocystis pneumonia....
Cicogna, C E, White, M H, Bernard, E M, Ishimura, T, Sun, M, Tong, W P, ...
Invasive pulmonary aspergillosis remains an important cause of morbidity and mortality among transplant recipients and patients receiving cancer chemotherapy. The lipid-associated formulation of...
Murphy, M, Bernard, E M, Ishimaru, T, Armstrong, D
Voriconazole, a new azole antifungal agent, showed potent activity against clinical isolates of Aspergillus spp. in vitro. For A. fumigatus, the MIC range was < 0.03 to 0.5 microgram/ml and the MIC...
Antimicrobial activities of squalamine mimics.
Kikuchi, K, Bernard, E M, Sadownik, A, Regen, S L, Armstrong, D
We investigated the antimicrobial properties of compounds with structural features that were designed to mimic those of squalamine, an antibiotic isolated from the stomach of the dogfish shark. The...
Pharmacokinetics of aerosol amphotericin B in rats.
Niki, Y, Bernard, E M, Schmitt, H J, Tong, W P, Edwards, F F, Armstrong, D
The distributions of amphotericin B (AmB) in tissue were compared after intraperitoneal or aerosol administration. Rats were sacrificed 24 h after receiving single or repeated daily doses; AmB...
MIC and fungicidal activity of terbinafine against clinical isolates of Aspergillus spp.
Schmitt, H J, Bernard, E M, Andrade, J, Edwards, F, Schmitt, B, Armstrong, D
Terbinafine and amphotericin B MICs for 90% of strains tested were 1.6 and 0.4 micrograms/ml against Aspergillus fumigatus (16 strains), 0.8 and 3.2 micrograms/ml against Aspergillus flavus (10...
Schmitt, H J, Bernard, E M, Häuser, M, Armstrong, D
Invasive pulmonary aspergillosis is a major life-threatening complication among transplant recipients and patients receiving cancer chemotherapy. In a rat model of progressive pulmonary aspergillosis...
Mayo, J B, Kiehn, T E, Wong, B, Bernard, E M, Armstrong, D
Seven Pseudomonas aeruginosa strains found to be susceptible to gentamicin by the Autobac I system and resistant by the Bauer-Kirby disk diffusion method were tested for the presence of mixed...
Brown, S T, Edwards, F F, Bernard, E M, Tong, W, Armstrong, D
Azithromycin, rifabutin, and rifapentine were used to treat or prevent disseminated Mycobacterium avium complex (MAC) infections produced in rats immunosuppressed with cyclosporine. Animals with...
Activities of antimicrobial agents against clinical isolates of Mycobacterium haemophilum.
Bernard, E M, Edwards, F F, Kiehn, T E, Brown, S T, Armstrong, D
Mycobacterium haemophilum, first described in 1978, can cause severe infections of skin, respiratory tract, bone, and other organs of immunocompromised patients. There is no standardized...
Restriction fragment length polymorphism analysis of clinical isolates of Mycobacterium haemophilum.
Kikuchi, K, Bernard, E M, Kiehn, T E, Armstrong, D, Riley, L W
Mycobacterium haemophilum is an emerging opportunistic pathogen, and since 1989, infections caused by this organism have been identified more frequently in the New York City area than in any other...
Evaluation of the Quantum II yeast identification system.
Kiehn, T E, Edwards, F F, Tom, D, Lieberman, G, Bernard, E M, Armstrong, D
We compared three methods for identifying clinical yeast isolates: Abbott Quantum II, API 20C, and a modified BBL Minitek system. The API 20C and modified Minitek systems agreed on the identification...
Model of recurrent pulmonary aspergillosis in rats.
Niki, Y, Bernard, E M, Edwards, F F, Schmitt, H J, Yu, B, Armstrong, D
Male Sprague-Dawley rats were treated with cortisone acetate and fed a low-protein diet for 3 weeks. At the end of week 2, animals were infected intratracheally with 10(5) conidia of Aspergillus...
Evaluation of the aldononitrile peracetate method for measuring arabinitol in serum.
Wong, B, Bernard, E M, Armstrong, D, Roboz, J, Suzuki, R, Holland, J F
Kiehn, T E, Nelson, P E, Bernard, E M, Edwards, F F, Koziner, B, Armstrong, D
A case of catheter-associated fungemia caused by Fusarium chlamydosporum is described in a patient with lymphocytic lymphoma. The fungus, which has been isolated from soil but not reported to cause...
Rate of arabinitol production by pathogenic yeast species.
Bernard, E M, Christiansen, K J, Tsang, S F, Kiehn, T E, Armstrong, D
D-Arabinitol is a five-carbon polyol that is produced by many fungi. Detection of the metabolite has been reported in serum from patients with invasive candidiasis. We studied the production and...
Bone infection caused by debaryomyces hansenii in a normal host: a case report.
Wong, B, Kiehn, T E, Edwards, F, Bernard, E M, Marcove, R C, De Harven, E, ...
Debaryomyces hansenii was isolated from a cystic lesion in the distal tibia of a healthy 23-year-old woman. Ascospores were demonstrated when the organism was incubated at 25 but not at 30 degrees C....
Aerosol and parenteral pneumocandins are effective in a rat model of pulmonary aspergillosis.
Kurtz, M B, Bernard, E M, Edwards, F F, Marrinan, J A, Dropinski, J, Douglas, C M, ...
The pneumocandins are semisynthetic analogs of echinocandin-like compounds that have shown efficacy in animal models of systemic candidiasis, disseminated aspergillosis, and pneumocystis pneumonia....
Cicogna, C E, White, M H, Bernard, E M, Ishimura, T, Sun, M, Tong, W P, ...
Invasive pulmonary aspergillosis remains an important cause of morbidity and mortality among transplant recipients and patients receiving cancer chemotherapy. The lipid-associated formulation of...
Murphy, M, Bernard, E M, Ishimaru, T, Armstrong, D
Voriconazole, a new azole antifungal agent, showed potent activity against clinical isolates of Aspergillus spp. in vitro. For A. fumigatus, the MIC range was < 0.03 to 0.5 microgram/ml and the MIC...
Antimicrobial activities of squalamine mimics.
Kikuchi, K, Bernard, E M, Sadownik, A, Regen, S L, Armstrong, D
We investigated the antimicrobial properties of compounds with structural features that were designed to mimic those of squalamine, an antibiotic isolated from the stomach of the dogfish shark. The...
Pharmacokinetics of aerosol amphotericin B in rats.
Niki, Y, Bernard, E M, Schmitt, H J, Tong, W P, Edwards, F F, Armstrong, D
The distributions of amphotericin B (AmB) in tissue were compared after intraperitoneal or aerosol administration. Rats were sacrificed 24 h after receiving single or repeated daily doses; AmB...
MIC and fungicidal activity of terbinafine against clinical isolates of Aspergillus spp.
Schmitt, H J, Bernard, E M, Andrade, J, Edwards, F, Schmitt, B, Armstrong, D
Terbinafine and amphotericin B MICs for 90% of strains tested were 1.6 and 0.4 micrograms/ml against Aspergillus fumigatus (16 strains), 0.8 and 3.2 micrograms/ml against Aspergillus flavus (10...
Schmitt, H J, Bernard, E M, Häuser, M, Armstrong, D
Invasive pulmonary aspergillosis is a major life-threatening complication among transplant recipients and patients receiving cancer chemotherapy. In a rat model of progressive pulmonary aspergillosis...
Mayo, J B, Kiehn, T E, Wong, B, Bernard, E M, Armstrong, D
Seven Pseudomonas aeruginosa strains found to be susceptible to gentamicin by the Autobac I system and resistant by the Bauer-Kirby disk diffusion method were tested for the presence of mixed...
Brown, S T, Edwards, F F, Bernard, E M, Tong, W, Armstrong, D
Azithromycin, rifabutin, and rifapentine were used to treat or prevent disseminated Mycobacterium avium complex (MAC) infections produced in rats immunosuppressed with cyclosporine. Animals with...
Activities of antimicrobial agents against clinical isolates of Mycobacterium haemophilum.
Bernard, E M, Edwards, F F, Kiehn, T E, Brown, S T, Armstrong, D
Mycobacterium haemophilum, first described in 1978, can cause severe infections of skin, respiratory tract, bone, and other organs of immunocompromised patients. There is no standardized...
Restriction fragment length polymorphism analysis of clinical isolates of Mycobacterium haemophilum.
Kikuchi, K, Bernard, E M, Kiehn, T E, Armstrong, D, Riley, L W
Mycobacterium haemophilum is an emerging opportunistic pathogen, and since 1989, infections caused by this organism have been identified more frequently in the New York City area than in any other...
Evaluation of the Quantum II yeast identification system.
Kiehn, T E, Edwards, F F, Tom, D, Lieberman, G, Bernard, E M, Armstrong, D
We compared three methods for identifying clinical yeast isolates: Abbott Quantum II, API 20C, and a modified BBL Minitek system. The API 20C and modified Minitek systems agreed on the identification...
Model of recurrent pulmonary aspergillosis in rats.
Niki, Y, Bernard, E M, Edwards, F F, Schmitt, H J, Yu, B, Armstrong, D
Male Sprague-Dawley rats were treated with cortisone acetate and fed a low-protein diet for 3 weeks. At the end of week 2, animals were infected intratracheally with 10(5) conidia of Aspergillus...
Evaluation of the aldononitrile peracetate method for measuring arabinitol in serum.
Wong, B, Bernard, E M, Armstrong, D, Roboz, J, Suzuki, R, Holland, J F
Kiehn, T E, Nelson, P E, Bernard, E M, Edwards, F F, Koziner, B, Armstrong, D
A case of catheter-associated fungemia caused by Fusarium chlamydosporum is described in a patient with lymphocytic lymphoma. The fungus, which has been isolated from soil but not reported to cause...
Rate of arabinitol production by pathogenic yeast species.
Bernard, E M, Christiansen, K J, Tsang, S F, Kiehn, T E, Armstrong, D
D-Arabinitol is a five-carbon polyol that is produced by many fungi. Detection of the metabolite has been reported in serum from patients with invasive candidiasis. We studied the production and...
Bone infection caused by debaryomyces hansenii in a normal host: a case report.
Wong, B, Kiehn, T E, Edwards, F, Bernard, E M, Marcove, R C, De Harven, E, ...
Debaryomyces hansenii was isolated from a cystic lesion in the distal tibia of a healthy 23-year-old woman. Ascospores were demonstrated when the organism was incubated at 25 but not at 30 degrees C....