Scientific Commons: E. M. Hol

A direct androgenic involvement in the expression of human corticotropin-releasing hormone (2006)

Bao, A.M, Fischer, D.F., Wu, Y.H., Hol, E.M., Balesar, R., Unmehopa, U.A., ...

We investigated the possibility of a direct action of androgens on the expression of the human corticotropin-releasing hormone (CRH), which plays a central role in the hypothalamic pituitary-adrenal...

Ubiquitin proteasome system as a pharmacological target in neurodegeneration (2006)

Hol, E.M., Fischer, D.F., Ovaa, H., Scheper, W.

hUPF2 silencing identifies physiologic substrates of mammalian nonsense-mediated mRNA decay (2006)

Wittmann, J., Hol, E.M., Jack, H.M.

Nonsense-mediated mRNA decay (NMD) is a conserved eukaryotic surveillance pathway that selectively degrades aberrant mRNAs with premature termination codons (PTCs). Although a small number of cases...

Frameshift proteins in autosomal dominant forms of Alzheimer disease and other tauopathies (2006)

Leeuwen, F.W. Van, Tijn, P. Van, Sonnemans, M.A.F., Hobo, B., Mann, D.M.A., Broeckhoven, C. Van, ...

Alzheimer-associated APP+1 transgenic mice: Frameshift beta-amyloid precursor protein is secreted in cerebrospinal fluid without inducing neuropathology (2006)

Fischer, D.F., Hol, E.M., Hobo, B., Leeuwen, F.W. Van

Biomarkers present in the cerebrospinal fluid (CSF) of Alzheimer Disease patients could be instrumental in guiding diagnosis and monitoring of progression of the disease. We have previously reported...

Molecular misreading: the frequency of dinucleotide deletions in neuronal mRNAs for beta-amyloid precursor protein and ubiquitin B (2005)

Gerez, L., Haan, A. De, Hol, E.M., Fischer, D.F., Leeuwen, F.W. Van, Steeg, H. Van, ...

Protein quality control in Alzheimer's disease: a fatal saviour (2005)

Scheper, W., Hol, E.M.

Diminished aromatase immunoreactivity in the hypothalamus, but not in the basal forebrain nuclei in Alzheimer's disease (2005)

Ishunina, T.A., Beurden, D. Van, Meulen, G. Van Der, Unmehopa, U.A., Hol, E.M., Huitinga, I., ...

Frameshifted beta-amyloid precursor protein (APP+1) is a secretory protein, and the level of APP+1 in cerebrospinal fluid is linked to Alzheimer pathology (2003)

Hol, E.M., Dijk, R. Van, Gerez, L., Sluijs, J.A., Hobo, B., Tonk, M.T., ...

+1 Proteins and aging (2002)

Leeuwen, F.W. Van, Gerez, L., Benne, R., Hol, E.M.

Molecular misreading: a new type of transcript mutation expressed during aging (2000)

Leeuwen, F.W. Van, Kamel, D., Sluijs, J.A., Sonnemans, M.A.F., Fischer, D.F., Benne, R., ...