E. Michelle Southard-Smith

Distant regulatory elements in a Sox10-ΒGEO BAC transgene are required for expression of Sox10 in the enteric nervous system and other neural crest-derived tissues (2006)

Deal, Karen K., Cantrell, V. Ashley, Chandler, Ronald L., Saunders, Thomas L., Mortlock, Douglas P., Southard-Smith, E. Michelle

Sox10 is an essential transcription factor required for development of neural crest-derived melanocytes, peripheral glia, and enteric ganglia. Multiple transcriptional targets regulated by Sox10 have...

Genome-wide linkage identifies novel modifier loci of aganglionosis in the Sox10Dom model of Hirschsprung disease (2005)

Owens, Sarah E., Broman, Karl W., Wiltshire, Tim, Elmore, J. Bradford, Bradley, Kevin M., Smith, Jeffrey R., ...

Hirschsprung disease (HSCR) is a complex disorder that exhibits incomplete penetrance and variable expressivity due to interactions among multiple susceptibility genes. Studies in HSCR families have...

Genome-wide Linkage Identifies Novel Modifier Loci of Aganglionosis in the Sox10Dom Model of Hirschsprung Disease (2005)

Owens, Sarah E., Broman, Karl W., Wiltshire, Tim, Elmore, J. Bradford, Bradley, Kevin M., Smith, Jeffrey R., ...

Hirschsprung disease (HSCR) is a complex disorder that exhibits incomplete penetrance and variable expressivity due to interactions among multiple susceptibility genes. Studies in HSCR families have...

Interactions between Sox10 and EdnrB modulate penetrance and severity of aganglionosis in the Sox10Dom mouse model of Hirschsprung disease (2004)

Cantrell, V. Ashley, Owens, Sarah E., Chandler, Ronald L., Airey, David C., Bradley, Kevin M., Smith, Jeffrey R., ...

Cumulative evidence suggests Hirschsprung disease (HSCR) is the consequence of multiple gene interactions that modulate the ability of enteric neural crest cells to populate the developing gut. One...

Interactions between Sox10 and EdnrB modulate penetrance and severity of aganglionosis in the Sox10Dom mouse model of Hirschsprung disease (2004)

Cantrell, V. Ashley, Owens, Sarah E., Chandler, Ronald L., Airey, David C., Bradley, Kevin M., Smith, Jeffrey R., ...

Cumulative evidence suggests that Hirschsprung disease (HSCR) is the consequence of multiple gene interactions that modulate the ability of enteric neural crest (NC) cells to populate the developing...

Interactions between Sox10 and EdnrB modulate penetrance and severity of aganglionosis in the Sox10Dom mouse model of Hirschsprung disease (2004)

Cantrell, V. Ashley, Owens, Sarah E., Chandler, Ronald L., Airey, David C., Bradley, Kevin M., Smith, Jeffrey R., ...

Interactions between Sox10 and EdnrB modulate penetrance and severity of aganglionosis in the Sox10Dom mouse model of Hirschsprung disease (2004)

Cantrell, V. Ashley, Owens, Sarah E., Chandler, Ronald L., Airey, David C., Bradley, Kevin M., Smith, Jeffrey R., ...

Cumulative evidence suggests Hirschsprung disease (HSCR) is the consequence of multiple gene interactions that modulate the ability of enteric neural crest cells to populate the developing gut. One...

The Sox10Dom Mouse: Modeling the Genetic Variation of Waardenburg-Shah (WS4) Syndrome (1999)

Southard-Smith, E. Michelle, Angrist, Misha, Ellison, Jane S., Agarwala, Richa, Baxevanis, Andreas D., Chakravarti, Aravinda, ...

Coordinate control and variation in X-linked gene expression among female mice (1997)

Burke, David T., Greenwood, Alex D., Southard-Smith, E. Michelle, Galecki, Andrzej T.

In normal female mammals, one of the two X Chromosome (Chr) homologs per cell is silenced coordinately during early embryogenesis. The genes located on the inactivated X homolog are predicted to be...

The X Chromosome in Quantitative Trait Locus Mapping

Broman, Karl W., Sen, Śaunak, Owens, Sarah E., Manichaikul, Ani, Southard-Smith, E. Michelle, Churchill, Gary A.

The X chromosome requires special treatment in the mapping of quantitative trait loci (QTL). However, most QTL mapping methods, and most computer programs for QTL mapping, have focused exclusively on...