Ando, M., Kawamura, Seiji, Nakamura, T., Tsubono, K., Tanaka, T., Funaki, I., ...
DECIGO pathfinder (DPF) is a milestone satellite mission for DECIGO (DECi-hertz Interferometer Gravitational wave Observatory) which is a future space gravitational wave antenna. DECIGO is expected...
The Japanese space gravitational wave antenna: DECIGO (2008)
Kawamura, Seiji, Ando, M., Nakamura, T., Tsubono, K., Tanaka, T., Funaki, I., ...
DECi-hertz Interferometer Gravitational wave Observatory (DECIGO) is the future Japanese space gravitational wave antenna. DECIGO is expected to open a new window of observation for gravitational...
The Japanese space gravitational wave antenna - DECIGO (2008)
Kawamura, Seiji, Ando, M., Nakamura, T., Tsubono, K., Tanaka, T., Funaki, I., ...
DECi-hertz Interferometer Gravitational wave Observatory (DECIGO) is the future Japanese space gravitational wave antenna. The goal of DECIGO is to detect gravitational waves from various kinds of...
Wang Zhai Ferrell, Trends Cell Biol, A. W. Murray, A. W. Murray, Curr Opin, ...
ine triphosphate (ATP) and 15 mM MgCl 2 . ATF2 (5 mg) and [g- P]ATP (1 mCi) were then added to the mixture, which was incubated for 10 min. Phosphorylated ATF2 was detected by electrophoresis and...
Degradation of c-Fos by the 26S proteasome is accelerated by c-Jun and multiple protein kinases.
Tsurumi, C, Ishida, N, Tamura, T, Kakizuka, A, Nishida, E, Okumura, E, ...
c-Fos is associated with c-Jun to increase the transcription of a number of target genes and is a nuclear proto-oncoprotein with a very short half-life. This instability of c-Fos may be important in...
Toda, T, Dhut, S, Superti-Furga, G, Gotoh, Y, Nishida, E, Sugiura, R, ...
We have isolated a gene, pmk1+, a third mitogen-activated protein kinase (MAPK) gene homolog from the fission yeast Schizosaccharomyces pombe. The predicted amino acid sequence shows the most...
Phosphorylation of the RNA polymerase II largest subunit during Xenopus laevis oocyte maturation.
Bellier, S, Dubois, M F, Nishida, E, Almouzni, G, Bensaude, O
Xenopus laevis oogenesis is characterized by an active transcription which ceases abruptly upon maturation. To survey changes in the characteristics of the transcriptional machinery which might...
Cofilin is a component of intranuclear and cytoplasmic actin rods induced in cultured cells.
Nishida, E, Iida, K, Yonezawa, N, Koyasu, S, Yahara, I, Sakai, H
Incubation of cultured cells under specific conditions induces a dramatic change in the actin organization: induction of intranuclear and/or cytoplasmic actin rods (actin paracrystal-like...
A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C.
Lee, K S, Irie, K, Gotoh, Y, Watanabe, Y, Araki, H, Nishida, E, ...
Mitogen-activated protein (MAP) kinases are activated in response to a variety of stimuli through a protein kinase cascade that results in their phosphorylation on tyrosine and threonine residues....
Gotoh, Y, Nishida, E, Shimanuki, M, Toda, T, Imai, Y, Yamamoto, M
Mitogen-activated protein kinase (MAPK) and its direct activator, MAPK kinase (MAPKK), have been suggested to play a pivotal role in a variety of signal transduction pathways in higher eukaryotes....
Two mammalian heat shock proteins, HSP90 and HSP100, are actin-binding proteins.
Koyasu, S, Nishida, E, Kadowaki, T, Matsuzaki, F, Iida, K, Harada, F, ...
Two high molecular weight heat shock proteins, HSP90 (Mr, 90,000) and HSP100 (Mr, 100,000), were separately purified from extracts of cultured cells of a mouse lymphoma cell line, L5178Y. Both of the...
Requirement for the MAP kinase kinase/MAP kinase cascade in Xenopus oocyte maturation.
Kosako, H, Gotoh, Y, Nishida, E
MAP kinase kinase (MAPKK) has been identified as a protein factor that can induce phosphorylation and activation of inactive MAP kinase in vitro. In this study, we produced an anti-Xenopus MAPKK...
Involvement of the MAP kinase cascade in Xenopus mesoderm induction.
Gotoh, Y, Masuyama, N, Suzuki, A, Ueno, N, Nishida, E
Mitogen-activated protein kinase (MAPK) is activated by MAPK kinase (MAPKK) in a variety of signaling pathways. This kinase cascade has been shown to function in cell proliferation and...
cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates.
Kosako, H, Nishida, E, Gotoh, Y
A Xenopus 45 kDa protein has been identified as an immediate upstream factor sufficient for full activation of MAP kinase, and is shown to be capable of undergoing autophosphorylation on serine,...
Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF.
Gotoh, Y, Moriyama, K, Matsuda, S, Okumura, E, Kishimoto, T, Kawasaki, H, ...
MAP kinase is activated and phosphorylated during M phase of the Xenopus oocyte cell cycle, and induces the interphase-M phase transition of microtubule dynamics in vitro. We have carried out...
Matsuda, S, Kosako, H, Takenaka, K, Moriyama, K, Sakai, H, Akiyama, T, ...
MAP kinase is thought to play a pivotal role not only in the growth factor-stimulated signalling pathway but also in the M phase phosphorylation cascade downstream of MPF. MAP kinase is fully active...
Kosako, H, Gotoh, Y, Matsuda, S, Ishikawa, M, Nishida, E
Xenopus MAP kinase activator, a 45 kDa protein, has been shown to function as a direct upstream factor sufficient for full activation and both tyrosine and serine/threonine phosphorylation of...
Regulation of a major microtubule-associated protein by MPF and MAP kinase.
Shiina, N, Moriguchi, T, Ohta, K, Gotoh, Y, Nishida, E
The interphase-M phase transition of microtubule dynamics is thought to be induced by phosphorylation reactions mediated by MPF and by MAP kinase functioning downstream of MPF. We have now identified...
A novel homo-oligomeric protein responsible for an MPF-dependent microtubule-severing activity.
Shiina, N, Gotoh, Y, Nishida, E
An activity that severs stable microtubules has previously been detected in M phase extracts, but not in interphase extracts, of Xenopus eggs. We show that incubation of interphase extracts with...
Studies on the interaction between actin and cofilin purified by a new method.
Yonezawa, N, Nishida, E, Maekawa, S, Sakai, H
Cofilin is a 21,000-Mr actin-binding protein that widely exists in mammalian tissues. (1) A new purification procedure for porcine brain cofilin has been developed that involves (NH4)2SO4...
Fukuda, M, Gotoh, Y, Nishida, E
The mitogen-activated protein kinase (MAPK) cascade consisting of MAPK and its direct activator, MAPK kinase (MAPKK), is essential for signaling of various extracellular stimuli to the nucleus. Upon...
A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses.
Moriguchi, T, Toyoshima, F, Masuyama, N, Hanafusa, H, Gotoh, Y, Nishida, E
Stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK), a member of the MAP kinase (MAPK) superfamily, is thought to play a key role in a variety of cellular responses. To date,...
Role of TAK1 and TAB1 in BMP signaling in early Xenopus development.
Shibuya, H, Iwata, H, Masuyama, N, Gotoh, Y, Yamaguchi, K, Irie, K, ...
Transforming growth factor-beta (TGF-beta) superfamily members elicit signals through stimulation of serine/threonine kinase receptors. Recent studies of this signaling pathway have identified two...
Yoneyama, M, Suhara, W, Fukuhara, Y, Fukuda, M, Nishida, E, Fujita, T
It has been hypothesized that certain viral infections directly activate a transcription factor(s) which is responsible for the activation of genes encoding type I interferons (IFNs) and...
Wada, A, Fukuda, M, Mishima, M, Nishida, E
Actin is a highly conserved, ubiquitous cytoskeletal protein, which is essential for multiple cellular functions. Despite its small size (Mr = 42 000), unpolymerized forms of actin, as well as...
Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint.
Toyoshima, F, Moriguchi, T, Wada, A, Fukuda, M, Nishida, E
M-phase-promoting factor (MPF), a complex of cdc2 and a B-type cyclin, is a key regulator of the G2/M cell cycle transition. Cyclin B1 accumulates in the cytoplasm through S and G2 phases and...
Yamaguchi, K, Nagai, S, Ninomiya-Tsuji, J, Nishita, M, Tamai, K, Irie, K, ...
Signals elicited by transforming growth factor-beta (TGF-beta) superfamily ligands are generated following the formation of heteromeric receptor complexes consisting of type I and type II receptors....
Adachi, M, Fukuda, M, Nishida, E
In response to extracellular stimuli, mitogen-activated protein kinase (MAPK, also known as ERK) translocates from the cytoplasm to the nucleus. MAP kinase kinase (MAPKK, also know as MEK), which...
Degradation of c-Fos by the 26S proteasome is accelerated by c-Jun and multiple protein kinases.
Tsurumi, C, Ishida, N, Tamura, T, Kakizuka, A, Nishida, E, Okumura, E, ...
c-Fos is associated with c-Jun to increase the transcription of a number of target genes and is a nuclear proto-oncoprotein with a very short half-life. This instability of c-Fos may be important in...
Toda, T, Dhut, S, Superti-Furga, G, Gotoh, Y, Nishida, E, Sugiura, R, ...
We have isolated a gene, pmk1+, a third mitogen-activated protein kinase (MAPK) gene homolog from the fission yeast Schizosaccharomyces pombe. The predicted amino acid sequence shows the most...
Phosphorylation of the RNA polymerase II largest subunit during Xenopus laevis oocyte maturation.
Bellier, S, Dubois, M F, Nishida, E, Almouzni, G, Bensaude, O
Xenopus laevis oogenesis is characterized by an active transcription which ceases abruptly upon maturation. To survey changes in the characteristics of the transcriptional machinery which might...
Cofilin is a component of intranuclear and cytoplasmic actin rods induced in cultured cells.
Nishida, E, Iida, K, Yonezawa, N, Koyasu, S, Yahara, I, Sakai, H
Incubation of cultured cells under specific conditions induces a dramatic change in the actin organization: induction of intranuclear and/or cytoplasmic actin rods (actin paracrystal-like...
A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C.
Lee, K S, Irie, K, Gotoh, Y, Watanabe, Y, Araki, H, Nishida, E, ...
Mitogen-activated protein (MAP) kinases are activated in response to a variety of stimuli through a protein kinase cascade that results in their phosphorylation on tyrosine and threonine residues....
Gotoh, Y, Nishida, E, Shimanuki, M, Toda, T, Imai, Y, Yamamoto, M
Mitogen-activated protein kinase (MAPK) and its direct activator, MAPK kinase (MAPKK), have been suggested to play a pivotal role in a variety of signal transduction pathways in higher eukaryotes....
Two mammalian heat shock proteins, HSP90 and HSP100, are actin-binding proteins.
Koyasu, S, Nishida, E, Kadowaki, T, Matsuzaki, F, Iida, K, Harada, F, ...
Two high molecular weight heat shock proteins, HSP90 (Mr, 90,000) and HSP100 (Mr, 100,000), were separately purified from extracts of cultured cells of a mouse lymphoma cell line, L5178Y. Both of the...
Requirement for the MAP kinase kinase/MAP kinase cascade in Xenopus oocyte maturation.
Kosako, H, Gotoh, Y, Nishida, E
MAP kinase kinase (MAPKK) has been identified as a protein factor that can induce phosphorylation and activation of inactive MAP kinase in vitro. In this study, we produced an anti-Xenopus MAPKK...
Involvement of the MAP kinase cascade in Xenopus mesoderm induction.
Gotoh, Y, Masuyama, N, Suzuki, A, Ueno, N, Nishida, E
Mitogen-activated protein kinase (MAPK) is activated by MAPK kinase (MAPKK) in a variety of signaling pathways. This kinase cascade has been shown to function in cell proliferation and...
cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates.
Kosako, H, Nishida, E, Gotoh, Y
A Xenopus 45 kDa protein has been identified as an immediate upstream factor sufficient for full activation of MAP kinase, and is shown to be capable of undergoing autophosphorylation on serine,...
Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF.
Gotoh, Y, Moriyama, K, Matsuda, S, Okumura, E, Kishimoto, T, Kawasaki, H, ...
MAP kinase is activated and phosphorylated during M phase of the Xenopus oocyte cell cycle, and induces the interphase-M phase transition of microtubule dynamics in vitro. We have carried out...
Matsuda, S, Kosako, H, Takenaka, K, Moriyama, K, Sakai, H, Akiyama, T, ...
MAP kinase is thought to play a pivotal role not only in the growth factor-stimulated signalling pathway but also in the M phase phosphorylation cascade downstream of MPF. MAP kinase is fully active...
Kosako, H, Gotoh, Y, Matsuda, S, Ishikawa, M, Nishida, E
Xenopus MAP kinase activator, a 45 kDa protein, has been shown to function as a direct upstream factor sufficient for full activation and both tyrosine and serine/threonine phosphorylation of...
Regulation of a major microtubule-associated protein by MPF and MAP kinase.
Shiina, N, Moriguchi, T, Ohta, K, Gotoh, Y, Nishida, E
The interphase-M phase transition of microtubule dynamics is thought to be induced by phosphorylation reactions mediated by MPF and by MAP kinase functioning downstream of MPF. We have now identified...
A novel homo-oligomeric protein responsible for an MPF-dependent microtubule-severing activity.
Shiina, N, Gotoh, Y, Nishida, E
An activity that severs stable microtubules has previously been detected in M phase extracts, but not in interphase extracts, of Xenopus eggs. We show that incubation of interphase extracts with...
Studies on the interaction between actin and cofilin purified by a new method.
Yonezawa, N, Nishida, E, Maekawa, S, Sakai, H
Cofilin is a 21,000-Mr actin-binding protein that widely exists in mammalian tissues. (1) A new purification procedure for porcine brain cofilin has been developed that involves (NH4)2SO4...
Fukuda, M, Gotoh, Y, Nishida, E
The mitogen-activated protein kinase (MAPK) cascade consisting of MAPK and its direct activator, MAPK kinase (MAPKK), is essential for signaling of various extracellular stimuli to the nucleus. Upon...
A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses.
Moriguchi, T, Toyoshima, F, Masuyama, N, Hanafusa, H, Gotoh, Y, Nishida, E
Stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK), a member of the MAP kinase (MAPK) superfamily, is thought to play a key role in a variety of cellular responses. To date,...
Role of TAK1 and TAB1 in BMP signaling in early Xenopus development.
Shibuya, H, Iwata, H, Masuyama, N, Gotoh, Y, Yamaguchi, K, Irie, K, ...
Transforming growth factor-beta (TGF-beta) superfamily members elicit signals through stimulation of serine/threonine kinase receptors. Recent studies of this signaling pathway have identified two...
Yoneyama, M, Suhara, W, Fukuhara, Y, Fukuda, M, Nishida, E, Fujita, T
It has been hypothesized that certain viral infections directly activate a transcription factor(s) which is responsible for the activation of genes encoding type I interferons (IFNs) and...
Wada, A, Fukuda, M, Mishima, M, Nishida, E
Actin is a highly conserved, ubiquitous cytoskeletal protein, which is essential for multiple cellular functions. Despite its small size (Mr = 42 000), unpolymerized forms of actin, as well as...
Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint.
Toyoshima, F, Moriguchi, T, Wada, A, Fukuda, M, Nishida, E
M-phase-promoting factor (MPF), a complex of cdc2 and a B-type cyclin, is a key regulator of the G2/M cell cycle transition. Cyclin B1 accumulates in the cytoplasm through S and G2 phases and...
Yamaguchi, K, Nagai, S, Ninomiya-Tsuji, J, Nishita, M, Tamai, K, Irie, K, ...
Signals elicited by transforming growth factor-beta (TGF-beta) superfamily ligands are generated following the formation of heteromeric receptor complexes consisting of type I and type II receptors....
Adachi, M, Fukuda, M, Nishida, E
In response to extracellular stimuli, mitogen-activated protein kinase (MAPK, also known as ERK) translocates from the cytoplasm to the nucleus. MAP kinase kinase (MAPKK, also know as MEK), which...