E. Ottinger

Cellular effects of phosphotyrosine-binding domain inhibitors on insulin receptor signaling and trafficking.

Giorgetti-Peraldi, S, Ottinger, E, Wolf, G, Ye, B, Burke, T R, Shoelson, S E

Shc and insulin receptor substrate 1 (IRS-1) are cytoplasmic substrates of tyrosine kinase receptors that engage, localize, and activate downstream SH2 enzymes. Each contains a...

Cellular effects of phosphotyrosine-binding domain inhibitors on insulin receptor signaling and trafficking.

Giorgetti-Peraldi, S, Ottinger, E, Wolf, G, Ye, B, Burke, T R, Shoelson, S E

Shc and insulin receptor substrate 1 (IRS-1) are cytoplasmic substrates of tyrosine kinase receptors that engage, localize, and activate downstream SH2 enzymes. Each contains a...