Scientific Commons: E. R. de Kloet

BACKGROUND: Controlled ovarian stimulation (COS) with urinary gonadotrophins but not recombinant gonadotrophins, adversely affect the implantation process. In this study, we investigated the effects...

Differential disinhibition of the neonatal hypothalamic-pituitary-adrenal axis in brain-specific CRH receptor 1-knockout mice (2006)

Schmidt, M. V., Deussing, J. M., Oitzl, M. S., Ohl, F., Levine, S., Wurst, W., ...

Metabolic signals modulate hypothalamic-pituitary-adrenal axis activation during maternal separation of the neonatal mouse (2006)

Schmidt, M. V., Levine, S., Alam, S., Harbich, D., Sterlemann, V., Ganea, K., ...

Stress, depression and hippocampal apoptosis (2006)

Lucassen, P.J., Heine, V.M., Muller, M.B., Wiegant, V.M., De Kloet, E.R., ...

In this review, we summarize and discuss recent studies on structural plasticity changes, particularly apoptosis, in the mammalian hippocampus in relation to stress and depression. Apoptosis...

Effects of urinary and recombinant gonadotrophins on gene expression profiles during the murine peri-implantation period (2006)

Sibug, R.M., Datson, N., Tijssen, A.M.I., Morsink, M., De Koning, J., De Kloet, E.R., ...

BACKGROUND: Controlled ovarian stimulation (COS) with urinary gonadotrophins but not recombinant gonadotrophins, adversely affect the implantation process. In this study, we investigated the effects...

Effects of urinary and recombinant gonadotrophins on gene expression profiles during the murine peri-implantation period (2006)

Sibug, R.M., Datson, N., Tijssen, A.M.I., Morsink, M., De Koning, J., De Kloet, E.R., ...

BACKGROUND: Controlled ovarian stimulation (COS) with urinary gonadotrophins but not recombinant gonadotrophins, adversely affect the implantation process. In this study, we investigated the effects...

Stress and the brain: From adaptation to disease (2005)

De Kloet, E. R., Joels, M., Holsboer, F.

Stress, genes and the mechanism of programming the brain for later life (2005)

De Kloet, E. R., Sibug, R. M., Helmerhorst, F. M., Schmidt, M. V.

Regulation of the developing hypothalamic-pituitary-adrenal axis in corticotropin releasing hormone receptor 1-deficient mice (vol 119, pg 589, 2003) (2005)

Schmidt, M. V., Oitzl, M. S., Müller, M. B., Ohl, F., Wurst, W., Holsboer, F., ...

Glucocorticoid receptor blockade disinhibits pituitary-adrenal activity during the stress hyporesponsive period of the mouse (2005)

Schmidt, M., Levine, S., Oitzl, M. S., Müller, M. B., Holsboer, F., ...

Urinary gonadotrophins but not recombinant gonadotrophins reduce expression of VEGF120 and its receptors flt-1 and flk-1 in the mouse uterus during the peri-implantation period (2005)

Sibug, R.M., De Koning, J., Tijssen, A.M.I., De Ruiter, M.C., De Kloet, E.R., Helmerhorst, F.M.

BACKGROUND: Ovarian stimulation in humans might affect the perinatal outcome and be considered as a stress factor in the implantation process. In this study we compared the effects of recombinant and...

Urinary gonadotrophins but not recombinant gonadotrophins reduce expression of VEGF120 and its receptors flt-1 and flk-1 in the mouse uterus during the peri-implantation period (2004)

Sibug, R.M., De Koning, J., Tijssen, A.M.I., De Ruiter, M.C., De Kloet, E.R., Helmerhorst, F.M.

BACKGROUND: Ovarian stimulation in humans might affect the perinatal outcome and be considered as a stress factor in the implantation process. In this study we compared the effects of recombinant and...

Regulation of the developing hypothalamic-pituitary-adrenal axis in corticotropin releasing hormone receptor 1-deficient mice (2003)

Schmidt, M., Oitzl, M. S., Müller, M. B., Ohl, F., Wurst, W., Holsboer, F., ...

Gonadotrophin stimulation reduces VEGF120 expression in the mouse uterus during the peri-implantation period (2002)

Sibug, R.M., Helmerhorst, F.M., Tijssen, A.M.I., De Kloet, E.R., De Koning, J.

BACKGROUND: Ovarian stimulation by gonadotrophin treatment exerts negative effects on implantation and embryonic development. We investigated whether gonadotrophin treatment affects VEGF120 mRNA...

Stress alleviates reduced expression of cell adhesion molecules (NCAM, L1), and deficits in learning and corticosterone regulation of apolipoprotein E knockout mice (2001)

Grootendorst, J., Oitzl, M. S., Dalm, S., Enthoven, L., Schachner, M., De Kloet, E. R., ...

Cell adhesion molecules (CAMs) involved in synaptic changes underlying learning and memory processes, are implicated in the effect of stress on behavioural performance. The present study was designed...

Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure. (2001)

Lucassen, P. J., Müller, M. B., Holsboer, F., Bauer, J., Holtrop, A., Wouda, J., ...

Cytokines and the brain corticosteroid receptor balance: Relevance to pathophysiology of neuroendocrine-immune communication (1994)

De Kloet, E. R., Oitzl, M. S., Schöbitz, B.

Cytokines in the healthy and diseased brain (1994)

Schöbitz, B., Holsboer, F., De Kloet, E. R.

Corticosterone modulates interleukin-evoked fever in the rat (1994)

Schöbitz, B., Holsboer, F., Sutano, W., Groß, G., Schönbaum, E., De Kloet, E. R.

Gene expression and function of interleukin 1, interleukin 6 and tumor necrosis factor in the brain (1994)

Schöbitz, B., De Kloet, E. R., Holsboer, F.

The role of the hypothalamic-pituitary-adrenocortical system during inflammatory conditions (1994)

Schöbitz, B., De Kloet, E. R., Holsboer, F.