Impact of race on the severity of acute episodes of asthma and adrenergic responsiveness. (2006)
El-Ekiaby, Amr, Brianas, Lori, Skowronski, Mary E., Coreno, Albert J., Galan, Gayle, Kaeberlein, Frank J., ...
RATIONALE: African Americans acutely ill with asthma come to emergency departments more frequently and are admitted to hospital more often than whites but the reasons are unclear. Objectives: To...
Airway cooling and rewarming. The second reaction sequence in exercise-induced asthma. (1992)
To determine if a relationship exists among the magnitude and rate of airway rewarming, and the severity of bronchial obstruction in thermally induced asthma, we had seven subjects perform three- to...
Productive infection of isolated human alveolar macrophages by respiratory syncytial virus. (1990)
Panuska, J R, Cirino, N M, Midulla, F, Despot, J E, McFadden, E R, Huang, Y T
Respiratory syncytial virus (RSV) is a significant cause of lower respiratory tract disease in children and individuals with cell-mediated immunodeficiencies. Airway epithelial cells may be infected...
Productive infection of isolated human alveolar macrophages by respiratory syncytial virus.
Panuska, J R, Cirino, N M, Midulla, F, Despot, J E, McFadden, E R, Huang, Y T
Respiratory syncytial virus (RSV) is a significant cause of lower respiratory tract disease in children and individuals with cell-mediated immunodeficiencies. Airway epithelial cells may be infected...
Acute effects of inhaled isoproterenol on the mechanical characteristics of the lungs in normal man
McFadden, E. R., Newton-Howes, Jan, Pride, N. B.
We investigated the effects of isoproterenol on the pulmonary mechanics of eight healthy male subjects. We measured the flow-volume, pressure-volume, resistance-volume, and pressure-flow...
McFadden, E R, Lenner, K A, Strohl, K P
To determine if postexercise thermal events play a role in exercise-induced asthma (EIA), nine normal and eight asthmatic subjects on three occasions exercised while they inhaled frigid air. During...
Airway cooling and rewarming. The second reaction sequence in exercise-induced asthma.
To determine if a relationship exists among the magnitude and rate of airway rewarming, and the severity of bronchial obstruction in thermally induced asthma, we had seven subjects perform three- to...
Direct recordings of the temperatures in the tracheobronchial tree in normal man.
McFadden, E R, Denison, D M, Waller, J F, Assoufi, B, Peacock, A, Sopwith, T
In an effect to determine how far inspired air could penetrate into the respiratory tract before being brought to body conditions, we measured the temperature in the airways of the anterior basilar...
Evaluation of Role Played by Mediators of Immediate Hypersensitivity in Exercise-induced Asthma
Deal, E. Chandler, Wasserman, Stephen I., Soter, Nicholas A., Ingram, R. H., McFadden, E. R.
To determine whether mediators of immediate hypersensitivity played a role in the pathogenesis of exercise-induced asthma, we measured the concentration of histamine and neutrophil-chemotactic...
A critical assessment of the mechanism by which hyperoxia attenuates exercise-induced asthma.
Resnick, A D, Deal, E C, Ingram, R H, McFadden, E R
Recent data demonstrate that the magnitude of the heat loss that occurs from the respiratory tract during exercise correlates with the degree of post-exertional obstruction that develops in...
Ingram, R H, Wellman, J J, McFadden, E R, Mead, J
Bronchodilatation was produced in normal subjects by the inhalation of atropine, a parasympatholytic agent, and isoproterenol, a beta adrenergic stimulator. Density dependence of maximal expiratory...
Strauss, R H, Ingram, R H, McFadden, E R
To evaluate the roles of circulating hydrogen ion and lactate in the production of exercise-induced asthma, two experiments were performed. In the first, we exercised six asthmatic subjects to...
Influence of heat and humidity on the airway obstruction induced by exercise in asthma.
Strauss, R H, McFadden, E R, Ingram, R H, Deal, E C, Jaeger, J J
We examined the degree of airway obstruction that developed in eight asthmatics who exercised while breathing air under four conditions: (a) ambient room temperature and water content; (b) body...
Intraairway thermal profiles during exercise and hyperventilation in normal man.
When large volumes of air are inhaled at rapid rates of ventilation, substantial segments of the tracheobronchial tree become involved in the conditioning process and the inspirate does not reach...
Productive infection of isolated human alveolar macrophages by respiratory syncytial virus.
Panuska, J R, Cirino, N M, Midulla, F, Despot, J E, McFadden, E R, Huang, Y T
Respiratory syncytial virus (RSV) is a significant cause of lower respiratory tract disease in children and individuals with cell-mediated immunodeficiencies. Airway epithelial cells may be infected...
Acute effects of inhaled isoproterenol on the mechanical characteristics of the lungs in normal man
McFadden, E. R., Newton-Howes, Jan, Pride, N. B.
We investigated the effects of isoproterenol on the pulmonary mechanics of eight healthy male subjects. We measured the flow-volume, pressure-volume, resistance-volume, and pressure-flow...
McFadden, E R, Lenner, K A, Strohl, K P
To determine if postexercise thermal events play a role in exercise-induced asthma (EIA), nine normal and eight asthmatic subjects on three occasions exercised while they inhaled frigid air. During...
Airway cooling and rewarming. The second reaction sequence in exercise-induced asthma.
To determine if a relationship exists among the magnitude and rate of airway rewarming, and the severity of bronchial obstruction in thermally induced asthma, we had seven subjects perform three- to...
Direct recordings of the temperatures in the tracheobronchial tree in normal man.
McFadden, E R, Denison, D M, Waller, J F, Assoufi, B, Peacock, A, Sopwith, T
In an effect to determine how far inspired air could penetrate into the respiratory tract before being brought to body conditions, we measured the temperature in the airways of the anterior basilar...
Evaluation of Role Played by Mediators of Immediate Hypersensitivity in Exercise-induced Asthma
Deal, E. Chandler, Wasserman, Stephen I., Soter, Nicholas A., Ingram, R. H., McFadden, E. R.
To determine whether mediators of immediate hypersensitivity played a role in the pathogenesis of exercise-induced asthma, we measured the concentration of histamine and neutrophil-chemotactic...
A critical assessment of the mechanism by which hyperoxia attenuates exercise-induced asthma.
Resnick, A D, Deal, E C, Ingram, R H, McFadden, E R
Recent data demonstrate that the magnitude of the heat loss that occurs from the respiratory tract during exercise correlates with the degree of post-exertional obstruction that develops in...
Ingram, R H, Wellman, J J, McFadden, E R, Mead, J
Bronchodilatation was produced in normal subjects by the inhalation of atropine, a parasympatholytic agent, and isoproterenol, a beta adrenergic stimulator. Density dependence of maximal expiratory...
Strauss, R H, Ingram, R H, McFadden, E R
To evaluate the roles of circulating hydrogen ion and lactate in the production of exercise-induced asthma, two experiments were performed. In the first, we exercised six asthmatic subjects to...
Influence of heat and humidity on the airway obstruction induced by exercise in asthma.
Strauss, R H, McFadden, E R, Ingram, R H, Deal, E C, Jaeger, J J
We examined the degree of airway obstruction that developed in eight asthmatics who exercised while breathing air under four conditions: (a) ambient room temperature and water content; (b) body...
Intraairway thermal profiles during exercise and hyperventilation in normal man.
When large volumes of air are inhaled at rapid rates of ventilation, substantial segments of the tracheobronchial tree become involved in the conditioning process and the inspirate does not reach...
Controlled-analysis of the effects of inhaled lignocaine in exercise-induced asthma.
Griffin, M P, McFadden, E R, Ingram, R H, Pardee, S
To determine whether anaesthesia of the intrathoracic airways would attenuate the development of exercise-induced asthma, we studied eight symptomless asthmatic patients by cycle ergometry after...
Bronchopleural fistula complicating massive pulmonary infarction
McFadden, E. R., Luparello, Frank
The clinical course of a patient who developed a lung abscess with a bronchopleural fistula following a massive infarction is described. Comparison of the events in this patient's illness with others...
Impact of Race on the Severity of Acute Episodes of Asthma and Adrenergic Responsiveness
El-Ekiaby, Amr, Brianas, Lori, Skowronski, Mary E., Coreno, Albert J., Galan, Gayle, Kaeberlein, Frank J., ...
Rationale: African Americans acutely ill with asthma come to emergency departments more frequently and are admitted to hospital more often than whites but the reasons are unclear.
Observations on the physiological interactions between obesity and asthma
Nicolacakis, Katina, Skowronski, Mary E., Coreno, Albert J., West, Erin, Nader, Nizar Z., Smith, Robert L., ...
To explore whether asthma and obesity share overlapping pathogenic features, we examined the impact of each alone, and in combination, on multiple aspects of lung function. We reasoned that if they...