Influence of genetic background on host resistance to experimental murine tularemia (1988)
Skamene, E., Kongshavn, P. A. L.
The response to experimental tularaemia was examined in inbred strains of mice. The kinetics of growth of Francisella tularensis live vaccine strain (LVS) in the livers and spleens of A and C57BL/6...
Morissette, C, Skamene, E, Gervais, F
The early endobronchial inflammation induced by Pseudomonas aeruginosa infection varies in resistant and susceptible strains of mice. Mice of the DBA/2 strain are severely afflicted by the infection,...
Gosselin, D, DeSanctis, J, Boulé, M, Skamene, E, Matouk, C, Radzioch, D
In the present study, we have investigated the mechanisms underlying mouse resistance to endobronchial infection with Pseudomonas aeruginosa enmeshed in agar beads. This was done by monitoring...
Govoni, G, Vidal, S, Gauthier, S, Skamene, E, Malo, D, Gros, P
The murine Bcg/Ity/Lsh locus determines the susceptibilities of inbred strains to infection with unrelated intracellular parasites, such as Mycobacterium bovis, Salmonella typhimurium, and Leishmania...
Hel, Z, Skamene, E, Radzioch, D
The production of tumor necrosis factor alpha (TNF-alpha), a key proinflammatory cytokine essential for the function of the immune system, is regulated at both the transcriptional and...
Yoshida, S, Goto, Y, Mizuguchi, Y, Nomoto, K, Skamene, E
It is known that Legionella pneumophila proliferates in peritoneal macrophage cultures derived from A/J mice but not in macrophage cultures derived from many other strains, including C57BL/6 mice. To...
Regulation of Mycobacterium bovis BCG and foreign body granulomas in mice by the Bcg gene.
Sato, I Y, Kobayashi, K, Kasama, T, Kaga, S, Kasahara, K, Kanemitsu, H, ...
Natural bactericidal resistance to Mycobacterium bovis BCG is under the control of a single gene, designated Bcg. Lung granuloma formation in susceptible (Bcgs) and resistant (Bcgr) mice was studied...
Influence of genetic background on host resistance to experimental murine tularemia.
Anthony, L S, Skamene, E, Kongshavn, P A
The host response to experimental murine tularemia was examined in different inbred mouse strains. The kinetics of growth of Francisella tularensis live vaccine strain (LVS) in the livers and spleens...
Gervais, F, Morris-Hooke, A, Tran, T A, Skamene, E
Innate resistance to infection by Listeria monocytogenes is genetically controlled and is critically dependent on prompt macrophage recruitment to the sites of infection. Experiments reported here...
The in vivo primary antibody response to sheep erythrocytes (SRBC) was determined in genetically resistant C57BL/6 and susceptible A/J mice during the course of infection with Plasmodium chabaudi....
Serum amyloid P-component-induced enhancement of macrophage listericidal activity.
Singh, P P, Gervais, F, Skamene, E, Mortensen, R F
Purified serum amyloid P component (SAP), the major acute-phase reactant of mice, augmented the in vitro listericidal activity of inflammatory (elicited) macrophages, bone marrow-derived monocytes,...
Pelletier, M, Forget, A, Bourassa, D, Skamene, E
At 4 to 6 weeks after intravenous infection with 2 X 10(4) CFU of dispersed Mycobacterium bovis bacilli (BCG), C3H/HeNCrIBR and C57BL/6NCrIBR mice exhibited a strong reaction to purified protein...
Denis, M, Forget, A, Miailhe, A C, Pelletier, M, Skamene, E
In mice, the early host response to intravenous infection with small doses of dispersed Mycobacterium bovis BCG is controlled by the Bcg gene. After infection with a low dose of M. bovis BCG, Lyt-1+...
Murine malaria: resistance of AXB/BXA recombinant inbred mice to Plasmodium chabaudi.
The level of resistance to infection with Plasmodium chabaudi is genetically controlled. We have previously reported that a single dominant gene is responsible for the variation in host resistance to...
Susceptibility and resistance of inbred mice to Giardia muris.
Belosevic, M, Faubert, G M, Skamene, E, MacLean, J D
The susceptibility and resistance of inbred mice to Giardia muris was studied during the acute and elimination phases of infection. The infection in susceptible A/J and C3H/He mice was characterized...
De Chastellier, C, Fréhel, C, Offredo, C, Skamene, E
The ability of the host to resist infection to a variety of intracellular pathogens, including mycobacteria, is strongly dependent upon the expression of the Bcg gene. Mouse strains which express the...
Ulczak, O M, Ghadirian, E, Skamene, E, Blackwell, J M, Kongshavn, P A
The response to reinfection with Ethiopian Leishmania donovani was evaluated in genetically determined noncure (H-2d) B10.D2 mice that are able to resolve infection due to sublethal irradiation...
Murine malaria: genetic control of resistance to Plasmodium chabaudi.
Stevenson, M M, Lyanga, J J, Skamene, E
Strain variation in the level of resistance to malaria was investigated in inbred strains of mice after infection with Plasmodium chabaudi. When infected intraperitoneally with 10(6) P....
Potter, M, O'Brien, A D, Skamene, E, Gros, P, Forget, A, Kongshavn, P A, ...
BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b congenic mice were developed by introgressively backcrossing the Idh-1b and Pep-3b markers of DBA/2 mice onto the BALB/c pi mice. This introduced a 30-centimorgan...
Measurement of 5′-Nucleotidase in Mouse Peritoneal Macrophages in Listeriosis
Pietrangeli, C. E., Skamene, E., Edelson, P. J., Kongshavn, P. A. L.
5′-Nucleotidase activity in peritoneal macrophages of mice was measured both before and after infection with Listeria monocytogenes in hosts which possessed high or low anti-listerial resistance...
Phenotypic expression of genetically controlled host resistance to Listeria monocytogenes.
Several inbred mouse strains, all of them derived from the C57BL background, have genetically determined increased resistance to infection with Listeria monocytogenes, whereas a variety of other...
Sadarangani, C, Skamene, E, Kongshavn, P A
The characteristics of the mononuclear phagocytes mediating resistance to infection with Listeria during the early phase (0 to 48 h) of the response have been investigated in genetically determined...
Bruisten, S. M., Skamene, E., Demant, P.
The influence of non-H-2 linked genes on the plasma levels of the H-2 S-region encoded proteins C4, Slp, and factor B was tested in Recombinant Inbred (RI) strains. The A X B and B X A RI strains...
Morissette, C, Skamene, E, Gervais, F
The early endobronchial inflammation induced by Pseudomonas aeruginosa infection varies in resistant and susceptible strains of mice. Mice of the DBA/2 strain are severely afflicted by the infection,...
Gosselin, D, DeSanctis, J, Boulé, M, Skamene, E, Matouk, C, Radzioch, D
In the present study, we have investigated the mechanisms underlying mouse resistance to endobronchial infection with Pseudomonas aeruginosa enmeshed in agar beads. This was done by monitoring...
Govoni, G, Vidal, S, Gauthier, S, Skamene, E, Malo, D, Gros, P
The murine Bcg/Ity/Lsh locus determines the susceptibilities of inbred strains to infection with unrelated intracellular parasites, such as Mycobacterium bovis, Salmonella typhimurium, and Leishmania...
Hel, Z, Skamene, E, Radzioch, D
The production of tumor necrosis factor alpha (TNF-alpha), a key proinflammatory cytokine essential for the function of the immune system, is regulated at both the transcriptional and...
Yoshida, S, Goto, Y, Mizuguchi, Y, Nomoto, K, Skamene, E
It is known that Legionella pneumophila proliferates in peritoneal macrophage cultures derived from A/J mice but not in macrophage cultures derived from many other strains, including C57BL/6 mice. To...
Regulation of Mycobacterium bovis BCG and foreign body granulomas in mice by the Bcg gene.
Sato, I Y, Kobayashi, K, Kasama, T, Kaga, S, Kasahara, K, Kanemitsu, H, ...
Natural bactericidal resistance to Mycobacterium bovis BCG is under the control of a single gene, designated Bcg. Lung granuloma formation in susceptible (Bcgs) and resistant (Bcgr) mice was studied...
Influence of genetic background on host resistance to experimental murine tularemia.
Anthony, L S, Skamene, E, Kongshavn, P A
The host response to experimental murine tularemia was examined in different inbred mouse strains. The kinetics of growth of Francisella tularensis live vaccine strain (LVS) in the livers and spleens...
Gervais, F, Morris-Hooke, A, Tran, T A, Skamene, E
Innate resistance to infection by Listeria monocytogenes is genetically controlled and is critically dependent on prompt macrophage recruitment to the sites of infection. Experiments reported here...
The in vivo primary antibody response to sheep erythrocytes (SRBC) was determined in genetically resistant C57BL/6 and susceptible A/J mice during the course of infection with Plasmodium chabaudi....
Serum amyloid P-component-induced enhancement of macrophage listericidal activity.
Singh, P P, Gervais, F, Skamene, E, Mortensen, R F
Purified serum amyloid P component (SAP), the major acute-phase reactant of mice, augmented the in vitro listericidal activity of inflammatory (elicited) macrophages, bone marrow-derived monocytes,...
Pelletier, M, Forget, A, Bourassa, D, Skamene, E
At 4 to 6 weeks after intravenous infection with 2 X 10(4) CFU of dispersed Mycobacterium bovis bacilli (BCG), C3H/HeNCrIBR and C57BL/6NCrIBR mice exhibited a strong reaction to purified protein...
Denis, M, Forget, A, Miailhe, A C, Pelletier, M, Skamene, E
In mice, the early host response to intravenous infection with small doses of dispersed Mycobacterium bovis BCG is controlled by the Bcg gene. After infection with a low dose of M. bovis BCG, Lyt-1+...
Murine malaria: resistance of AXB/BXA recombinant inbred mice to Plasmodium chabaudi.
The level of resistance to infection with Plasmodium chabaudi is genetically controlled. We have previously reported that a single dominant gene is responsible for the variation in host resistance to...
Susceptibility and resistance of inbred mice to Giardia muris.
Belosevic, M, Faubert, G M, Skamene, E, MacLean, J D
The susceptibility and resistance of inbred mice to Giardia muris was studied during the acute and elimination phases of infection. The infection in susceptible A/J and C3H/He mice was characterized...
De Chastellier, C, Fréhel, C, Offredo, C, Skamene, E
The ability of the host to resist infection to a variety of intracellular pathogens, including mycobacteria, is strongly dependent upon the expression of the Bcg gene. Mouse strains which express the...
Ulczak, O M, Ghadirian, E, Skamene, E, Blackwell, J M, Kongshavn, P A
The response to reinfection with Ethiopian Leishmania donovani was evaluated in genetically determined noncure (H-2d) B10.D2 mice that are able to resolve infection due to sublethal irradiation...
Murine malaria: genetic control of resistance to Plasmodium chabaudi.
Stevenson, M M, Lyanga, J J, Skamene, E
Strain variation in the level of resistance to malaria was investigated in inbred strains of mice after infection with Plasmodium chabaudi. When infected intraperitoneally with 10(6) P....
Potter, M, O'Brien, A D, Skamene, E, Gros, P, Forget, A, Kongshavn, P A, ...
BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b congenic mice were developed by introgressively backcrossing the Idh-1b and Pep-3b markers of DBA/2 mice onto the BALB/c pi mice. This introduced a 30-centimorgan...
Measurement of 5′-Nucleotidase in Mouse Peritoneal Macrophages in Listeriosis
Pietrangeli, C. E., Skamene, E., Edelson, P. J., Kongshavn, P. A. L.
5′-Nucleotidase activity in peritoneal macrophages of mice was measured both before and after infection with Listeria monocytogenes in hosts which possessed high or low anti-listerial resistance...
Phenotypic expression of genetically controlled host resistance to Listeria monocytogenes.
Several inbred mouse strains, all of them derived from the C57BL background, have genetically determined increased resistance to infection with Listeria monocytogenes, whereas a variety of other...
Sadarangani, C, Skamene, E, Kongshavn, P A
The characteristics of the mononuclear phagocytes mediating resistance to infection with Listeria during the early phase (0 to 48 h) of the response have been investigated in genetically determined...
Bruisten, S. M., Skamene, E., Demant, P.
The influence of non-H-2 linked genes on the plasma levels of the H-2 S-region encoded proteins C4, Slp, and factor B was tested in Recombinant Inbred (RI) strains. The A X B and B X A RI strains...
Barrera, L F, Kramnik, I, Skamene, E, Radzioch, D
Reactive nitrogen intermediates (RNI) have been implicated in the interferon-gamma (IFN-gamma)-induced anti-microbial action of macrophages against a wide variety of pathogens. We have been studying...
Chung, S, Gorczynski, R, Cruz, B, Fingerote, R, Skamene, E, Perlman, S, ...
Induction of immune coagulants has been implicated in the pathogenesis of murine hepatitis virus strain 3 (MHV-3)-induced fulminant hepatic necrosis. Previous work from our laboratory has shown that...
Kramnik, I, Radzioch, D, Skamene, E
The Bcg gene has been shown to control natural resistance of mice to intravenous infection with low doses of Mycobacterium bovis (bacillus Calmette-Guérin; BCG). In the present study, we evaluated...
Enhanced primary resistance to Listeria monocytogens in T cell-deprived mice
Chan, Carol, Kongshavn, Patricia A. L., Skamene, E.
The present studies reinvestigate the role of the T cell in the development of resistance to Listeria monocytogenes. Doubly thymus-deprived adult thymectomized irradiated bone marrow-reconstituted...
Enhanced resistance to Listeria monocytogenes in splenectomized mice.
Skamene, E, Chayasirisobhon, W
Mice infected with live Listeria monocytogenes intravenously from 1 week to 3 months following splenectomy exhibit greatly enhanced antibacterial resistance to this micro-organism as compared to...
Iványi, J., Marvanova, Helena, Skamene, E.
It was found in bursectomized chickens that selective inhibition of IgM or IgG immunoglobulin synthesis occurs with equal frequency. Alterations in the immunoelectrophoretic pattern of...
Sírová, M, Hovorka, O, Ríha, I, Ríhová, B, Baudys, M, Kim, S W, ...
The mouse Nramp1 (Bcg) gene on chromosome 1 exerts pleiotropic effects on macrophage function. The gene is known to affect presentation of mycobacteria, and other antigens in vitro, so that...
Increased phagocytic activity of splenectomized mice challenged with Listeria monocytogenes.
Skamene, E, Chayasirisobhon, W, Konshavn, P A
Adult splenectomized mice exhibit increased resistance to infection with Listeria monocytogenes. Phagocytosis, by reticulo-endothelial cells, of test particles (51Cr-labelled sheep erythrocytes) is...
Stevenson, M M, Kondratieva, T K, Apt, A S, Tam, M F, Skamene, E
In vitro and in vivo T cell responses were determined during the course of bronchopulmonary infection with mucoid Pseudomonas aeruginosa. T cell responses were compared in two inbred mouse strains,...
Apt, A S, Avdienko, V G, Nikonenko, B V, Kramnik, I B, Moroz, A M, Skamene, E
We have studied the impact of distinct haplotypes and of different alleles at specific H-2 loci on: (i) the susceptibility to lethal form of experimental tuberculosis; (ii) the level of DTH to...
Denis, M, Forget, A, Skamene, E
A murine monoclonal antibody to Mycobacterium bovis (BCG) (230A4A6) was used to identify an antigenic determinant expressed at the surface of murine peritoneal macrophages infected in vitro. This...
Goodpasture's syndrome--effects of plasmapheresis.
Two patients with Goodpasture's syndrome, who underwent plasmapheresis are presented. One patient received prednisone but the other patient received no concomitant cytotoxic therapy. Results indicate...
Pleiotropic effects of the Bcg gene: III. Respiratory burst in Bcg-congenic macrophages.
Denis, M, Forget, A, Pelletier, M, Skamene, E
Macrophage respiratory burst, as assessed by H2O2 and O2- production, and HMS and chemiluminescence activity was investigated in a variety of conditions in macrophages from Bcg-congenic mice....
Oswald, I P, Lantier, F, Moutier, R, Bertrand, M F, Skamene, E
The aim of the present study was to determine whether the Ity gene, which controls the resistance to S. typhimurium infection in mice, also governs the resistance to S. abortusovis, a serotype...
Bourassa, D, Forget, A, Pelletier, M, Skamene, E, Turcotte, R
Congenic Bcgr (C.D2, resistant) and Bcgs (BALB/c, susceptible) mice were infected intravenously with Mycobacterium bovis (BCG, strain Montreal) in order to establish the relationship between...
Denis, M, Forget, A, Pelletier, M, Turcotte, R, Skamene, E
The effect of the Bcg gene on the early host response to intravenous infection with a variety of BCG substrains and some atypical mycobacteria was investigated. The numbers of live bacilli of BCG...
A quantitative study of the binding of ALS to various cell types
The fraction of antibody which bound to the lymphocyte surface, was determined in the [125I]IgG preparations of rabbit-anti-mouse ALS prepared by different immunization protocols. This fraction...
LIPES, J, SKAMENE, E, NEWKIRK, M M
In previous studies we have established a link between cytomegalovirus (CMV) infection and an autoimmune response to the U1–70 k protein of the spliceosome in man. This autoimmune response,...
Newkirk, M M, Nowak, U, Skamene, E, Iera, D, Desbarats, J
Liver disease can be associated with a breakdown in self-tolerance and the production of autoantibodies such as rheumatoid factors (RF), which bind to IgG. Here we investigated whether primary,...
Rheumatoid factor induction in murine models of liver injury
Nowak, U, Gill, K, Skamene, E, Newkirk, M M
Alcoholic liver disease and hepatitis C are associated with the production of autoantibodies such as rheumatoid factors (RF), which bind to IgG and can aid in host defence, but are also associated...
Comparative genomics and host resistance against infectious diseases.
Qureshi, S. T., Skamene, E., Malo, D.
The large size and complexity of the human genome have limited the identification and functional characterization of components of the innate immune system that play a critical role in front-line...